Product Name

  • Name

    (S)-(+)-2,2-Dimethylcyclopropanecarboxamide

  • EINECS 278-334-3
  • CAS No. 75885-58-4
  • Article Data9
  • CAS DataBase
  • Density 1.028 g/cm3
  • Solubility
  • Melting Point 135-137 °C(lit.)
  • Formula C6H11NO
  • Boiling Point 225.1 °C at 760 mmHg
  • Molecular Weight 113.159
  • Flash Point 89.933 °C
  • Transport Information
  • Appearance white to light yellow crystal powder
  • Safety 26-36
  • Risk Codes 22-36/37/38
  • Molecular Structure Molecular Structure of 75885-58-4 ((S)-(+)-2,2-Dimethylcyclopropanecarboxamide)
  • Hazard Symbols HarmfulXn,IrritantXi
  • Synonyms Cyclopropanecarboxamide,2,2-dimethyl-, (S)-;(+)-2,2-Dimethylcyclopropanecarboxamide;(S)-2,2-Dimethylcyclopropanecarboxamide;S-(+)-2,2-Dimethylcyclopropane-1-carboxamide;
  • PSA 43.09000
  • LogP 1.21810

Synthetic route

(+)-1S-2,2-dimethylcyclopropane-carboxylic acid
14590-53-5

(+)-1S-2,2-dimethylcyclopropane-carboxylic acid

(S)-2,2-dimethylcyclopropanecarboxamide
75885-58-4

(S)-2,2-dimethylcyclopropanecarboxamide

Conditions
ConditionsYield
Stage #1: (+)-1S-2,2-dimethylcyclopropane-carboxylic acid With thionyl chloride In dichloromethane at 20℃;
Stage #2: With ammonia In dichloromethane at -15℃;		92.1%
Multi-step reaction with 2 steps
1: 93 percent / pyridine / 1.5 h / Ambient temperature
2: 83 percent / 3 M NH3 / ethanol / 0.75 h
View Scheme
(S)-ethyl 2,2-dimethylcyclopropanecarboxylate
89007-61-4

(S)-ethyl 2,2-dimethylcyclopropanecarboxylate

(S)-2,2-dimethylcyclopropanecarboxamide
75885-58-4

(S)-2,2-dimethylcyclopropanecarboxamide

Conditions
ConditionsYield
With thionyl chloride; ammonia In dichloromethane90.7%
With ammonia; calcium chloride In methanol at 100 - 110℃;10 g
(+)-N-<<(2,2-dimethylcyclopropyl)carbonyl>oxy>succinimide
107871-21-6

(+)-N-<<(2,2-dimethylcyclopropyl)carbonyl>oxy>succinimide

(S)-2,2-dimethylcyclopropanecarboxamide
75885-58-4

(S)-2,2-dimethylcyclopropanecarboxamide

Conditions
ConditionsYield
With ammonium hydroxide In ethanol for 0.75h;83%
2,2,2-Trichloro-1-((S)-2,2-dimethyl-cyclopropyl)-ethanone
220263-88-7

2,2,2-Trichloro-1-((S)-2,2-dimethyl-cyclopropyl)-ethanone

(S)-2,2-dimethylcyclopropanecarboxamide
75885-58-4

(S)-2,2-dimethylcyclopropanecarboxamide

Conditions
ConditionsYield
With aminolysis72%
(RS)-2,2-dimethylcyclopropanecarboxamide
1759-55-3

(RS)-2,2-dimethylcyclopropanecarboxamide

A

(R)-2,2-dimethylcyclopropanecarboxylic acid
28624-52-4

(R)-2,2-dimethylcyclopropanecarboxylic acid

B

(S)-2,2-dimethylcyclopropanecarboxamide
75885-58-4

(S)-2,2-dimethylcyclopropanecarboxamide

Conditions
ConditionsYield
With water In acetonitrile at 30℃; for 2.33333h; pH=8.2; Solvent; Concentration; Enzymatic reaction; enantioselective reaction;A n/a
B 43.5%
With R-amidase from Delftia tsuruhatensis CCTC M 205114 at 35℃; for 18h; Large scale reaction; Enzymatic reaction; optical yield given as %ee; enantioselective reaction;A n/a
B 34.2%
2,2-dimethylcyclopropane carboxylic acid 2,2,2-trifluoroethyl ester
645413-67-8

2,2-dimethylcyclopropane carboxylic acid 2,2,2-trifluoroethyl ester

A

C8H11F3O2

C8H11F3O2

B

(S)-2,2-dimethylcyclopropanecarboxamide
75885-58-4

(S)-2,2-dimethylcyclopropanecarboxamide

Conditions
ConditionsYield
With ammonia; Candida antarctica Type B lipase In tert-butyl alcohol at 30 - 40℃; for 20h; Product distribution / selectivity; Enzymatic reaction;A n/a
B 40%
(R)-2,2,2-Trichloro-1-((S)-2,2-dimethyl-cyclopropyl)-ethanol
220263-87-6

(R)-2,2,2-Trichloro-1-((S)-2,2-dimethyl-cyclopropyl)-ethanol

(S)-2,2-dimethylcyclopropanecarboxamide
75885-58-4

(S)-2,2-dimethylcyclopropanecarboxamide

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 72 percent / Na2Cr2O7, H2SO4 / acetic acid
2: 72 percent / aminolysis
View Scheme
2,2-dimethylcyclopropane-1-carboxylic acid
75885-59-5

2,2-dimethylcyclopropane-1-carboxylic acid

(S)-2,2-dimethylcyclopropanecarboxamide
75885-58-4

(S)-2,2-dimethylcyclopropanecarboxamide

Conditions
ConditionsYield
Multi-step reaction with 3 steps
2: 93 percent / pyridine / 1.5 h / Ambient temperature
3: 83 percent / 3 M NH3 / ethanol / 0.75 h
View Scheme
C9H16O3

C9H16O3

A

C9H16O3

C9H16O3

B

(S)-2,2-dimethylcyclopropanecarboxamide
75885-58-4

(S)-2,2-dimethylcyclopropanecarboxamide

Conditions
ConditionsYield
With ammonia; Candida antarctica Type B lipase In tert-butyl alcohol at 30℃; for 20h; Product distribution / selectivity; Enzymatic reaction;A n/a
B n/a
C8H13BrO2

C8H13BrO2

A

C8H13BrO2

C8H13BrO2

B

(S)-2,2-dimethylcyclopropanecarboxamide
75885-58-4

(S)-2,2-dimethylcyclopropanecarboxamide

Conditions
ConditionsYield
With ammonia; Candida antarctica Type B lipase In tert-butyl alcohol at 30℃; for 20h; Product distribution / selectivity; Enzymatic reaction;A n/a
B n/a
C8H13ClO2

C8H13ClO2

A

C8H13ClO2

C8H13ClO2

B

(S)-2,2-dimethylcyclopropanecarboxamide
75885-58-4

(S)-2,2-dimethylcyclopropanecarboxamide

Conditions
ConditionsYield
With ammonia; Candida antarctica Type B lipase In tert-butyl alcohol at 30℃; for 20h; Product distribution / selectivity; Enzymatic reaction;A n/a
B n/a
ethyl (E)-7-chloro-2-((S)-2,2-dimethylcyclopropanecarboxamido)-2-heptenoate
1022895-93-7

ethyl (E)-7-chloro-2-((S)-2,2-dimethylcyclopropanecarboxamido)-2-heptenoate

A

ethyl-7-Chloro-2-oxoheptanoate
78834-75-0

ethyl-7-Chloro-2-oxoheptanoate

B

(S)-2,2-dimethylcyclopropanecarboxamide
75885-58-4

(S)-2,2-dimethylcyclopropanecarboxamide

Conditions
ConditionsYield
Stage #1: ethyl (E)-7-chloro-2-((S)-2,2-dimethylcyclopropanecarboxamido)-2-heptenoate With toluene-4-sulfonic acid In dichloromethane at 20℃;
Stage #2: With sodium hydroxide; water In dichloromethane pH=8 - 9; Product distribution / selectivity;
Stage #1: ethyl (E)-7-chloro-2-((S)-2,2-dimethylcyclopropanecarboxamido)-2-heptenoate With methanesulfonic acid In toluene at 30℃;
Stage #2: With sodium hydroxide; water In toluene pH=8 - 9; Product distribution / selectivity;
(S)-isopropyl 2,2-dimethylcyclopropanecarboxylate

(S)-isopropyl 2,2-dimethylcyclopropanecarboxylate

(S)-2,2-dimethylcyclopropanecarboxamide
75885-58-4

(S)-2,2-dimethylcyclopropanecarboxamide

Conditions
ConditionsYield
With ammonia; calcium chloride In methanol at 100 - 110℃;10 g
(S)-methyl 2,2-dimethylcyclopropanecarboxylate

(S)-methyl 2,2-dimethylcyclopropanecarboxylate

(S)-2,2-dimethylcyclopropanecarboxamide
75885-58-4

(S)-2,2-dimethylcyclopropanecarboxamide

Conditions
ConditionsYield
With ammonia; calcium chloride In methanol at 100 - 110℃; Solvent; Reagent/catalyst; Temperature;9 g
ethyl-7-Chloro-2-oxoheptanoate
78834-75-0

ethyl-7-Chloro-2-oxoheptanoate

(S)-2,2-dimethylcyclopropanecarboxamide
75885-58-4

(S)-2,2-dimethylcyclopropanecarboxamide

(Z)-7-chloro-2-((S)-2,2-dimethylcyclopropanecarboxamido)-2-heptenoic acid ethyl ester
877758-94-6

(Z)-7-chloro-2-((S)-2,2-dimethylcyclopropanecarboxamido)-2-heptenoic acid ethyl ester

Conditions
ConditionsYield
Stage #1: ethyl-7-Chloro-2-oxoheptanoate; (S)-2,2-dimethylcyclopropanecarboxamide With toluene-4-sulfonic acid In toluene for 10h; Reflux;
Stage #2: at 30℃; for 1h; Solvent; Temperature; Irradiation;		99.5%
5,10,15,20-tetrakis(3-bromophenyl)porphyrin

5,10,15,20-tetrakis(3-bromophenyl)porphyrin

(S)-2,2-dimethylcyclopropanecarboxamide
75885-58-4

(S)-2,2-dimethylcyclopropanecarboxamide

C68H66N8O4

C68H66N8O4

Conditions
ConditionsYield
With tris-(dibenzylideneacetone)dipalladium(0); caesium carbonate; 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene In tetrahydrofuran at 100℃; for 60h; Inert atmosphere; Schlenk technique;97%
(S)-2,2-dimethylcyclopropanecarboxamide
75885-58-4

(S)-2,2-dimethylcyclopropanecarboxamide

5,15-bis(2,6-dibromophenyl)-10,20-bis(3,5-dimethoxyphenyl)porphyrin

5,15-bis(2,6-dibromophenyl)-10,20-bis(3,5-dimethoxyphenyl)porphyrin

C72H74N8O8

C72H74N8O8

Conditions
ConditionsYield
With palladium diacetate; caesium carbonate; 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene In tetrahydrofuran at 100℃; for 48h;88%
(S)-2,2-dimethylcyclopropanecarboxamide
75885-58-4

(S)-2,2-dimethylcyclopropanecarboxamide

5,15-bis(2,6-dibromophenyl)-10,20-bis[4-(tert-butyl)phenyl]porphyrin

5,15-bis(2,6-dibromophenyl)-10,20-bis[4-(tert-butyl)phenyl]porphyrin

C76H82N8O4

C76H82N8O4

Conditions
ConditionsYield
With palladium diacetate; caesium carbonate; 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene In tetrahydrofuran at 100℃; for 40h;86%
(S)-2,2-dimethylcyclopropanecarboxamide
75885-58-4

(S)-2,2-dimethylcyclopropanecarboxamide

β-bromo-5,10,15,20-tetraphenylporphyrin

β-bromo-5,10,15,20-tetraphenylporphyrin

(S)-(+)-2,2-dimethylcyclopropanecarboxylic acid (5,10,15,20-tetraphenylporphyrin-2-yl)amide

(S)-(+)-2,2-dimethylcyclopropanecarboxylic acid (5,10,15,20-tetraphenylporphyrin-2-yl)amide

Conditions
ConditionsYield
With caesium carbonate; 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene; palladium diacetate In tetrahydrofuran at 100℃; for 24h;86%
(S)-2,2-dimethylcyclopropanecarboxamide
75885-58-4

(S)-2,2-dimethylcyclopropanecarboxamide

5,15-bis(2,6-dibromophenyl)-10,20-bis[3,5-di(tert-butyl)phenyl]porphyrin

5,15-bis(2,6-dibromophenyl)-10,20-bis[3,5-di(tert-butyl)phenyl]porphyrin

C84H98N8O4

C84H98N8O4

Conditions
ConditionsYield
With palladium diacetate; caesium carbonate; 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene In tetrahydrofuran at 100℃; for 48h;85%
With caesium carbonate; 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene; palladium diacetate In tetrahydrofuran at 100℃; for 48h;85%
With palladium diacetate; caesium carbonate; 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene Inert atmosphere;85%
With palladium diacetate; caesium carbonate; 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene In 1,4-dioxane at 100℃; for 72h; Schlenk technique; Inert atmosphere; Sealed tube;
5,15-bis(2,6-dibromophenyl)-10,20-bis[3,5-di(tert-butyl)phenyl]porphyrin

5,15-bis(2,6-dibromophenyl)-10,20-bis[3,5-di(tert-butyl)phenyl]porphyrin

(S)-2,2-dimethylcyclopropanecarboxamide
75885-58-4

(S)-2,2-dimethylcyclopropanecarboxamide

C20H8N4H2(C6H3(C(CH3)3)2)2(C6H3(NHCOC3H3(CH3)2)2)2

C20H8N4H2(C6H3(C(CH3)3)2)2(C6H3(NHCOC3H3(CH3)2)2)2

Conditions
ConditionsYield
With palladium diacetate; caesium carbonate; 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene In 1,4-dioxane at 100℃; Schlenk technique; Inert atmosphere; Sealed tube; Molecular sieve;85%
(S)-2,2-dimethylcyclopropanecarboxamide
75885-58-4

(S)-2,2-dimethylcyclopropanecarboxamide

5,15-bis(2,6-dibromophenyl)-10,20-bis(2,4,6-trimethylphenyl)porphyrin

5,15-bis(2,6-dibromophenyl)-10,20-bis(2,4,6-trimethylphenyl)porphyrin

C74H78N8O4

C74H78N8O4

Conditions
ConditionsYield
With palladium diacetate; caesium carbonate; 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene In tetrahydrofuran at 100℃; for 56h;84%
5,15-bis(2,6-dibromophenyl)-10,20-bis(3,5-di(2,4,6-trimethylphenyl)phenyl)porphyrin

5,15-bis(2,6-dibromophenyl)-10,20-bis(3,5-di(2,4,6-trimethylphenyl)phenyl)porphyrin

(S)-2,2-dimethylcyclopropanecarboxamide
75885-58-4

(S)-2,2-dimethylcyclopropanecarboxamide

C104H106N8O4

C104H106N8O4

Conditions
ConditionsYield
With palladium diacetate; caesium carbonate; 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene In tetrahydrofuran at 100℃; for 72h; Inert atmosphere;82%
With palladium diacetate; caesium carbonate; 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene In tetrahydrofuran at 100℃; for 72h; Inert atmosphere; Schlenk technique;82%
(S)-2,2-dimethylcyclopropanecarboxamide
75885-58-4

(S)-2,2-dimethylcyclopropanecarboxamide

5,15-bis(2,6-dibromophenyl)porphyrin

5,15-bis(2,6-dibromophenyl)porphyrin

C56H58N8O4

C56H58N8O4

Conditions
ConditionsYield
With palladium diacetate; caesium carbonate; 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene In tetrahydrofuran at 100℃; for 60h;79%
(S)-2,2-dimethylcyclopropanecarboxamide
75885-58-4

(S)-2,2-dimethylcyclopropanecarboxamide

5,15-bis(2,6-dibromophenyl)-10,20-diphenylporphyrin

5,15-bis(2,6-dibromophenyl)-10,20-diphenylporphyrin

C68H66N8O4

C68H66N8O4

Conditions
ConditionsYield
With palladium diacetate; caesium carbonate; 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene In tetrahydrofuran at 100℃; for 60h;78%
(S)-2,2-dimethylcyclopropanecarboxamide
75885-58-4

(S)-2,2-dimethylcyclopropanecarboxamide

5,15-bis(2,6-dibromophenyl)-10,20-bis(4-trifluoromethylphenyl)porphyrin

5,15-bis(2,6-dibromophenyl)-10,20-bis(4-trifluoromethylphenyl)porphyrin

C70H64F6N8O4

C70H64F6N8O4

Conditions
ConditionsYield
With palladium diacetate; caesium carbonate; 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene In tetrahydrofuran at 100℃; for 60h;77%
(S)-2,2-dimethylcyclopropanecarboxamide
75885-58-4

(S)-2,2-dimethylcyclopropanecarboxamide

5,15-bis(2,6-dibromophenyl)-10,20-bisheptylporphyrin

5,15-bis(2,6-dibromophenyl)-10,20-bisheptylporphyrin

C70H86N8O4

C70H86N8O4

Conditions
ConditionsYield
With palladium diacetate; caesium carbonate; 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene In tetrahydrofuran at 100℃; for 60h;74%
(S)-2,2-dimethylcyclopropanecarboxamide
75885-58-4

(S)-2,2-dimethylcyclopropanecarboxamide

5,15-bis(2,6-dibromophenyl)-10,20-bis(4-acetylphenyl)porphyrin

5,15-bis(2,6-dibromophenyl)-10,20-bis(4-acetylphenyl)porphyrin

C72H70N8O6

C72H70N8O6

Conditions
ConditionsYield
With palladium diacetate; caesium carbonate; 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene In tetrahydrofuran at 100℃; for 60h;66%
(S)-2,2-dimethylcyclopropanecarboxamide
75885-58-4

(S)-2,2-dimethylcyclopropanecarboxamide

5,15-bis(2,6-dibromophenyl)-10,20-bis(2,6-dimethoxyphenyl)-porphyrin

5,15-bis(2,6-dibromophenyl)-10,20-bis(2,6-dimethoxyphenyl)-porphyrin

C72H74N8O8

C72H74N8O8

Conditions
ConditionsYield
With palladium diacetate; caesium carbonate; 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene In tetrahydrofuran at 100℃; for 60h;59%
With palladium diacetate; caesium carbonate; 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene In 1,4-dioxane at 100℃; for 72h; Schlenk technique; Inert atmosphere; Sealed tube;
5,15-bis(2,6-dibromophenyl)-10,20-bis(2,6-dimethoxyphenyl)porphyrin

5,15-bis(2,6-dibromophenyl)-10,20-bis(2,6-dimethoxyphenyl)porphyrin

(S)-2,2-dimethylcyclopropanecarboxamide
75885-58-4

(S)-2,2-dimethylcyclopropanecarboxamide

C20H8N4H2(C6H3(OCH3)2)2(C6H3(NHCOC3H3(CH3)2)2)2

C20H8N4H2(C6H3(OCH3)2)2(C6H3(NHCOC3H3(CH3)2)2)2

Conditions
ConditionsYield
With palladium diacetate; caesium carbonate; 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene In 1,4-dioxane at 100℃; Schlenk technique; Inert atmosphere; Sealed tube; Molecular sieve;59%
(S)-2,2-dimethylcyclopropanecarboxamide
75885-58-4

(S)-2,2-dimethylcyclopropanecarboxamide

5,15-bis(2,6-dibromophenyl)-10,20-bis(2,3,4,5,6-pentafluorophenyl)porphyrin

5,15-bis(2,6-dibromophenyl)-10,20-bis(2,3,4,5,6-pentafluorophenyl)porphyrin

C68H56F10N8O4

C68H56F10N8O4

Conditions
ConditionsYield
With palladium diacetate; caesium carbonate; 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene In tetrahydrofuran at 100℃; for 60h;46%
8-bromo-2-oxooctanoic acid

8-bromo-2-oxooctanoic acid

(S)-2,2-dimethylcyclopropanecarboxamide
75885-58-4

(S)-2,2-dimethylcyclopropanecarboxamide

(Z)-8-Bromo-2-[((S)-2,2-dimethyl-cyclopropanecarbonyl)-amino]-oct-2-enoic acid
107912-87-8

(Z)-8-Bromo-2-[((S)-2,2-dimethyl-cyclopropanecarbonyl)-amino]-oct-2-enoic acid

Conditions
ConditionsYield
In toluene Heating;44%
C40H28Br4N4O3

C40H28Br4N4O3

(S)-2,2-dimethylcyclopropanecarboxamide
75885-58-4

(S)-2,2-dimethylcyclopropanecarboxamide

A

C52H48Br2N6O5

C52H48Br2N6O5

B

C64H68N8O7

C64H68N8O7

Conditions
ConditionsYield
With palladium diacetate; caesium carbonate; 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene In tetrahydrofuran at 125℃; for 65h; Inert atmosphere;A 21%
B 41%
...Expand
2-oxooctanoic acid
328-51-8

2-oxooctanoic acid

(S)-2,2-dimethylcyclopropanecarboxamide
75885-58-4

(S)-2,2-dimethylcyclopropanecarboxamide

(+)-(Z)-2-(2,2-dimethylcyclopropanecarboxamido)-2-octenoic acid

(+)-(Z)-2-(2,2-dimethylcyclopropanecarboxamido)-2-octenoic acid

Conditions
ConditionsYield
In toluene for 17h; Heating;31%
7-bromo-2-oxoheptanoic acid
107872-93-5

7-bromo-2-oxoheptanoic acid

(S)-2,2-dimethylcyclopropanecarboxamide
75885-58-4

(S)-2,2-dimethylcyclopropanecarboxamide

(Z)-7-bromo-2 ((2s)-2,2-dimethylcyclopropanecarboxamido)-2-heptenoic acid
78834-80-7

(Z)-7-bromo-2 ((2s)-2,2-dimethylcyclopropanecarboxamido)-2-heptenoic acid

Conditions
ConditionsYield
In toluene Heating;28%
2-Oxobutyric acid
600-18-0

2-Oxobutyric acid

(S)-2,2-dimethylcyclopropanecarboxamide
75885-58-4

(S)-2,2-dimethylcyclopropanecarboxamide

(Z)-2-[((S)-2,2-Dimethyl-cyclopropanecarbonyl)-amino]-but-2-enoic acid

(Z)-2-[((S)-2,2-Dimethyl-cyclopropanecarbonyl)-amino]-but-2-enoic acid

Conditions
ConditionsYield
In toluene Heating;
(S)-2,2-dimethylcyclopropanecarboxamide
75885-58-4

(S)-2,2-dimethylcyclopropanecarboxamide

(+)-1S-2,2-dimethylcyclopropane-carboxylic acid
14590-53-5

(+)-1S-2,2-dimethylcyclopropane-carboxylic acid

Conditions
ConditionsYield
hydrolysis;

(S)-(+)-2,2-Dimethylcyclopropanecarboxamide Chemical Properties

Molecular Structure of Cyclopropanecarboxamide,2,2-dimethyl-, (1S)- (CAS NO.75885-58-4):

IUPAC Name: (1S)-2,2-dimethylcyclopropane-1-carboxamide 
Empirical Formula: C6H11NO
Molecular Weight: 113.1576 
H bond acceptors: 2
H bond donors: 2
Freely Rotating Bonds: 1
Polar Surface Area: 43.09 Å2
Index of Refraction: 1.48
Molar Refractivity: 31.264 cm3
Molar Volume: 110.074 cm3
Surface Tension: 36.109 dyne/cm
Density: 1.028 g/cm3
Flash Point: 89.933 °C
Enthalpy of Vaporization: 46.161 kJ/mol
Boiling Point: 225.092 °C at 760 mmHg
Vapour Pressure: 0.088 mmHg at 25°C
Melting point: 135-137 °C(lit.)
EINECS: 278-334-3
Product Categories: AMIDE; Amides; Chiral Compounds; chiral; API intermediates; API; Amides (Chiral); Chiral Building Blocks; Cyclopropanes; Simple 3-Membered Ring Compounds; Synthetic Organic Chemistry; Chiral Compound; Chiral Building Blocks; Organic Building Blocks

(S)-(+)-2,2-Dimethylcyclopropanecarboxamide Safety Profile

Hazard Codes: HarmfulXn,IrritantXi
Risk Statements: 22-36/37/38
R22:Harmful if swallowed. 
R36/37/38:Irritating to eyes, respiratory system and skin.
Safety Statements: 26-36
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. 
S36:Wear suitable protective clothing.
WGK Germany: 3
Hazard Note: Irritant

(S)-(+)-2,2-Dimethylcyclopropanecarboxamide Specification

 Cyclopropanecarboxamide,2,2-dimethyl-, (1S)- , with CAS number of 75885-58-4, can be called Cyclopropanecarboxamide, 2,2-dimethyl-, (S)- ; (+)-2,2-Dimethylcyclopropanecarboxamide ; S-(+)-2,2-Dimethylcyclopropane-1-carboxamide ; (S)-2,2-Dimethylcyclopropanecarboxamide . It is a white to light yellow crystal powde.

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