1-(4-Chlorobenzhydryl)piperazine supplier

Name
1-(4-Chlorobenzhydryl)piperazine
EINECS 206-137-4
CAS No. 303-26-4
Article Data24
CAS DataBase
Density 1.158 g/cm³
Solubility 144.6mg/L at 25℃
Melting Point 65-70 °C(lit.)
Formula C₁₇H₁₉ClN₂
Boiling Point 409.1 °C at 760 mmHg )
Molecular Weight 286.804
Flash Point 193.3 °C
Transport Information
Appearance white solid
Safety 26-37/39-24/25
Risk Codes 36/37/38
Molecular Structure
Hazard Symbols Xi
Synonyms Piperazine,1-(p-chloro-a-phenylbenzyl)-(6CI,7CI,8CI);1-(4-Chloro-a-phenylbenzyl)piperazine;N-(4-Chlorophenyl)phenylmethylpiperazine;NSC 86164;Piperazine,1-[(4-chlorophenyl)phenylmethyl]-;1-[(4-Chlorophenyl) phenylmethyl] piperazine;
PSA 15.27000
LogP 3.60130

Synthetic route

: 1-[(4-chlorophenyl)phenylmethyl]-4-[(4-methylphenyl)sulfonyl]piperazine

: 99-96-7
4-hydroxy-benzoic acid

: 303-26-4
N-(4-chlorobenzhydryl)piperazine

Conditions

Conditions	Yield
With sodium hydroxide; sodium chloride; hydrogen bromide In hexane; water; acetic acid; toluene	84.8%

: 110-85-0
piperazine

: 134-83-8
1-chloro-4-(chloro(phenyl)methyl)benzene

: 303-26-4
N-(4-chlorobenzhydryl)piperazine

Conditions

Conditions	Yield
With K2CO3; Ki In dichloromethane; butanone	57%
With Ki; potassium carbonate In dichloromethane; butanone	57%
With Ki; potassium carbonate In dichloromethane; butanone	57%

: 7755-92-2
piperazine-1-carbaldehyde

: 134-83-8
1-chloro-4-(chloro(phenyl)methyl)benzene

: 303-26-4
N-(4-chlorobenzhydryl)piperazine

Conditions

Conditions	Yield
With hydrogenchloride
With sodium hydroxide

(+-)-1-benzyl-4-<4-chloro-benzhydryl>-piperazine: (+-)-1-benzyl-4-<4-chloro-benzhydryl>-piperazine

: 303-26-4
N-(4-chlorobenzhydryl)piperazine

Conditions

Conditions	Yield
With ethanol; nickel at 150℃; under 73550.8 Torr; Hydrogenation;

(+-)-4-<4-chloro-benzhydryl>-piperazine-1-carboxylic acid ethyl ester: (+-)-4-<4-chloro-benzhydryl>-piperazine-1-carboxylic acid ethyl ester

: 303-26-4
N-(4-chlorobenzhydryl)piperazine

Conditions

Conditions	Yield
With potassium hydroxide
With hydrogenchloride

: 941576-98-3
(R)-(+)-4-(4-chlorophenyl)-phenylmethyl-piperazine-1-carboxylic acid-2,2,2-trichloroethylester hydrochloride

: 303-26-4
N-(4-chlorobenzhydryl)piperazine

Conditions

Conditions	Yield
With hydrogenchloride; zinc In tetrahydrofuran; methanol at 5 - 20℃; for 1h;
With acetic acid; zinc In methanol; toluene at 41 - 45℃; for 1.41667h;

: 941577-01-1
C20H20Cl4N2O2

: 303-26-4
N-(4-chlorobenzhydryl)piperazine

Conditions

Conditions	Yield
With acetic acid; zinc In methanol for 1h;

: 80476-89-7
ethyl {4-[(4-chlorophenyl)phenylmethyl]piperazin-1-yl}carboxylate

: 303-26-4
N-(4-chlorobenzhydryl)piperazine

Conditions

Conditions	Yield
With potassium hydroxide In methanol for 24h; Heating;

: 119-56-2
(4-chlorophenyl)phenylmethanol

: 303-26-4
N-(4-chlorobenzhydryl)piperazine

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: SOCl2 / CH2Cl2 / 1 h / 0 °C 2: acetonitrile / Heating View Scheme
Multi-step reaction with 2 steps 1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 20 °C 2: acetonitrile / Reflux View Scheme
Multi-step reaction with 2 steps 1: hydrogenchloride; calcium chloride / water / 4 h / 20 °C / Reflux 2: tetra-(n-butyl)ammonium iodide; potassium carbonate / tetrahydrofuran / 8 h / Reflux View Scheme

: 104-88-1
4-chlorobenzaldehyde

: 303-26-4
N-(4-chlorobenzhydryl)piperazine

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: tetrahydrofuran / 1 h / 20 °C 2: SOCl2 / CH2Cl2 / 1 h / 0 °C 3: acetonitrile / Heating View Scheme

: phenylmagnesium bromide

isopropyl magnesium halide: isopropyl magnesium halide

: 303-26-4
N-(4-chlorobenzhydryl)piperazine

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: tetrahydrofuran / 1 h / 20 °C 2: SOCl2 / CH2Cl2 / 1 h / 0 °C 3: acetonitrile / Heating View Scheme

: N-(2-hydroxyethyl)-12-bromododecanesulfonamide

: 303-26-4
N-(4-chlorobenzhydryl)piperazine

Conditions

Conditions	Yield
In water; N-ethyl-N,N-diisopropylamine

: 1155402-49-5
C24H23ClN2O2

: 303-26-4
N-(4-chlorobenzhydryl)piperazine

Conditions

Conditions	Yield
With sodium hydroxide; water In isopropyl alcohol at 90℃; for 2 - 3h; Product distribution / selectivity; Heating / reflux;

: 628717-39-5
4-[(4-chloro-phenyl)-phenyl-methyl]-piperazine-1-carboxylic acid 4-nitro-phenyl ester

: 303-26-4
N-(4-chlorobenzhydryl)piperazine

Conditions

Conditions	Yield
With sodium hydroxide; water In isopropyl alcohol at 90℃; for 48h; Product distribution / selectivity;

: 134-85-0
4-chlorobenzophenone

: 303-26-4
N-(4-chlorobenzhydryl)piperazine

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: sodium tetrahydroborate / tetrahydrofuran; methanol / 0.5 h / 0 °C 2: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 20 °C 3: acetonitrile / Reflux View Scheme
Multi-step reaction with 3 steps 1: sodium tetrahydroborate / methanol / 1.25 h / 0 - 20 °C 2: hydrogenchloride; calcium chloride / water / 4 h / 20 °C / Reflux 3: tetra-(n-butyl)ammonium iodide; potassium carbonate / tetrahydrofuran / 8 h / Reflux View Scheme
Multi-step reaction with 3 steps 1.1: sodium tetrahydroborate / ethanol / 0.5 h 1.2: Cooling with ice 2.1: hydrogenchloride; calcium chloride / water / 4 h / 85 °C 3.1: potassium carbonate / N,N-dimethyl-formamide / 0.17 h 3.2: 8 h / 80 °C View Scheme
Multi-step reaction with 3 steps 1: sodium tetrahydroborate / methanol / 20 °C 2: tetrabutylammomium bromide; hydrogenchloride / water; toluene / 40 - 45 °C 3: toluene / 60 - 100 °C View Scheme
Multi-step reaction with 3 steps 1: sodium tetrahydroborate / methanol 2: thionyl chloride / dichloromethane / 20 °C 3: N,N-dimethyl-formamide / 80 °C View Scheme

: 110-85-0
piperazine

: 134-83-8
1-chloro-4-(chloro(phenyl)methyl)benzene

A: 303-26-4
N-(4-chlorobenzhydryl)piperazine

B: 1,4-bis-(4-chloro-benzhydryl)-piperazine

Conditions

Conditions	Yield
With potassium carbonate In acetonitrile at 85℃; Sealed tube;	A n/a B 7.6 %Chromat.

...Expand

: 52017-21-7
(3-bromo-3-methyl-n-butyl)benzene

: 303-26-4
N-(4-chlorobenzhydryl)piperazine

: 106-99-0
buta-1,3-diene

: (E)-1-((4-chlorophenyl)(phenyl)methyl)-4-(5,5-dimethyl-7-phenylhept-2-en-1-yl)piperazine

Conditions

Conditions	Yield
With tetrakis(triphenylphosphine) palladium(0); potassium acetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl In tetrahydrofuran; N,N-dimethyl acetamide at 20℃; for 48h; Heck Reaction; Schlenk technique; Irradiation; Inert atmosphere;	99%

...Expand

: 50-00-0
formaldehyd

: 303-26-4
N-(4-chlorobenzhydryl)piperazine

: propargyl ether mycophenolate

: mycophenoyl methyl ester-7-(butynyloxy-N-(chlorobenzhydryl)piperazine)

Conditions

Conditions	Yield
With copper(l) iodide In 1,4-dioxane at 120℃; for 1h;	99%

...Expand

: 1918-79-2
2-methylthiophene-5-carboxylic acid

: 303-26-4
N-(4-chlorobenzhydryl)piperazine

: 1-[(4-chlorophenyl)(phenyl)methyl]-4-[(5-methyl-2-thienyl)carbonyl]piperazine

Conditions

Conditions	Yield
With 4-methyl-morpholine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃;	98%

: 1146300-32-4
7-chloro-1-(2,4-difluorophenyl)-1,4-dihydro-8-methyl-6-nitro-4-oxoquinolone-3-carboxylic acid

: 303-26-4
N-(4-chlorobenzhydryl)piperazine

: 1146300-51-7
7-(4-((4-chlorophenyl)(phenyl)methyl)piperazin-1-yl)-1-(2,4-difluorophenyl)-1,4-dihydro-8-methyl-6-nitro-4-oxoquinoline-3-carboxylic acid

Conditions

Conditions	Yield
With potassium carbonate In dimethyl sulfoxide Microwave irradiation;	96%

: 303-26-4
N-(4-chlorobenzhydryl)piperazine

: 5-(ethoxymethylene)thiazolidine-2,4-dione

: (Z)-5-((4-((4-chlorophenyl)(phenyl)methyl)piperazin-1-yl)methylene)thiazolidine-2,4-dione

Conditions

Conditions	Yield
Stage #1: N-(4-chlorobenzhydryl)piperazine; 5-(ethoxymethylene)thiazolidine-2,4-dione With triethylamine In acetonitrile Stage #2: at 45℃;	96%

: 213774-43-7
N-(3-Hydroxypropyl)-5-chloropentanesulfonamide

: 7285-11-2
chloroform methanol

: 303-26-4
N-(4-chlorobenzhydryl)piperazine

: N-(3-hydroxypropyl)-5-[4-[(4-chlorophenyl)phenylmethyl]-1-piperazinyl]pentanesulfonamide

Conditions

Conditions	Yield
In water; N-ethyl-N,N-diisopropylamine	95.1%

...Expand

: 36961-64-5
2-(2-chloroethoxy)acetamide

: 303-26-4
N-(4-chlorobenzhydryl)piperazine

: 83881-37-2, 163837-41-0, 163837-43-2
2-(2-(4-((4-chlorophenyl)(phenyl)methyl)piperazin-1-yl)ethoxy)acetamide

Conditions

Conditions	Yield
Stage #1: N-(4-chlorobenzhydryl)piperazine With tetrabutylammomium bromide; potassium carbonate In water at 25℃; Stage #2: 2-(2-chloroethoxy)acetamide In water at 80℃;	95%
With potassium iodide; sodium chloride; sodium carbonate; sodium sulfate In di-isopropyl ether; water; toluene	79.6%

: 303-26-4
N-(4-chlorobenzhydryl)piperazine

: 737828-47-6
N-((tert-butyloxy)carbonyl)-N'-(1-(methyl)-3-(phenyl)propyl)iminodiacetic acid monoamide

: 737828-55-6
(2-{4-[(4-chloro-phenyl)-phenyl-methyl]-piperazin-1-yl}-2-oxo-ethyl)-[(1-methyl-3-phenyl-propylcarbamoyl)-methyl]-carbamic acid tert-butyl ester

Conditions

Conditions	Yield
With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃; for 16h;	94%
With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃; for 16h;

: 7285-11-2
chloroform methanol

: 213774-14-2
N,N-diethyl-6-chlorohexanesulfonamide

: 303-26-4
N-(4-chlorobenzhydryl)piperazine

: N,N-Diethyl-6-[4-[(4-chlorophenyl)phenylmethyl]-1-piperazinyl]hexanesulfonamide

Conditions

Conditions	Yield
In water; N-ethyl-N,N-diisopropylamine	94%

...Expand

: 303-26-4
N-(4-chlorobenzhydryl)piperazine

: 79-04-9
chloroacetyl chloride

: 802009-62-7
2-chloro-1-(4-((4-chlorophenyl)(phenyl)methyl)piperazin-1-yl)ethanone

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 20℃; Inert atmosphere;	94%
With triethylamine In dichloromethane at 0 - 20℃; for 7h;	45%

: 303-26-4
N-(4-chlorobenzhydryl)piperazine

: 287714-41-4
rosuvastatin

: 1235588-98-3
(E)-7-{4-(4-fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]-pyrimidin-5-yl}-(3R,5S)-3,5-dihydroxy-hept-6-enoic acid 1-[(4-chlorophenyl)-phenyl-methyl]piperazinium salt

Conditions

Conditions	Yield
In Isopropyl acetate at 20 - 60℃; for 4.5h; Product distribution / selectivity;	93%

: 213774-12-0
N,N-dimethyl-6-chlorohexanesulfonamide

: 7285-11-2
chloroform methanol

: 303-26-4
N-(4-chlorobenzhydryl)piperazine

: N,N-Dimethyl-6-[4-[(4-chlorophenyl)phenylmethyl]-1-piperazinyl]hexanesulfonamide

Conditions

Conditions	Yield
In water; N-ethyl-N,N-diisopropylamine	92.1%

...Expand

: 303-26-4
N-(4-chlorobenzhydryl)piperazine

: 115700-26-0
7-chloro-6-(difluoromethoxy)-1,4-dihydro-1-ethyl4-oxo-3-quinolinecarboxylic acid

: 7-{4-[(4-Chloro-phenyl)-phenyl-methyl]-piperazin-1-yl}-6-difluoromethoxy-1-ethyl-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid

Conditions

Conditions	Yield
at 130 - 140℃; for 3h;	92%

: 303-26-4
N-(4-chlorobenzhydryl)piperazine

: 737828-50-1
N-((tert-butyloxy)carbonyl)-N'-(2-(4-(4-bromophenyl)thiazole))iminodiacetic acid monoamide

: 737828-59-0
{[4-(4-bromo-phenyl)-thiazol-2-ylcarbamoyl]-methyl}-(2-{4-[(4-chloro-phenyl)-phenyl-methyl]-piperazin-1-yl}-2-oxo-ethyl)-carbamic acid tert-butyl ester

Conditions

Conditions	Yield
With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃; for 16h;	92%

: 889868-60-4
ethyl 3-(o-trifluoroacetamidophenyl)-1-propargyl carbonate

: 303-26-4
N-(4-chlorobenzhydryl)piperazine

: 2-{4-[(4-chloro-phenyl)-phenyl-methyl]-piperazin-1-ylmethyl}-1H-indole

Conditions

Conditions	Yield
With tetrakis(triphenylphosphine) palladium(0) In tetrahydrofuran at 80℃; for 8h;	92%
With tetrakis(triphenylphosphine) palladium(0) In tetrahydrofuran at 80℃; for 8h; Inert atmosphere;	92%

: 213774-30-2
N-(2-Hydroxyethyl)-6-chlorohexanesulfonamide

: 7285-11-2
chloroform methanol

: 303-26-4
N-(4-chlorobenzhydryl)piperazine

: N-(2-hydroxyethyl)-6-[4-[(4-chlorophenyl)phenylmethyl]-1-piperazinyl]hexanesulfonamide

Conditions

Conditions	Yield
In water; N-ethyl-N,N-diisopropylamine	91.5%

...Expand

: 213774-42-6
N-(2-Hydroxyethyl)-5-chloropentanesulfonamide

: 7285-11-2
chloroform methanol

: 303-26-4
N-(4-chlorobenzhydryl)piperazine

: N-(2-hydroxyethyl)-5-[4-[(4-chlorophenyl)phenylmethyl]-1-piperazinyl]pentanesulfonamide

Conditions

Conditions	Yield
In water; N-ethyl-N,N-diisopropylamine	91.4%

...Expand

: N-n-butyl-N-methyl-6-chlorohexanesulfonamide

: 7285-11-2
chloroform methanol

: 303-26-4
N-(4-chlorobenzhydryl)piperazine

: N-n-butyl-N-methyl-6-[4-[(4-chlorophenyl)phenylmethyl]-1-piperazinyl]hexanesulfonamide

Conditions

Conditions	Yield
In water; N-ethyl-N,N-diisopropylamine	91.4%

...Expand

: 303-26-4
N-(4-chlorobenzhydryl)piperazine

: (2-{4-[(4-chlorophenyl)phenylmethyl]piperazin-1-yl}ethoxy)acetic acid ethyl ester

Conditions

Conditions	Yield
With triethylamine	90.8%
With triethylamine	90.8%
With triethylamine In (2-chloro-ethoxy)-acetic acid ethyl ester	89.4%
With triethylamine In (2-chloro-ethoxy)-acetic acid ethyl ester	89.4%

: 303-26-4
N-(4-chlorobenzhydryl)piperazine

: 1711-07-5
3-fluorobenzoyl chloride

: {4-[(4-chlorophenyl)phenylmethyl]piperazin-1-yl}-(3-fluorophenyl)methanone

Conditions

Conditions	Yield
With dmap; triethylamine In 1,2-dichloro-ethane at 20℃;	90%

: 1146300-31-3
7-chloro-1-cyclopropyl-1,4-dihydro-8-methyl-6-nitro-4-oxoquinolone-3-carboxylic acid

: 303-26-4
N-(4-chlorobenzhydryl)piperazine

: 1146300-34-6
7-(4-((4-chlorophenyl)(phenyl)methyl)piperazin-1-yl)-1-cyclopropyl-1,4-dihydro-8-methyl-6-nitro-4-oxoquinoline-3-carboxylic acid

Conditions

Conditions	Yield
With potassium carbonate In dimethyl sulfoxide Microwave irradiation;	90%

: 1146300-33-5
1-tert-butyl-7-chloro-1-1,4-dihydro-8-methyl-6-nitro-4-oxoquinolone-3-carboxylic acid

: 303-26-4
N-(4-chlorobenzhydryl)piperazine

: 1146300-68-6
1-tert-butyl-7-(4-((4-chlorophenyl)(phenyl)methyl)piperazin-1-yl)-1,4-dihydro-8-methyl-6-nitro-4-oxoquinoline-3-carboxylic acid

Conditions

Conditions	Yield
With potassium carbonate In dimethyl sulfoxide Microwave irradiation;	90%

: 303-26-4
N-(4-chlorobenzhydryl)piperazine

: 194996-03-7
2-([(tert-butoxy)carbonyl]{2-[(4-methoxybenzyl)amino]-2-oxoethyl}amino)acetic acid

: 737828-54-5
N-((t-butyloxy)carbonyl)-N'-(4-methoxybenzyl)-N"-1-(4-chlorobenzhydryl)piperazine iminodiacetic acid diamide

Conditions

Conditions	Yield
With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃; for 16h;	89%
With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃; for 16h;	89%
With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃; for 16h;

: 959908-92-0
(Z)-3-(4-phenylbutan-2-ylcarbamoyl)acrylic acid

: 303-26-4
N-(4-chlorobenzhydryl)piperazine

: (Z)-4-(4-((4-chlorophenyl)(phenyl)methyl)piperazin-1-yl)-N-(4-phenylbutan-2-yl)-4-oxobut-2-enamide

Conditions

Conditions	Yield
With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃; for 16h;	89%

: 83881-47-4
(2-Chloro-ethoxy)-acetic acid methyl ester

: 303-26-4
N-(4-chlorobenzhydryl)piperazine

: 83881-46-3, 163837-44-3, 163837-46-5
methyl 2-[2-[4-[(4-chlorophenyl)phenylmethyl]-1-piperazinyl]ethoxy]-acetate

Conditions

Conditions	Yield
With triethylamine	88.7%
With triethylamine	88.7%
With potassium iodide; sodium carbonate In methanol; dichloromethane; toluene	67.5%
With potassium iodide; sodium carbonate In methanol; dichloromethane; toluene	55.1%

: 75-15-0
carbon disulfide

: 39186-58-8
4-bromo-2,2-diphenylbutyronitrile

: 303-26-4
N-(4-chlorobenzhydryl)piperazine

: 4-[(4-chloro-phenyl)-phenyl-methyl]-piperazine-1-carbodithioic acid 3-cyano-3,3-diphenyl-propyl ester

Conditions

Conditions	Yield
Stage #1: carbon disulfide; N-(4-chlorobenzhydryl)piperazine With potassium phosphate In acetone at 20℃; for 0.5h; Stage #2: 4-bromo-2,2-diphenylbutyronitrile In acetone at 20℃;	88%

...Expand

: 24424-99-5
di-tert-butyl dicarbonate

: 303-26-4
N-(4-chlorobenzhydryl)piperazine

: 454217-55-1, 454217-56-2, 454217-59-5
1-[(4-chlorophenyl)phenylmethyl]-4-(tert-butoxycarbonyl)-piperazine

Conditions

Conditions	Yield
Stage #1: di-tert-butyl dicarbonate; N-(4-chlorobenzhydryl)piperazine With sodium hydroxide In water; toluene at 35℃; for 5h; Stage #2: In n-heptane at 0 - 64℃; for 8.5h;	87.9%

: 1351231-59-8
C17H21FN2O5

: 303-26-4
N-(4-chlorobenzhydryl)piperazine

: 1351231-52-1
tert-butyl (S)-4-(4-((4-chlorophenyl)(phenyl)methyl)piperazin-1-yl)-1-(5-fluoroisoindolin-2-yl)-1,4-dioxobutan-2-ylcarbamate

Conditions

Conditions	Yield
With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine In dichloromethane	87%

: 303-26-4
N-(4-chlorobenzhydryl)piperazine

: 191281-21-7
N-((tert-butyloxy)carbonyl)-N'-(4-methylbenzyl) iminodiacetic acid monoamide

: 737828-53-4
(2-{4-[(4-chloro-phenyl)-phenyl-methyl]-piperazin-1-yl}-2-oxo-ethyl)-[(4-methyl-benzylcarbamoyl)-methyl]-carbamic acid tert-butyl ester

Conditions

Conditions	Yield
With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃; for 16h;	86%
With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃; for 16h;

1-(4-Chlorobenzhydryl)piperazine Specification

The 1-(4-Chlorobenzhydryl)piperazine, with the CAS registry number 303-26-4,is also known as N-(p-Chlorobenzhydryl)piperazine. It belongs to the product categories of Halogenated Heterocycles;Heterocyclic Building Blocks.This chemical's molecular formula is C₁₇H₁₉ClN₂ and molecular weight is 286.80.Its EINECS number is 206-137-4. What's more,Its systematic name is N-(4-Chlorobenzhydryl)piperazine.It is a White Solid and store in the Refrigerator.It is a metabolite of Cetirizine and Hydroxyzine.

Physical properties about 1-(4-Chlorobenzhydryl)piperazine are:
(1)ACD/LogP: 3.164; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): 0.22; (4)ACD/LogD (pH 7.4): 1.61; (5)ACD/BCF (pH 5.5): 1.00; (6)ACD/BCF (pH 7.4): 4.19; (7)ACD/KOC (pH 5.5): 1.44; (8)ACD/KOC (pH 7.4): 35.11; (9)#H bond acceptors: 2; (10)#H bond donors: 1; (11)#Freely Rotating Bonds: 3; (12)Index of Refraction: 1.592; (13)Molar Refractivity: 83.824 cm3; (14)Molar Volume: 247.642 cm3; (15)Surface Tension: 44.0519981384277 dyne/cm; (16)Density: 1.158 g/cm3; (17)Flash Point: 193.269 °C; (18)Enthalpy of Vaporization: 66.124 kJ/mol; (19)Boiling Point: 409.11 °C at 760 mmHg; (20)Vapour Pressure: 0 mmHg at 25°C.

You can still convert the following datas into molecular structure:
(1)SMILES:Clc1ccc(cc1)C(c2ccccc2)N3CCNCC3;
(2)Std. InChI:InChI=1S/C17H19ClN2/c18-16-8-6-15(7-9-16)17(14-4-2-1-3-5-14)20-12-10-19-11-13-20/h1-9,17,19H,10-13H2;
(3)Std. InChIKey:UZKBSZSTDQSMDR-UHFFFAOYSA-N.

Safety Information of 1-(4-Chlorobenzhydryl)piperazine:
The 1-(4-Chlorobenzhydryl)piperazine is Irritating to eyes, respiratory system and skin.When you use ie wear suitable gloves and eye/face protection and avoid contact with skin and eyes.In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.

Product Name

1-(4-Chlorobenzhydryl)piperazine

Synthetic route

1-(4-Chlorobenzhydryl)piperazine Specification

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