1,7-Dihydroxynaphthalene supplier

Name
1,7-Dihydroxynaphthalene
EINECS 209-383-0
CAS No. 575-38-2
Article Data13
CAS DataBase
Density 1.33 g/cm³
Solubility Slightly soluble in water.
Melting Point 178-182 °C
Formula C₁₀H₈O₂
Boiling Point 375.4 °C at 760 mmHg
Molecular Weight 160.172
Flash Point 193.5 °C
Transport Information
Appearance Yellowish to white powder
Safety 26-36-37/39-36/37
Risk Codes 36/37/38
Molecular Structure
Hazard Symbols Xi
Synonyms 1,7-Dihydroxynaphthalene;C.I. 76635;NC 002;NSC 62686;
PSA 40.46000
LogP 2.25100

Synthetic route

: 51850-49-8
1,7-diacetoxynaphthalene

A: 575-38-2
1,7-Dihydroxynaphthalene

B: 7-hydroxynaphthalen-1-yl acetate

C: 7-acetoxy-1-hydroxynaphthalene

Conditions

Conditions	Yield
With lipase of Pseudomonas sp; water In various solvent(s) at 25℃; for 0.6h; Hydrolysis; deacetylation;	A n/a B n/a C 78%

...Expand

: 135-19-3
β-naphthol

A: 581-43-1
2,6-Dihydroxynaphthalene

B: 575-38-2
1,7-Dihydroxynaphthalene

C: 575-44-0
1,6-dihydroxynaphthalene

D: 582-17-2
2,7-Dihydroxynaphthalene

Conditions

Conditions	Yield
With dihydrogen peroxide; hydrogen fluoride; antimony pentafluoride at -40℃; for 0.25h; Mechanism; Product distribution;	A 25.5% B 29% C 11% D 3.5%
With dihydrogen peroxide; hydrogen fluoride; antimony pentafluoride at -40℃; for 0.25h;	A 25.5% B 29% C 11% D 3.5%

...Expand

: 90-15-3
α-naphthol

A: 575-38-2
1,7-Dihydroxynaphthalene

B: 83-56-7
1,5-dihydroxynaphthalene

Conditions

Conditions	Yield
With dihydrogen peroxide; hydrogen fluoride; antimony pentafluoride at -20℃; for 0.5h; Mechanism; Product distribution;	A 17.5% B 25.5%
With dihydrogen peroxide; hydrogen fluoride; antimony pentafluoride at -20℃; for 0.5h;	A 17.5% B 25.5%

: 19061-33-7
6-methoxy-1,4-dihydro-1,4-epoxidonaphthalene

: 575-38-2
1,7-Dihydroxynaphthalene

Conditions

Conditions	Yield
With sodium hydride; ethanethiol In N,N-dimethyl-formamide at 130℃; for 7.5h;	23%

: 90-51-7
6-amino-4-hydroxy-2-naphthalenesulfonic acid

: 575-38-2
1,7-Dihydroxynaphthalene

Conditions

Conditions	Yield
With sulfuric acid at 200℃;
With hydrogenchloride at 200℃;
With phosphoric acid at 200℃;
With formic acid at 200℃;

: 132-57-0
7-hydroxy-naphthalene-1-sulfonic acid

: 575-38-2
1,7-Dihydroxynaphthalene

Conditions

Conditions	Yield
With potassium hydroxide at 245 - 255℃; durch Verschmelzen;
With potassium hydroxide

: 119-28-8
8-amino-2-naphthalenesulfonic acid

: furan-2,3,5(4H)-trione pyridine (1:1)

A: 575-38-2
1,7-Dihydroxynaphthalene

B: 118-46-7
8-amino-2-naphthol

C: 20191-62-2
8-hydroxy-naphthalene-2-sulfonic acid

Conditions

Conditions	Yield
at 260℃; unter Druck;

...Expand

: 90-40-4
2-amino-8-hydroxy-naphthalene-3,6-disulphonic acid

: 575-38-2
1,7-Dihydroxynaphthalene

Conditions

Conditions	Yield
With sulfuric acid at 200℃;
With hydrogenchloride at 200℃;
With phosphoric acid at 200℃;
With formic acid at 200℃;

: 86699-99-2
1,7-dihydroxy-2-naphthoic acid

: 575-38-2
1,7-Dihydroxynaphthalene

Conditions

Conditions	Yield
With aniline

: 135-19-3
β-naphthol

A: 581-43-1
2,6-Dihydroxynaphthalene

B: 575-38-2
1,7-Dihydroxynaphthalene

Conditions

Conditions	Yield
With hydrogen fluoride; boron trifluoride; dihydrogen peroxide at -50℃; for 0.5h; Mechanism; Product distribution; other naphthol, other temp.;

4.6-dihydroxy-naphthalene-disulfonic acid-(2.7): 4.6-dihydroxy-naphthalene-disulfonic acid-(2.7)

: 575-38-2
1,7-Dihydroxynaphthalene

Conditions

Conditions	Yield
With sulfuric acid at 200℃;
With hydrogenchloride at 200℃;
With phosphoric acid at 200℃;
With formic acid at 200℃;

4.6-dihydroxy-naphthalene-sulfonic acid-(2): 4.6-dihydroxy-naphthalene-sulfonic acid-(2)

: 575-38-2
1,7-Dihydroxynaphthalene

Conditions

Conditions	Yield
With sulfuric acid at 200℃;
With hydrogenchloride at 200℃;
With phosphoric acid at 200℃;
With formic acid at 200℃;

7-hydroxy-naphthalene-sulfonic acid-(1): 7-hydroxy-naphthalene-sulfonic acid-(1)

: 575-38-2
1,7-Dihydroxynaphthalene

Conditions

Conditions	Yield
With potassium hydroxide at 230℃;
With potassium hydroxide; sodium hydroxide at 230℃;

: 132-57-0
7-hydroxy-naphthalene-1-sulfonic acid

potash: potash

: 575-38-2
1,7-Dihydroxynaphthalene

Conditions

Conditions	Yield
Verschmelzen;

: 7664-93-9
sulfuric acid

: 90-40-4
2-amino-8-hydroxy-naphthalene-3,6-disulphonic acid

: 575-38-2
1,7-Dihydroxynaphthalene

Conditions

Conditions	Yield
at 200℃;

: 86699-99-2
1,7-dihydroxy-2-naphthoic acid

: 7732-18-5
water

A: 124-38-9
carbon dioxide

B: 575-38-2
1,7-Dihydroxynaphthalene

Conditions

Conditions	Yield
at 160℃;

...Expand

: 86699-99-2
1,7-dihydroxy-2-naphthoic acid

: 62-53-3
aniline

A: 124-38-9
carbon dioxide

B: 575-38-2
1,7-Dihydroxynaphthalene

...Expand

: 104-92-7
1-bromo-4-methoxy-benzene

sodium: sodium

: 575-38-2
1,7-Dihydroxynaphthalene

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 22 percent / NaNH2, t-butyl alcohol / 2-methyl-propan-2-ol; tetrahydrofuran / 12 h / 55 °C 2: 23 percent / NaH, C2H5SH / dimethylformamide / 7.5 h / 130 °C View Scheme

: 575-38-2
1,7-Dihydroxynaphthalene

: 4861-79-4
magnesium methyl carbonate

: 86699-99-2
1,7-dihydroxy-2-naphthoic acid

Conditions

Conditions	Yield
In N,N-dimethyl-formamide at 180℃; under 25857.4 Torr; for 6h;	100%

: 575-38-2
1,7-Dihydroxynaphthalene

: 77-78-1
dimethyl sulfate

: 5309-18-2
1,7-dimethoxynaphthalene

Conditions

Conditions	Yield
With potassium hydroxide In water for 5h;	98%
With sodium hydroxide for 1h; Heating;	96%
With tetrabutylammomium bromide; potassium hydroxide In tetrahydrofuran; water at 0℃;	95%

: 575-38-2
1,7-Dihydroxynaphthalene

: 4049-33-6
tetra-O-acetyl-β-D-xylopyranose

: naphthalene-1,7-diyl bis(2,3,4-tri-O-acetyl-β-D-xylopyranoside)

Conditions

Conditions	Yield
With boron trifluoride diethyl etherate; triethylamine In dichloromethane at 20℃; for 2h;	96%

: 358-23-6
trifluoromethylsulfonic anhydride

: 575-38-2
1,7-Dihydroxynaphthalene

: 152873-81-9
naphthalene-1,7-diyl bis(trifluoromethanesulfonate)

Conditions

Conditions	Yield
With pyridine	95%
With pyridine 1.) 0 deg C, 5 min, 2.) 0 deg C to r.t., 24 h; Yield given;

potassium thiocyanate: potassium thiocyanate

: 575-38-2
1,7-Dihydroxynaphthalene

: 2,8-dihydroxy-thionaphthoic acid amide

Conditions

Conditions	Yield
With hydrogen fluoride	95%

: 575-38-2
1,7-Dihydroxynaphthalene

: 20009-42-1
bispropargyl ether of 1,7-dihydroxynaphthalene

Conditions

Conditions	Yield
	91%

: 264276-67-7
3,5-bis((tetrahydro-2H-pyran-2-yl)oxy)benzoic acid

: 575-38-2
1,7-Dihydroxynaphthalene

: C44H48O12

Conditions

Conditions	Yield
Stage #1: 3,5-bis((tetrahydro-2H-pyran-2-yl)oxy)benzoic acid With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine In dichloromethane at 20℃; for 0.25h; Stage #2: 1,7-Dihydroxynaphthalene In dichloromethane at 20℃; for 3h;	91%

: 575-38-2
1,7-Dihydroxynaphthalene

: 4923-53-9
6-hydroxy-[1,4]naphthoquinone

Conditions

Conditions	Yield
With methylene blue In methanol; water at 20℃; under 7500.75 Torr; for 0.266667h; Irradiation; Flow reactor;	87%
With oxone In water; acetonitrile at 20℃; for 10h;	15%
With methanol; potassium nitrososulfonate

: 575-38-2
1,7-Dihydroxynaphthalene

: 71-43-2
benzene

: 7-hydroxy-4-phenyl-1-tetralone

Conditions

Conditions	Yield
With aluminum tri-bromide at 25℃; for 48h;	87%

: 575-38-2
1,7-Dihydroxynaphthalene

: 108-24-7
acetic anhydride

: 51850-49-8
1,7-diacetoxynaphthalene

Conditions

Conditions	Yield
With pyridine for 3h; Inert atmosphere;	86%
at 100℃;
With pyridine at 100℃;

: 575-38-2
1,7-Dihydroxynaphthalene

: 22009-38-7
7-hydroxy-1-tetralone

Conditions

Conditions	Yield
With aluminum tri-bromide; cyclohexane In various solvent(s) at 20℃; for 28h; Hydrogenation;	83%
With aluminum tri-bromide; cyclohexane In various solvent(s) at 25℃; for 24h;	80%

: 575-38-2
1,7-Dihydroxynaphthalene

: 79-03-8
propionyl chloride

: 7-(propanoyloxy)naphthalen-1-yl propanoate

Conditions

Conditions	Yield
With pyridine In tetrahydrofuran at 20℃; for 5h;	83%

: 575-38-2
1,7-Dihydroxynaphthalene

: 74-88-4
methyl iodide

: 843652-67-5
1,7-dimethoxynaphthalen-2(1H)-one

Conditions

Conditions	Yield
With potassium carbonate In butanone Heating / reflux;	80%

: 575-38-2
1,7-Dihydroxynaphthalene

: 1514896-23-1
3-(2-bromoacetyl)-4-hydroxyfuran-2(5H)-one

: 1514896-33-3
3,3'-{2,2'-[naphthalene-1,7-diylbis(oxy)]bis(acetyl)}bis[4-hydroxyfuran-2(5H)-one]

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 0 - 20℃; for 16h;	79%

: 575-38-2
1,7-Dihydroxynaphthalene

: 40244-90-4
Chlorodiisopropylphosphane

: C22H34O2P2

Conditions

Conditions	Yield
With triethylamine In tetrahydrofuran at 85℃; for 1.5h; Inert atmosphere;	79%
With triethylamine In toluene at 35℃; for 10h; Inert atmosphere; Schlenk technique;

: 575-38-2
1,7-Dihydroxynaphthalene

: 575-44-0
1,6-dihydroxynaphthalene

: 2283-11-6
hexaethylphosphoric triamide

: 749885-09-4
C28H32N2O4P2

Conditions

Conditions	Yield
Stage #1: 1,7-Dihydroxynaphthalene; hexaethylphosphoric triamide In acetonitrile at 20℃; for 0.333333h; Stage #2: 1,6-dihydroxynaphthalene In acetonitrile at 20℃; for 48h;	77%

...Expand

: 1807-68-7
diazodimedone

: 575-38-2
1,7-Dihydroxynaphthalene

: 1-hydroxy-9,9-dimethyl-9,10-dihydrobenzo[kl]xanthen-11(8H)-one

Conditions

Conditions	Yield
With dichloro(pentamethylcyclopentadienyl)rhodium (III) dimer; acetic acid In 1,4-dioxane at 100℃; for 12h; Inert atmosphere; Schlenk technique;	76%

: 50-00-0
formaldehyd

: 575-38-2
1,7-Dihydroxynaphthalene

: 109-77-3
malononitrile

: 2,10-diamino-4,12-dihydronaphtho<1,2-b:7,8-b'>dipyran-3,11-dicarbonitrile

Conditions

Conditions	Yield
With piperidine In ethanol for 1h; Heating;	75%

...Expand

: 581-43-1
2,6-Dihydroxynaphthalene

: 575-38-2
1,7-Dihydroxynaphthalene

: 2283-11-6
hexaethylphosphoric triamide

: 749885-11-8
cyclo[(1,7-naphthylene)(2,6-naphthylene)-bis(diethyl phosphoramidite)]

Conditions

Conditions	Yield
Stage #1: 1,7-Dihydroxynaphthalene; hexaethylphosphoric triamide In acetonitrile at 20℃; for 0.333333h; Stage #2: 2.6-dihydroxynaphthalene In acetonitrile at 20℃; for 48h;	75%

...Expand

: 67-56-1
methanol

: 575-38-2
1,7-Dihydroxynaphthalene

A: 5309-18-2
1,7-dimethoxynaphthalene

B: 67247-13-6
7-methoxynaphth-1-ol

Conditions

Conditions	Yield
With hydrogenchloride for 168h; Ambient temperature;	A n/a B 74%

...Expand

: 575-38-2
1,7-Dihydroxynaphthalene

: 407-25-0
trifluoroacetic anhydride

: 1,7-bis(trifluoroacetoxy)naphthalene

Conditions

Conditions	Yield
In diethyl ether for 48h; Ambient temperature;	73%

: 575-38-2
1,7-Dihydroxynaphthalene

: 369384-87-2
C35H20Cl2N4O4

polymer; monomers: 2-(β-naphthylamino)-4,6-bis-(2-naphthoxy-3-carbonyl chloride)-S-triazine; 1,7-dihydroxynaphthalene: polymer; monomers: 2-(β-naphthylamino)-4,6-bis-(2-naphthoxy-3-carbonyl chloride)-S-triazine; 1,7-dihydroxynaphthalene

Conditions

Conditions	Yield
With cetyltrimethylammonim bromide In N,N-dimethyl-formamide Heating;	73%

: 94582-84-0
thiosulfuric acid S-(2-amino-5-diethylamino-3-methylphenyl) ester

: 575-38-2
1,7-Dihydroxynaphthalene

: 9-Diethylamino-3-hydroxy-11-methyl-benzo[a]phenothiazin-5-one

Conditions

Conditions	Yield
Stage #1: thiosulfuric acid S-(2-amino-5-diethylamino-3-methylphenyl) ester; 1,7-Dihydroxynaphthalene In dimethyl sulfoxide at 20℃; for 0.75h; Stage #2: With potassium dichromate In dimethyl sulfoxide at 20℃; for 0.333333h; Stage #3: With hydrogenchloride In methanol; water; dimethyl sulfoxide at 20℃; for 1h;	73%

: 94582-84-0
thiosulfuric acid S-(2-amino-5-diethylamino-3-methylphenyl) ester

: 575-38-2
1,7-Dihydroxynaphthalene

: 9-diethylamino-3-hydroxy-11-methyl-benzo[a]phenoxazin-5-one

Conditions

Conditions	Yield
With potassium dichromate In dimethyl sulfoxide for 0.333333h;	73%

: 575-38-2
1,7-Dihydroxynaphthalene

: 619-66-9
4-Carboxybenzaldehyde

: 1050414-41-9
naphthalene-1,7-diyl bis(4-formylbenzoate)

Conditions

Conditions	Yield
With dmap; dicyclohexyl-carbodiimide In dichloromethane at 20℃; for 48h;	72%
With dmap; dicyclohexyl-carbodiimide In dichloromethane at 20℃; for 72h;	51%
With dmap; dicyclohexyl-carbodiimide In dichloromethane at 20℃; for 72h;	51%

: 575-38-2
1,7-Dihydroxynaphthalene

: 582-17-2
2,7-Dihydroxynaphthalene

: 2283-11-6
hexaethylphosphoric triamide

: 749885-12-9
cyclo[(1,7-naphthylene)(2,7-naphthylene)-bis(diethyl phosphoramidite)]

Conditions

Conditions	Yield
Stage #1: 1,7-Dihydroxynaphthalene; hexaethylphosphoric triamide In acetonitrile at 20℃; for 0.333333h; Stage #2: 2,7-Dihydroxynaphthalene In acetonitrile at 20℃; for 48h;	71%

...Expand

: 575-38-2
1,7-Dihydroxynaphthalene

: 83-56-7
1,5-dihydroxynaphthalene

: 2283-11-6
hexaethylphosphoric triamide

: 749885-10-7
cyclo[(1,7-naphthylene)(1,5-naphthylene)-bis(diethyl phosphoramidite)]

Conditions

Conditions	Yield
Stage #1: 1,7-Dihydroxynaphthalene; hexaethylphosphoric triamide In acetonitrile at 20℃; for 0.333333h; Stage #2: 1,5-dihydroxynaphthalene In acetonitrile at 20℃; for 48h;	71%

...Expand

: 575-38-2
1,7-Dihydroxynaphthalene

: 915777-42-3
3-(ethyl(3-hydroxy-4-nitrosophenyl)amino)propane-1-sulfonic acid hydrochloride

: 1228763-87-8
C21H20N2O6S

Conditions

Conditions	Yield
In N,N-dimethyl-formamide at 140℃; for 4h; Inert atmosphere;	71%

: 13716-10-4
di(tert-butyl)chlorophosphine

: 575-38-2
1,7-Dihydroxynaphthalene

: 1,7-bis(ditertbutylphosphinyl)naphthalenediol

Conditions

Conditions	Yield
With sodium hydride In tetrahydrofuran for 4h; Reflux; Inert atmosphere;	71%
With triethylamine In toluene at 35℃; for 10h; Inert atmosphere; Schlenk technique;

1,7-Dihydroxynaphthalene Chemical Properties

Chemical Name: 1,7-Dihydroxynaphthalene
IUPAC NAME: naphthalene-1,7-diol
CAS No.: 575-38-2
EINECS: 209-383-0
RTECS: QJ4746666
RTECS Class:Mutagen
Molecular Formula: C₁₀H₈O₂
Molecular Weight: 160.17 g/mol
Melting Point: 180-184 °C(lit.)
Density: 1.33 g/cm³
Flash Point: 193.5 °C
Boiling Point: 375.4 °C at 760 mmHg
1,7-NAPHTHALENEDIOL (575-38-2) is stable under normal temperatures and pressures.but incompatible with strong oxidizing agents.Following is the structure:

The chemical synonymous of 1,7-NAPHTHALENEDIOL (575-38-2) are c.i.76635 ; 1,7-DIHYDROXYNAPHTHALENE ; 1,7-NAPHTHALENEDIOL ; naphthalene-1,7-diol ; 1,7-Napthalenediol ; 1,7-NAPHTHALENEDIOL 97% ; 1,7-DihydroxylNaphthalene ; 1,7-Dihydroxynaphthalin

1,7-Dihydroxynaphthalene Uses

1,7-NAPHTHALENEDIOL (575-38-2) is mainly used as a pharmaceutical intermediate.

1,7-Dihydroxynaphthalene Production

Product Categories about 1,7-NAPHTHALENEDIOL (575-38-2) are Intermediates of Dyes and Pigments ; FINE Chemical & INTERMEDIATES ; Naphthalene derivatives

1,7-Dihydroxynaphthalene Toxicity Data With Reference

mic-sat 1600 nmol/plate

MUREAV Mutation Research. 371 (1996),293.

1,7-Dihydroxynaphthalene Safety Profile

Mutation data reported. When heated to decomposition it emits acrid smoke and irritating vapors.
Hazard Codes:
Xn: Harmful

Risk Statements about 1,7-NAPHTHALENEDIOL (575-38-2):
    R22 Harmful if swallowed.
    R36/37/38 Irritating to eyes, respiratory system and skin.
Safety Statements about 1,7-NAPHTHALENEDIOL (575-38-2):
    S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
    S37/39 Wear suitable gloves and eye/face protection.

1,7-Dihydroxynaphthalene Specification

1. Storage: Store in a cool, dry place. Store in a tightly closed container.
2. Handling: Avoid breathing dust, vapor, mist, or gas. Avoid contact with skin and eyes.
3. Personal Protection: Compatible chemical-resistant gloves. Chemical safety goggles.
4. Fire Fighting: Extinguish using Water spray. Carbon dioxide, dry chemical powder, or appropriate foam. Wear self-contained breathing apparatus and protective clothing to prevent contact with skin and eyes.

Product Name

1,7-Dihydroxynaphthalene

Synthetic route

1,7-Dihydroxynaphthalene Chemical Properties

1,7-Dihydroxynaphthalene Uses

1,7-Dihydroxynaphthalene Production

1,7-Dihydroxynaphthalene Toxicity Data With Reference

1,7-Dihydroxynaphthalene Safety Profile

1,7-Dihydroxynaphthalene Specification

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