1,1-Dimethyl-1,2-ethanediamine supplier

Name
1,2-DIAMINO-2-METHYLPROPANE
EINECS 212-374-4
CAS No. 811-93-8
Article Data30
CAS DataBase
Density 0.864 g/cm³
Solubility
Melting Point 120-121℃
Formula C₄H₁₂N₂
Boiling Point 130.9 °C at 760 mmHg
Molecular Weight 88.1527
Flash Point 23.9 °C
Transport Information
Appearance
Safety 26-36/37/39-45-16
Risk Codes 10-34
Molecular Structure
Hazard Symbols C,F
Synonyms (2-Amino-1,1-dimethylethyl)amine;1,1-Dimethyl-1,2-ethanediamine;1,1-Dimethylethylenediamine;1,2-Diamino-2-methylpropane;2,2-Dimethylethylenediamine;2,3-Diamino-2-methylpropane;2-Amino-2-methylpropylamine;2-Methyl-1,2-diaminopropane;2-Methyl-1,2-propanediamine;C,C-Dimethylethylenediamine;Isobutylenediamine;NSC 114220;NSC 17717;
PSA 52.04000
LogP 1.08300

Synthetic route

: 173337-04-7
3-amino-3-methylbutanamide

: 811-93-8
1,1-dimethylethylenediamine

Conditions

Conditions	Yield
With water; sodium hydroxide In water at 0 - 72℃; for 5h; Concentration;	89%

: 1,1-dimethyl-2-nitro-ethylamine

: 811-93-8
1,1-dimethylethylenediamine

Conditions

Conditions	Yield
With potassium hydroxide; hydrogen; nickel In methanol at 20℃; under 760.051 Torr; for 16h;	52%

: 2658-24-4
2,2-dimethylaziridine

: 811-93-8
1,1-dimethylethylenediamine

Conditions

Conditions	Yield
With ammonia; ammonium chloride at 100℃; under 41188.4 Torr;

: 70183-48-1
α-amino-isobutyraldehyde-oxime

A: 5434-90-2
2,2,5,5-tetramethyl-piperazine

B: 811-93-8
1,1-dimethylethylenediamine

Conditions

Conditions	Yield
With sodium amalgam; acetic acid
With sodium amalgam; ethanol; acetic acid

: 76-39-1
2-nitro-2-methylpropanol

: 811-93-8
1,1-dimethylethylenediamine

Conditions

Conditions	Yield
With ammonia; nickel at 40℃; under 55163.1 Torr; Hydrogenation;

: 113185-80-1
N,N'-(1,1-dimethyl-ethanediyl)-bis-acetamide

: 811-93-8
1,1-dimethylethylenediamine

Conditions

Conditions	Yield
With hydrogenchloride; water

: 24884-68-2
1,2-dinitro-2-methylpropane

: 811-93-8
1,1-dimethylethylenediamine

Conditions

Conditions	Yield
With acetic acid; platinum under 58840.6 Torr; Hydrogenation;

: 3335-66-8
N-nitro-tert-butylamine

: 811-93-8
1,1-dimethylethylenediamine

Conditions

Conditions	Yield
With methanol; nickel Hydrogenation;

: 19355-69-2
2-amino-2-cyanopropane

: 811-93-8
1,1-dimethylethylenediamine

Conditions

Conditions	Yield
With lithium aluminium tetrahydride; diethyl ether
With hydrogenchloride; methanol; palladium Hydrogenation;
With hydrogenchloride; ethanol; palladium Hydrogenation;

: 115-11-7
isobutene

: 811-93-8
1,1-dimethylethylenediamine

Conditions

Conditions	Yield
With diethyl ether; mixture of gaseous nitrogen oxides bei der Reduktion des entstehenden Isobutylennitrosits mit Zinn und Salzsaeure;

: 40652-06-0
N-(1-cyano-1-methyl-ethyl)acetamide

: 811-93-8
1,1-dimethylethylenediamine

Conditions

Conditions	Yield
(i) H2, Raney-Ni, (ii) aq. KOH; Multistep reaction;

: 80704-02-5
N1-benzyl-2-methylpropane-1,2-diamine

: 811-93-8
1,1-dimethylethylenediamine

Conditions

Conditions	Yield
With hydrogen; palladium on activated charcoal In hydrogenchloride

: 2-Acetamido-isobutylamin

: 811-93-8
1,1-dimethylethylenediamine

Conditions

Conditions	Yield
With potassium hydroxide Heating;

: 2305-59-1
5,5-Dimethyl-4,5-dihydro-1H-imidazole

: 811-93-8
1,1-dimethylethylenediamine

Conditions

Conditions	Yield
With sodium hydroxide In methanol; water for 4h; Heating; Yield given;

α-amino-isobutyraldehyde-oxime-hydrochloride: α-amino-isobutyraldehyde-oxime-hydrochloride

A: 5434-90-2
2,2,5,5-tetramethyl-piperazine

B: 811-93-8
1,1-dimethylethylenediamine

Conditions

Conditions	Yield
With sodium amalgam; acetic acid

: 7647-01-0
hydrogenchloride

: 19355-69-2
2-amino-2-cyanopropane

palladium: palladium

: 811-93-8
1,1-dimethylethylenediamine

Conditions

Conditions	Yield
Hydrogenation;

...Expand

: 64-17-5
ethanol

: 19355-69-2
2-amino-2-cyanopropane

sodium: sodium

: 811-93-8
1,1-dimethylethylenediamine

...Expand

α-amino-isobutyraldoxime hydrochloride: α-amino-isobutyraldoxime hydrochloride

A: 5434-90-2
2,2,5,5-tetramethyl-piperazine

B: 811-93-8
1,1-dimethylethylenediamine

Conditions

Conditions	Yield
With sodium amalgam; ethanol; acetic acid

: 76-39-1
2-nitro-2-methylpropanol

: 7664-41-7
ammonia

: 811-93-8
1,1-dimethylethylenediamine

Conditions

Conditions	Yield
bei Einw. erst bei -35grad, dann bei +40grad, und folgender Druckhydrierung in Gegenwart von Raney-Nickel bei ca. 40grad;

: 64-17-5
ethanol

: 70183-48-1
α-amino-isobutyraldehyde-oxime

: 64-19-7
acetic acid

sodium amalgam: sodium amalgam

A: 5434-90-2
2,2,5,5-tetramethyl-piperazine

B: 811-93-8
1,1-dimethylethylenediamine

...Expand

: 1314968-50-7
2,4,4-trimethyl-2,3-dihydroimidazole

: 811-93-8
1,1-dimethylethylenediamine

Conditions

Conditions	Yield
With potassium hydroxide; water at 25 - 40℃; for 16.5 - 19.5h; Heating / reflux;

: 549505-81-9
2-methyl-2-nitropropanamine

: 811-93-8
1,1-dimethylethylenediamine

Conditions

Conditions	Yield
With propylamine; hydrogen; Grace Raney Nickel In methanol; water at 49 - 52℃; under 29583 - 31390.6 Torr; Product distribution / selectivity; autoclave;

: 124-68-5
2-Amino-2-methyl-1-propanol

: 811-93-8
1,1-dimethylethylenediamine

Conditions

Conditions	Yield
With ammonia; hydrogen; magnesium chloride at 190℃; under 7500.75 Torr; for 8h; Reagent/catalyst; Pressure; Autoclave;

: 350-46-9
4-Fluoronitrobenzene

: 811-93-8
1,1-dimethylethylenediamine

: 440102-93-2
2-methyl-N1-(4-nitrophenyl)propane-1,2-diamine

Conditions

Conditions	Yield
With potassium carbonate In 1,4-dioxane for 3h; Heating / reflux;	100%
With potassium carbonate In N,N-dimethyl-formamide for 16h; Reflux;	100%
With potassium carbonate In 1,4-dioxane at 100℃; for 3h; Sealed tube;	65%
With potassium carbonate In 1,4-dioxane at 100℃; for 3h; Sealed tube;	65%

: 57-13-6
urea

: 811-93-8
1,1-dimethylethylenediamine

: 24572-33-6
4,4-dimethyltetrahydro-2H-imidazol-2-one

Conditions

Conditions	Yield
In ethylene glycol at 130 - 180℃; for 4h;	99.4%
at 130 - 180℃; for 5h; Inert atmosphere;	83.4%

: 1450-72-2
5-methyl-2-hydroxyacetophenone

: 811-93-8
1,1-dimethylethylenediamine

: 1400693-08-4
2-(1-(2-amino-2-methylpropylimino)ethyl)-4-methylphenol

Conditions

Conditions	Yield
In methanol at 20℃; for 24h;	99%

: 506-68-3
bromocyane

: 811-93-8
1,1-dimethylethylenediamine

: 5,5-dimethyl-4,5-dihydro-imidazol-2-amine

Conditions

Conditions	Yield
In water at 0 - 20℃; for 3h;	99%

: 2-{[(3E)-4-(4-{[4-methoxy-2-(propan-2-yl)-5-{(2S,3S,4R,5R,6R)-3,4,5-tris(acetyloxy)-6-[(acetyloxy)methyl]oxan-2-yl}phenyl]methyl}-3-methylphenyl)-2,2-dimethylbut-3-enoyl]amino}-2-methylpropanoic acid

: 811-93-8
1,1-dimethylethylenediamine

: 1240305-12-7
(1S)-2,4,6-tri-O-acetyl-1-[5-({4-[(1E)-4-({1-[(2-amino-2-methylpropyl)amino]-2-methyl-1-oxopropan-2-yl}amino)-3,3-dimethyl-4-oxobut-1-en-1-yl]-2-methylphenyl}methyl)-2-methoxy-4-(propan-2-yl)phenyl]-1,5-anhydro-3-O-formyl-D-glucitol

Conditions

Conditions	Yield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In chloroform; N,N-dimethyl-formamide at 20℃;	99%

: 123013-13-8
3-tert-butyl-2-hydroxy-5-methoxybenzaldehyde

: 811-93-8
1,1-dimethylethylenediamine

: 1482507-91-4
C28H40N2O4

Conditions

Conditions	Yield
In ethanol at 100℃; for 2h; Inert atmosphere; Schlenk technique; Reflux; Glovebox;	98%

: 13139-17-8
N-(Benzyloxycarbonyloxy)succinimide

: 811-93-8
1,1-dimethylethylenediamine

: 156892-82-9
(2-amino-2-methylpropyl)carbamic acid benzyl ester

Conditions

Conditions	Yield
In dichloromethane 1.) -40 deg C, 3 h, 2.) -40 deg C to r.t., overnight;	97%

: 28170-07-2
benzyl phenyl carbonate

: 811-93-8
1,1-dimethylethylenediamine

: 156892-82-9
(2-amino-2-methylpropyl)carbamic acid benzyl ester

Conditions

Conditions	Yield
In ethanol at 20℃;	97%
In ethanol at 80℃; for 18h;	97%
Stage #1: benzyl phenyl carbonate; 1,1-dimethylethylenediamine In ethanol at 20℃; Stage #2: With hydrogenchloride; water In ethanol pH=< 3; Stage #3: With sodium hydroxide In dichloromethane; water	87%

: 50-00-0
formaldehyd

: 811-93-8
1,1-dimethylethylenediamine

: 873-74-5
4-Aminobenzonitrile

: 3-({5,5-dimethyl-3-[2-(p-cyanophenyl)-1-diazenyl]-1-imidazolidinyl}methyl)-4,4-dimethyl-1-[2-(p-cyanophenyl)-1-diazenyl]imidazolidine

Conditions

Conditions	Yield
Stage #1: 4-Aminobenzonitrile With hydrogenchloride; sodium nitrite In water at 0℃; for 0.5h; Stage #2: formaldehyd; 1,1-dimethylethylenediamine With sodium hydrogencarbonate In water for 0.5h; cooling;	97%

...Expand

: 7803-58-9
SULFAMIDE

: 811-93-8
1,1-dimethylethylenediamine

: 144432-67-7
3,3-dimethyl-1,2,5-thiadiazolidine-1,1-dioxide

Conditions

Conditions	Yield
With pyridine for 16.5h; Heating / reflux;	97%
With pyridine for 16h; Reflux;
With pyridine Reflux;

: 80466-56-4
2-amino-5-nitropyrimidine-4,6-diol

: 811-93-8
1,1-dimethylethylenediamine

: 84812-27-1
2-Amino-6-(2-amino-2-methylpropylamino)-4-hydroxy-5-nitropyrimidine monohydrochloride

Conditions

Conditions	Yield
In ethanol	97%

: 541-59-3
maleiimide

: 811-93-8
1,1-dimethylethylenediamine

: 2-(5,5-dimethyl-3-oxo-piperazin-2-yl)acetamide

Conditions

Conditions	Yield
In ethanol at 20℃; for 1h;	97%
In ethanol at 20℃; for 1h;	12.3g

: 2-fluoro-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzaldehyde

: 811-93-8
1,1-dimethylethylenediamine

: 2-(2-fluoro-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)-4,4-dimethylimidazolidine

Conditions

Conditions	Yield
In diethyl ether for 24h;	97%

: 16308-68-2
allyl phenyl carbonate

: 811-93-8
1,1-dimethylethylenediamine

: (2-amino-2-methylpropyl)carbamic acid allyl ester

Conditions

Conditions	Yield
In ethanol at 20℃;	96%
In ethanol at 80℃; for 18h;	96%

: 3-methyl-5-[{BF4-Bu3N+(CH2)3}2CH3C]-salicylaldehyde

: 811-93-8
1,1-dimethylethylenediamine

: 4BF4(1-)*C84H160N6O2(4+)

Conditions

Conditions	Yield
In dichloromethane Molecular sieve; Inert atmosphere;	96%

: 2735-73-1
1,3-diacetyl-1,3-dihydro-benzoimidazol-2-one

: 811-93-8
1,1-dimethylethylenediamine

: 87484-88-6
1,1-dimethyl-2-(methylcarbonylamino)ethylamine

Conditions

Conditions	Yield
In tetrahydrofuran at 20℃; for 0.3h;	95%

: 118-48-9
isatoic anhydride

: 811-93-8
1,1-dimethylethylenediamine

: 2-methyl-1,2-bis{(2-aminobenzoyl)amino}propane

Conditions

Conditions	Yield
In N,N-dimethyl-formamide at 50℃; for 3.5h;	95%

: 1194-02-1
4-fluorobenzonitrile

: 811-93-8
1,1-dimethylethylenediamine

: 440102-94-3
4-((2-amino-2-methylpropyl)amino)benzonitrile

Conditions

Conditions	Yield
In dimethyl sulfoxide at 120℃; for 24h;	95%
at 180℃; for 0.416667h; Microwave irradiation;	88%

: 373638-28-9
C25H23NO5

: 811-93-8
1,1-dimethylethylenediamine

: 373634-03-8
C29H33N3O4

Conditions

Conditions	Yield
With 1-hydroxy-7-aza-benzotriazole; diisopropyl-carbodiimide In DMF (N,N-dimethyl-formamide) at 20℃;	94%

: 148-53-8
3-methoxy-2-hydroxybenzaldehyde

: 811-93-8
1,1-dimethylethylenediamine

: 263570-01-0
N,N′-bis(2-hydroxy-3-methoxybenzylidene)-1,2-diamino-2-methylpropane

Conditions

Conditions	Yield
With salicylaldehyde In methanol for 3h; Reflux; Dean-Stark;	94%
In methanol
In methanol

: 37942-07-7
3,5-di-tert-butyl-2-hydroxybenzaldehyde

: 811-93-8
1,1-dimethylethylenediamine

: N,N'-bis(3,5-di-t-butylsalicylidene)-1,2-diamino-2-methylpropane

Conditions

Conditions	Yield
In ethanol for 3h; Heating;	93%
In dichloromethane for 3h; Solvent; Reflux;	91%

: 37942-07-7
3,5-di-tert-butyl-2-hydroxybenzaldehyde

: 811-93-8
1,1-dimethylethylenediamine

: 875710-46-6
N,N'-bis(3,5-di-tert-butylsalicylidene)-2-methyl-1,2-diaminopropane

Conditions

Conditions	Yield
In ethanol for 3h; Heating / reflux;	93%
In methanol; chloroform

: 38834-26-3
(η5-Cp)Fe(CO)3PF6

: 811-93-8
1,1-dimethylethylenediamine

: 91178-28-8
C5H5Fe(CO)2CONHCH2C(CH3)2NH3(1+)*PF6(1-)

Conditions

Conditions	Yield
In diethyl ether A suspn. of complex in N2-satd. Et2O was stirred for 1 h with excess of diamine under N2 atm. at room temp.;; ppt. was filtered, washed with Et2O, recrystd. from CH3CN-Et2O at 0°C; elem. anal.;;	93%

: C20H29NO6

: 811-93-8
1,1-dimethylethylenediamine

: C23H37N3O5

Conditions

Conditions	Yield
at 25℃;	93%

: dispiro[adamantane-2,2'-[1,3,5]trioxolane-4',1"-cyclohexane]-3"-yl 4-nitrophenylcarbonate

: 811-93-8
1,1-dimethylethylenediamine

: dispiro[adamantane-2,2'-[1,3,5]trioxolane-4',1"-cyclohexane]-3"-yl N-(2-amino-2-methylpropyl)carbamate

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃; for 1h;	93%
With N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃; for 1h;	93%

: (1s,4s)-dispiro[cyclohexane-1,3'-[1,2,4]trioxolane-5',2"-tricyclo[3.3.1.1(3,7)]decan]-4-ylacetic acid

: 811-93-8
1,1-dimethylethylenediamine

: cis-adamantane-2-spiro-3'-8'-[[[(2'-amino-2'-methylpropyl)amino]carbonyl]methyl]-1',2',4'-trioxaspiro[4.5]decane

Conditions

Conditions	Yield
Stage #1: (1s,4s)-dispiro[cyclohexane-1,3'-[1,2,4]trioxolane-5',2"-tricyclo[3.3.1.1(3,7)]decan]-4-ylacetic acid With chloroformic acid ethyl ester; triethylamine In dichloromethane at -10 - -5℃; Inert atmosphere; Stage #2: 1,1-dimethylethylenediamine In ethanol; dichloromethane at 20℃; Product distribution / selectivity;	92.81%

: 89-95-2
2-methyl-benzyl alcohol

: 811-93-8
1,1-dimethylethylenediamine

: 30180-37-1
α,α-[(1,1-dimethylethylene)dinitrilo]di-o-cresol

Conditions

Conditions	Yield
In ethanol at 20℃; for 2h; Condensation;	92%

: 811-93-8
1,1-dimethylethylenediamine

: 373638-25-6
6-benzyloxy-3,4-dihydro-1H-isoquinoline-1,2-dicarboxylic acid 2-tert-butyl ester

: 1-(2-amino-2-methyl-propylcarbamoyl)-6-benzyloxy-3,4-dihydro-1H-isoquinoline-2-carboxylic acid tert-butyl ester

Conditions

Conditions	Yield
With 1-hydroxy-7-aza-benzotriazole; diisopropyl-carbodiimide In DMF (N,N-dimethyl-formamide) at 20℃;	92%
With 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride

: 811-93-8
1,1-dimethylethylenediamine

: 380151-85-9
2-(2'-formylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

: 4,4-dimethyl-2-[2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]imidazolidine

Conditions

Conditions	Yield
In dichloromethane for 24h;	92%

: 50-00-0
formaldehyd

: 94-09-7
p-aminoethylbenzoate

: 811-93-8
1,1-dimethylethylenediamine

: 3-({5,5-dimethyl-3-[2-(p-ethoxycarbonylphenyl)-1-diazenyl]-1-imidazolidinyl}methyl)-4,4-dimethyl-1-[2-(p-ethoxycarbonylphenyl)-1-diazenyl]imidazolidine

Conditions

Conditions	Yield
Stage #1: p-aminoethylbenzoate With hydrogenchloride; sodium nitrite In water at 0℃; for 0.5h; Stage #2: formaldehyd; 1,1-dimethylethylenediamine With sodium hydrogencarbonate In water for 0.5h; cooling;	92%

...Expand

1,1-Dimethyl-1,2-ethanediamine Specification

The 1,2-Propanediamine,2-methyl-, with the CAS registry number 811-93-8, is also known as 1,2-Propanediamine, 2-methyl-. Its EINECS registry number is 212-374-4. Its IUPAC name is called 2-methylpropane-1,2-diamine. This chemical's classification code is Drug / Therapeutic Agent.

Physical properties of 1,2-Propanediamine,2-methyl-: (1)ACD/LogP: -1.34; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): -5.29; (4)ACD/LogD (pH 7.4): -3.89; (5)ACD/BCF (pH 5.5): 1; (6)ACD/BCF (pH 7.4): 1; (7)ACD/KOC (pH 5.5): 1; (8)ACD/KOC (pH 7.4): 1; (9)#H bond acceptors: 2; (10)#H bond donors: 4; (11)#Freely Rotating Bonds: 3; (12)Index of Refraction: 1.454; (13)Molar Refractivity: 27.61 cm³; (14)Molar Volume: 101.9 cm³; (15)Surface Tension: 33 dyne/cm; (16)Density: 0.864 g/cm³; (17)Flash Point: 23.9 °C; (18)Enthalpy of Vaporization: 36.85 kJ/mol; (19)Boiling Point: 130.9 °C at 760 mmHg; (20)Vapour Pressure: 9.52 mmHg at 25°C.

Uses of 1,2-Propanediamine,2-methyl-: it can be used to produce (2-amino-2-methyl-propyl)-urea. It will need solvent H₂O with reaction time of 10 hours. The yield is about 57%.

When you are using this chemical, please be cautious about it as the following:
This chemical may destroy living tissue on contact and may catch fire in contact with air which only need brief contact with an ignition source and has a very low flash point or evolve highly flammable gases in contact with water. It is flammable which can causes burns. You should keep it away from sources of ignition - No smoking. In case of contact with eyes, you should rinse immediately with plenty of water and seek medical advice. Whenever you will contact it, please wear suitable protective clothing, gloves and eye/face protection. In case of accident or if you feel unwell seek medical advice immediately (show the label where possible).

You can still convert the following datas into molecular structure:
(1)Canonical SMILES: CC(C)(CN)N
(2)InChI: InChI=1S/C4H12N2/c1-4(2,6)3-5/h3,5-6H2,1-2H3
(3)InChIKey: OPCJOXGBLDJWRM-UHFFFAOYSA-N

The toxicity data is as follows:

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
mouse	LD50	intraperitoneal	500mg/kg (500mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) SKIN AND APPENDAGES (SKIN): HAIR: OTHER	Chimica Therapeutica. Vol. 4, Pg. 136, 1969.

Product Name

1,2-DIAMINO-2-METHYLPROPANE

Synthetic route

1,1-Dimethyl-1,2-ethanediamine Specification

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