1,5-Diamino-4,8-dihydroxyanthraquinone supplier

Name
1,5-DIAMINO-4,8-DIHYDROXYANTHRAQUINONE
EINECS 205-655-8
CAS No. 145-49-3
Article Data15
CAS DataBase
Density 1.684 g/cm³
Solubility
Melting Point 300℃
Formula C₁₄H₁₀N₂O₄
Boiling Point 649.43 °C at 760 mmHg
Molecular Weight 270.244
Flash Point 346.563 °C
Transport Information
Appearance
Safety 26-36/37/39
Risk Codes 36/37/38
Molecular Structure
Hazard Symbols Xi
Synonyms Anthraquinone,1,5-diamino-4,8-dihydroxy- (6CI,7CI,8CI);1,5-Diamino-4,8-dihydroxy-9,10-anthraquinone;1,5-Diamino-4,8-dihydroxyanthraquinone;1,5-Dihydroxy-4,8-diamino-9,10-anthraquinone;1,5-Dihydroxy-4,8-diaminoanthraquinone;4,8-Diamino-1,5-dihydroxyanthraquinone;4,8-Diaminoanthrarufin;NSC 144052;NSC 3244;
PSA 126.64000
LogP 2.20000

Synthetic route

: 128-91-6
1,5-dihydroxy-4,8-dinitro-anthraquinone

: 145-49-3
4,8-diamino-1,5-dihydroxyanthraquinone

Conditions

Conditions	Yield
With sodium hydroxide; palladium-carbon In hydrogen	97.8%

: 129-44-2
1,5-diaminoanthraquinone

: 145-49-3
4,8-diamino-1,5-dihydroxyanthraquinone

Conditions

Conditions	Yield
Stage #1: 1,5-diaminoanthraquinone With sulfuric acid at 0℃; for 0.25h; Stage #2: With sodium chlorate at 0 - 20℃; for 3.75h;	83%

: 128-86-9
Alizarin Saphirol B

: 145-49-3
4,8-diamino-1,5-dihydroxyanthraquinone

Conditions

Conditions	Yield
With sodium dithionite; water; boric acid
durch Abspaltung beider Sulfogruppen;
With pyridine; sodium dithionite; water

: 129-44-2
1,5-diaminoanthraquinone

A: 145-49-3
4,8-diamino-1,5-dihydroxyanthraquinone

B: 1,5-diamino-2,4,6,8-tetrahydroxy-anthraquinone

Conditions

Conditions	Yield
With manganese(IV) oxide; sulfuric acid
With manganese(IV) oxide; sulfuric acid

: 85192-94-5
1,5-diazido-anthraquinone

: 145-49-3
4,8-diamino-1,5-dihydroxyanthraquinone

Conditions

Conditions	Yield
With sulfuric acid

: 128-86-9
Alizarin Saphirol B

: 7732-18-5
water

Na2S2O4: Na2S2O4

: 145-49-3
4,8-diamino-1,5-dihydroxyanthraquinone

...Expand

4.8-dinitro-anthrarufin: 4.8-dinitro-anthrarufin

: 145-49-3
4,8-diamino-1,5-dihydroxyanthraquinone

Conditions

Conditions	Yield
With hydrogenchloride; acetic acid; tin(ll) chloride weiteres Reagens: Wasser;

sodium-salt of/the/ 4.8-diamino-1.5-dihydroxy-9.10-dioxo-9.10-dihydro-anthracene-disulfonic acid-(2.6): sodium-salt of/the/ 4.8-diamino-1.5-dihydroxy-9.10-dioxo-9.10-dihydro-anthracene-disulfonic acid-(2.6)

: 145-49-3
4,8-diamino-1,5-dihydroxyanthraquinone

Conditions

Conditions	Yield
With sodium hydroxide; zinc anschliessendes Erwaermen;

sodium salt of/the/ 4.8-diamino-anthrarufin-disulfonic acid-(2.6): sodium salt of/the/ 4.8-diamino-anthrarufin-disulfonic acid-(2.6)

: 145-49-3
4,8-diamino-1,5-dihydroxyanthraquinone

Conditions

Conditions	Yield
With sodium dithionite at 85 - 90℃;

sodium salt of/the/ 4.8-diamino-anthrarufin-sulfonic acid-(2): sodium salt of/the/ 4.8-diamino-anthrarufin-sulfonic acid-(2)

: 145-49-3
4,8-diamino-1,5-dihydroxyanthraquinone

Conditions

Conditions	Yield
With sodium dithionite; water Kochen des Reaktionsprodukts mit Sodaloesung;

: 7664-93-9
sulfuric acid

: 129-44-2
1,5-diaminoanthraquinone

manganese dioxide: manganese dioxide

A: 145-49-3
4,8-diamino-1,5-dihydroxyanthraquinone

B: 1,5-diamino-2,4,6,8-tetrahydroxy-anthraquinone

Conditions

Conditions	Yield
at 30 - 40℃;

...Expand

: 82-35-9
1.5-dinitroanthraquinone

A: 145-49-3
4,8-diamino-1,5-dihydroxyanthraquinone

B x.x-diamino-x.x-dioxy-anthraquinone: x.x-diamino-x.x-dioxy-anthraquinone

Conditions

Conditions	Yield
With sulfuric acid; sulfur das Produkt bei 40-45grad halten, in Schwefelsaeure giessen und mit Wasser versetzen, bis die Temperatur auf 100-110grad gestiegen ist;

: 60080-32-2
1,5-bis-hydroxyamino-anthraquinone

A: 145-49-3
4,8-diamino-1,5-dihydroxyanthraquinone

B x.x-diamino-x.x-dioxy-anthraquinone: x.x-diamino-x.x-dioxy-anthraquinone

Conditions

Conditions	Yield
With sulfuric acid; water

: 7647-01-0
hydrogenchloride

: 128-91-6
1,5-dihydroxy-4,8-dinitro-anthraquinone

SnCl2: SnCl2

: 145-49-3
4,8-diamino-1,5-dihydroxyanthraquinone

...Expand

: 7664-93-9
sulfuric acid

: 85192-94-5
1,5-diazido-anthraquinone

: 145-49-3
4,8-diamino-1,5-dihydroxyanthraquinone

: 7664-93-9
sulfuric acid

: 60080-32-2
1,5-bis-hydroxyamino-anthraquinone

: 7732-18-5
water

A: 145-49-3
4,8-diamino-1,5-dihydroxyanthraquinone

B x.x-diamino-x.x-dioxy-anthraquinone: x.x-diamino-x.x-dioxy-anthraquinone

Conditions

Conditions	Yield
at 100 - 110℃;

...Expand

: 82-35-9
1.5-dinitroanthraquinone

: 145-49-3
4,8-diamino-1,5-dihydroxyanthraquinone

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: tin dichloride; water; NaOH-solution / Verduennen und Filtrieren in ein Gemisch aus konz. Salzsaeure und Wasser 2: concentrated sulfuric acid; water View Scheme
In ice-water; sulfuric acid; N,N-dimethyl-formamide

: 145-49-3
4,8-diamino-1,5-dihydroxyanthraquinone

A: 81-60-7
1,4,5,8-tetrahydroxy-anthraquinone

B: 6374-78-3
1-amino-4,5,8-trihydroxyanthraquinone

C: 69837-14-5
leuco-1,4,5,8-tetrahydroxyanthraquinone

D: 5-Amino-8,9,10-trihydroxy-2,3-dihydro-anthracene-1,4-dione

Conditions

Conditions	Yield
With sodium dithionite In water at 100℃; for 0.666667h;	A 2.5% B 1.3% C 92% D 6.4%

...Expand

: 145-49-3
4,8-diamino-1,5-dihydroxyanthraquinone

: 81-60-7
1,4,5,8-tetrahydroxy-anthraquinone

Conditions

Conditions	Yield
With sodium hydroxide; sodium dithionite at 100℃; for 1h;	80%
With hydrogenchloride at 180℃;
With sodium dithionite; nitrobenzene 1.) 100 deg C; Multistep reaction;

: 145-49-3
4,8-diamino-1,5-dihydroxyanthraquinone

: 121-69-7
N,N-dimethyl-aniline

: 1,5-diamino-2,6-di(p-dimethylanilino)-4,8-dihydroxyanthraquinone

Conditions

Conditions	Yield
With hydrogenchloride; aluminium trichloride at 20℃; for 2h;	75%

Na2S4: Na2S4

: 145-49-3
4,8-diamino-1,5-dihydroxyanthraquinone

: 23478-60-6
leuco-1,4,5,8-tetrahydroxyanthraquinone

Conditions

Conditions	Yield
With sodium hydroxide In water	74%

: 574-98-1
2-(2-bromoethyl)isoindoline-1,3-dione

: 145-49-3
4,8-diamino-1,5-dihydroxyanthraquinone

: 2-(2-((5-amino-4,8-dihydroxy-9,10-dioxo-9,10-dihydroanthracene-1-yl)amino)ethyl)isoindoline-1,3-dione

Conditions

Conditions	Yield
In N,N-dimethyl-formamide at 110℃; for 24h;	61%

: 145-49-3
4,8-diamino-1,5-dihydroxyanthraquinone

: 106-89-8
epichlorohydrin

: [1,5-(chloro-2-hydroxypropylamino)-4,8-dihydroxy]-9,10-anthracenedione

Conditions

Conditions	Yield
With acetic acid at 90℃; for 0.5h;	56%

: 67-56-1
methanol

: 145-49-3
4,8-diamino-1,5-dihydroxyanthraquinone

: 3860-63-7
Disperse blue 26

Conditions

Conditions	Yield
With sulfuric acid at 170℃;

: 5187-37-1
tetraacetyl diborate

: 145-49-3
4,8-diamino-1,5-dihydroxyanthraquinone

: 1,5-bis-acetylamino-4,8-bis-diacetoxyboranyloxy-anthraquinone

Conditions

Conditions	Yield
With acetic anhydride

: 328-99-4
m-(trifluoromethyl)benzoyl fluoride

: 145-49-3
4,8-diamino-1,5-dihydroxyanthraquinone

: 6417-47-6
1,5-dihydroxy-4,8-bis-(3-trifluoromethyl-benzoylamino)-anthraquinone

Conditions

Conditions	Yield
With pyridine; nitrobenzene

: 145-49-3
4,8-diamino-1,5-dihydroxyanthraquinone

: 368-94-5
4-trifluoromethyl-benzoyl fluoride

: 1,5-dihydroxy-4,8-bis-(4-trifluoromethyl-benzoylamino)-anthraquinone

Conditions

Conditions	Yield
With pyridine; nitrobenzene

: 145-49-3
4,8-diamino-1,5-dihydroxyanthraquinone

: 18084-26-9
3-Bromoalizarin

: 1,5-bis-(3,4-dihydroxy-9,10-dioxo-9,10-dihydro-[2]anthrylamino)-4,8-dihydroxy-anthraquinone

Conditions

Conditions	Yield
With sodium acetate; nitrobenzene; copper dichloride

: 145-49-3
4,8-diamino-1,5-dihydroxyanthraquinone

: 5138-23-8
4,8-diamino-1,5-dihydroxy-9,10-dioxo-9,10-dihydro-anthracene-2-sulfonic acid

Conditions

Conditions	Yield
With sulfuric acid; boric acid

: 145-49-3
4,8-diamino-1,5-dihydroxyanthraquinone

: 1,4,5,8,10-pentahydroxy-anthrone

Conditions

Conditions	Yield
With alkaline aqueous Na2S2O4
With sodium dithionite

: 145-49-3
4,8-diamino-1,5-dihydroxyanthraquinone

: 6374-78-3
1-amino-4,5,8-trihydroxyanthraquinone

Conditions

Conditions	Yield
With manganese(IV) oxide; sulfuric acid Versetzen mit Wasser und anschliessendes Erwaermen;

: 145-49-3
4,8-diamino-1,5-dihydroxyanthraquinone

: 1,5-diamino-2,4,6,8-tetrahydroxy-anthraquinone

Conditions

Conditions	Yield
With manganese(IV) oxide; sulfuric acid man behandelt die erhaltene Verbindung in konz. Schwefelsaeure mit krystallinischer Borsaeure;

: 5187-37-1
tetraacetyl diborate

: 145-49-3
4,8-diamino-1,5-dihydroxyanthraquinone

: 108-24-7
acetic anhydride

: 1,5-bis-acetylamino-4,8-bis-diacetoxyboranyloxy-anthraquinone

...Expand

: 145-49-3
4,8-diamino-1,5-dihydroxyanthraquinone

: 108-24-7
acetic anhydride

: 121614-37-7
1,5-bis-acetylamino-4,8-dihydroxy-anthraquinone

Conditions

Conditions	Yield
With acetic acid

: 145-49-3
4,8-diamino-1,5-dihydroxyanthraquinone

: 17243-13-9
5-chlorosulfonyl-2-hydroxybenzoic acid

: 1,5-bis-(3-carboxy-4-hydroxy-benzenesulfonylamino)-4,8-dihydroxy-anthraquinone

Conditions

Conditions	Yield
With sodium acetate; nitrobenzene at 120℃;

: 145-49-3
4,8-diamino-1,5-dihydroxyanthraquinone

: 98-88-4
benzoyl chloride

: 6370-58-7
1,5-bis-benzoylamino-4,8-dihydroxy-anthraquinone

Conditions

Conditions	Yield
With nitrobenzene

: 145-49-3
4,8-diamino-1,5-dihydroxyanthraquinone

: 79-04-9
chloroacetyl chloride

: 121614-42-4
1,5-bis-(2-chloro-acetylamino)-4,8-dihydroxy-anthraquinone

Conditions

Conditions	Yield
With nitrobenzene

: 50606-96-7
4-heptylbenzoyl chloride

: 145-49-3
4,8-diamino-1,5-dihydroxyanthraquinone

: 1,5-bis-(4-n-heptylbenzoylamino)-4,8-dihydroxy-anthraquinone

Conditions

Conditions	Yield
In chlorobenzene for 1h; Heating;

: 50606-96-7
4-heptylbenzoyl chloride

: 145-49-3
4,8-diamino-1,5-dihydroxyanthraquinone

: 1,5-bis-(4-n-heptylbenzoylamino)-4,8-bis-(4-n-heptylbenzoyloxy)-anthraquinone

Conditions

Conditions	Yield
In pyridine for 0.5h; Heating;

: 49763-65-7
4-pentylbenzoyl chloride

: 145-49-3
4,8-diamino-1,5-dihydroxyanthraquinone

: C38H38N2O6

Conditions

Conditions	Yield
With pyridine

: 145-49-3
4,8-diamino-1,5-dihydroxyanthraquinone

: 117-12-4
1,5-dihydroxyanthraquinone

Conditions

Conditions	Yield
With sulfuric acid; N,N-dimethyl-formamide; sodium nitrite 1) water, 0 deg C, 2 h, 2) 65 deg C, 180 min; Yield given. Multistep reaction;

1,5-Diamino-4,8-dihydroxyanthraquinone Chemical Properties

Chemical Name: 1,5-Diamino-4,8-dihydroxyanthraquinone
IUPAC NAME: 1,5-Diamino-4,8-dihydroxyanthracene-9,10-dione
CAS No.: 145-49-3
EINECS: 205-655-8
RTECS: CB6480000
Molecular Formula: C₁₄H₁₀N₂O₄
Molecular Weight: 270.24 g/mol
Density: 1.683 g/cm³
Flash Point: 346.6 °C
Boiling Point: 649.4 °C at 760 mmHg
Following is the structure of 1,5-Diamino-4,8-dihydroxyanthraquinone (145-49-3):

Product Categories about 1,5-Diamino-4,8-dihydroxyanthraquinone (145-49-3) are Intermediates of Dyes and Pigments ; Aminoanthraquinones ; Anthraquinones ; Hydroxyanthraquinones
The chemical synonymous of 1,5-Diamino-4,8-dihydroxyanthraquinone (145-49-3) are 1,5-Diamino-4,8-dihydroxy-10-anthracenedione ; 1,5-Diamino-4,8-dihydroxyanthrachinon ; 1,5-Diamino-4,8-dihydroxy-anthraquinon ; 1,5-Diamino-4,8-dihydroxyanthraquinone ; 1,5-Dihydroxy-4,8-diaminoanthrachinon ; 10-Anthracenedione,1,5-diamino-4,8-dihydroxy-9 ; 4,8-Diamino-1,5-dihydroxyanthraquinone ; 4,8-Diamino-anthrarufi

1,5-Diamino-4,8-dihydroxyanthraquinone Uses

The major use of 1,5-Diamino-4,8-dihydroxyanthraquinone (145-49-3) is as an intermediate for disperse dye,it also used for the synthesis of dyes.

1,5-Diamino-4,8-dihydroxyanthraquinone Toxicity Data With Reference

1.	eye-rbt 20 mg/24H MOD	28ZPAK Sbornik Vysledku Toxixologickeho Vysetreni Latek A Pripravku Marhold, J.V.,Institut Pro Vychovu Vedoucicn Pracovniku Chemickeho Prumyclu Praha,Czechoslovakia.: 1972,103.
2.	mmo-sat 50 µg/plate	MUREAV Mutation Research. 40 (1976),203.
3.	mma-sat 50 µg/plate	MUREAV Mutation Research. 40 (1976),203.
4.	ivn-mus LD50:56 mg/kg	CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010) NX#03923 .

1,5-Diamino-4,8-dihydroxyanthraquinone Consensus Reports

Reported in EPA TSCA Inventory.

1,5-Diamino-4,8-dihydroxyanthraquinone Safety Profile

Poison by intravenous route. An eye irritant. Mutation data reported. When heated to decomposition it emits toxic fumes of NO_x.
Risk Statements about 1,5-Diamino-4,8-dihydroxyanthraquinone (145-49-3):
R36/37/38: Irritating to eyes, respiratory system and skin.
Safety Statements about 1,5-Diamino-4,8-dihydroxyanthraquinone (145-49-3):
S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36/37/39: Wear suitable protective clothing, gloves and eye/face protection.

Product Name

1,5-DIAMINO-4,8-DIHYDROXYANTHRAQUINONE

Synthetic route

1,5-Diamino-4,8-dihydroxyanthraquinone Chemical Properties

1,5-Diamino-4,8-dihydroxyanthraquinone Uses

1,5-Diamino-4,8-dihydroxyanthraquinone Toxicity Data With Reference

1,5-Diamino-4,8-dihydroxyanthraquinone Consensus Reports

1,5-Diamino-4,8-dihydroxyanthraquinone Safety Profile

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