Country:China (Mainland)
Year Established: 2009Business type: Other
Integral:
Tigecycline, with the trade name of Tygacil, has its chemical name of (4S,4aS,5aR,12aS)-9-[2-(tert-butylamino)acetamido]-4,7-bis(dimethylamino)-l,4,4a,5,5a,6,11,12a-octahydro-3,10,12,12a-tetrahydroxy-l,ll-dioxo-2-naphthacenecarboxamide. With its chemical formula of C29H39N5O8 and molecular weight of 585.65, tigecycline (tygacil) is a tetracycline derivative (a glycylcycline) for intravenous infusion.
Molecular modelling of tigecycline:
1. molar refraction:151.25
2. molar volume;(m3/mol): 402.5
3. parachor(90.2K): 1203.9
4. surface tension(dyne/cm): 80.0
5. polarizability(10-24cm3): 59.96
The side effects of tigecycline is mostly presented as Hives, Diarrhea, Severe headache, Nausea, and Vaginal itching or discharge. When comes to its storage, it should be kept at room temperature between 15-30 C (59-86 F).
As to the usage of tygacil, it could function in many ways. This medicine could be applied to treat the omplicated skin infections caused by susceptible strains of bacteria including Streptococcus anginosus group, Bacteroides fragilis and so on; It could also be use in the treatment of complicated intra-abdominal infections caused by susceptible strains; Tygacil could then be used in the application of treating community-acquired bacterial pneumonia. In addition, it may have potential in the usage in acute myeloid leukaemia.
Accompanied with the occurrence of rampant bacterial infections and bacterial resistance, tygacil is very urgent to research on some new drugs. And some industries are devoted in the research of new drugs, such as Hangzhou Holypharm biotech Co.,Ltd, which is professional supplier of active pharmaceutical ingredients and intermediates; agrochemicals and Veterinary products.
FDA approved new indication for TYGACIL (tigecycline) for the treatment of adult patients with Community-Acquired Bacterial Pneumonia on June 17, 2005
Velcade(bortezomib)is a chemotherapy drug used to treat certain cancers, including myeloma and lymphoma. This drug is thought to inhibit many proteins (known as proteasomes) that cancer cells need to survive and multiply.
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