1,2-Dichloro-2-ethoxyethane supplier

Name
1,2-Dichloro-2-ethoxyethane
EINECS 210-794-2
CAS No. 623-46-1
Density 1.167
Solubility
Melting Point -72oC
Formula C4H8 Cl2 O
Boiling Point 145 °C at 760 mmHg
Molecular Weight 143.013
Flash Point 43.3 °C
Transport Information UN 1993
Appearance Clear, very deep brown-yellow liquid.
Safety Human systemic effects. When heated to decomposition it emits toxic vapors of Cl⁻.
Risk Codes R10;R22;R36/37/38
Molecular Structure
Hazard Symbols
Synonyms Ether,1,2-dichloroethyl ethyl (6CI,7CI,8CI); 1,2-Dichloro-1-ethoxyethane;1,2-Dichloro-2-ethoxyethane; 1,2-Dichloroethyl ethyl ether; NSC 163477; a,b-Dichloroethyl ethyl ether
PSA 9.23000
LogP 1.82660

Synthetic route

: 107-20-0
2-chloroethanal

: 64-17-5
ethanol

: 623-46-1
1,2-dichloro-2-ethoxyethane

Conditions

Conditions	Yield
With hydrogenchloride

: 60-29-7
diethyl ether

A: 7081-78-9
1-chloroethyl ethyl ether

B: 623-46-1
1,2-dichloro-2-ethoxyethane

Conditions

Conditions	Yield
With chlorine

: 60-29-7
diethyl ether

: 623-46-1
1,2-dichloro-2-ethoxyethane

Conditions

Conditions	Yield
at 34℃; Chlorieren unter Belichtung;
Chlorieren;
With chlorine

: 7081-78-9
1-chloroethyl ethyl ether

: 623-46-1
1,2-dichloro-2-ethoxyethane

Conditions

Conditions	Yield
With chlorine

: 928-56-3
E/Z-2-chlorovinyl ethyl ether

: 623-46-1
1,2-dichloro-2-ethoxyethane

Conditions

Conditions	Yield
With hydrogenchloride

: 109-92-2
ethyl vinyl ether

: 623-46-1
1,2-dichloro-2-ethoxyethane

Conditions

Conditions	Yield
With tetrachloromethane; chlorine
With chlorine
With chlorine In diethyl ether at -15℃; Darkness; Green chemistry;

: 109-92-2
ethyl vinyl ether

A: 623-46-1
1,2-dichloro-2-ethoxyethane

B: 687-44-5
1,1,2-trichloro-2-ethoxy-ethane

Conditions

Conditions	Yield
With chlorine

: 621-62-5
chloroacetaldehyde diethyl acetal

: 623-46-1
1,2-dichloro-2-ethoxyethane

Conditions

Conditions	Yield
With hydrogenchloride

: 7647-01-0
hydrogenchloride

: 123-63-7
paracetaldehyde

: 107-07-3
2-chloro-ethanol

A: 14689-97-5
1,1-di(2-chloroethoxy)ethane

B: 623-46-1
1,2-dichloro-2-ethoxyethane

Conditions

Conditions	Yield
at 0 - 10℃;

...Expand

: 7782-50-5
chlorine

: 109-92-2
ethyl vinyl ether

: 623-46-1
1,2-dichloro-2-ethoxyethane

: 7647-01-0
hydrogenchloride

: 75-07-0
acetaldehyde

: 107-07-3
2-chloro-ethanol

: 623-46-1
1,2-dichloro-2-ethoxyethane

...Expand

: 107-20-0
2-chloroethanal

: 7647-01-0
hydrogenchloride

: 64-17-5
ethanol

: 623-46-1
1,2-dichloro-2-ethoxyethane

...Expand

: 7647-01-0
hydrogenchloride

: 621-62-5
chloroacetaldehyde diethyl acetal

: 623-46-1
1,2-dichloro-2-ethoxyethane

Conditions

Conditions	Yield
at 100 - 110℃;

: 14689-97-5
1,1-di(2-chloroethoxy)ethane

: 10026-13-8, 874483-75-7
phosphorus pentachloride

: 623-46-1
1,2-dichloro-2-ethoxyethane

: 64-17-5
ethanol

: 623-46-1
1,2-dichloro-2-ethoxyethane

: 621-62-5
chloroacetaldehyde diethyl acetal

Conditions

Conditions	Yield
With sodium ethanolate at 20℃; for 1h; Cooling with ice; Green chemistry;	96.7%

: 623-46-1
1,2-dichloro-2-ethoxyethane

: 17356-08-0
thiourea

: 96-50-4
2-thiazolylamine

Conditions

Conditions	Yield
Hantzsch thiazole synthesis;	90%
	90%
With water

: 623-46-1
1,2-dichloro-2-ethoxyethane

: 62530-07-8
2-thioureidobenzimidazole

: 14374-16-4
N-(Thiazolyl-2')-2-benzimidazolylamine

Conditions

Conditions	Yield
for 2h; Heating;	85%

: 623-46-1
1,2-dichloro-2-ethoxyethane

: 1-(3,4,5-trimethoxybenzylidene)thiosemicarbazide

: 1-(3,4,5-trimethoxybenzilidene)-2-(thiazol-2-yl)hydrazine

Conditions

Conditions	Yield
In ethanol for 3h; Heating;	75%

: 2-benzylsulfanyl-6-(2-chloro-phenyl)-pyrido[2,3-d]pyrimidin-7-ylamine

: 623-46-1
1,2-dichloro-2-ethoxyethane

: 610786-19-1
C22H15ClN4S

Conditions

Conditions	Yield
With triethylamine In water; acetonitrile at 20℃;	63%

: 943247-34-5
tert-butyl {3-[3-[(aminocarbonothioyl)amino]-5-(trifluoromethyl)-1H-indazol-1-yl]propyl}carbamate

: 623-46-1
1,2-dichloro-2-ethoxyethane

: 943246-92-2
tert-butyl {3-[3-(1,3-thiazol-2-ylamino)-5-(trifluoromethyl)-1H-indazol-1-yl]propyl}carbamate

Conditions

Conditions	Yield
Stage #1: tert-butyl {3-[3-[(aminocarbonothioyl)amino]-5-(trifluoromethyl)-1H-indazol-1-yl]propyl}carbamate; 1,2-dichloro-2-ethoxyethane In ethanol; water at 90℃; for 4h; Stage #2: With di-tert-butyl dicarbonate; sodium hydrogencarbonate In ethanol; water; ethyl acetate at 20℃;	61%

: 623-46-1
1,2-dichloro-2-ethoxyethane

: dilithio-1,3-dithiepin-2-carbodithiolate

: 2-(4-ethoxy-1,3-dithiolan-2-ylidene)-1,3-dithiepin

Conditions

Conditions	Yield
1.) -70 deg C; 2.) r.t.;	60%

: 952206-52-9
2-amino-3-chloro-5-(2.4-dichloro-phenyl)-isonicotinonitrile

: 623-46-1
1,2-dichloro-2-ethoxyethane

: 952206-53-0
8-chloro-6-(2,4-dichloro-phenyl)-imidazo[1,2-a]pyridine-7-carbonitrile

Conditions

Conditions	Yield
at 150℃; for 0.283333h; Microwave irradiation;	60%

: 2-(benzylthio)-6-(4-fluorophenoxy)pyrido[2,3-d]pyrimidin-7-amine

: 623-46-1
1,2-dichloro-2-ethoxyethane

: phenoxy-tricyclic-imidazole

Conditions

Conditions	Yield
With triethylamine In water; acetonitrile at 20℃;	57%

: 623-46-1
1,2-dichloro-2-ethoxyethane

: 1-(3,5-dimethoxy-4-ethoxybenzoyl)thiosemicarbazide

: 1-(3,5-dimethoxy-4-ethoxybenzoyl)-2-(thiazol-2-yl)hydrazine

Conditions

Conditions	Yield
In ethanol for 3h; Heating;	55%

: 943247-20-9
N-(5-bromo-1H-indazol-3-yl)thiourea

: 623-46-1
1,2-dichloro-2-ethoxyethane

: 943246-87-5
5-bromo-N-1,3-thiazol-2-yl-1H-indazol-3-amine

Conditions

Conditions	Yield
In ethanol; water at 20 - 80℃; for 3h;	55%

: 623-46-1
1,2-dichloro-2-ethoxyethane

: 1-(3,4,5-trimethoxybenzoyl)thiosemicarbazide

: 1-(3,4,5-trimethoxybenzoyl)-2-(thiazol-2-yl)hydrazine

Conditions

Conditions	Yield
In ethanol for 3h; Heating;	50%

: 623-46-1
1,2-dichloro-2-ethoxyethane

(Et4N)2: (Et4N)2

: 110789-38-3
4,5-(ethoxyethylenedithio)-1,3-dithiole-2-thione

Conditions

Conditions	Yield
In acetone for 21h; Heating;	50%

: 2-[2-(1H-indazol-3-yl)-7,7-dimethyl-6-oxo-6,7-dihydro-3H-imidazo[4,5-f]indol-5-yl]-thioacetamide

: 623-46-1
1,2-dichloro-2-ethoxyethane

: 2-(1H-indazol-3-yl)-7,7-dimethyl-5-thiazol-2-ylmethyl-5,7-dihydro-3H-imidazo[4,5-f]indol-6-one

Conditions

Conditions	Yield
In N,N-dimethyl-formamide at 140℃; for 3.5h;	48%

: 623-46-1
1,2-dichloro-2-ethoxyethane

: 1295645-06-5
4-(2-benzyloxy-5-bromophenyl)-4-thiocarbamoylpiperidine-1-carboxylic acid tert-butyl ester

: 1295645-07-6
4-(2-benzyloxy-5-bromophenyl)-4-thiazol-2-ylpiperidine-1-carboxylic acid tert-butyl ester

Conditions

Conditions	Yield
Stage #1: 1,2-dichloro-2-ethoxyethane; 4-(2-benzyloxy-5-bromophenyl)-4-thiocarbamoylpiperidine-1-carboxylic acid tert-butyl ester In N,N-dimethyl-formamide at 75℃; for 16h; Sealed; Stage #2: With di-tert-butyl dicarbonate; triethylamine In dichloromethane for 0.5h;	46%

: 623-46-1
1,2-dichloro-2-ethoxyethane

: 1-(3,5-dimethoxy-4-ethoxybenzylidene)thiosemicarbazide

: 1-(3,5-dimethoxy-4-ethoxybenzilidene)-2-(thiazol-2-yl)hydrazine

Conditions

Conditions	Yield
In ethanol for 3h; Heating;	45%

: 623-46-1
1,2-dichloro-2-ethoxyethane

: 1-(3,4-methylenedioxybenzylidene)thiosemicarbazide

: 1-(3,4-methylenedioxybenzilidene)-2-(thiazol-2-yl)hydrazine

Conditions

Conditions	Yield
In ethanol for 3h; Heating;	40%

: 623-46-1
1,2-dichloro-2-ethoxyethane

: 1-(3,4-methylenedioxybenzoyl)thiosemicarbazide

: 1-(3,4-methylenedioxybenzoyl)-2-(thiazol-2-yl)hydrazine

Conditions

Conditions	Yield
In ethanol for 3h; Heating;	35%

: 623-46-1
1,2-dichloro-2-ethoxyethane

: 2-(benzhydrylthio)ethanethioamide

: 2-(benzhydrylthiomethyl)thiazole

Conditions

Conditions	Yield
In N,N-dimethyl-formamide at 90 - 125℃; for 4h;	34%

: 623-46-1
1,2-dichloro-2-ethoxyethane

: 1093964-97-6
N-[5-(2-thienyl)-1H-indazol-3-yl]thiourea

: 1093967-47-5
N-1,3-thiazol-2-yl-5-(2-thienyl)-1H-indazole-3-amine

Conditions

Conditions	Yield
Stage #1: 1,2-dichloro-2-ethoxyethane; N-[5-(2-thienyl)-1H-indazol-3-yl]thiourea In ethanol; water at 90℃; Stage #2: With sodium hydrogencarbonate In ethanol; water; ethyl acetate	18%

: 623-46-1
1,2-dichloro-2-ethoxyethane

: 1391944-18-5
3-(2-chloro-6-fluorophenyl)-5-(1-(3-chlorophenyl)-5-(trifluoromethyl)-1H-pyrazol-4-yl)isoxazole-4-carbothioamide

: 1391944-16-3
3-(2-chloro-6-fluorophenyl)-5-(1-(3-chlorophenyl)-5-(trifluoromethyl)-1H-pyrazol-4-yl)-4-(thiazol-2-yl)isoxazole

Conditions

Conditions	Yield
In N,N-dimethyl-formamide at 90 - 130℃; for 4h;	17%
In N,N-dimethyl-formamide at 90 - 130℃; for 4h;	17%

: 623-46-1
1,2-dichloro-2-ethoxyethane

: 6086-42-6
4,4-dimethylimidazolidine-2-thione

: 3-((5,5-dimethyl-4,5-dihydro-1H-imidazol-2-yl)thio)-6,6-dimethyl-2,3,5,6-tetrahydroimidazo[2,1-b]thiazole dihydrochloride

Conditions

Conditions	Yield
With hydrogenchloride In ethanol; water at 40℃; for 21h; Inert atmosphere;	16%

: 623-46-1
1,2-dichloro-2-ethoxyethane

: 637776-05-7
3β-acetoxy-androsta-5,16-dien-17-thiocarboxamide

: 637776-26-2
3β-acetoxy-17-(2'-thiazolyl)-androsta-5,16-diene

Conditions

Conditions	Yield
In N,N-dimethyl-formamide for 0.5h; Heating;	15.75%

: 623-46-1
1,2-dichloro-2-ethoxyethane

: 389076-82-8
3β-acetoxy-androsta-5,16-dien-17-carboxamide

: 388083-41-8
3β-acetoxy-17-(2'-oxazolyl)-androsta-5,16-diene

Conditions

Conditions	Yield
In N,N-dimethyl-formamide for 0.5h; Heating; 1;	15.1%

: 188290-36-0
thiophene

: 623-46-1
1,2-dichloro-2-ethoxyethane

: 31161-25-8
2,2'-(2-chloro-1,1-ethanediyl)dithiophene

Conditions

Conditions	Yield
With phosphorus pentaoxide; chloroform

: 110-86-1
pyridine

: 623-46-1
1,2-dichloro-2-ethoxyethane

: 1-(1-ethoxy-2-chloro-ethyl)-pyridinium; chloride

Conditions

Conditions	Yield
With diethyl ether

: 6738-06-3
phenylethynylmagnesium bromide

: 623-46-1
1,2-dichloro-2-ethoxyethane

: ethyl-(1-chloromethyl-3-phenyl-prop-2-ynyl)-ether

: 5346-38-3
pyridine-2-carbothioamide

: 623-46-1
1,2-dichloro-2-ethoxyethane

: 2433-17-2
2-(pyridine-2-yl)thiazole

: 463-51-4
Ketene

: 64-17-5
ethanol

: 623-46-1
1,2-dichloro-2-ethoxyethane

: 20460-26-8
3-ethoxy-4-chloro-butyric acid ethyl ester

Conditions

Conditions	Yield
With aluminium trichloride

...Expand

1,2-Dichloro-2-ethoxyethane Chemical Properties

Chemical Name: 1,2-Dichloro-2-ethoxyethane
IUPAC NAME: 1,2-Dichloro-2-ethoxyethane
CAS No.: 623-46-1
EINECS: 210-794-2
Molecular Formula: C₄H₈Cl₂O
Molecular Weight: 143.01 g/mol
Density: 1.152 g/cm³
Flash Point: 43.3 °C
Boiling Point: 145 °C at 760 mmHg
Following is the structure of 1,2-Dichloro-2-ethoxyethane (CAS No.623-46-1):

The chemical synonymous of 1,2-Dichloro-2-ethoxyethane (CAS No.623-46-1) are 1,2-Dichlorodiethyl Ether ; 1,2-Dichloro-2-ethoxyethane ; 1,2-Dichloroethyl Ether ; 1,2-Dichloroethyl Ethyl Ether ; A,B-Dichloroethyl Ether ; Ethyl-1,2-Dichloroethyl Ether ; 1,2-Dichloro-1-Ethoxy-Ethan ; Ether, 1,2-Dichloroethyl Ethyl

1,2-Dichloro-2-ethoxyethane Toxicity Data With Reference

ihl-hmn TCLo:12 pph:BAH

VCVGK* Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia . (Hazardous substances. Galogen and oxygen containing substances),Bandman A.L. et al.,Chimia.: 1994,281.

1,2-Dichloro-2-ethoxyethane Safety Profile

Human systemic effects. When heated to decomposition it emits toxic vapors of Cl⁻.
Hazard Codes: Harmful Xn
Risk Statements about 1,2-Dichloro-2-ethoxyethane (CAS No.623-46-1):
R10:Flammable.
R22:Harmful if swallowed.
R36/37/38:Irritating to eyes, respiratory system and skin.
Safety Statements about 1,2-Dichloro-2-ethoxyethane (CAS No.623-46-1):
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.

Product Name

1,2-Dichloro-2-ethoxyethane

Synthetic route

1,2-Dichloro-2-ethoxyethane Chemical Properties

1,2-Dichloro-2-ethoxyethane Toxicity Data With Reference

1,2-Dichloro-2-ethoxyethane Safety Profile

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