1-(2,3-Dichlorophenyl)-piperazine supplier

Name
1-(2,3-Dichlorophenyl)-piperazine hydrochloride
EINECS
CAS No. 41202-77-1
Article Data12
CAS DataBase
Density 1.272 g/cm³
Solubility
Melting Point 242-244ºC
Formula C₁₀H₁₂Cl₂N₂
Boiling Point 365.1 °C at 760 mmHg
Molecular Weight 231.125
Flash Point 174.6 °C
Transport Information
Appearance Brown Oil
Safety
Risk Codes R36/37/38
Molecular Structure
Hazard Symbols R36/37/38:;
Synonyms 4-(2,3-Dichlorophenyl)piperazine;DCPP;N-(2,3-Dichlorophenyl)piperazine;Piperazine,1-(2,3-dichlorophenyl)-;
PSA 15.27000
LogP 2.79680

Synthetic route

: 608-27-5
2,3-dichloroaniline

: 334-22-5
N,N-bis(chloro-2-ethyl)amine

: 41202-77-1
1-(2,3-dichlorophenyl)piperazine

Conditions

Conditions	Yield
Stage #1: 2,3-dichloroaniline; N,N-bis(chloro-2-ethyl)amine With tetrabutylammomium bromide; toluene-4-sulfonic acid In 5,5-dimethyl-1,3-cyclohexadiene for 48h; Stage #2: With ammonium hydroxide pH=6 - 7;	88%

: 110-85-0
piperazine

: 56961-77-4
1-bromo-2,3-dichlorobenzene

A: 41202-77-1
1-(2,3-dichlorophenyl)piperazine

B: 1,1'-(2-chloro-1,3-phenylene)bispiperazine

Conditions

Conditions	Yield
With tris(dibenzylideneacetone)dipalladium (0); (R)-2,2'-bis(diphenylphosphanyl)-1,1'-binaphthyl; sodium t-butanolate In toluene for 18h; Heating;	A 62% B 7%

...Expand

: 110-85-0
piperazine

: 87-61-6
1,2,3-trichlorobenzene

: 41202-77-1
1-(2,3-dichlorophenyl)piperazine

Conditions

Conditions	Yield
With tris-(dibenzylideneacetone)dipalladium(0); 2-dicyclohexylphosphino-2′,6′-di-i-propoxy-1,1′-biphenyl; sodium t-butanolate In 1,4-dioxane at 100℃; for 0.166667h;	37%

: 608-27-5
2,3-dichloroaniline

: 111-42-2
2,2'-iminobis[ethanol]

: 41202-77-1
1-(2,3-dichlorophenyl)piperazine

Conditions

Conditions	Yield
With phosphorus pentoxide; triethylamine hydrochloride at 220℃; for 4h;	31%
With phosphorus pentaoxide; triethylamine hydrochloride at 200℃; for 3h;	21%
Stage #1: 2,3-dichloroaniline; 2,2'-iminobis[ethanol] With phosphorus pentoxide; triethylamine hydrochloride at 220℃; for 4h; Inert atmosphere; Stage #2: With sodium hydroxide In water at 0℃; pH=10;	15%

: 110-85-0
piperazine

: 56961-77-4
1-bromo-2,3-dichlorobenzene

: 41202-77-1
1-(2,3-dichlorophenyl)piperazine

Conditions

Conditions	Yield
With 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; 1,8-diazabicyclo[5.4.0]undec-7-ene; sodium t-butanolate; tris(dibenzylideneacetone)dipalladium (0) In toluene at 60 - 70℃; Buchwald amination;

: 1-(2,3-dichlorophenyl)-piperazine hydrochloride

: 41202-77-1
1-(2,3-dichlorophenyl)piperazine

Conditions

Conditions	Yield
With sodium hydroxide In dichloromethane; water for 0.5h;

: C21H32BClN2O4

: 41202-77-1
1-(2,3-dichlorophenyl)piperazine

Conditions

Conditions	Yield
With copper dichloride In methanol; water at 80℃;

: 821-48-7
bis-(2-chloroethyl)amine hydrochloride

: 608-27-5
2,3-dichloroaniline

: 41202-77-1
1-(2,3-dichlorophenyl)piperazine

Conditions

Conditions	Yield
With potassium iodide at 150℃; Inert atmosphere;

: 76911-01-8
5-hexynyl p-toluenesulfonate

: 41202-77-1
1-(2,3-dichlorophenyl)piperazine

: 1-(2,3-dichlorophenyl)-4-(hex-5-yn-1-yl)piperazine

Conditions

Conditions	Yield
With potassium carbonate; sodium iodide In acetone for 12h; Reflux;	98%

: 41202-77-1
1-(2,3-dichlorophenyl)piperazine

: 194719-57-8
2-(6-bromohexyl)–2H-naphtho[1,8-cd]isothiazole1,1-dioxide

: 2-{6-[4-(2,3-dichlorophenyl)piperazin-1-yl]hexyl}-(2H)naphtho[1,8-cd][1,2]thiazole-1,1(2H)-dione hydrochloride

Conditions

Conditions	Yield
Stage #1: 1-(2,3-dichlorophenyl)piperazine; 2-(6-bromohexyl)–2H-naphtho[1,8-cd]isothiazole1,1-dioxide With tetrabutylammomium bromide; potassium carbonate; sodium hydroxide In acetonitrile for 0.0138889h; Microwave irradiation; Stage #2: With hydrogenchloride In 1,4-dioxane; acetone	98%

: 41202-77-1
1-(2,3-dichlorophenyl)piperazine

: 150758-78-4
8-(2-Bromoethyl)-8-azaspiro<4,5>decane-7,9-dione

: 8-{2-[4-(2,3-dichloro-phenyl)-piperazin-1-yl]-ethyl}-8-aza-spiro[4.5]decane-7,9-dione

Conditions

Conditions	Yield
With triethylamine at 160 - 180℃; for 0.5h;	97%

: 389131-94-6
toluenesulfonic acid 3-azidobutyl ester

: 41202-77-1
1-(2,3-dichlorophenyl)piperazine

: 1-(4-azidobutyl)-4-(2,3-dichlorophenyl)piperazine

Conditions

Conditions	Yield
With potassium carbonate; sodium iodide In acetone for 12h; Reflux;	97%

: 3-(trans-4-(2-iodoethyl)cyclohexyl)-1,1-dimethylurea

: 41202-77-1
1-(2,3-dichlorophenyl)piperazine

: 839712-12-8
Cariprazine

Conditions

Conditions	Yield
With sodium carbonate In acetonitrile for 18h; Reflux; Green chemistry;	96.8%

: 2-(trans-4-(3,3-dimethylureido)cyclohexyl)ethyl methanesulfonate

: 41202-77-1
1-(2,3-dichlorophenyl)piperazine

: 839712-12-8
Cariprazine

Conditions

Conditions	Yield
With sodium carbonate In acetonitrile for 17h; Reflux; Green chemistry;	96.2%

: 5-(ethoxymethylene)thiazolidine-2,4-dione

: 41202-77-1
1-(2,3-dichlorophenyl)piperazine

: (Z)-5-((4-(2,3-dichlorophenyl)piperazin-1-yl)methylene)thiazolidine-2,4-dione

Conditions

Conditions	Yield
Stage #1: 5-(ethoxymethylene)thiazolidine-2,4-dione; 1-(2,3-dichlorophenyl)piperazine With triethylamine In acetonitrile Stage #2: at 45℃;	96%

: N-(2-formyl-trans-cyclopropylmethyl)quinoline-4-carboxamide

: 41202-77-1
1-(2,3-dichlorophenyl)piperazine

: N-(2-((4-(2,3-dichlorophenyl)piperazin-1-yl)methyl)-trans-cyclopropylmethyl)quinoline-4-carboxamide

Conditions

Conditions	Yield
With sodium tris(acetoxy)borohydride; acetic acid In 1,2-dichloro-ethane at 20℃; for 6h; Inert atmosphere;	96%

: 3-(trans-4-(2-fluoroethyl)cyclohexyl)-1,1-dimethylurea

: 41202-77-1
1-(2,3-dichlorophenyl)piperazine

: 839712-12-8
Cariprazine

Conditions

Conditions	Yield
With sodium carbonate In acetonitrile for 20h; Reflux; Green chemistry;	95.4%

: 41202-77-1
1-(2,3-dichlorophenyl)piperazine

: 5332-06-9
4-bromobutanenitrile

: 486393-38-8
4‐[4‐(2,3‐dichlorophenyl)piperazin‐1‐yl]butannitrile

Conditions

Conditions	Yield
With potassium carbonate; potassium iodide In acetone for 16h; Reflux;	95%
With triethylamine In dichloromethane for 48h;	70%
With triethylamine In dichloromethane

: 13287-42-8
(2-bromoethyl)oxirane

: 41202-77-1
1-(2,3-dichlorophenyl)piperazine

: 944344-39-2
1-(2,3-dichlorophenyl)-4-(2-(oxiran-2-yl)ethyl)piperazine

Conditions

Conditions	Yield
With potassium carbonate In acetone for 24h; Heating;	95%
With potassium carbonate In acetone for 24h; Heating / reflux;	95%
With potassium carbonate In acetone for 24h; Reflux;

: 109-65-9
1-bromo-butane

: 41202-77-1
1-(2,3-dichlorophenyl)piperazine

: 1383430-54-3
1-butyl-4-(2,3-dichlorophenyl)piperazine

Conditions

Conditions	Yield
With potassium carbonate In acetone Reflux;	95%

: 1,1-dimethyl-3-((trans)-4-(2-oxoethyl)cyclohexyl)urea

: 41202-77-1
1-(2,3-dichlorophenyl)piperazine

: 839712-12-8
Cariprazine

Conditions

Conditions	Yield
With sodium tris(acetoxy)borohydride In 1,2-dichloro-ethane at 20℃; for 18h; Green chemistry;	95%

: 32315-10-9
bis(trichloromethyl) carbonate

: 100-01-6
4-nitro-aniline

: 41202-77-1
1-(2,3-dichlorophenyl)piperazine

: 4-(2,3-dichlorophenyl)-N-(4-nitrophenyl)piperazine-1-carboxamide

Conditions

Conditions	Yield
Stage #1: bis(trichloromethyl) carbonate; 4-nitro-aniline With triethylamine In dichloromethane at 0℃; for 0.166667h; Stage #2: 1-(2,3-dichlorophenyl)piperazine In dichloromethane at 20℃; for 1h;	95%

...Expand

: 638-53-9
tridecanoic acid

: 41202-77-1
1-(2,3-dichlorophenyl)piperazine

: 1-(4-(2,3-dichlorophenyl)piperazin-1-yl)tridecan-1-one

Conditions

Conditions	Yield
Stage #1: tridecanoic acid With N-ethyl-N,N-diisopropylamine; HATU In N,N-dimethyl-formamide at 20℃; for 0.333333h; Stage #2: 1-(2,3-dichlorophenyl)piperazine In N,N-dimethyl-formamide at 20℃;	95%

: 100-09-4
4-methoxybenzoic acid

: 41202-77-1
1-(2,3-dichlorophenyl)piperazine

: (4-(2,3-dichlorophenyl)piperazin-1-yl)(4-methoxyphenyl)methanone

Conditions

Conditions	Yield
Stage #1: 4-methoxybenzoic acid With N-ethyl-N,N-diisopropylamine; HATU In N,N-dimethyl-formamide at 20℃; for 0.333333h; Stage #2: 1-(2,3-dichlorophenyl)piperazine In N,N-dimethyl-formamide at 20℃;	95%

: 1975-51-5
2-methyl-4-nitrobenzoic acid

: 41202-77-1
1-(2,3-dichlorophenyl)piperazine

: (4-(2,3-dichlorophenyl)piperazin-1-yl)(2-methyl-4-nitrophenyl)methanone

Conditions

Conditions	Yield
Stage #1: 2-methyl-4-nitrobenzoic acid With N-ethyl-N,N-diisopropylamine; HATU In N,N-dimethyl-formamide at 20℃; for 0.333333h; Stage #2: 1-(2,3-dichlorophenyl)piperazine In N,N-dimethyl-formamide at 20℃;	95%

: 50-84-0
2,4 dichlorobenzoic acid

: 41202-77-1
1-(2,3-dichlorophenyl)piperazine

: (2,4-dichlorophenyl)(4-(2,3-dichlorophenyl)piperazin-1-yl)methanone

Conditions

Conditions	Yield
Stage #1: 2,4 dichlorobenzoic acid With N-ethyl-N,N-diisopropylamine; HATU In N,N-dimethyl-formamide at 20℃; for 0.333333h; Stage #2: 1-(2,3-dichlorophenyl)piperazine In N,N-dimethyl-formamide at 20℃;	95%

: 2-(4-methylenecyclohexyl)ethyl 4-methylbenzenesulfonate

: 41202-77-1
1-(2,3-dichlorophenyl)piperazine

: 1-(2,3-dichlorophenyl)-4-(2-(4-methylenecyclohexyl)ethyl)piperazine

Conditions

Conditions	Yield
With potassium carbonate In acetonitrile at 80℃; Inert atmosphere;	95%

: 120004-79-7
7-(4-chlorobutoxy)-3,4-dihydroquinoline-2(1H)-one

: 41202-77-1
1-(2,3-dichlorophenyl)piperazine

: 129722-12-9
aripiprazole

Conditions

Conditions	Yield
Stage #1: 7-(4-chlorobutoxy)-3,4-dihydroquinolin-2(1H)-one With sodium iodide In N,N-dimethyl-formamide at 70 - 80℃; for 1h; Stage #2: 1-(2,3-dichlorophenyl)piperazine With potassium carbonate In N,N-dimethyl-formamide at 70 - 80℃; for 4h;	94%
With potassium carbonate In N,N-dimethyl-formamide at 100℃;	57 mg

: 532-27-4
1-chloroacetophenone

: 41202-77-1
1-(2,3-dichlorophenyl)piperazine

: 1184171-35-4
2-(4-(2,3-dichlorophenyl)piperazin-1-yl)-1-phenylethanone

Conditions

Conditions	Yield
With sodium carbonate In ethanol for 4h; Reflux;	94%

: 3-(trans-4-(2-chloroethyl)cyclohexyl)-1,1-dimethylurea

: 41202-77-1
1-(2,3-dichlorophenyl)piperazine

: 839712-12-8
Cariprazine

Conditions

Conditions	Yield
With sodium carbonate In acetone for 18h; Reflux; Green chemistry;	92.6%

: 2-(trans-4-(3,3-dimethylureido)cyclohexyl)ethyl 4-methylbenzenesulfonate

: 41202-77-1
1-(2,3-dichlorophenyl)piperazine

: 839712-12-8
Cariprazine

Conditions

Conditions	Yield
With potassium carbonate In acetonitrile for 22h; Reflux; Green chemistry;	92.5%

: 5394-18-3
2-(4-bromobutyl)isoindoline-1,3-dione

: 41202-77-1
1-(2,3-dichlorophenyl)piperazine

: 367275-36-3
2-{4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butyl}-1H-isoindole-1,3(2H)-dione

Conditions

Conditions	Yield
In xylene at 70 - 125℃; for 24h;	92%
In xylene at 70 - 125℃; for 24h;	92%
With potassium carbonate In acetone Reflux;	83%

: 106-94-5
propyl bromide

: 41202-77-1
1-(2,3-dichlorophenyl)piperazine

: 871351-88-1
1-(2,3-dichlorophenyl)-4-propylpiperazine

Conditions

Conditions	Yield
With potassium carbonate In acetone Reflux;	92%

: 77287-34-4, 77287-35-5, 60100-09-6
formamide

: 41202-77-1
1-(2,3-dichlorophenyl)piperazine

: 1418125-57-1
4-(2,3-dichlorophenyl)piperazine-1-carbaldehyde

Conditions

Conditions	Yield
With sodium methylate In tetrahydrofuran; methanol at 20℃; for 6h;	92%

: 1-(3-(dimethylamino)propyl)-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-5-carbaldehyde

: 41202-77-1
1-(2,3-dichlorophenyl)piperazine

: 1507401-67-3
3-(5-((4-(2,3-dichlorophenyl)piperazin-1-yl)methyl)-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-1-yl)-N,N-dimethylpropan-1-amine

Conditions

Conditions	Yield
With sodium tris(acetoxy)borohydride; acetic acid In 1,2-dichloro-ethane at 20℃; Inert atmosphere;	92%

: 32315-10-9
bis(trichloromethyl) carbonate

: 98-16-8
3-trifluoromethylaniline

: 41202-77-1
1-(2,3-dichlorophenyl)piperazine

: 4-(2,3-dichlorophenyl)-N-(3-(trifluoromethyl)phenyl)piperazine-1-carboxamide

Conditions

Conditions	Yield
Stage #1: bis(trichloromethyl) carbonate; 3-trifluoromethylaniline With triethylamine In dichloromethane at 0℃; for 0.166667h; Stage #2: 1-(2,3-dichlorophenyl)piperazine In dichloromethane at 20℃; for 1h;	92%

...Expand

: 951-82-6
3,4,5-trimethoxyphenyl acetic acid

: 41202-77-1
1-(2,3-dichlorophenyl)piperazine

: 1-(4-(2,3-dichlorophenyl)piperazin-1-yl)-2-(3,4,5-trimethoxyphenyl)ethenone

Conditions

Conditions	Yield
Stage #1: 3,4,5-trimethoxyphenyl acetic acid With N-ethyl-N,N-diisopropylamine; HATU In N,N-dimethyl-formamide at 20℃; for 0.333333h; Stage #2: 1-(2,3-dichlorophenyl)piperazine In N,N-dimethyl-formamide at 20℃;	92%

: 41202-77-1
1-(2,3-dichlorophenyl)piperazine

: 215790-29-7
trans-2-(1-(4-(N-tert-butoxycarbonyl)amino)cyclohexyl)acetaldehyde

: trans N-tert-butoxycarbonyl-4-{2-[4-(2,3-dichlorophenyl)-piperazin-1-yl]ethyl}-cyclohexylamine

Conditions

Conditions	Yield
With sodium tris(acetoxy)borohydride; N-ethyl-N,N-diisopropylamine In 1,2-dichloro-ethane at 20℃; Inert atmosphere;	91%
With sodium tris(acetoxy)borohydride In dichloromethane	75%
With sodium tris(acetoxy)borohydride In 1,2-dichloro-ethane at 20℃;	69%
With platinum on carbon; hydrogen In methanol; toluene at 80℃; Reagent/catalyst; Temperature;

1-(2,3-Dichlorophenyl)-piperazine Chemical Properties

Molecular Structure of 1-(2,3-Dichlorophenyl)-piperazine hydrochloride (CAS NO.41202-77-1):

IUPAC Name: 1-(2,3-dichlorophenyl)piperazin-4-ium
Empirical Formula: C₁₀H₁₃Cl₃N₂
Molecular Weight: 267.5826
H bond acceptors: 2
H bond donors: 1
Freely Rotating Bonds: 1
Polar Surface Area: 3.24 Å²
Density: 1.272 g/cm³
Flash Point: 174.6 °C
Enthalpy of Vaporization: 61.14 kJ/mol
Boiling Point: 365.1 °C at 760 mmHg
Vapour Pressure: 1.6E-05 mmHg at 25 °C
Melting point: 242-244 °C
Product Categories: pharmacetical; PiperazineDerivative; Piperazine derivates; API intermediates; Aromatics Compounds; Aromatics; Intermediates & Fine Chemicals; Pharmaceuticals; Aripiprazole; piperazines

1-(2,3-Dichlorophenyl)-piperazine Safety Profile

Hazard Codes: Irritant Xi
Risk Statements: 36/37/38
R36/37/38:Irritating to eyes, respiratory system and skin.
Safety Statements: 26-36/37/39
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection.
Hazard Note: Irritant

1-(2,3-Dichlorophenyl)-piperazine Specification

1-(2,3-Dichlorophenyl)-piperazine hydrochloride , with CAS number of 41202-77-1, can be called 1-(2,3-Dichlorophenyl)piperazine hydrochloride (1:1) ; 1-(2,3-Dichlorphenyl)piperazinhydrochlorid ; piperazine, 1-(2,3-dichlorophenyl)-, hydrochloride (1:1) ; 1-(2,3-Dichlorophenyl)-Piperazine HCl . It is a kind of brown oil.

Product Name

1-(2,3-Dichlorophenyl)-piperazine hydrochloride

Synthetic route

1-(2,3-Dichlorophenyl)-piperazine Chemical Properties

1-(2,3-Dichlorophenyl)-piperazine Safety Profile

1-(2,3-Dichlorophenyl)-piperazine Specification

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