1,8-Octanediol
Conditions | Yield |
---|---|
With Pd(OH)2/C In methanol for 5h; Reflux; | 96% |
8-(tetrahydro-2H-pyran-2-yloxy)octan-1-ol
1,8-Octanediol
Conditions | Yield |
---|---|
With tin(ll) chloride In methanol Substitution; | 95% |
With cerium(III) chloride In methanol at 20℃; for 2h; detetrahydropyranylation; | 90% |
tert-Butyl-[8-(2-methoxy-ethoxymethoxy)-octyloxy]-dimethyl-silane
1,8-Octanediol
Conditions | Yield |
---|---|
With cerium(III) chloride In acetonitrile for 1h; Heating; | 92% |
1,8-di(2-terahydropyranyloxy)-octane
1,8-Octanediol
Conditions | Yield |
---|---|
With toluene-4-sulfonic acid In methanol; water for 8h; Heating; | 89% |
Conditions | Yield |
---|---|
With formic acid; F6P(1-)*C16H22N3Ru(1+); water In 1-methyl-pyrrolidin-2-one at 25℃; for 24h; Inert atmosphere; Sealed tube; | 89% |
With 1-hydroxytetraphenylcyclopentadienyl(tetraphenyl-2,4-cyclopentadien-1-one)-μ-hydrotetracarbonyldiruthenium(II); Ru(Cp)(PPh2PytBu)2(MeCN)PF6; water In isopropyl alcohol at 80℃; for 3h; Inert atmosphere; regioselective reaction; | 80% |
Conditions | Yield |
---|---|
With 4-methylmorpholine N-oxide In dimethyl sulfoxide at 20℃; for 65.5h; | A 26% B 83% |
Conditions | Yield |
---|---|
With lithium aluminium tetrahydride | 81% |
With copper chromite at 250℃; under 308913 Torr; Hydrogenation; | |
With ethanol; sodium | |
With lithium aluminium tetrahydride; diethyl ether |
tert-Butyl-(8-methoxymethoxy-octyloxy)-dimethyl-silane
A
1,8-Octanediol
B
8-(tert-butyldimethylsiloxy)octan-1-ol
Conditions | Yield |
---|---|
With dimethylboron bromide; sodium hydrogencarbonate 1) CH2Cl2, -78 deg C, 1h, 2) THF, 5 min; Yield given. Multistep reaction; | A n/a B 81% |
With dimethylboron bromide; sodium hydrogencarbonate 1) CH2Cl2, -78 deg C, 1h, 2) THF, 5 min; Yield given. Multistep reaction; | A 10% B n/a |
C30H50O3Si2
A
1,8-Octanediol
B
8-(tert-butyldimethylsiloxy)octan-1-ol
Conditions | Yield |
---|---|
With tetrabutyl ammonium fluoride In tetrahydrofuran; dichloromethane for 8h; Ambient temperature; | A 4% B 80% |
With tetrabutyl ammonium fluoride In tetrahydrofuran; dichloromethane for 8h; Product distribution; Ambient temperature; var. silyl ethers; other reagents; selectivity of protecting group removal; | A 4% B 80% |
(1-(allyloxy)(8-(tert-butyl)dimethylsiloxy))octane
1,8-Octanediol
Conditions | Yield |
---|---|
With Pd(OH)2/C In isopropyl alcohol for 1.5h; Reflux; | 78% |
1,2-cyclooctene
1,8-Octanediol
Conditions | Yield |
---|---|
With potassium permanganate; Tulsion T-40 exchange resin In dichloromethane; tert-butyl alcohol at 20℃; for 4h; oxidative cleavage; | 73% |
Conditions | Yield |
---|---|
With 9-borabicyclo[3.3.1]nonane dimer; dimethylsulfide borane complex Product distribution; | A 11% B 67% |
1-(allyloxy)-8-(prop-2-yn-1-yloxy)octane
A
1,8-Octanediol
B
8-allyloxyoctan-1-ol
Conditions | Yield |
---|---|
With Pd(OH)2/C In isopropyl alcohol for 2h; Reflux; | A 54% B 36% |
A
1,8-Octanediol
B
8-((4-methoxybenzyl)oxy)octan-1-ol
Conditions | Yield |
---|---|
With Pd(OH)2/C In isopropyl alcohol for 3h; Reflux; | A 47% B 49% |
1,8-bis(4-methoxybenzyloxy)octane
A
1,8-Octanediol
B
8-((4-methoxybenzyl)oxy)octan-1-ol
Conditions | Yield |
---|---|
With Pd(OH)2/C In methanol for 5h; Reflux; | A 46% B 24% |
1,8-Bis(trifluorosilyl)octane
1,8-Octanediol
Conditions | Yield |
---|---|
With 3-chloro-benzenecarboperoxoic acid In N,N-dimethyl-formamide for 3h; r.t. then 50 deg C; | 35% |
Conditions | Yield |
---|---|
Multistep reaction; | 33% |
1,8-Octanediol
Conditions | Yield |
---|---|
With copper dichloride In tetrahydrofuran at -78℃; for 0.75h; | 33% |
Conditions | Yield |
---|---|
With potassium hydroxide; samarium diiodide In tetrahydrofuran; water for 0.01h; Ambient temperature; | 23% |
With cobalt(II) oxide; hydrogen In 1,4-dioxane at 189.84℃; under 30003 Torr; for 10h; Autoclave; | 94.8 %Chromat. |
octa-2,4,6-triyne-1,8-diol
1,8-Octanediol
Conditions | Yield |
---|---|
With ethyl acetate; platinum Hydrogenation; | |
With diethyl ether; nickel at 150℃; under 73550.8 Torr; Hydrogenation; |
3,5-octadiyn-1,8-diol
1,8-Octanediol
Conditions | Yield |
---|---|
With platinum(IV) oxide; acetic acid ester Hydrogenation; |
Conditions | Yield |
---|---|
With ethanol; hydrogen; platinum |
Conditions | Yield |
---|---|
With lithium aluminium tetrahydride; diethyl ether | |
With ethanol; sodium | |
With ethanol; sodium | |
With ethanol; sodium |
Conditions | Yield |
---|---|
With Dimethyl ether; sodium; sodium chloride at -23℃; beim Einleiten von Sauerstoff in Gegenwart von p-Terphenyl und Isooctan und Hydrieren des Reaktionsprodukts an Palladium/Kohle in Aether; |
Conditions | Yield |
---|---|
With hydrogen; nickel In methanol |
Conditions | Yield |
---|---|
(i) NaIO4, aq. H2SO4, EtOH, (ii) NaBH4, NaOH; Multistep reaction; |
(8Z)-heptadec-8-en-1-ol
1,8-Octanediol
Conditions | Yield |
---|---|
(i) O3, AcOEt, (ii) LiAlH4, Py; Multistep reaction; |
Conditions | Yield |
---|---|
With magnesium; iodine 1. THF, reflux, 1h; 2. THF, r.t., 1h; Yield given. Multistep reaction; |
Conditions | Yield |
---|---|
With lithium triethylborohydride In various solvent(s) for 0.416667h; Thermodynamic data; ΔH; |
(Z)-Cyclooctene
A
Cyclooctene oxide
B
1,8-Octanediol
C
(1R,2S)-Cyclooctane-1,2-diol
Conditions | Yield |
---|---|
With lithium aluminium tetrahydride; oxygen 1.) 80 deg C; Yield given. Multistep reaction. Yields of byproduct given. Title compound not separated from byproducts; | |
With lithium aluminium tetrahydride; oxygen 1) 80 grad C,101.3 kPa; Yield given. Multistep reaction. Yields of byproduct given. Title compound not separated from byproducts; |
1,8-Octanediol
8-bromooctanol
Conditions | Yield |
---|---|
With hydrogen bromide In water; toluene for 8h; Reflux; | 100% |
With hydrogen bromide In water; toluene for 8h; Reflux; | 100% |
With hydrogen bromide In toluene Heating; | 99% |
Conditions | Yield |
---|---|
With potassium bromide; cyfluthrin In dichloromethane; water | A 100% B n/a |
1,8-Octanediol
anilino(tert-butyldimethyl)silane
Conditions | Yield |
---|---|
With tetrabutyl ammonium fluoride In N,N-dimethyl-formamide at 20℃; for 1h; | 99% |
Conditions | Yield |
---|---|
With Amberlite IRA 93 (PCl5 form) In hexane for 5h; Heating; | 98% |
With oxalyl dichloride; chloro(triphenyl)phosphonium chloride In chloroform-d1 at 20℃; for 7h; Appel reaction; | 71% |
With toluene-4-sulfonic acid; 1-butyl-3-methylimidazolium chloride In toluene at 200℃; under 10343 Torr; for 0.166667h; microwave irradiation; | 50% |
With pyridine; thionyl chloride | |
Multi-step reaction with 2 steps 1: cooling 2: 94 percent / hexabutylguanidinium chloride / 4 h / 120 °C View Scheme |
3,4-dihydro-2H-pyran
1,8-Octanediol
8-(tetrahydro-2H-pyran-2-yloxy)octan-1-ol
Conditions | Yield |
---|---|
With Dowex 50X2 In toluene at 30℃; for 5h; | 98% |
With Dowex50WX2 In toluene at 30℃; for 5h; | 98% |
With Dowex 50x2 In toluene at 30℃; for 5h; | 98% |
1,8-Octanediol
tert-butyldimethylsilyl chloride
8-(tert-butyldimethylsiloxy)octan-1-ol
Conditions | Yield |
---|---|
Stage #1: 1,8-Octanediol With 1H-imidazole In dichloromethane at 0℃; for 0.25h; Stage #2: tert-butyldimethylsilyl chloride In dichloromethane at 0 - 20℃; for 1h; | 98% |
With dmap; triethylamine In dichloromethane Ambient temperature; | 72% |
Stage #1: 1,8-Octanediol With sodium hydride In tetrahydrofuran at 20℃; for 2h; Stage #2: tert-butyldimethylsilyl chloride In tetrahydrofuran at 20℃; | 67% |
Conditions | Yield |
---|---|
With novozyme 435 at 70℃; under 15.0015 - 45.0045 Torr; for 48h; Enzymatic reaction; | 98% |
1,8-Octanediol
Tert-butyl isocyanate
1,8-bis(N-tert-butylcarbamoyloxy)octane
Conditions | Yield |
---|---|
With MoCl2O2(dmf)2 In dichloromethane at 20℃; for 0.5h; Inert atmosphere; | 98% |
Conditions | Yield |
---|---|
With C24H33IrN4O3; water; sodium hydroxide for 18h; Reflux; | 97% |
With sodium bromate; sodium hydrogensulfite In acetonitrile for 2h; Heating; | 91% |
With Iron(III) nitrate nonahydrate; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; potassium chloride; oxygen In 1,2-dichloro-ethane at 25℃; for 48h; | 86% |
With Iron(III) nitrate nonahydrate; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; potassium chloride; oxygen In 1,2-dichloro-ethane at 20℃; for 48h; Schlenk technique; | 86% |
Conditions | Yield |
---|---|
Stage #1: 1,8-Octanediol With sodium hydride In N,N-dimethyl-formamide at 0℃; for 0.25h; Stage #2: benzyl bromide In N,N-dimethyl-formamide at 0 - 20℃; for 3h; | 97% |
Stage #1: 1,8-Octanediol With sodium hydride In tetrahydrofuran at 60℃; for 0.5h; Substitution; Stage #2: benzyl bromide In tetrahydrofuran at 60℃; for 12h; Substitution; |
Conditions | Yield |
---|---|
With novozyme 435 In hexane at 70℃; for 48h; Enzymatic reaction; | 97% |
Conditions | Yield |
---|---|
With 4-(dimethylamino)pyridinium tosylate; diisopropyl-carbodiimide In dichloromethane at 0℃; Inert atmosphere; | 97% |
1,8-Octanediol
8-hydroxyoctanal
Conditions | Yield |
---|---|
With copper(l) iodide; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; N,N,N,N,-tetramethylethylenediamine; oxygen In acetonitrile at 20℃; for 30h; | 97% |
1,8-Octanediol
(1S,5R,7S)-1,5,7-Trimethyl-2,4-dioxo-3-aza-bicyclo[3.3.1]nonane-7-carbonyl chloride
C32H48N2O8
Conditions | Yield |
---|---|
With dmap; triethylamine In dichloromethane Heating; | 96% |
1,8-Octanediol
p-toluenesulfonyl chloride
1,8-bis(p-toluenesulfonyloxy)octane
Conditions | Yield |
---|---|
With pyridine at 0℃; for 3h; | 96% |
With pyridine at 0℃; for 2.5h; | 91% |
With pyridine In dichloromethane at 5 - 15℃; for 0.333333h; | 90.9% |
Conditions | Yield |
---|---|
With dmap; triethylamine In dichloromethane at 20℃; for 24h; | 96% |
With triethylamine In dichloromethane at 20℃; for 24h; Inert atmosphere; | 60% |
In pyridine; dichloromethane Ambient temperature; | 55% |
With pyridine In N,N-dimethyl-formamide at 20℃; for 1h; | |
With dmap; triethylamine In dichloromethane at 20℃; for 24h; |
Conditions | Yield |
---|---|
Wilkinson's catalyst In toluene at 130℃; for 3h; | 96% |
Conditions | Yield |
---|---|
With novozyme 435 In toluene at 70℃; for 48h; Enzymatic reaction; | 96% |
Conditions | Yield |
---|---|
With novozyme 435 In 2,2,4-trimethylpentane at 70℃; for 48h; Enzymatic reaction; | 96% |
3,4-dihydro-2H-pyran
1,8-Octanediol
A
8-(tetrahydro-2H-pyran-2-yloxy)octan-1-ol
B
1,8-di(2-terahydropyranyloxy)-octane
Conditions | Yield |
---|---|
With Dowex 50W x 2 (50-100 mesh) In toluene at 30℃; for 4.5h; | A 95% B 2% |
With aluminium trichloride; silica gel In 1,2-dichloro-ethane at 20℃; for 1.9h; | A 92% B 3% |
copper(II) sulfate In acetonitrile at 20℃; for 12h; | A 83% B n/a |
Conditions | Yield |
---|---|
With triethylamine In dichloromethane at 0 - 20℃; | 95% |
With pyridine at 0℃; | 69% |
Conditions | Yield |
---|---|
With tetrabutyl ammonium fluoride In N,N-dimethyl-formamide at 20℃; for 0.0833333h; | 95% |
Conditions | Yield |
---|---|
With novozyme 435 at 80℃; for 42h; | 95% |
1,8-Octanediol
2,2,5-trimethyl-1,3-dioxane-5-carboxylic anhydride
1,8-bis-((2,2,5-trimethyl-1,3-dioxan-5-yl)propanoyloxy)octane
Conditions | Yield |
---|---|
With dmap In pyridine; dichloromethane at 20℃; for 4h; Inert atmosphere; | 95% |
Conditions | Yield |
---|---|
With ammonium hydroxide; 1,3-Diiodo-5,5-dimethyl-2,4-imidazolidinedione at 60℃; for 24h; | 94% |
With ammonium hydroxide; 1,3-Diiodo-5,5-dimethyl-2,4-imidazolidinedione at 60℃; for 24h; | 94% |
Conditions | Yield |
---|---|
With novozyme 435 In tetrahydrofuran at 55℃; for 48h; Enzymatic reaction; | 94% |
Conditions | Yield |
---|---|
With HY-Zeolite In chloroform for 3.5h; Heating; | 93% |
With sulfuric acid In toluene at 75℃; for 15h; | 89% |
With sulfuric acid In water; pentane for 12h; Reflux; | 68% |
3,4-dihydro-2H-pyran
1,8-Octanediol
1,8-di(2-terahydropyranyloxy)-octane
Conditions | Yield |
---|---|
copper(II) sulfate In acetonitrile at 20℃; for 12h; | 93% |
IUPAC Name: Octane-1,8-diol
Synonyms of 1,8-Octanediol (CAS NO.629-41-4): EINECS 211-090-8 ; Octane-1,8-diol
CAS NO: 629-41-4
Molecular Formula of 1,8-Octanediol (CAS NO.629-41-4): C8H18O2
Molecular Weight: 146.2273
Molecular Structure:
Product Categories: Industrial/Fine Chemicals ; Miscellaneous ; alpha,omega-Alkanediols ; alpha,omega-Bifunctional Alkanes ; Monofunctional & alpha,omega-Bifunctional Alkanes ; Linear hydrocarbon series
Melting Point: 57-61 °C
Polar Surface Area: 18.46 Å2
Index of Refraction: 1.454
Molar Refractivity: 42.18 cm3
Molar Volume: 155.6 cm3
Surface Tension: 37 dyne/cm
Density of 1,8-Octanediol (CAS NO.629-41-4): 0.939 g/cm3
Flash Point: 128 °C
Enthalpy of Vaporization: 60.07 kJ/mol
Boiling Point: 278.8 °C at 760 mmHg
Vapour Pressure: 0.000507 mmHg at 25°C
It can be used as intermediates of cosmetics, plasticizers and specialty additives.
It is derived by OCTYLDODECYL ETHYLHEXANOATE as raw materials, copper - chromium oxide as catalyst and hydrogenation at high temperature under high pressure.
Hazard Codes: Xi,Xn
Risk Statements: 20/21/22-36/37/38
R20/21/22: Harmful by inhalation, in contact with skin and if swallowed.
R36/37/38: Irritating to eyes, respiratory system and skin.
Safety Statements: 26-37/39
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S37/39: Wear suitable gloves and eye/face protection.
WGK Germany: 3
HS Code: 29053980
About|Contact|Cas|Product Name|Molecular|Country|Encyclopedia
Message|New Cas|MSDS|Service|Advertisement|CAS DataBase|Article Data|Manufacturers | Chemical Catalog
©2008 LookChem.com,License: ICP
NO.:Zhejiang16009103
complaints:service@lookchem.com Desktop View