Product Name

  • Name

    1,1,2,2-Tetrafluoroethyl methyl ether

  • EINECS 207-039-4
  • CAS No. 425-88-7
  • Article Data10
  • CAS DataBase
  • Density 1.238 g/cm3
  • Solubility
  • Melting Point -107 °C
  • Formula C3H4F4O
  • Boiling Point 10.1 °C at 760 mmHg
  • Molecular Weight 132.058
  • Flash Point -20 °C
  • Transport Information
  • Appearance Colorless Volatile liquid
  • Safety 36/37/39-45-33-26-16-9
  • Risk Codes 23/24/25-36/37/38-12
  • Molecular Structure Molecular Structure of 425-88-7 (1,1,2,2-Tetrafluoroethyl methyl ether)
  • Hazard Symbols ToxicT,IrritantXi,HighlyF+
  • Synonyms Ether,methyl 1,1,2,2-tetrafluoroethyl (7CI,8CI);1,1,2,2-Tetrafluoro-1-methoxyethane;HFE 254pc;Methyl 1,1,2,2-tetrafluoroethyl ether;
  • PSA 9.23000
  • LogP 1.49070

Synthetic route

polytetrafluoroethylene
116-14-3

polytetrafluoroethylene

sodium methylate
124-41-4

sodium methylate

1,1,2,2-tetrafluoro-1-methoxyethane
425-88-7

1,1,2,2-tetrafluoro-1-methoxyethane

Conditions
ConditionsYield
under 14710.2 Torr;
In 1,4-dioxane
methyl hypofluorite
36336-08-0

methyl hypofluorite

1,1,2-trifluoroethylene
359-11-5

1,1,2-trifluoroethylene

A

1,1,2,2-tetrafluoro-1-methoxyethane
425-88-7

1,1,2,2-tetrafluoro-1-methoxyethane

B

(1,2,2,2-tetrafluoroethyl)methyl ether
50285-05-7

(1,2,2,2-tetrafluoroethyl)methyl ether

Conditions
ConditionsYield
In [D3]acetonitrile at -78 - 20℃; Title compound not separated from byproducts;
...Expand
methanol
67-56-1

methanol

polytetrafluoroethylene
116-14-3

polytetrafluoroethylene

1,1,2,2-tetrafluoro-1-methoxyethane
425-88-7

1,1,2,2-tetrafluoro-1-methoxyethane

Conditions
ConditionsYield
With sodium methylate
benzophenone
119-61-9

benzophenone

1,1,2,2-tetrafluoro-1-methoxyethane
425-88-7

1,1,2,2-tetrafluoro-1-methoxyethane

1,1-diphenyl-2,2,3,3-tetrafluoro-3-methoxypropan-1-ol

1,1-diphenyl-2,2,3,3-tetrafluoro-3-methoxypropan-1-ol

Conditions
ConditionsYield
With potassium hexamethylsilazane In toluene at 20℃; for 0.25h; Inert atmosphere;99%
1,1,2,2-tetrafluoro-1-methoxyethane
425-88-7

1,1,2,2-tetrafluoro-1-methoxyethane

difluoroacetic acid methyl ester
433-53-4

difluoroacetic acid methyl ester

Conditions
ConditionsYield
With water; fluorinated γ-alumina at 180℃; for 0.02h; Product distribution / selectivity; Inert atmosphere; Gas phase;94.5%
1,1,2,2-tetrafluoro-1-methoxyethane
425-88-7

1,1,2,2-tetrafluoro-1-methoxyethane

2,2-difluoroacetyl fluoride
2925-22-6

2,2-difluoroacetyl fluoride

Conditions
ConditionsYield
With alumina; hydrogen fluoride at 220 - 230℃;90%
With aluminum oxide at 200 - 300℃;90%
With antimony pentafluoride In 1,2-dichloro-ethane at 25℃; for 3h; Autoclave;
1,1,2,2-tetrafluoro-1-methoxyethane
425-88-7

1,1,2,2-tetrafluoro-1-methoxyethane

A

Methyl fluoride
593-53-3

Methyl fluoride

B

2,2-difluoroacetyl fluoride
2925-22-6

2,2-difluoroacetyl fluoride

Conditions
ConditionsYield
antimony pentafluoride In neat (no solvent)A n/a
B 88%
aluminum phosphate treatment with HF at 300C for 72 h at 210℃; Product distribution / selectivity; Inert atmosphere;
With monoaluminum phosphate; hydrogen fluoride at 200℃; Inert atmosphere; Autoclave;
1,1,2,2-tetrafluoro-1-methoxyethane
425-88-7

1,1,2,2-tetrafluoro-1-methoxyethane

4,4'-Difluorobenzophenone
345-92-6

4,4'-Difluorobenzophenone

1,1-bis(4-fluorophenyl)-2,2,3,3-tetrafluoro-3-methoxypropan-1-ol

1,1-bis(4-fluorophenyl)-2,2,3,3-tetrafluoro-3-methoxypropan-1-ol

Conditions
ConditionsYield
With potassium hexamethylsilazane In toluene at 20℃; for 0.25h; Inert atmosphere;75%
1,1,2,2-tetrafluoro-1-methoxyethane
425-88-7

1,1,2,2-tetrafluoro-1-methoxyethane

N-benzylidene-4-(trifluoromethyl)aniline
351-98-4

N-benzylidene-4-(trifluoromethyl)aniline

N-(4-trifluoromethylphenyl)-1-phenyl-2,2,3,3-tetrafluoro-3-methoxypropylamine

N-(4-trifluoromethylphenyl)-1-phenyl-2,2,3,3-tetrafluoro-3-methoxypropylamine

Conditions
ConditionsYield
With potassium hexamethylsilazane In N,N-dimethyl-formamide at -10℃; for 0.5h;61%
1,1,2,2-tetrafluoro-1-methoxyethane
425-88-7

1,1,2,2-tetrafluoro-1-methoxyethane

potassium 2,2-difluoroacetate

potassium 2,2-difluoroacetate

Conditions
ConditionsYield
With methanol; potassium hydroxide at 50℃; for 8 - 16h; Product distribution / selectivity;51.7%
1,1,2,2-tetrafluoro-1-methoxyethane
425-88-7

1,1,2,2-tetrafluoro-1-methoxyethane

N-[phenylmethylidene]-3-(trifluoromethyl)aniline

N-[phenylmethylidene]-3-(trifluoromethyl)aniline

N-(3-trifluoromethylphenyl)-1-phenyl-2,2,3,3-tetrafluoro-3-methoxypropylamine

N-(3-trifluoromethylphenyl)-1-phenyl-2,2,3,3-tetrafluoro-3-methoxypropylamine

Conditions
ConditionsYield
With potassium hexamethylsilazane In N,N-dimethyl-formamide at -10℃; for 0.5h;49%
1,1,2,2-tetrafluoro-1-methoxyethane
425-88-7

1,1,2,2-tetrafluoro-1-methoxyethane

chloromethyl-(1,1,2,2-tetrafluoro-ethyl)-ether
428-93-3

chloromethyl-(1,1,2,2-tetrafluoro-ethyl)-ether

Conditions
ConditionsYield
With chlorine Irradiation;
With chlorine Irradiation;
1,1,2,2-tetrafluoro-1-methoxyethane
425-88-7

1,1,2,2-tetrafluoro-1-methoxyethane

1,1,2,2-Tetrafluorethyldichlormethylether
32776-68-4

1,1,2,2-Tetrafluorethyldichlormethylether

Conditions
ConditionsYield
With chlorine Irradiation;
With chlorine
1,1,2,2-tetrafluoro-1-methoxyethane
425-88-7

1,1,2,2-tetrafluoro-1-methoxyethane

1,1,2,2-Tetrafluorethyltrichlormethylether
32776-69-5

1,1,2,2-Tetrafluorethyltrichlormethylether

Conditions
ConditionsYield
With chlorine Irradiation;
1,1,2,2-tetrafluoro-1-methoxyethane
425-88-7

1,1,2,2-tetrafluoro-1-methoxyethane

(2-Chlor-1,1,2,2-tetrafluor-ethyl)-trichlormethyl-ether
32776-70-8

(2-Chlor-1,1,2,2-tetrafluor-ethyl)-trichlormethyl-ether

Conditions
ConditionsYield
With chlorine Irradiation;
1,1,2,2-tetrafluoro-1-methoxyethane
425-88-7

1,1,2,2-tetrafluoro-1-methoxyethane

chlorine
7782-50-5

chlorine

chloromethyl-(1,1,2,2-tetrafluoro-ethyl)-ether
428-93-3

chloromethyl-(1,1,2,2-tetrafluoro-ethyl)-ether

Conditions
ConditionsYield
Irradiation;
1,1,2,2-tetrafluoro-1-methoxyethane
425-88-7

1,1,2,2-tetrafluoro-1-methoxyethane

A

C3H3F4O

C3H3F4O

B

C3H3F4O

C3H3F4O

Conditions
ConditionsYield
With clorine at -0.15℃; Kinetics; Further Variations:; Temperatures;
methanol
67-56-1

methanol

1,1,2,2-tetrafluoro-1-methoxyethane
425-88-7

1,1,2,2-tetrafluoro-1-methoxyethane

1,1,2,2,3,3-hexafluoro-1-[(1,2,2-trifluoroethenyl)oxy]-3-(trifluoromethoxy)-propane
40573-09-9

1,1,2,2,3,3-hexafluoro-1-[(1,2,2-trifluoroethenyl)oxy]-3-(trifluoromethoxy)-propane

A

methyl 4-oxaperfluoropentanoate
356-69-4

methyl 4-oxaperfluoropentanoate

B

perfluoro-3,7-dioxaoctanoic acid methyl ester
1093074-17-9

perfluoro-3,7-dioxaoctanoic acid methyl ester

Conditions
ConditionsYield
With oxygen; perfluoro (3,6-dioxa-heptanoic acid) methyl ester; boron trifluoride at 85℃;
...Expand
1,1,2,2-tetrafluoro-1-methoxyethane
425-88-7

1,1,2,2-tetrafluoro-1-methoxyethane

A

methylene chloride
74-87-3

methylene chloride

B

difluoroacetyl chloride
381-72-6

difluoroacetyl chloride

C

2,2-difluoroacetyl fluoride
2925-22-6

2,2-difluoroacetyl fluoride

Conditions
ConditionsYield
With calcium chloride at 200℃; Inert atmosphere; Autoclave;A 71.386 %Chromat.
B 16.22 %Chromat.
C 10.657 %Chromat.
...Expand
1,1,2,2-tetrafluoro-1-methoxyethane
425-88-7

1,1,2,2-tetrafluoro-1-methoxyethane

A

methylene chloride
74-87-3

methylene chloride

B

difluoroacetyl chloride
381-72-6

difluoroacetyl chloride

Conditions
ConditionsYield
With calcium chloride at 200℃; Temperature; Inert atmosphere; Autoclave;A 70.762 %Chromat.
B 27.992 %Chromat.
1,1,2,2-tetrafluoro-1-methoxyethane
425-88-7

1,1,2,2-tetrafluoro-1-methoxyethane

difluoroacetyl chloride
381-72-6

difluoroacetyl chloride

Conditions
ConditionsYield
Stage #1: 1,1,2,2-tetrafluoro-1-methoxyethane With hydrogen fluoride at 175℃; Inert atmosphere; Autoclave;
Stage #2: With calcium chloride at 160℃; Inert atmosphere; Autoclave;		93.769 %Chromat.
methanol
67-56-1

methanol

1,1,2,2-tetrafluoro-1-methoxyethane
425-88-7

1,1,2,2-tetrafluoro-1-methoxyethane

3-dimethylaminoacrylonitrile
2407-68-3

3-dimethylaminoacrylonitrile

methylhydrazine
60-34-4

methylhydrazine

methyl 3-(difluoromethyl)-1-methyl-1H-pyrazole carboximidoate hydrochloric acid salt

methyl 3-(difluoromethyl)-1-methyl-1H-pyrazole carboximidoate hydrochloric acid salt

Conditions
ConditionsYield
Stage #1: 1,1,2,2-tetrafluoro-1-methoxyethane; 3-dimethylaminoacrylonitrile With FeCl3/C; triethylamine In toluene at 10 - 15℃; for 2h; Inert atmosphere;
Stage #2: methylhydrazine With sodium hydroxide In water; toluene at 0℃; for 3h;
Stage #3: methanol Further stages;
...Expand
1,1,2,2-tetrafluoro-1-methoxyethane
425-88-7

1,1,2,2-tetrafluoro-1-methoxyethane

methyl 1,2,2-trifluorovinyl ether
3823-94-7

methyl 1,2,2-trifluorovinyl ether

Conditions
ConditionsYield
With sodium ethanolate

1,1,2,2-Tetrafluoroethyl methyl ether Specification

The Ethane,1,1,2,2-tetrafluoro-1-methoxy-, with CAS registry number 425-88-7, belongs to the following product category: refrigerants. It has the systematic name of 1,1,2,2-tetrafluoro-1-methoxyethane. And its IUPAC name is the same one. What's more, its EINECS is 207-039-4.

Physical properties of Ethane,1,1,2,2-tetrafluoro-1-methoxy-: (1)ACD/LogP: 0.91; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): 0.91; (4)ACD/LogD (pH 7.4): 0.91; (5)ACD/BCF (pH 5.5): 2.88; (6)ACD/BCF (pH 7.4): 2.88; (7)ACD/KOC (pH 5.5): 74.24; (8)ACD/KOC (pH 7.4): 74.24; (9)#H bond acceptors: 1; (10)#H bond donors: 0; (11)#Freely Rotating Bonds: 2; (12)Polar Surface Area: 9.23 Å2; (13)Index of Refraction: 1.272; (14)Molar Refractivity: 18.27 cm3; (15)Molar Volume: 106.6 cm3; (16)Polarizability: 7.24×10-24cm3; (17)Surface Tension: 12.7 dyne/cm; (18)Enthalpy of Vaporization: 24.75 kJ/mol; (19)Vapour Pressure: 1280 mmHg at 25°C.

Uses of Ethane,1,1,2,2-tetrafluoro-1-methoxy-: it can be used to produce difluoroacetyl fluoride and fluoromethane. This reaction will need solvent neat (no solvent). The yield is about 88%.

When you are using this chemical, please be cautious about it as the following:
The Ethane,1,1,2,2-tetrafluoro-1-methoxy- is extremely flammable, so keep it away from sources of ignition. This chemical is toxic by inhalation, in contact with skin and if swallowed. You should keep its container in a well-ventilated place and take precautionary measures against static discharges. This chemical also irritates to eyes, respiratory system and skin. When use it, wear suitable protective clothing, gloves and eye/face protection. If contact with eyes, rinse immediately with plenty of water and seek medical advice. In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)

You can still convert the following datas into molecular structure:
(1)SMILES: FC(F)C(F)(F)OC
(2)InChI: InChI=1/C3H4F4O/c1-8-3(6,7)2(4)5/h2H,1H3
(3)InChIKey: YQQHEHMVPLLOKE-UHFFFAOYAF
(4)Std. InChI: InChI=1S/C3H4F4O/c1-8-3(6,7)2(4)5/h2H,1H3
(5)Std. InChIKey: YQQHEHMVPLLOKE-UHFFFAOYSA-N

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