Product Name

  • Name

    1,1,3,3-Tetramethoxypropane

  • EINECS 203-037-2
  • CAS No. 102-52-3
  • Article Data23
  • CAS DataBase
  • Density 0.964 g/cm3
  • Solubility Immiscible with water
  • Melting Point
  • Formula C7H16O4
  • Boiling Point 183 °C at 760 mmHg
  • Molecular Weight 164.202
  • Flash Point 54.4 °C
  • Transport Information UN 1993 3/PG 3
  • Appearance clear colourless to yellow-brown liquid
  • Safety 16-26-36/37/39
  • Risk Codes 10-36/37/38
  • Molecular Structure Molecular Structure of 102-52-3 (1,1,3,3-Tetramethoxypropane)
  • Hazard Symbols FlammableF
  • Synonyms Malonaldehyde,bis(dimethyl acetal) (6CI,7CI,8CI);AI3-28938;Malonaldehyde tetramethyl acetal;NSC 27794;Tetramethoxypropane;Propane, 1,1,3,3-tetramethoxy-;
  • PSA 36.92000
  • LogP 0.61430

Synthetic route

methoxyethene
107-25-5

methoxyethene

trimethyl orthoformate
149-73-5

trimethyl orthoformate

A

malonaldehydebis(dimethylacetal)
102-52-3

malonaldehydebis(dimethylacetal)

B

1,1,3,5,5-pentamethoxy-pentane
55546-58-2

1,1,3,5,5-pentamethoxy-pentane

Conditions
ConditionsYield
With boron trifluoride diethyl etherate In dichloromethane at -78℃; for 6h;A 65%
B 8%
methanol
67-56-1

methanol

cyclohexa-1,4-diene
1165952-92-0

cyclohexa-1,4-diene

A

methyl 3,3-dimethoxypropionate
7424-91-1

methyl 3,3-dimethoxypropionate

B

malonaldehydebis(dimethylacetal)
102-52-3

malonaldehydebis(dimethylacetal)

C

malonic acid dimethyl ester
108-59-8

malonic acid dimethyl ester

Conditions
ConditionsYield
With hydrogenchloride; ozone -40 deg C, then ca. 30 min reflux; Yields of byproduct given;A 60%
B n/a
C n/a
With hydrogenchloride; ozone at -40℃; -40 deg C, then ca. 30 min reflux; Yield given;A 60%
B n/a
C n/a
With hydrogenchloride; ozone at -40℃; Product distribution;A 60%
B n/a
C n/a
vinyl acetate
108-05-4

vinyl acetate

trimethyl orthoformate
149-73-5

trimethyl orthoformate

malonaldehydebis(dimethylacetal)
102-52-3

malonaldehydebis(dimethylacetal)

Conditions
ConditionsYield
With iron(III) chloride; sodium hydrogencarbonate 1) 2 h, reflux; 2) 20 deg C, 2 h;36%
With iron(III) chloride at 60℃;
methanol
67-56-1

methanol

1,1,3-trimethoxy-3-acethoxypropane
98561-07-0

1,1,3-trimethoxy-3-acethoxypropane

malonaldehydebis(dimethylacetal)
102-52-3

malonaldehydebis(dimethylacetal)

Conditions
ConditionsYield
With boron fluoride ether
methoxyethene
107-25-5

methoxyethene

trifluoroborane diethyl ether
109-63-7

trifluoroborane diethyl ether

trimethyl orthoformate
149-73-5

trimethyl orthoformate

A

1-ethoxy-1,3,3-trimethoxypropane
123-59-1

1-ethoxy-1,3,3-trimethoxypropane

B

malonaldehydebis(dimethylacetal)
102-52-3

malonaldehydebis(dimethylacetal)

methoxyethene
107-25-5

methoxyethene

trimethyl orthoformate
149-73-5

trimethyl orthoformate

malonaldehydebis(dimethylacetal)
102-52-3

malonaldehydebis(dimethylacetal)

Conditions
ConditionsYield
With boron fluoride ether
at 84℃; under 37.5038 Torr; for 1h; Reactivity; Gas phase;
With boron trifluoride diethyl etherate Reactivity; Gas phase;
With boron fluoride ether
methanol
67-56-1

methanol

Propargylic aldehyde
624-67-9

Propargylic aldehyde

malonaldehydebis(dimethylacetal)
102-52-3

malonaldehydebis(dimethylacetal)

Conditions
ConditionsYield
(i) N-methylpiperidine, (ii) HCl; Multistep reaction;
methanol
67-56-1

methanol

3-phenoxy-propenal
2862-47-7

3-phenoxy-propenal

malonaldehydebis(dimethylacetal)
102-52-3

malonaldehydebis(dimethylacetal)

methanol
67-56-1

methanol

3,3-dimethoxypropanal
19060-10-7

3,3-dimethoxypropanal

malonaldehydebis(dimethylacetal)
102-52-3

malonaldehydebis(dimethylacetal)

Conditions
ConditionsYield
With hydrogenchloride
methanol
67-56-1

methanol

(Z)-1,1,6,6-Tetramethoxy-3-hexen
123331-77-1

(Z)-1,1,6,6-Tetramethoxy-3-hexen

A

methyl 3,3-dimethoxypropionate
7424-91-1

methyl 3,3-dimethoxypropionate

B

malonaldehydebis(dimethylacetal)
102-52-3

malonaldehydebis(dimethylacetal)

Conditions
ConditionsYield
With hydrogenchloride; ozone 1.) -40 deg C, 2.) reflux, 1 h; Yield given. Multistep reaction;
With hydrogenchloride; reflux; ozone
methanol
67-56-1

methanol

cyclopenta-1,3-diene
542-92-7

cyclopenta-1,3-diene

A

malonaldehydebis(dimethylacetal)
102-52-3

malonaldehydebis(dimethylacetal)

B

methyl 3-oxopropionate
63857-17-0

methyl 3-oxopropionate

C

3t-methoxy-propenal
78923-06-5

3t-methoxy-propenal

D

3,3-dimethoxypropanal
19060-10-7

3,3-dimethoxypropanal

Conditions
ConditionsYield
With 2,3-dimercapto-succinic acid; ozone 1) -78 deg C; Yield given. Multistep reaction. Yields of byproduct given;
With 2,3-dimercapto-succinic acid; ozone 1) -78 deg C; Yield given. Multistep reaction. Yields of byproduct given. Title compound not separated from byproducts;
linoleic acid
60-33-3

linoleic acid

A

malonaldehydebis(dimethylacetal)
102-52-3

malonaldehydebis(dimethylacetal)

B

acrolein
107-02-8

acrolein

Conditions
ConditionsYield
With ozone In various solvent(s) for 0.5h; pH=8; Product distribution; Oxidation;
all cis 5,8,11,14-eicosatetraenoic acid
506-32-1

all cis 5,8,11,14-eicosatetraenoic acid

A

malonaldehydebis(dimethylacetal)
102-52-3

malonaldehydebis(dimethylacetal)

B

acrolein
107-02-8

acrolein

Conditions
ConditionsYield
With ozone In various solvent(s) for 0.5h; pH=8; Product distribution; Oxidation;
vinyl acetate
108-05-4

vinyl acetate

iron(III) chloride
7705-08-0

iron(III) chloride

trimethyl orthoformate
149-73-5

trimethyl orthoformate

malonaldehydebis(dimethylacetal)
102-52-3

malonaldehydebis(dimethylacetal)

Conditions
ConditionsYield
at 60℃; reagiert analog mit Orthoameisensaeure-triaethylester in Gegenwart von FeCl3, AlCl3, SnCl2 oder SnCl4;
at 60℃;
methanol
67-56-1

methanol

1,1,diacetoxy-3,3-dimethoxy-propane

1,1,diacetoxy-3,3-dimethoxy-propane

malonaldehydebis(dimethylacetal)
102-52-3

malonaldehydebis(dimethylacetal)

Conditions
ConditionsYield
With boron fluoride ether
methanol
67-56-1

methanol

1,5-dimethylcyclohexa-1,4-diene
4190-06-1

1,5-dimethylcyclohexa-1,4-diene

A

malonaldehydebis(dimethylacetal)
102-52-3

malonaldehydebis(dimethylacetal)

B

3,5-dimethoxy-[1,2]dioxolane

3,5-dimethoxy-[1,2]dioxolane

C

3,5-dimethoxy-3,5-dimethyl-[1,2]dioxolane

3,5-dimethoxy-3,5-dimethyl-[1,2]dioxolane

Conditions
ConditionsYield
With toluene-4-sulfonic acid; ozone In dichloromethane at -78℃; Title compound not separated from byproducts;A 10 % Spectr.
B 15 % Spectr.
C 75 % Spectr.
methanol
67-56-1

methanol

acrolein
107-02-8

acrolein

A

malonaldehydebis(dimethylacetal)
102-52-3

malonaldehydebis(dimethylacetal)

B

1,1,3-trimethoxypropane
14315-97-0

1,1,3-trimethoxypropane

C

3-methoxy-1-propanal
2806-84-0

3-methoxy-1-propanal

Conditions
ConditionsYield
With carbon dioxide; oxygen; sodium phosphate; copper(l) chloride; palladium dichloride at 50℃; under 90007.2 Torr; for 24h; Michael addition;A 17.5 % Chromat.
B 54.6 % Chromat.
C 26.2 % Chromat.
methanol
67-56-1

methanol

acrolein
107-02-8

acrolein

A

malonaldehydebis(dimethylacetal)
102-52-3

malonaldehydebis(dimethylacetal)

B

1,1,3-trimethoxypropane
14315-97-0

1,1,3-trimethoxypropane

C

3-methoxy-1-propanal
2806-84-0

3-methoxy-1-propanal

D

3,3-dimethoxypropanal
19060-10-7

3,3-dimethoxypropanal

Conditions
ConditionsYield
With carbon dioxide; polystyrene-supported benzoquinone; oxygen; palladium dichloride at 50℃; under 67505.4 Torr; for 12h;A 46.7 % Chromat.
B 12.9 % Chromat.
C 3.9 % Chromat.
D 20.4 % Chromat.
vinyl acetate
108-05-4

vinyl acetate

trimethyl orthoformate
149-73-5

trimethyl orthoformate

A

malonaldehydebis(dimethylacetal)
102-52-3

malonaldehydebis(dimethylacetal)

B

1,1,3-trimethoxy-3-acethoxypropane
98561-07-0

1,1,3-trimethoxy-3-acethoxypropane

Conditions
ConditionsYield
at 80℃; for 1h; Gas phase;
With boron trifluoride diethyl etherate at 80℃; under 22.5023 Torr; for 1h; Reactivity; Gas phase;
vinyl acetate
108-05-4

vinyl acetate

trimethyl orthoformate
149-73-5

trimethyl orthoformate

A

malonaldehydebis(dimethylacetal)
102-52-3

malonaldehydebis(dimethylacetal)

B

1,1,3-trimethoxy-3-acethoxypropane
98561-07-0

1,1,3-trimethoxy-3-acethoxypropane

C

1,3-diacetoxy-1,3-dimethoxy-propane
15874-25-6

1,3-diacetoxy-1,3-dimethoxy-propane

Conditions
ConditionsYield
With p-benzoquinone; PtCl2(PhCN)2 at 30℃; for 24h;
With p-benzoquinone at 30℃; for 2h;
With p-benzoquinone at 30℃; for 2.3h;
With p-benzoquinone for 2h;
isobutyl vinyl ether
109-53-5

isobutyl vinyl ether

trimethyl orthoformate
149-73-5

trimethyl orthoformate

A

1,3,3-trimethoxy-1-(isobutoxy)propane

1,3,3-trimethoxy-1-(isobutoxy)propane

B

malonaldehydebis(dimethylacetal)
102-52-3

malonaldehydebis(dimethylacetal)

Conditions
ConditionsYield
Stage #1: isobutyl vinyl ether; trimethyl orthoformate; iron(III) chloride at -5 - 20℃;
Stage #2: With sodium carbonate
vinyl isopropyl ether
926-65-8

vinyl isopropyl ether

trimethyl orthoformate
149-73-5

trimethyl orthoformate

malonaldehydebis(dimethylacetal)
102-52-3

malonaldehydebis(dimethylacetal)

Conditions
ConditionsYield
iron(III) chloride at -15℃; for 7h; Product distribution / selectivity;
iron(III) chloride at 2℃; for 7h; Product distribution / selectivity;
iron(III) chloride at 35℃; for 7h; Product distribution / selectivity;
vinyl isopropyl ether
926-65-8

vinyl isopropyl ether

trimethyl orthoformate
149-73-5

trimethyl orthoformate

A

1,3,3-trimethoxy-1-(isopropoxy)propane
603151-66-2

1,3,3-trimethoxy-1-(isopropoxy)propane

B

malonaldehydebis(dimethylacetal)
102-52-3

malonaldehydebis(dimethylacetal)

Conditions
ConditionsYield
Stage #1: vinyl isopropyl ether; trimethyl orthoformate; iron(III) chloride at -5 - 20℃;
Stage #2: With sodium carbonate
-butyl vinyl ether
111-34-2

-butyl vinyl ether

trimethyl orthoformate
149-73-5

trimethyl orthoformate

A

1,3,3-trimethoxy-1-(n-butoxy)propane
768388-22-3

1,3,3-trimethoxy-1-(n-butoxy)propane

B

malonaldehydebis(dimethylacetal)
102-52-3

malonaldehydebis(dimethylacetal)

Conditions
ConditionsYield
Stage #1: -butyl vinyl ether; trimethyl orthoformate; iron(III) chloride at -5 - 20℃;
Stage #2: With sodium carbonate
vinyl propyl ether
764-47-6

vinyl propyl ether

trimethyl orthoformate
149-73-5

trimethyl orthoformate

A

1,3,3-trimethoxy-1-(n-propoxy)propane
603151-65-1

1,3,3-trimethoxy-1-(n-propoxy)propane

B

malonaldehydebis(dimethylacetal)
102-52-3

malonaldehydebis(dimethylacetal)

Conditions
ConditionsYield
Stage #1: vinyl propyl ether; trimethyl orthoformate; iron(III) chloride at -5 - 20℃;
Stage #2: With sodium carbonate
5-Amino-1,3-dimethylpyrazole
3524-32-1

5-Amino-1,3-dimethylpyrazole

malonaldehydebis(dimethylacetal)
102-52-3

malonaldehydebis(dimethylacetal)

1,3-dimethylpyrazolo<3,4-b>pyridine
116834-97-0

1,3-dimethylpyrazolo<3,4-b>pyridine

Conditions
ConditionsYield
zinc(II) chloride In hydrogenchloride; ethanol for 1h; Heating;100%
malonaldehydebis(dimethylacetal)
102-52-3

malonaldehydebis(dimethylacetal)

methyl 2-chloro-3-hydrazinylbenzoate hydrochloride
1143025-56-2

methyl 2-chloro-3-hydrazinylbenzoate hydrochloride

methyl 2-chloro-3-(1H-pyrazol-1-yl)benzoate
1143025-57-3

methyl 2-chloro-3-(1H-pyrazol-1-yl)benzoate

Conditions
ConditionsYield
In ethanol at 80℃; for 2h;100%
In ethanol at 80℃; for 2h;100%
malonaldehydebis(dimethylacetal)
102-52-3

malonaldehydebis(dimethylacetal)

5-aminoimidazole-4-carboxamide hydrochloride
72-40-2

5-aminoimidazole-4-carboxamide hydrochloride

C7H6N4O

C7H6N4O

Conditions
ConditionsYield
In ethanol at 100℃; for 20h; Autoclave;100%
malonaldehydebis(dimethylacetal)
102-52-3

malonaldehydebis(dimethylacetal)

N-methylaniline
100-61-8

N-methylaniline

3-(N-Methylanilino)-2-propenal
14189-82-3

3-(N-Methylanilino)-2-propenal

Conditions
ConditionsYield
Stage #1: malonaldehydebis(dimethylacetal); N-methylaniline at 30℃; for 0.166667h;
Stage #2: With hydrogenchloride In water at 24℃; for 2.5h; Temperature;
99.6%
malonaldehydebis(dimethylacetal)
102-52-3

malonaldehydebis(dimethylacetal)

trimethylsilyl cyanide
7677-24-9

trimethylsilyl cyanide

2,4,4-trimethoxybutanenitrile
112890-36-5

2,4,4-trimethoxybutanenitrile

Conditions
ConditionsYield
With boron trifluoride diethyl etherate at 0℃; for 3h;99%
With boron trifluoride diethyl etherate at 0℃; for 3h; Inert atmosphere; Neat (no solvent);92%
With boron trifluoride diethyl etherate at 0℃; for 3h;
malonaldehydebis(dimethylacetal)
102-52-3

malonaldehydebis(dimethylacetal)

nickel(II) acetate tetrahydrate
6018-89-9

nickel(II) acetate tetrahydrate

4,5-dimethyl-1,2-phenylenediamine
3171-45-7

4,5-dimethyl-1,2-phenylenediamine

{7,16-dihydro-2,3,11,12-tetramethyldibenzo{b,i}{1,4,8,11}tetraazacyclotetradecinato-N5,N9,N14,N18}nickel(II)
57574-24-0

{7,16-dihydro-2,3,11,12-tetramethyldibenzo{b,i}{1,4,8,11}tetraazacyclotetradecinato-N5,N9,N14,N18}nickel(II)

Conditions
ConditionsYield
In water; N,N-dimethyl-formamide reflux for 10 h; filtn., chromy.; elem. anal.;;99%
malonaldehydebis(dimethylacetal)
102-52-3

malonaldehydebis(dimethylacetal)

C24H24N4O

C24H24N4O

C27H24N4O

C27H24N4O

Conditions
ConditionsYield
With acetic acid at 110℃; for 16h;99%
malonaldehydebis(dimethylacetal)
102-52-3

malonaldehydebis(dimethylacetal)

phenylhydrazine
100-63-0

phenylhydrazine

1-phenylpyrazole
1126-00-7

1-phenylpyrazole

Conditions
ConditionsYield
With hydrogenchloride In ethanol at 60℃; for 4h;98%
With hydrogenchloride In ethanol for 1h; Heating;93%
With hydrogenchloride In methanol for 1h; Reflux;90%
With hydrogenchloride; water In ethanol for 4h; Reflux;85%
With hydrogenchloride In ethanol; water Heating;
N-(3-isopropoxy-propyl)-3-cyano-4-methyl-2-pyridone
1267247-06-2

N-(3-isopropoxy-propyl)-3-cyano-4-methyl-2-pyridone

malonaldehydebis(dimethylacetal)
102-52-3

malonaldehydebis(dimethylacetal)

C29H35N4O6(1-)

C29H35N4O6(1-)

Conditions
ConditionsYield
In ethanol for 21h; Heating / reflux;98%
1-butyl-4-methyl-2,6-dioxo-1,2,5,6-tetrahydropyridine-3-carbonitrile
137996-30-6

1-butyl-4-methyl-2,6-dioxo-1,2,5,6-tetrahydropyridine-3-carbonitrile

malonaldehydebis(dimethylacetal)
102-52-3

malonaldehydebis(dimethylacetal)

C25H27N4O4(1-)*K(1+)
927811-20-9

C25H27N4O4(1-)*K(1+)

Conditions
ConditionsYield
With potassium acetate In butan-1-ol at 100 - 110℃; for 4.5h; Heating / reflux;98%
(2-chloro-4-fluorophenyl)hydrazine

(2-chloro-4-fluorophenyl)hydrazine

malonaldehydebis(dimethylacetal)
102-52-3

malonaldehydebis(dimethylacetal)

1-(2-chloro-4-fluorophenyl)-1H-pyrazole

1-(2-chloro-4-fluorophenyl)-1H-pyrazole

Conditions
ConditionsYield
With hydrogenchloride In ethanol; water at 90℃; for 16h;98%
1-phenylpyrazol-5-amine
826-85-7

1-phenylpyrazol-5-amine

malonaldehydebis(dimethylacetal)
102-52-3

malonaldehydebis(dimethylacetal)

1-phenyl-1H-pyrazolo[3,4-b]pyridine
20208-81-5

1-phenyl-1H-pyrazolo[3,4-b]pyridine

Conditions
ConditionsYield
zinc(II) chloride In hydrogenchloride; ethanol for 1h; Heating;97%
malonaldehydebis(dimethylacetal)
102-52-3

malonaldehydebis(dimethylacetal)

2,2-Dimethyl-1,3-propanediol
126-30-7

2,2-Dimethyl-1,3-propanediol

bis(5,5-dimethyl-1,3-dioxan-2-yl)-methane
30859-70-2

bis(5,5-dimethyl-1,3-dioxan-2-yl)-methane

Conditions
ConditionsYield
With hydrogenchloride at 140℃; for 0.5h;97%
With o-toluenesulfonic acid In toluene85%
With toluene-4-sulfonic acid In toluene Heating;85%
With toluene-4-sulfonic acid In toluene at 80 - 90℃;
malonaldehydebis(dimethylacetal)
102-52-3

malonaldehydebis(dimethylacetal)

5-chloro-2-nitrophenylhydrazine
1966-16-1

5-chloro-2-nitrophenylhydrazine

1-(5-chloro-2-nitro-phenyl)-1H-pyrazole
60418-31-7

1-(5-chloro-2-nitro-phenyl)-1H-pyrazole

Conditions
ConditionsYield
With sulfuric acid In ethanol; acetic acid for 6h; Heating;97%
malonaldehydebis(dimethylacetal)
102-52-3

malonaldehydebis(dimethylacetal)

(2,5-difluorophenyl)hydrazine

(2,5-difluorophenyl)hydrazine

1-(2,5-difluoro-phenyl)-1H-pyrazole
1143517-62-7

1-(2,5-difluoro-phenyl)-1H-pyrazole

Conditions
ConditionsYield
With hydrogenchloride; water In ethanol for 17h; Heating / reflux;97%
malonaldehydebis(dimethylacetal)
102-52-3

malonaldehydebis(dimethylacetal)

[14C]urea
594-05-8

[14C]urea

pyrimidin-2[(14)C]-ol hydrochloride
83056-70-6

pyrimidin-2[(14)C]-ol hydrochloride

Conditions
ConditionsYield
With hydrogenchloride In ethanol at 85℃; for 1.3h;97%
malonaldehydebis(dimethylacetal)
102-52-3

malonaldehydebis(dimethylacetal)

[15N2]pyrazole
55949-00-3

[15N2]pyrazole

Conditions
ConditionsYield
With hydrazinium sulfate In ethanol; water at 75℃; for 2h;96.3%
With [15N2]-hydrazinium sulfate In ethanol; water at 20 - 75℃; for 24.25h;67%
malonaldehydebis(dimethylacetal)
102-52-3

malonaldehydebis(dimethylacetal)

trimethyleneglycol
504-63-2

trimethyleneglycol

di(1,3-dioxan-2-yl)methane
30963-84-9

di(1,3-dioxan-2-yl)methane

Conditions
ConditionsYield
With toluene-4-sulfonic acid In toluene at 110℃; for 24h;96%
With o-toluenesulfonic acid In toluene92%
With toluene-4-sulfonic acid In toluene Heating;92%
malonaldehydebis(dimethylacetal)
102-52-3

malonaldehydebis(dimethylacetal)

3-hydrazinobenzoic acid
38235-71-1

3-hydrazinobenzoic acid

3-(1H-pyrazol-1-yl)benzoic acid

3-(1H-pyrazol-1-yl)benzoic acid

Conditions
ConditionsYield
In ethanol; water for 2h; Heating / reflux;96%
In ethanol; water for 48h; Reflux;73%
With acetic acid In water at 150℃; for 0.0833333h; Microwave irradiation;
malonaldehydebis(dimethylacetal)
102-52-3

malonaldehydebis(dimethylacetal)

2-(trifluoromethyl)phenylhydrazine
365-34-4

2-(trifluoromethyl)phenylhydrazine

1-(2-(trifluoromethyl)phenyl)-1H-pyrazole
84401-17-2

1-(2-(trifluoromethyl)phenyl)-1H-pyrazole

Conditions
ConditionsYield
With hydrogenchloride In ethanol; water at 80 - 90℃; for 3h;96%
With hydrogenchloride In ethanol; water Heating;
With hydrogenchloride In ethanol; water at 90℃; for 3h;
malonaldehydebis(dimethylacetal)
102-52-3

malonaldehydebis(dimethylacetal)

5-pyridin-4-yl-2H-pyrazol-3-yl-amine
91912-53-7

5-pyridin-4-yl-2H-pyrazol-3-yl-amine

2-(pyridin-4-yl)pyrazolo[1.5-a]pyrimidine
905281-89-2

2-(pyridin-4-yl)pyrazolo[1.5-a]pyrimidine

Conditions
ConditionsYield
With acetic acid at 110℃; for 16h;96%
N-ethyl-3-cyano-4-methyl-2-pyridone
201217-33-6

N-ethyl-3-cyano-4-methyl-2-pyridone

N-(3-isopropoxy-propyl)-3-cyano-4-methyl-2-pyridone
1267247-06-2

N-(3-isopropoxy-propyl)-3-cyano-4-methyl-2-pyridone

malonaldehydebis(dimethylacetal)
102-52-3

malonaldehydebis(dimethylacetal)

C25H27N4O5(1-)*K(1+)

C25H27N4O5(1-)*K(1+)

Conditions
ConditionsYield
With potassium acetate In 4-methyl-2-pentanone at 104 - 106℃; for 3h;95.5%
2,3-dimethyl-2,3-butane diol
76-09-5

2,3-dimethyl-2,3-butane diol

malonaldehydebis(dimethylacetal)
102-52-3

malonaldehydebis(dimethylacetal)

1,3-bis(4',4',5',5'-tetramethyl-1,3-dioxolan-2-yl)methane
86444-84-0

1,3-bis(4',4',5',5'-tetramethyl-1,3-dioxolan-2-yl)methane

Conditions
ConditionsYield
With toluene-4-sulfonic acid In benzene for 1h; Heating;95%
With toluene-4-sulfonic acid In benzene at 90℃; for 2h;95%
With toluene-4-sulfonic acid In benzene at 90℃; for 2h; Condensation;95%
With 4 A molecular sieve; toluene-4-sulfonic acid In benzene Heating;
malonaldehydebis(dimethylacetal)
102-52-3

malonaldehydebis(dimethylacetal)

indan-1,2,3-trione hydrate
485-47-2

indan-1,2,3-trione hydrate

(E)-3-Hydroxy-2-(2-hydroxy-1,3-dioxo-indan-2-yl)-propenal
77708-56-6

(E)-3-Hydroxy-2-(2-hydroxy-1,3-dioxo-indan-2-yl)-propenal

Conditions
ConditionsYield
In water at 50 - 55℃; for 2h;95%
malonaldehydebis(dimethylacetal)
102-52-3

malonaldehydebis(dimethylacetal)

(2S,4S)-pentane-2,4-diol
72345-23-4

(2S,4S)-pentane-2,4-diol

malonedialdehyde bis[(S,S)-1,3-dimethylpropylene] acetal
116185-04-7

malonedialdehyde bis[(S,S)-1,3-dimethylpropylene] acetal

Conditions
ConditionsYield
With o-toluenesulfonic acid In toluene95%
With toluene-4-sulfonic acid In toluene Heating;95%
malonaldehydebis(dimethylacetal)
102-52-3

malonaldehydebis(dimethylacetal)

ethylene glycol
107-21-1

ethylene glycol

di(1,3-dioxolan-2-yl)methane
4405-17-8

di(1,3-dioxolan-2-yl)methane

Conditions
ConditionsYield
With toluene-4-sulfonic acid In toluene Heating;95%
With o-toluenesulfonic acid In toluene
malonaldehydebis(dimethylacetal)
102-52-3

malonaldehydebis(dimethylacetal)

4-(tert-butyl)-1,2-diaminobenzene
68176-57-8

4-(tert-butyl)-1,2-diaminobenzene

nickel(II) acetate tetrahydrate
6018-89-9

nickel(II) acetate tetrahydrate

{7,16-dihydro-2,12-di-tert-butyldibenzo{b,i}{1,4,8,11}tetraazacyclotetradecinato-N5,N9,N14,N18}nickel(II)
96411-84-6

{7,16-dihydro-2,12-di-tert-butyldibenzo{b,i}{1,4,8,11}tetraazacyclotetradecinato-N5,N9,N14,N18}nickel(II)

Conditions
ConditionsYield
In water; N,N-dimethyl-formamide reflux for 12 h; filtn., washing (water), chromy., elem. anal.;95%
malonaldehydebis(dimethylacetal)
102-52-3

malonaldehydebis(dimethylacetal)

4-methoxyphenylhydrazine hydrochloride
19501-58-7

4-methoxyphenylhydrazine hydrochloride

1-(4-methoxyphenyl)-1H-pyrazole
35715-67-4

1-(4-methoxyphenyl)-1H-pyrazole

Conditions
ConditionsYield
In ethanol for 1h; Reflux;95%
In ethanol; water Reflux;82.6%
4-methoxycarbonyl-2-nitrophenylhydrazine
87054-48-6

4-methoxycarbonyl-2-nitrophenylhydrazine

malonaldehydebis(dimethylacetal)
102-52-3

malonaldehydebis(dimethylacetal)

C11H9N3O4

C11H9N3O4

Conditions
ConditionsYield
With hydrogenchloride In ethanol; water for 2.5h; Reflux;95%
malonaldehydebis(dimethylacetal)
102-52-3

malonaldehydebis(dimethylacetal)

2-Thiobarbituric acid
91759-32-9

2-Thiobarbituric acid

C11H8N4O4S2*ClH

C11H8N4O4S2*ClH

Conditions
ConditionsYield
With hydrogenchloride at 50 - 60℃; for 0.5h;93%

1,1,3,3-Tetramethoxypropane Chemical Properties

IUPAC Name: 1,1,3,3-Tetramethoxypropane
Synonyms of 1,1,3,3-Tetramethoxypropane (CAS NO.203-037-2): Malonaldehyde bis(dimethyl acetal) ; Malonaldehyde tetramethyl acetal ; Tetramethoxypropane ; Malonaldehyde, bis(dimethyl acetal) (8CI) ; Propane, 1,1,3,3-tetramethoxy-
CAS NO: 203-037-2
Molecular Formula: C7H16O4
Molecular Weight: 164.20
Molecular Structure:
EINECS: 203-037-2
H bond acceptors: 4
H bond donors: 0
Freely Rotating Bonds: 6
Polar Surface Area: 36.92 Å2
Index of Refraction: 1.401
Molar Refractivity: 41.37 cm3
Molar Volume: 170.2 cm3
Surface Tension: 25.8 dyne/cm
Density: 0.964 g/cm3
Flash Point: 54.4 °C
Enthalpy of Vaporization: 40.21 kJ/mol
Boiling Point: 183 °C at 760 mmHg
Vapour Pressure: 1.08 mmHg at 25°C
Water solubility: Immiscible
Sensitive: Moisture Sensitive
Appearance: 1,1,3,3-Tetramethoxypropane (CAS NO.203-037-2) is clear colourless to yellow-brown liquid.
SMILES: O(C)C(OC)CC(OC)OC
InChI: InChI=1/C7H16O4/c1-8-6(9-2)5-7(10-3)11-4/h6-7H,5H2,1-4H3
InChIKey: XHTYQFMRBQUCPX-UHFFFAOYAP
Std. InChI: InChI=1S/C7H16O4/c1-8-6(9-2)5-7(10-3)11-4/h6-7H,5H2,1-4H3
Std. InChIKey: XHTYQFMRBQUCPX-UHFFFAOYSA-N

1,1,3,3-Tetramethoxypropane Safety Profile

Safety Information of 1,1,3,3-Tetramethoxypropane (CAS NO.203-037-2) :
Hazard Codes: FlammableF
Risk Statements: 10-36/37/38
R10: Flammable. 
R36/37/38:Irritating to eyes, respiratory system and skin.
Safety Statements: 16-26-36/37/39
S16:Keep away from sources of ignition. 
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. 
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection.
RIDADR: UN 1993 3/PG 3
WGK Germany: 1
F: 21
Hazard Note: Irritant
HazardClass: 3
PackingGroup: III
HS Code: 29110000
 

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