(S)-(-)-2-Methyl-2-Propanesulfinamide supplier

Name
(S)-(-)-2-Methyl-2-Propanesulfinamide
EINECS 640-158-3
CAS No. 343338-28-3
Article Data10
CAS DataBase
Density 1.124 g/cm³
Solubility
Melting Point 97-101 °C(lit.)
Formula C₃H₁₁CNOS
Boiling Point 220 °C at 760 mmHg
Molecular Weight 121.203
Flash Point 86.8 °C
Transport Information
Appearance white to light yellow crystal powder
Safety 16-26-36/37-24/25
Risk Codes 11-19-36/37-40
Molecular Structure
Hazard Symbols Xi
Synonyms 2-Propanesulfinamide,2-methyl-, [S(S)]-;(S)-(-)-tert-Butyl sulfinamide;(S)-2-Methyl-2-propanesulfinamide;(S)-tert-Butanesulfinamide;(S)-tert-Butylsulfinamide;
PSA 62.30000
LogP 1.97330

Synthetic route

: 861821-86-5
2-Methyl-propane-2-sulfinic acid (1R,2S)-1-(2,4,6-trimethyl-benzenesulfonylamino)-indan-2-yl ester

: 343338-28-3
(S)-2-methylpropane-2-sulfinamide

Conditions

Conditions	Yield
With lithium amide; ammonia In tetrahydrofuran at -78℃;	90%

: 594836-47-2
2-Methyl-propane-2-sulfinic acid (1R,2S)-1-phenyl-2-(toluene-4-sulfonylamino)-propyl ester

A: 108591-33-9
N-((1R,2S)-1-hydroxy-1-phenylpropan-2-yl)-4-methylbenzene sulfonamide

B: 343338-28-3
(S)-2-methylpropane-2-sulfinamide

Conditions

Conditions	Yield
With ammonia; lithium; ferric nitrate In tetrahydrofuran at -78 - -45℃;	A n/a B 90%

: (SS)-((1R,2S)-N-methylephedrine) tert-butanesulfinate

: 343338-28-3
(S)-2-methylpropane-2-sulfinamide

Conditions

Conditions	Yield
With Iron(III) nitrate nonahydrate; lithium amide; ammonia In tetrahydrofuran at -78 - -45℃; for 1.33333h; optical yield given as %ee;	84%

: (S)-tert-butylsulfinyl hydrazide

: 343338-28-3
(S)-2-methylpropane-2-sulfinamide

Conditions

Conditions	Yield
With acetic acid; zinc In dichloromethane at 35 - 42℃; for 16h; Green chemistry;	76%
With acetic acid; zinc In dichloromethane at 35 - 42℃; for 16h;	76%
With acetic acid; zinc In dichloromethane at 35 - 42℃; for 16h;	76%

: 60011-16-7
(SS)-(+)-tert-butyl tert-butanethiosulfinate

: 343338-28-3
(S)-2-methylpropane-2-sulfinamide

Conditions

Conditions	Yield
With ammonia; n-hexyllithium at -60 - 0℃; for 1h;	75%

: 110-06-5
di-tert-butyl disulfide

: 343338-28-3
(S)-2-methylpropane-2-sulfinamide

Conditions

Conditions	Yield
Stage #1: di-tert-butyl disulfide With bis(acetylacetonate)oxovanadium; (1R,2S)-1-[(3,5-di-tert-butyl-2-hydroxybenzylidene)amino]-2-indanol; dihydrogen peroxide In acetone at 0℃; Stage #2: With ammonia; lithium; ferric nitrate In tetrahydrofuran at -78℃;	60%

: 446021-65-4
2-Methyl-propane-2-sulfinic acid (1R,2S)-1-(2,4,6-trimethyl-benzenesulfonylamino)-indan-2-yl ester

: 343338-28-3
(S)-2-methylpropane-2-sulfinamide

Conditions

Conditions	Yield
With lithium amide; ammonia In tetrahydrofuran at -78℃;

: phenyl 2-methylpropane-2-sulfinate

A: 196929-78-9
(R)-2-methylpropane-2-sulfinamide

B: 343338-28-3
(S)-2-methylpropane-2-sulfinamide

C: 108-95-2
phenol

Conditions

Conditions	Yield
With lithium hexamethyldisilazane In tetrahydrofuran at 0 - 20℃; for 1.5h; Inert atmosphere;	A n/a B n/a C n/a

...Expand

: 4-chloro-2-((S)-1-((4-methylphenyl)sulfonamido)ethyl)phenyl (S)-2-methylpropane-2-sulfinate

: 343338-28-3
(S)-2-methylpropane-2-sulfinamide

Conditions

Conditions	Yield
With lithium hexamethyldisilazane In tetrahydrofuran at -10 - -5℃; Large scale; Green chemistry;

: 123-72-8
butyraldehyde

: 343338-28-3
(S)-2-methylpropane-2-sulfinamide

: 849404-66-6
[N(E),S(S)]-2-methyl-N-(butylidene)-2-propanesulfinamide

Conditions

Conditions	Yield
With titanium(IV) tetraethanolate In dichloromethane for 3h;	100%
With copper(II) sulfate In dichloromethane for 20h;	92%
With pyridinium p-toluenesulfonate; magnesium sulfate In dichloromethane at 20℃; for 20h;	85%

: 1121-60-4
pyridine-2-carbaldehyde

: 343338-28-3
(S)-2-methylpropane-2-sulfinamide

: (S)-(E)-2-methyl-N-(pyridin-2-ylmethylene)propane-2-sulfinamide

Conditions

Conditions	Yield
With caesium carbonate In dichloromethane at 20℃; for 12h;	100%
With potassium hydrogensulfate In toluene at 45℃;	95%
With phosphotungstic acid In toluene for 3h; Inert atmosphere; Green chemistry;	93%
With copper(II) sulfate In dichloromethane at 50℃; for 16h;	61%
With titanium(IV) tetraethanolate In neat (no solvent) at 70℃; for 0.166667 - 0.25h; Inert atmosphere; Sealed tube; Microwave irradiation;	41%

: 851753-43-0
4-(2-fluoro-6-formyl-phenyl)-piperazine-1-carboxylic acid tert-butyl ester

: 343338-28-3
(S)-2-methylpropane-2-sulfinamide

: 869478-18-2
4-{2-fluoro-6-[((SS)-2-methyl-propane-2-sulfinylimino)-methyl]-phenyl}-piperazine-1-carboxylic acid tert-butyl ester

Conditions

Conditions	Yield
With titanium(IV) tetraethanolate In tetrahydrofuran; ethanol at 20℃; for 16h;	100%
With titanium(IV) tetraethanolate
With titanium(IV) tetraethanolate In tetrahydrofuran; ethanol at 20℃;

: 626219-95-2
4-(2-formyl-4-(trifluoromethyl)phenyl)piperazine-1-carboxylic acid tert-butyl ester

: 343338-28-3
(S)-2-methylpropane-2-sulfinamide

: 869478-23-9
4-{2-[((SS)-2-methyl-propane-2-sulfinylimino)-methyl]-4-trifluoromethyl-phenyl}-piperazine-1-carboxylic acid tert-butyl ester

Conditions

Conditions	Yield
With titanium(IV) tetraethanolate In tetrahydrofuran; ethanol at 20℃; for 16h;	100%
With titanium(IV) tetraethanolate In tetrahydrofuran; ethanol at 20℃;	99%
With titanium(IV) tetraethanolate In tetrahydrofuran at 20℃;
With titanium(IV) tetraethanolate In tetrahydrofuran; ethanol at 20℃;

: 179556-15-1
2-(4-tert-butoxycarbonyl-1-piperazinyl)-3-formylpyridine

: 343338-28-3
(S)-2-methylpropane-2-sulfinamide

: 2-(4-Boc-piperazinyl)-3-(S-tert-butylsulfinyliminomethylidene)pyridine

Conditions

Conditions	Yield
With titanium(IV) tetraethanolate In tetrahydrofuran at 20℃; for 8h;	100%

: 934346-19-7
5-bromothiazole-4-carboxaldehyde

: 343338-28-3
(S)-2-methylpropane-2-sulfinamide

: C8H11BrN2OS2

Conditions

Conditions	Yield
With titanium(IV) tetraethanolate at 20℃;	100%

: 960234-41-7
2-(cyclopropylthio)-5-nitrobenzaldehyde

: 343338-28-3
(S)-2-methylpropane-2-sulfinamide

: 960234-69-9
(S,E)-N-(2-(cyclopropylthio)-5-nitrobenzylidene)-2-methylpropane-2-sulfinamide

Conditions

Conditions	Yield
With titanium(IV) tetraethanolate In dichloromethane at 73℃; for 6h;	100%
With titanium(IV) tetraethanolate In dichloromethane at 73℃; for 6h;	100%

: (3aS,6S,6aS)-2,2-dimethyl-6-vinyltetrahydrofuro[3,4-d][1,3]dioxol-4-ol

: 343338-28-3
(S)-2-methylpropane-2-sulfinamide

: 1359756-28-7
(S)-N-((3aS,4R,6S,6aS)-2,2-dimethyl-6-vinyl-tetrahydrofuro[3,4-d][1,3]dioxol-4-yl)-2-methylpropane-2-sulfinamide

Conditions

Conditions	Yield
With caesium carbonate In dichloromethane for 3h; Reflux; Inert atmosphere; stereospecific reaction;	100%

: 31224-43-8
3-fluoropyridine-2-carbaldehyde

: 343338-28-3
(S)-2-methylpropane-2-sulfinamide

: 1416800-04-8
(S,E)-N-((3-fluoropyridin-2-yl)methylene)-2-methylpropane-2-sulfinamide

Conditions

Conditions	Yield
With copper(II) sulfate In dichloromethane at 20℃; for 3h;	100%
With copper(II) sulfate In dichloromethane at 20℃; for 3h;
copper(II) sulfate In dichloromethane at 20℃; for 3h;

: 343338-28-3
(S)-2-methylpropane-2-sulfinamide

: 190011-87-1
1-(3-chloro-2,6-difluoro-phenyl)-carboxaldehyde

: 1422510-32-4
(S,E)-N-(3-chloro-2,6-difluorobenzylidene)-2-methylpropane-2-sulfinamide

Conditions

Conditions	Yield
With caesium carbonate In dichloromethane at 20℃;	100%

: 206181-90-0
3-chloro-2-pyridinecarboxaldehyde

: 343338-28-3
(S)-2-methylpropane-2-sulfinamide

: (S)-N-((1E)-(3-chloro-2-pyridinyl)methylidene)-2-methyl-2-propanesulfinamide

Conditions

Conditions	Yield
With caesium carbonate In dichloromethane at 20℃; for 12h;	100%
With copper(II) sulfate In dichloromethane at 20℃; for 2h;	2.5 g

: (4-fluorophenyl)(2-(4-(6-(1-methyl-1H-pyrazol-4-yl)pyrrolo[2,1-f][1,2,4]triazin-4-yl)piperazin-1-yl)pyrimidin-5-yl)methanone

: 343338-28-3
(S)-2-methylpropane-2-sulfinamide

: (S,Z)-N-((4-fluorophenyl)(2-(4-(6-(1-methyl-1H-pyrazol-4-yl)pyrrolo[2,1-f][1,2,4]triazin-4-yl)piperazin-1-yl)pyrimidin-5-yl)methylene)-2-methylpropane-2-sulfinamide

Conditions

Conditions	Yield
With ethyl orthotitanate In tetrahydrofuran at 70℃; for 18h;	100%

: 54087-03-5
6-chloropyridine-2-carboxaldehyde

: 343338-28-3
(S)-2-methylpropane-2-sulfinamide

: (S)-N-[(1E)-(6-chloropyridin-2-yl)methylidene]-2-methylpropane-2-sulfinamide

Conditions

Conditions	Yield
With caesium carbonate In dichloromethane at 20℃; for 17h;	100%
With caesium carbonate In dichloromethane at 20℃; for 17h;	3.58 g

: C16H22O5

: 343338-28-3
(S)-2-methylpropane-2-sulfinamide

: C20H31NO5S

Conditions

Conditions	Yield
With pyridinium p-toluenesulfonate; magnesium sulfate In toluene at 40℃; for 5h;	100%

: allyl-N-methyl-N-(3-oxopropyl)carbamate

: 343338-28-3
(S)-2-methylpropane-2-sulfinamide

: (E)-allyl (3-((tert-butylsulfinyl)imino)propyl)(methyl)carbamate

Conditions

Conditions	Yield
With pyridinium p-toluenesulfonate; magnesium sulfate In dichloromethane at 20℃;	100%

: 65873-72-5
6-methoxy-3-pyridinecarboxaldehyde

: 343338-28-3
(S)-2-methylpropane-2-sulfinamide

: (E)-N-((6-methoxypyridin-3-yl)methylene)-2-methylpropane-2-sulfinamide

Conditions

Conditions	Yield
With titanium(IV) tetraethanolate In tetrahydrofuran at 80℃; for 15h; Inert atmosphere;	100%

: 459-57-4
4-fluorobenzaldehyde

: 343338-28-3
(S)-2-methylpropane-2-sulfinamide

: (S,E)-N-(4-fluorobenzylidene)-2-methylpropane-2-sulfinamide

Conditions

Conditions	Yield
With titanium (IV) ethoxide at 60℃; for 12h;	100%
Stage #1: 4-fluorobenzaldehyde With titanium(IV) isopropylate In tetrahydrofuran at 20℃; for 0.166667h; Inert atmosphere; Stage #2: (S)-2-methylpropane-2-sulfinamide In tetrahydrofuran at 20℃; Inert atmosphere;

: 1260878-78-1
4-chloro-3-fluoro-2-formylpyridine

: 343338-28-3
(S)-2-methylpropane-2-sulfinamide

: (S)-N-((4-chloro-3-fluoropyridin-2-yl)methylene)-2-methylpropane-2-sulfinamide

Conditions

Conditions	Yield
With caesium carbonate In dichloromethane at 20℃; for 1h;	100%
With caesium carbonate In dichloromethane at 20℃; for 1h;

: 31181-89-2
5-chloro-2-pyridine carboxaldehyde

: 343338-28-3
(S)-2-methylpropane-2-sulfinamide

: (S,E)-N-((5-chloropyridin-2-yl)methylene)-2-methylpropane-2-sulfinamide

Conditions

Conditions	Yield
With caesium carbonate In dichloromethane at 40℃; for 12h;	100%
With titanium(IV) tetraethanolate In neat (no solvent) at 70℃; for 0.166667 - 0.25h; Inert atmosphere; Sealed tube; Microwave irradiation;	54%

: C12H13BrO2

: 343338-28-3
(S)-2-methylpropane-2-sulfinamide

: C16H22BrNO2S

Conditions

Conditions	Yield
With titanium(IV) tetraethanolate at 20℃;	100%

: C12H13BrO3

: 343338-28-3
(S)-2-methylpropane-2-sulfinamide

: C16H22BrNO2S

Conditions

Conditions	Yield
With titanium(IV) tetraethanolate at 20℃;	100%

: 5-(2,3-dichlorophenyl)-6-methyl-2-{3-oxo-3H-spiro[1-benzofuran-2,4'-piperidin]-1'-yl}pyrimidine-4-carbonitrile

: 343338-28-3
(S)-2-methylpropane-2-sulfinamide

: (S)-N-((E)-1'-(4-cyano-5-(2,3-dichlorophenyl)-6-methylpyrimidin-2-yl)-3H-spiro[benzofuran-2,4'-piperidin]-3-ylidene)-2-methylpropane-2-sulfinamide

Conditions

Conditions	Yield
With titanium(IV) tetraethanolate at 90℃; for 4h;	100%

: 780801-58-3
3,5-difluoro-2-pyridinecarboxaldehyde

: 343338-28-3
(S)-2-methylpropane-2-sulfinamide

: (S,E)-N-((3,5-difluoropyridin-2-yl)methylene)-2-methylpropane-2-sulfinamide

Conditions

Conditions	Yield
With copper(II) sulfate In dichloromethane at 20℃; for 23h;	100%

: C12H13BrO2

: 343338-28-3
(S)-2-methylpropane-2-sulfinamide

: C17H24BrNOS

Conditions

Conditions	Yield
With titanium(IV) tetraethanolate at 20℃;	100%

: 5-fluoro-2-(2-(4-methoxybenzyloxy)ethyl)benzaldehyde

: 343338-28-3
(S)-2-methylpropane-2-sulfinamide

: C21H26FNO3S

Conditions

Conditions	Yield
With caesium carbonate In dichloromethane at 25℃; for 16h; Inert atmosphere;	100%

: 63071-13-6
4-chloro-2-pyridinecarbaldehyde

: 343338-28-3
(S)-2-methylpropane-2-sulfinamide

: N-((4-chloropyridin-2-yl)methylene)-2-methylpropane-2-sulfinamide

Conditions

Conditions	Yield
With caesium carbonate In dichloromethane at 20℃; for 1h;	100%

: 60611-24-7
2-fluoro-6-(trifluoromethyl)benzaldehyde

: 343338-28-3
(S)-2-methylpropane-2-sulfinamide

: C12H13F4NOS

Conditions

Conditions	Yield
With titanium(IV) tetraethanolate In tetrahydrofuran at 40℃; for 24h; Inert atmosphere;	99.8%

: 851753-68-9
4-(2-formyl-4-methyl-phenyl)-piperazine-1-carboxylic acid tert-butyl ester

: 343338-28-3
(S)-2-methylpropane-2-sulfinamide

: 869478-27-3
4-{4-methyl-2-[((SS)-2-methyl-propane-2-sulfinylimino)-methyl]-phenyl}-piperazine-1-carboxylic acid tert-butyl ester

Conditions

Conditions	Yield
With titanium(IV) tetraethanolate In tetrahydrofuran; ethanol at 20℃; for 16h;	99%
With titanium(IV) tetraethanolate In tetrahydrofuran; ethanol at 20℃;

: 626219-95-2
4-(2-formyl-4-(trifluoromethyl)phenyl)piperazine-1-carboxylic acid tert-butyl ester

: 343338-28-3
(S)-2-methylpropane-2-sulfinamide

: 2-{[4-(tert-butoxycarbonyl)-1-piperazinyl]-5-trifluoromethyl-benzylidene}-t-butanesulfinamide

Conditions

Conditions	Yield
With titanium(IV) tetraethanolate In tetrahydrofuran	99%

: 851753-43-0
4-(2-fluoro-6-formyl-phenyl)-piperazine-1-carboxylic acid tert-butyl ester

: 343338-28-3
(S)-2-methylpropane-2-sulfinamide

: (S)-N-{2-[4-(tert-butoxycarbonyl)-1-piperazinyl]-3-fluoro-benzylidene}-t-butanesulfinamide

Conditions

Conditions	Yield
With titanium(IV) tetraethanolate In tetrahydrofuran; ethanol at 20℃;	99%

(S)-(-)-2-Methyl-2-Propanesulfinamide Chemical Properties

Molecule structure of (S)-(-)-2-Methyl-2-propanesulfinamide (CAS NO.343338-28-3):

Molecular Formula: C₃H₁₁CNOS
Molecular Weight: 121.20 g/mol
Index of Refraction: 1.523
Density: 1.124 g/cm³
Melting Point: 97-101 °C(lit.)
Boiling Point: 220 °C at 760 mmHg
Flash Point: 86.8 °C
Molar Refractivity: 32.94 cm³
Molar Volume: 107.7 cm³
Surface Tension: 49.8 dyne/cm
Enthalpy of Vaporization: 45.64 kJ/mol
Vapour Pressure: 0.116 mmHg at 25 °C
InChI: InChI=1/C4H11NOS/c1-4(2,3)7(5)6/h5H2,1-3H3
InChIKey: CESUXLKAADQNTB-UHFFFAOYAH
Product Categories: blocks; BuildingBlocks; Sulfonamides; chiral; CHIRAL COMPOUNDS; Asymmetric Synthesis; Sulfur Compounds (for Synthesis); Synthetic Organic Chemistry; CHIRAL CHEMICALS; Sulfur Compounds; Asymmetric Synthesis; Chiral Auxiliaries; Sulfur-Based

(S)-(-)-2-Methyl-2-Propanesulfinamide Safety Profile

Hazard Codes: Xi
WGK Germany: 3
Hazard Note: Irritant/Keep Cold

(S)-(-)-2-Methyl-2-Propanesulfinamide Specification

(S)-(-)-2-Methyl-2-propanesulfinamide (CAS NO.343338-28-3) is also named as 2-Propanesulfinamide,2-methyl-, [S(S)]- ; (S)-(-)-tert-Butyl sulfinamide ; (S)-2-Methyl-2-propanesulfinamide ; (S)-tert-Butanesulfinamide ; (S)-tert-Butylsulfinamide . (S)-(-)-2-Methyl-2-propanesulfinamide (CAS NO.343338-28-3) is white to light yellow crystal powder.

Product Name

(S)-(-)-2-Methyl-2-Propanesulfinamide

Synthetic route

(S)-(-)-2-Methyl-2-Propanesulfinamide Chemical Properties

(S)-(-)-2-Methyl-2-Propanesulfinamide Safety Profile

(S)-(-)-2-Methyl-2-Propanesulfinamide Specification

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