1,2-HYDRAZINEDICARBOXAMIDE supplier

Name
BIUREA
EINECS 203-747-2
CAS No. 110-21-4
Article Data120
CAS DataBase
Density 1.461g/cm³
Solubility
Melting Point 247-250 °C
Formula C2H6 N4 O2
Boiling Point °Cat760mmHg
Molecular Weight 118.095
Flash Point °C
Transport Information
Appearance WHITE POWDER
Safety Moderately toxic by ingestion. When heated to decomposition it emits toxic vapors of NO_x.
Risk Codes 36/37/38
Molecular Structure
Hazard Symbols
Synonyms Biurea(6CI,7CI,8CI);1,1'-Hydrazobis(formamide);Bicarbamamide;Bicarbamimidic acid;Cellmic 142;Diurea;FE 823;HDCA;Hydradicarbonamide;Hydrazine,1,2-bis(aminocarbonyl)-;Hydrazine-N,N'-bis(carboxamide);Hydrazinedicarboxylicacid diamide;Hydrazocarbonamide;Hydrazodicarbamide;Hydrazodicarbonamide;Hydrazodicarboxamide;KBH 30;LDA;LDA (fire retardant);N,N'-Biscarbamoylhydrazine;NSC 1897;S 3176;Ureidourea;
PSA 110.24000
LogP 0.42040

Synthetic route

: 123-77-3
Azodicarboxamid

: 110-21-4
hydrazodicarboxamide

Conditions

Conditions	Yield
With hydrazine hydrate In acetonitrile at 20℃; for 1.5h;	98%
With hydrogen sulfide; water beim Kochen;
With hydrogenchloride beim Kochen;
With water; sodium carbonate beim Kochen;

sodium chlorobiuret salt: sodium chlorobiuret salt

: 110-21-4
hydrazodicarboxamide

Conditions

Conditions	Yield
With ammonia; aluminum (III) chloride; zinc(II) chloride In water at 10 - 60℃; for 1h;	97%
With ammonia; aluminum (III) chloride; zinc(II) chloride In water at 10 - 60℃; for 1h;	96%
With ammonia; cadmium(II) chloride; zinc(II) chloride In water at 10 - 60℃; for 1h;	96%

: 108-19-0
BIURET

: 110-21-4
hydrazodicarboxamide

Conditions

Conditions	Yield
Stage #1: BIURET With sodium hypochlorite In water at 5 - 10℃; Stage #2: With ammonia; zinc(II) chloride In water at 100℃; for 0.5h; Product distribution / selectivity;	96%
Stage #1: BIURET With sodium hypochlorite In water at 5 - 10℃; Stage #2: With ammonia In water at 100℃; for 0.5h; Product distribution / selectivity;	95%
Stage #1: BIURET With sodium hypochlorite In ethanol; water at 5 - 10℃; Stage #2: With ammonia In ethanol; water at 100℃; for 0.5h; Product distribution / selectivity;	85%

: chlorobiuret sodium salt

: 110-21-4
hydrazodicarboxamide

Conditions

Conditions	Yield
With ammonia; zinc(II) chloride In water at 10 - 100℃; for 0.5h; Product distribution / selectivity;	93%
With ammonia; hydrogenchloride In water at 10 - 100℃; for 0.5h; Product distribution / selectivity;	92%
With ammonia; nickel diacetate In water at 10 - 100℃; for 0.5h; Product distribution / selectivity;	92%
With ammonia In water at 10 - 100℃; for 0.5h; Product distribution / selectivity;	87%

: 81824-93-3
(E)-2-(3,4,5-trimethoxybenzylidene)hydrazine carboxamide

A: 110-21-4
hydrazodicarboxamide

B: 7251-01-6
(1E, 2E)-1,2-bis(3,4,5-trimethoxybenzylidene)hydrazine

Conditions

Conditions	Yield
In tetrahydrofuran at 120 - 150℃; Rearrangement; elimination;	A n/a B 87%

: (E)-2-benzylidenehydrazine-1-carboxamide

A: 110-21-4
hydrazodicarboxamide

B: 28867-76-7
benzaldehyde benzylidenehydrazone

Conditions

Conditions	Yield
In tetrahydrofuran at 120 - 150℃; Rearrangement; elimination;	A n/a B 85%

: 16742-62-4
3,4-methylenedioxybenzaldehyde semicarbazone

A: 110-21-4
hydrazodicarboxamide

B: (2E,N'E)-3-(benzo[d][1,3]dioxol-5-yl)-N'-(benzo[d][1,3]dioxol-5-ylmethylene)-2-cyanoacrylohydrazide

Conditions

Conditions	Yield
In tetrahydrofuran at 120 - 150℃; Rearrangement; elimination;	A n/a B 84%

: 120445-53-6
(E)-2-(4-methoxybenzylidene)hydrazine carboxamide

A: 110-21-4
hydrazodicarboxamide

B: 41097-47-6
N,N'-Bis-[1-(4-methoxy-phenyl)-meth-(E)-ylidene]-hydrazine

Conditions

Conditions	Yield
In tetrahydrofuran at 120 - 150℃; Rearrangement; elimination;	A n/a B 83%

: 2,4-dimethoxybenzaldehyde semicarbazone

A: 110-21-4
hydrazodicarboxamide

B: 134691-71-7
(1E,2E)-1,2-bis(3,4-dimethoxybenzylidene)hydrazine

Conditions

Conditions	Yield
In tetrahydrofuran at 120 - 150℃; Rearrangement; elimination;	A n/a B 68%

: 27991-08-8
N-acetoacetylphenylhydroxyloamine

A: 110-21-4
hydrazodicarboxamide

B: 100-65-2
N-Phenylhydroxylamine

C: 57303-41-0
1-carbamido-3-methyl-2-pyrazolin-5-one

D: 495-48-7
azoxybenzene

Conditions

Conditions	Yield
With semicarbazide hydrochloride; sodium carbonate In ethanol for 24h; Ambient temperature; Further byproducts given;	A 63% B 35% C 15.5% D 30%

...Expand

: 898-22-6
triethyl 1,3,5-triazine-2,4,6-tricarboxylate

: 4426-72-6, 51433-48-8
hydrazine carboxamide

A: 110-21-4
hydrazodicarboxamide

B: 57041-78-8
Ethyloxamatcarbamylhydrazon

C: 95234-60-9
3-oxo-5-imino-6-ethoxycarbonyl-2,3,4,5-tetrahydro-1,2,4-triazine

D: 91173-78-3
3,5-diethoxycarbonyl-1,2,4-triazole

Conditions

Conditions	Yield
In ethanol for 1h; Heating;	A 34% B 63% C 51% D 23%

...Expand

: 898-22-6
triethyl 1,3,5-triazine-2,4,6-tricarboxylate

A: 110-21-4
hydrazodicarboxamide

B: 57041-78-8
Ethyloxamatcarbamylhydrazon

C: 95234-60-9
3-oxo-5-imino-6-ethoxycarbonyl-2,3,4,5-tetrahydro-1,2,4-triazine

D: 91173-78-3
3,5-diethoxycarbonyl-1,2,4-triazole

Conditions

Conditions	Yield
With hydrazine carboxamide In ethanol for 1h; Heating;	A 34% B 63% C 51% D 23%

...Expand

: 1118-02-1
trimethylsilyl isocyanate

: 110-21-4
hydrazodicarboxamide

Conditions

Conditions	Yield
With hydrazine In hexane at 60℃; for 6h;	62%

: 563-41-7
semicarbazide hydrochloride

: 106089-51-4
4-chloro-3-(1-chlorovinyl)-6-methyl-2-pyrone

A: 110-21-4
hydrazodicarboxamide

B: 106089-56-9
3,6-dimethylpyrano<4,3-c>pyrazol-4(1H)-one

Conditions

Conditions	Yield
With sodium acetate In ethanol for 21h; Heating;	A n/a B 49%

...Expand

: 563-41-7
semicarbazide hydrochloride

: 110-21-4
hydrazodicarboxamide

Conditions

Conditions	Yield
With ethyl acetoacetate In water a) from 5 deg C to 10 deg C, 15 min, b) reflux, 3 h;	37%
With water; sodium carbonate
With selenium(IV) oxide; water at 60℃;

: 934-48-5
3,5-dimethylpyrazole-1-carboxamide

: 110-21-4
hydrazodicarboxamide

Conditions

Conditions	Yield
In water for 0.75h; Heating;	26%

: 2492-30-0
acetophenone semicarbazone

: 110-21-4
hydrazodicarboxamide

Conditions

Conditions	Yield
beim Erhitzen;

: 2492-30-0
acetophenone semicarbazone

A: 110-21-4
hydrazodicarboxamide

B: 729-43-1
acetophenonazine

Conditions

Conditions	Yield
at 240℃;
at 240℃;

: 506-68-3
bromocyane

: 110-21-4
hydrazodicarboxamide

Conditions

Conditions	Yield
With water; hydrazinium sulfate

: 504-20-1
phorone

: 563-41-7
semicarbazide hydrochloride

A: 110-21-4
hydrazodicarboxamide

B: 2,6-dimethyl-6-semicarbazido-hept-2-en-4-one semicarbazone

Conditions

Conditions	Yield
With ethanol; water; potassium acetate

...Expand

: 13125-56-9
carbamoyl azide

: 110-21-4
hydrazodicarboxamide

Conditions

Conditions	Yield
at 110 - 120℃; und Kochen der Reaktionsprodukte mit Wasser;
With benzene at 100 - 115℃; und Kochen der Reaktionsprodukte mit Wasser;

: 624-46-4
butan-2-one semicarbazone

A: 3232-84-6
urazole

B: 110-21-4
hydrazodicarboxamide

C: 5921-54-0
butan-2-one azine

Conditions

Conditions	Yield
beim Destillieren;

...Expand

: 624-46-4
butan-2-one semicarbazone

: 110-21-4
hydrazodicarboxamide

Conditions

Conditions	Yield
beim Erhitzen;

: bromo-acetone semicarbazone

: 64-17-5
ethanol

A: 21178-87-0
hydroxy-acetone semicarbazone

B: 110-21-4
hydrazodicarboxamide

...Expand

: 4-semicarbazido-pentan-2-one semicarbazone

: 64-17-5
ethanol

: 110-21-4
hydrazodicarboxamide

: 64-17-5
ethanol

: 53646-01-8
1-chloro-propan-2-one semicarbazone

A: 21178-87-0
hydroxy-acetone semicarbazone

B: 110-21-4
hydrazodicarboxamide

...Expand

: 64-17-5
ethanol

: 6-methyl-4-semicarbazido-heptan-2-one semicarbazone

: 110-21-4
hydrazodicarboxamide

: 64-17-5
ethanol

: 2-(1-semicarbazido-ethyl)-3-semicarbazono-butyric acid ethyl ester

: 110-21-4
hydrazodicarboxamide

: 420-05-3
cyanic acid

: 110-21-4
hydrazodicarboxamide

: 110-21-4
hydrazodicarboxamide

: 123-77-3
Azodicarboxamid

Conditions

Conditions	Yield
With acetic acid; copper(I) bromide at 20℃; under 760.051 Torr; for 12h; Reagent/catalyst; Temperature; Sealed tube;	99%
With tetra-N-butylammonium tribromide; sodium nitrite In 1,2-dimethoxyethane; water at 65℃; under 760.051 Torr; for 20h; Reagent/catalyst; Solvent; Pressure; Temperature; Sealed tube;	98%
With hydrogenchloride; iron(III) chloride; dihydrogen peroxide; ozone In water at 40℃; pH=2 - 5; Temperature;	97.4%

: 110-21-4
hydrazodicarboxamide

: 2937-79-3
1,3,4-oxadiazole-2,5-diamine

Conditions

Conditions	Yield
With pyridine; p-toluenesulfonyl chloride In ethanol at 79 - 80℃; for 20h; Reagent/catalyst; Solvent; Temperature; Inert atmosphere;	98%

: stannous octoate

: 110-21-4
hydrazodicarboxamide

: 124-30-1
1-aminooctadecane

: 81329-56-8
4-octadecyl-[1,2,4]triazolidine-3,5-dione

Conditions

Conditions	Yield
In 1-methyl-pyrrolidin-2-one	90%

...Expand

: 655-86-7
2,3-diaminephenazine

: 110-21-4
hydrazodicarboxamide

: 106050-79-7
phenazine benzimidazolone

Conditions

Conditions	Yield
With hydrogenchloride; sodium chloride In water at 320℃; for 0.216667h;	89.9%

: 872-50-4
1-methyl-pyrrolidin-2-one

: 110-21-4
hydrazodicarboxamide

: 3232-84-6
urazole

Conditions

Conditions	Yield
In water; acetone	89%

: 111-26-2
hexan-1-amine

: 110-21-4
hydrazodicarboxamide

: 81329-55-7
4-hexyl-[1,2,4]triazolidine-3,5-dione

Conditions

Conditions	Yield
With sodium hydroxide In N-methy pyrrolidone	81%
In 1-methyl-pyrrolidin-2-one	81%

: 110-21-4
hydrazodicarboxamide

: 1761-71-3
4,4'-diaminodicyclohexylmethane

: 81529-52-4
4,4'-bis-(1,2,4-triazolidine-3,5-dion-4-yl)-dicyclohexylmethane

Conditions

Conditions	Yield
In 1-methyl-pyrrolidin-2-one; water	75%

: 110-21-4
hydrazodicarboxamide

: 2,3-dihydro-[1,3,4]-oxadiazole-2,5-diamine

Conditions

Conditions	Yield
With pyridine; p-toluenesulfonyl chloride In N,N-dimethyl-formamide at 140℃; for 5h; Inert atmosphere;	75%

: 110-21-4
hydrazodicarboxamide

: 100-46-9
benzylamine

: 16312-86-0
4-benzyl-1,2,4-triazolidine-3,5-dione

Conditions

Conditions	Yield
With sodium hydroxide In 1-methyl-pyrrolidin-2-one	70%
In 1-methyl-pyrrolidin-2-one	70%

: 110-21-4
hydrazodicarboxamide

A: 7681-52-9
sodium hypochlorite

B: sodium azide

C: 916329-38-9
hydrogen azide

Conditions

Conditions	Yield
With sodium hydroxide; sulfuric acid In water ice cooling; distn. with H2SO4;	A n/a B n/a C 9%
With NaOH; H2SO4 In water ice cooling; distn. with H2SO4;	A n/a B n/a C 9%

...Expand

1,2-HYDRAZINEDICARBOXAMIDE Chemical Properties

IUPAC Name: 1,2-Hydrazinedicarboxamide
The MF of 1,2-Hydrazinedicarboxamide (110-21-4) is C₂H₆N₄O₂.

The MW of 1,2-Hydrazinedicarboxamide (110-21-4) is 118.09.
Synonyms of 1,2-Hydrazinedicarboxamide (110-21-4): Hydrazine-1,2-dicarboxamide ; 1, 2-Hydrazinedicarboxamide ; 1,1'-Hydrazinebisformamide ; 1,1-Hydrazoformamide
Product Categories: Pharmaceutical Intermediates;Hydrazines,Hydrazones and Oximes
Apperance: White powder
Index of Refraction: 1.547
Density: 1.461 g/ml
EINECS: 203-747-2
Melting Point: 239-241 °C

1,2-HYDRAZINEDICARBOXAMIDE Uses

1,2-Hydrazinedicarboxamide (110-21-4) is used as the production of ADC foaming agent.

1,2-HYDRAZINEDICARBOXAMIDE Production

It is chemically classified as an amide. Amides/imides react with azo and diazo compounds to generate toxic gases. Flammable gases are formed by the reaction of organic amides/imides with strong reducing agents. Amides are very weak bases (weaker than water). Imides are less basic yet and in fact react with strong bases to form salts. That is, they can react as acids. Mixing amides with dehydrating agents such as P2O5 or SOCl2 generates the corresponding nitrile. The combustion of these compounds generates mixed oxides of nitrogen (NOx).

1,2-HYDRAZINEDICARBOXAMIDE Toxicity Data With Reference

orl-rat LD50:>2 g/kg

ATDAEI Acute Toxicity Data. Journal of the American College of Toxicology, Part B. 15 (Suppl 1),(1996),S92.

1,2-HYDRAZINEDICARBOXAMIDE Safety Profile

Moderately toxic by ingestion. When heated to decomposition it emits toxic vapors of NO_x.Safety information of 1,2-Hydrazinedicarboxamide (110-21-4):
Risk Statements
36/37/38 Irritating to eyes, respiratory system and skin
Safety Statements
24/25 Avoid contact with skin and eyes

Product Name

BIUREA

Synthetic route

1,2-HYDRAZINEDICARBOXAMIDE Chemical Properties

1,2-HYDRAZINEDICARBOXAMIDE Uses

1,2-HYDRAZINEDICARBOXAMIDE Production

1,2-HYDRAZINEDICARBOXAMIDE Toxicity Data With Reference

1,2-HYDRAZINEDICARBOXAMIDE Safety Profile

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