• Name

  1,4-BIS(CHLORODIFLUOROMETHYL)BENZENE

• EINECS 700-265-9
• CAS No. 2629-68-7
• Article Data8
• CAS DataBase
• Density 1.467 g/cm³
• Solubility
• Melting Point 11-12 °C
• Formula C₈H₄Cl₂F₄
• Boiling Point 208.136 °C at 760 mmHg
• Molecular Weight 247.019
• Flash Point 92.667 °C
• Transport Information
• Appearance
• Safety 26-36/37/39
• Risk Codes 36/37/38
• Molecular Structure
• Hazard Symbols Xi
• Synonyms a,a'-Dichloro-a,a,a',a'-tetrafluoro-p-xylene;p-Xylene, a,a'-dichloro-a,a,a',a'-tetrafluoro- (7CI,8CI);p-Bis(chlorodifluoromethyl)benzene;
• PSA 0.00000
• LogP 4.26280

Synthetic route

369-54-0

p-bis(difluoromethyl)benzene

2629-68-7

1,4-bis-(difluorochloromethyl)-benzene

Conditions

Conditions	Yield
With chlorine at 60℃; under 760.051 Torr; for 1.66667h; Time; Temperature; Reagent/catalyst; Irradiation;	99.49%
With chlorine In tetrachloromethane Irradiation;
With chlorine; dibenzoyl peroxide In tetrachloromethane at 80℃; for 9h; Reagent/catalyst; Solvent; Temperature;

68-36-0

1,4-bis(trichloromethyl)benzene

A

13947-94-9

1-(chlorodifluoromethyl)-4-(trifluoromethyl)benzene

B

2629-68-7

1,4-bis-(difluorochloromethyl)-benzene

C

13947-95-0

1-fluorodichloromethyl-4-difluorochloromethyl-benzene

Conditions

Conditions	Yield
With hydrogen fluoride In 1,2-dichloro-ethane at 45℃; under 2280.15 Torr; for 10h;	A 3.3% B n/a C 4%

...Expand

369-54-0

p-bis(difluoromethyl)benzene

A

dichloro-tetrafluoro-p-xylene

B

2629-68-7

1,4-bis-(difluorochloromethyl)-benzene

Conditions

Conditions	Yield
With chlorine In tetrachloromethane

2629-68-7

1,4-bis-(difluorochloromethyl)-benzene

108-98-5

thiophenol

3200-14-4

C20H14F4S2

Conditions

Conditions	Yield
Stage #1: thiophenol With N,N,N,N,N,N-hexamethylphosphoric triamide; sodium hydride Stage #2: 1,4-bis-(difluorochloromethyl)-benzene	70%

2629-68-7

1,4-bis-(difluorochloromethyl)-benzene

108-95-2

phenol

1154741-12-4

1,4-bis(difluorophenoxymethyl)benzene

Conditions

Conditions	Yield
Stage #1: phenol With N,N,N,N,N,N-hexamethylphosphoric triamide; sodium hydride Stage #2: 1,4-bis-(difluorochloromethyl)-benzene	65%
With 1-methyl-pyrrolidin-2-one; sodium methylate at 100℃; for 8h; Reagent/catalyst; Temperature; Inert atmosphere;	48.7%

2629-68-7

1,4-bis-(difluorochloromethyl)-benzene

A

3345-29-7

1,1,2,2,9,9,10,10-octafluoro[2.2]paracyclophane

B

(Z)-2,3,8,8,9,9-Hexafluoro-tricyclo[8.2.2.24,7]hexadeca-1(13),2,4(16),5,7(15),10(14),11-heptaene

Conditions

Conditions	Yield
With zinc In N,N-dimethyl acetamide at 100℃; for 4h; Substitution;	A 60.5% B 6%

2629-68-7

1,4-bis-(difluorochloromethyl)-benzene

3345-29-7

1,1,2,2,9,9,10,10-octafluoro[2.2]paracyclophane

Conditions

Conditions	Yield
With potassium iodide; zinc In N,N-dimethyl acetamide at 120 - 142℃; for 6h; Catalytic behavior; Reagent/catalyst; Solvent; Temperature;	45.7%
With lithium aluminium tetrahydride; titanium tetrachloride In tetrahydrofuran Heating;	22%

2629-68-7

1,4-bis-(difluorochloromethyl)-benzene

651-12-7

α,α'-dibromo-α,α,α',α'-tetrafluoro-p-xylene

3345-29-7

1,1,2,2,9,9,10,10-octafluoro[2.2]paracyclophane

Conditions

Conditions	Yield
With calcium chloride; zinc In N,N-dimethyl acetamide at 120 - 140℃; for 4h; Catalytic behavior; Reagent/catalyst;	31.4%

2629-68-7

1,4-bis-(difluorochloromethyl)-benzene

A

3345-29-7

1,1,2,2,9,9,10,10-octafluoro[2.2]paracyclophane

B

dodecafluoro[2,2]paracyclophane

Conditions

Conditions	Yield
With aluminium In N,N-dimethyl-formamide at 0 - 20℃; for 50h;	A 22% B 20%

1,4-Bis(chlorodifluoromethyl)benzene Chemical Properties

1,4-Bis(chlorodifluoromethyl)benzene Safety Profile

1,4-Bis(chlorodifluoromethyl)benzene Specification