1-Amino-2-methylpropan-2-ol supplier

Name
1-Amino-2-methylpropan-2-ol
EINECS
CAS No. 2854-16-2
Article Data51
CAS DataBase
Density 0.93 g/cm³
Solubility
Melting Point 8.72°C (estimate)
Formula C₄H₁₁NO
Boiling Point 167.2 °C at 760 mmHg
Molecular Weight 89.1374
Flash Point 54.9 °C
Transport Information
Appearance
Safety 26-39
Risk Codes 22-37/38-41
Molecular Structure
Hazard Symbols Xn
Synonyms 1,1-Dimethylethanolamine;2-Amino-a,a-dimethylethanol;2-Hydroxy-2-methyl-1-propylamine;2-Hydroxyisobutylamine;2-Methyl-2-hydroxypropylamine;3-Amino-2-methyl-2-propanol;NSC 17697;1-amino-2-methylpropan-2-ol;2-Aminodimethylethanol;
PSA 46.25000
LogP 0.41630

Synthetic route

: 344868-41-3
1-dibenzylamino-2-methyl-propan-2-ol

: 2854-16-2
1-Amino-2-methyl-propan-2-ol

Conditions

Conditions	Yield
With palladium 10% on activated carbon; hydrogen In methanol at 20℃; for 24h;	99%

: 625-08-1
3-Hydroxy-3-methylbutyric acid

: 2854-16-2
1-Amino-2-methyl-propan-2-ol

Conditions

Conditions	Yield
Stage #1: 3-Hydroxy-3-methylbutyric acid With 4-methyl-morpholine; diphenyl phosphoryl azide In tetrahydrofuran at 25℃; for 2.25h; Curtius Rearrangement; Stage #2: With water In tetrahydrofuran for 2h; Reagent/catalyst; Reflux;	85%

: 75-86-5
2-hydroxy-2-methylpropanenitrile

: 2854-16-2
1-Amino-2-methyl-propan-2-ol

Conditions

Conditions	Yield
Stage #1: 2-hydroxy-2-methylpropanenitrile With lithium aluminium tetrahydride In diethyl ether at 0 - 20℃; for 23h; Inert atmosphere; Stage #2: With Glauber's salt at 0 - 20℃; for 8h; Inert atmosphere;	81%
Stage #1: 2-hydroxy-2-methylpropanenitrile With lithium aluminium tetrahydride In tetrahydrofuran at 0℃; for 4.25h; Reflux; Stage #2: With potassium fluoride; Glauber's salt In tetrahydrofuran at 0 - 35℃;	56%
With lithium aluminium tetrahydride	51.5%

: 558-30-5
2-methyl-1,2-epoxypropane

: 2854-16-2
1-Amino-2-methyl-propan-2-ol

Conditions

Conditions	Yield
With ammonia In methanol	67.9%
Stage #1: 2-methyl-1,2-epoxypropane With triethylamine; benzylamine In water at 20℃; Stage #2: With 5% Pd(II)/C(eggshell); hydrogen In methanol at 20℃; for 1.5h;	62%
With ammonia; water at 120℃; for 0.5h; Microwave irradiation;	44%

: 73825-96-4
1-(ethylamino)-2-methylpropan-2-ol

A: 75-04-7
ethylamine

B: 2854-16-2
1-Amino-2-methyl-propan-2-ol

C: 75-07-0
acetaldehyde

D: 67-64-1
acetone

Conditions

Conditions	Yield
With water at 25℃; anodic oxidation, pH 10, carbonate buffer; Further byproducts given;	A 35% B 18% C 34% D 43%

...Expand

: 73825-96-4
1-(ethylamino)-2-methylpropan-2-ol

A: 50-00-0
formaldehyd

B: 75-04-7
ethylamine

C: 2854-16-2
1-Amino-2-methyl-propan-2-ol

D: 75-07-0
acetaldehyde

E: 67-64-1
acetone

Conditions

Conditions	Yield
With water at 25℃; Product distribution; Mechanism; anodic oxidation, carbonate buffer, pH 10; effect of substituents investigated with different types of β-alkanolamines;	A 18% B 35% C 18% D 34% E 43%

...Expand

: 558-30-5
2-methyl-1,2-epoxypropane

A: 79365-81-4
1,1,5,5-tetramethyl-3-azapentane-1,5-diol

B: 2854-16-2
1-Amino-2-methyl-propan-2-ol

Conditions

Conditions	Yield
With ammonium hydroxide at 100℃; for 15h; sealed vial;	A 40% B n/a

: 14352-53-5
2-hydroxy-2-methyl-propionaldehyde oxime

: 2854-16-2
1-Amino-2-methyl-propan-2-ol

Conditions

Conditions	Yield
With ethanol; nickel at 100℃; under 58840.6 Torr;
With hydrogen; nickel In methanol

: azido-tert-butyl alcohol

: 2854-16-2
1-Amino-2-methyl-propan-2-ol

Conditions

Conditions	Yield
With ethanol; platinum Hydrogenation;

: 917-64-6
methyl magnesium iodide

: 459-73-4
GlyOEt*HCl

: 2854-16-2
1-Amino-2-methyl-propan-2-ol

Conditions

Conditions	Yield
With diethyl ether

: methylmagnesium iodide

: 459-73-4
GlyOEt*HCl

: 2854-16-2
1-Amino-2-methyl-propan-2-ol

Conditions

Conditions	Yield
analog verlaeuft die Reaktion mit Alaninaethylester;

: 13686-33-4
t-butyl azide

: 2854-16-2
1-Amino-2-methyl-propan-2-ol

Conditions

Conditions	Yield
(i) (irradiation), cyclohexane, (ii) picric acid, toluene; Multistep reaction;

: 30489-30-6
1-(4,4-dimethyl-3,3-diphenyl-4,5-dihydro-3H-pyrrol-2-yl)-3-(2-hydroxy-2-methyl-propyl)-urea

: 2854-16-2
1-Amino-2-methyl-propan-2-ol

Conditions

Conditions	Yield
With potassium hydroxide Heating;

: 18296-11-2
2-methyl-2-[(trimethylsilyl)oxy]propanenitrile

: 2854-16-2
1-Amino-2-methyl-propan-2-ol

Conditions

Conditions	Yield
With lithium aluminium tetrahydride Yield given;

: 167108-05-6
N-(β-hydroxy-isobutyl)-phthalimide

: 7664-93-9
sulfuric acid

A: 2854-16-2
1-Amino-2-methyl-propan-2-ol

B: 78-84-2
isobutyraldehyde

...Expand

: 558-30-5
2-methyl-1,2-epoxypropane

: 7664-41-7
ammonia

A: 2854-16-2
1-Amino-2-methyl-propan-2-ol

B bis-<β-oxy-isobutyl>-amine: bis-<β-oxy-isobutyl>-amine

C tris-<β-oxy-isobutyl>-amine: tris-<β-oxy-isobutyl>-amine

...Expand

dimethyl-ethylene oxide: dimethyl-ethylene oxide

: 2854-16-2
1-Amino-2-methyl-propan-2-ol

Conditions

Conditions	Yield
With ammonium hydroxide; water

N-<β-oxy-isobutyl>-phthalimide: N-<β-oxy-isobutyl>-phthalimide

: 2854-16-2
1-Amino-2-methyl-propan-2-ol

Conditions

Conditions	Yield
With sulfuric acid

: 6400-94-8
2-methyl-2-nitrooxy-propionaldehyde (E)-oxime

: 64-19-7
acetic acid

platinum oxide: platinum oxide

A: 7664-41-7
ammonia

B: 2854-16-2
1-Amino-2-methyl-propan-2-ol

Conditions

Conditions	Yield
Hydrogenation;

...Expand

: 7757-82-6
sodium sulfate

: 75-86-5
2-hydroxy-2-methylpropanenitrile

: 2854-16-2
1-Amino-2-methyl-propan-2-ol

Conditions

Conditions	Yield
In water	4.8 g (41%)

: 558-30-5
2-methyl-1,2-epoxypropane

: 100-46-9
benzylamine

: 2854-16-2
1-Amino-2-methyl-propan-2-ol

Conditions

Conditions	Yield
Stage #1: 2-methyl-1,2-epoxypropane; benzylamine With triethylamine In water at 20℃; Stage #2: With 10% Pd/C; hydrogen In methanol at 20℃;

: 78-81-9
isobutylamine

: 2854-16-2
1-Amino-2-methyl-propan-2-ol

Conditions

Conditions	Yield
With dipotassium peroxodisulfate; sulfuric acid In water at 80℃; for 4h; Reagent/catalyst; Solvent; Sealed tube;

: 1214248-50-6
rac-2-chloro-N-[2-(6-fluoro-2,3-dihydro-benzofuran-3-ylamino)-4H-benzo[d][1,3]oxazin-6-yl]-acetamide

: 2854-16-2
1-Amino-2-methyl-propan-2-ol

: 1214250-00-6
rac-N-[2-(6-Fluoro-2,3-dihydro-benzofuran-3-ylamino)-4H-benzo[d][1,3]oxazin-6-yl]-2-(2-hydroxy-2-methyl-propylamino)-acetamide

Conditions

Conditions	Yield
In acetonitrile	100%

: 1578244-55-9
8-chloro-N-(2-methoxy-4-(1-methyl-1H-pyrazol-4-yl)phenyl)pyrido[3,4-d]-pyrimidin-2-amine

: 2854-16-2
1-Amino-2-methyl-propan-2-ol

: 1578244-28-6
1-((2-((2-methoxy-4-(1-methyl-1H-pyrazol-4-yl)phenyl)amino)pyrido[3,4-d]pyrimidin-8-yl)amino)-2-methylpropan-2-ol

Conditions

Conditions	Yield
In 1-methyl-pyrrolidin-2-one at 130℃; for 8h; Sealed tube;	100%

: 5-{2-[4-(benzyloxy)phenyl]tetrahydrofuran-2-yl}pyridine-2-carboxylic acid

: 2854-16-2
1-Amino-2-methyl-propan-2-ol

: 5-{2-[4-(benzyloxy)phenyl]tetrahydrofuran-2-yl}-N-(2-hydroxy-2-methylpropyl)pyridine-2-carboxamide

Conditions

Conditions	Yield
With 4-methyl-morpholine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate In dichloromethane; N,N-dimethyl-formamide at 20℃;	100%

: 2854-16-2
1-Amino-2-methyl-propan-2-ol

: 98-58-8
4-bromobenzenesulfonyl chloride

: 500730-57-4
4-bromo-N-(2-hydroxy-2-methylpropyl)-benzenesulfonamide

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In tetrahydrofuran at 20℃; for 0.75h;	98%
With triethylamine In dichloromethane at 0 - 20℃; for 1h;	64%
With sodium hydroxide
With triethylamine In dichloromethane at 20℃; Inert atmosphere;

: 3-((5-methyl-5H-chromeno[3,4-c]pyridine-8-carboxamido)methyl)benzoic acid

: 2854-16-2
1-Amino-2-methyl-propan-2-ol

: N-(3-(2-hydroxy-2-methylpropylcarbamoyl)benzyl)-5-methyl-5H-chromeno[3,4-c]pyridine-8-carboxamide

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine; HATU In N,N-dimethyl-formamide at 20℃; for 1.5h; Inert atmosphere;	98%

: ethyl 2-(1-((1r,4r)-4-(cyanomethyl)cyclohexyl)-6-(phenylsulfonyl)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-2-yl)acetate

: 2854-16-2
1-Amino-2-methyl-propan-2-ol

: 2-(1-((1r,4r)-4-(cyanomethyl)cyclohexyl)-6-(phenylsulfonyl)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-2-yl)-N-(2-hydroxy-2-methylpropyl)acetamide

Conditions

Conditions	Yield
In N,N-dimethyl acetamide at 50 - 110℃; for 18.75h;	98%
In N,N-dimethyl acetamide at 110 - 125℃; for 5.75h;	98%

: ethyl 2-(1-((1r,4r)-4-(cyanomethyl)cyclohexyl)-6-(phenylsulfonyl)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-2-yl)acetate

: 2854-16-2
1-Amino-2-methyl-propan-2-ol

: 2-(1-((1r,4r)-4-(cyanomethyl)cyclohexyl)-6-(phenylsulfonyl)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-2-yl)-N-(2-hydroxy-2-methylpropyl)acetamide

Conditions

Conditions	Yield
In N,N-dimethyl acetamide at 110 - 125℃; for 5.75h;	98%
In N,N-dimethyl acetamide at 50 - 125℃; for 50h;

: 2854-16-2
1-Amino-2-methyl-propan-2-ol

: 586-75-4
4-chlorobenzoyl chloride

: 32159-00-5
4-bromo-N-(2-hydroxy-2-methylpropyl)benzamide

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In tetrahydrofuran at 20℃; for 0.75h;	98%

: tricarbonyl[(8,9,10,11-η)-(2E,6E,8E,10E)-dodeca-2,6,8,10-tetraenoic acid]iron

: 2854-16-2
1-Amino-2-methyl-propan-2-ol

: tricarbonyl[(8,9,10,11-η)-(2E,6E,8E,10E)-N-(2-hydroxy-2-methylpropyl) dodeca-2,6,8,10-tetraenamide]iron

Conditions

Conditions	Yield
Stage #1: tricarbonyl[(8,9,10,11-η)-(2E,6E,8E,10E)-dodeca-2,6,8,10-tetraenoic acid]iron With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃; for 0.0833333h; Inert atmosphere; Stage #2: 1-Amino-2-methyl-propan-2-ol In dichloromethane for 4.5h; Inert atmosphere;	97.5%

: 24424-99-5
di-tert-butyl dicarbonate

: 2854-16-2
1-Amino-2-methyl-propan-2-ol

: 183059-24-7
tert-butyl (2-hydroxy-2-methylpropyl)carbamate

Conditions

Conditions	Yield
	97.4%
In dichloromethane at 0 - 20℃; for 5h;	87.7%

: 2854-16-2
1-Amino-2-methyl-propan-2-ol

: 431-03-8
dimethylglyoxal

: 141089-23-8
2,2',5,5,5',5'-Hexamethyl-2,2'-bioxazolidine

Conditions

Conditions	Yield
In benzene for 12h; Heating;	97%

: 1380836-83-8
N-(4-trifluoromethoxy-phenyl)-2-chloro-4-fluoro-5-nitro-benzoic acid amide

: 2854-16-2
1-Amino-2-methyl-propan-2-ol

: 1380836-85-0
N-(4-trifluoromethoxy-phenyl)-2-chloro-4-(2-hydroxy-2-methyl-propylamino)-5-nitro-benzoic acid amide

Conditions

Conditions	Yield
With caesium carbonate In N,N-dimethyl-formamide at 50℃; for 1h;	97%
With caesium carbonate In N,N-dimethyl-formamide at 50℃; for 1h;	97%

: (2E,4E,8Z,10E,12E)-tetradeca-2,4,8,10,12-pentaenoic acid

: 2854-16-2
1-Amino-2-methyl-propan-2-ol

: 78886-66-5
N-(2-methyl-2-hydroxypropyl)-tetradeca-(2E,4E,8Z,10E,12E)-pentaeneamide

Conditions

Conditions	Yield
With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine In chloroform; acetonitrile at 20℃; for 0.5h; Inert atmosphere;	97%
Stage #1: (2E,4E,8Z,10E,12E)-tetradeca-2,4,8,10,12-pentaenoic acid With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine In chloroform for 0.5h; Stage #2: 1-Amino-2-methyl-propan-2-ol In chloroform for 4h; Inert atmosphere;	92%

: 103-71-9
phenyl isocyanate

: 2854-16-2
1-Amino-2-methyl-propan-2-ol

: 1-(2-hydroxy-2-methyl-propyl)-3-phenyl-urea

Conditions

Conditions	Yield
In ethyl acetate at 0 - 22℃; for 24h;	96%

: 2854-16-2
1-Amino-2-methyl-propan-2-ol

: 431-03-8
dimethylglyoxal

A: 141089-13-6
1-Acetyl-1-methyl-N-(2-hydroxy-2-methylpropyl)methanimine

B: 141089-20-5
1-(2,5,5-Trimethyl-oxazolidin-2-yl)-ethanone

Conditions

Conditions	Yield
With magnesium sulfate In dichloromethane at 25℃; for 4h;	A 96% B n/a

...Expand

: 1446507-68-1
4-chloro-6-(6-(trifluoromethyl)pyridin-2-yl)-N-(2-(trifluoro-methyl)-pyridin-4-yl)-1,3,5-triazin-2-amine

: 2854-16-2
1-Amino-2-methyl-propan-2-ol

: 1446502-11-9
2-methyl-1-[(4-[6-(trifluoromethyl)pyridin-2-yl]-6-{[2-(trifluoromethyl)pyridin-4-yl]amino}-1,3,5-triazin-2-yl)amino]propan-2-ol

Conditions

Conditions	Yield
Stage #1: 4-chloro-6-(6-(trifluoromethyl)pyridin-2-yl)-N-(2-(trifluoro-methyl)-pyridin-4-yl)-1,3,5-triazin-2-amine With N-ethyl-N,N-diisopropylamine In 2-methyltetrahydrofuran at 20℃; Inert atmosphere; Large scale; Stage #2: 1-Amino-2-methyl-propan-2-ol In 2-methyltetrahydrofuran at 20 - 30℃; Large scale;	96%
With sodium hydrogencarbonate In tetrahydrofuran Concentration; Reflux;
With sodium hydrogencarbonate In tetrahydrofuran at 75 - 80℃;

: 1033280-93-1
1-[4-(i-propyl)phenyl]-pentane-1,4-dione

: 2854-16-2
1-Amino-2-methyl-propan-2-ol

: 1-(2-(4-isopropylphenyl)-5-methyl-1H-pyrrol-1-yl)-2-methylpropan-2-ol

Conditions

Conditions	Yield
With toluene-4-sulfonic acid In ethanol at 160℃; under 7757.43 Torr; for 0.5h; Sealed tube; Microwave irradiation;	96%

: 110-78-1
Propyl isocyanate

: 2854-16-2
1-Amino-2-methyl-propan-2-ol

: 1-(2-hydroxy-2-methyl-propyl)-3-propyl-urea

Conditions

Conditions	Yield
In ethyl acetate for 5h; Heating;	95%

: 2094-99-7
1-(1-isocyanato-1-methylethyl)-3-(1-methylethenyl)benzene

: 2854-16-2
1-Amino-2-methyl-propan-2-ol

: 1-(2-hydroxy-2-methyl-propyl)-3-<1-(3-isopropenyl-phenyl)-1-methyl-ethyl>-urea

Conditions

Conditions	Yield
In ethyl acetate at 0 - 22℃; for 24h;	95%

: 2854-16-2
1-Amino-2-methyl-propan-2-ol

: 1493-27-2
ortho-nitrofluorobenzene

: 851190-77-7
2-methyl-1-[(2-nitrophenyl)amino]propan-2-ol

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 16h;	95%
With N-ethyl-N,N-diisopropylamine In DMF (N,N-dimethyl-formamide) at 80℃; for 24h;

: 369-36-8
6-fluoro-3-nitroaniline

: 2854-16-2
1-Amino-2-methyl-propan-2-ol

: 122-51-0
orthoformic acid triethyl ester

: 2-methyl-1-(5-nitro-1H-benzo[d]imidazol-1-yl)propan-2-ol

Conditions

Conditions	Yield
Stage #1: 6-fluoro-3-nitroaniline; 1-Amino-2-methyl-propan-2-ol In dimethyl sulfoxide at 120℃; Stage #2: orthoformic acid triethyl ester In dimethyl sulfoxide at 20 - 100℃;	95%

...Expand

: 1314128-32-9
4-(cyclopropylmethoxy)-N-(2-formyl-1,4-dimethyl-1H-indol-5-yl)benzamide

: 2854-16-2
1-Amino-2-methyl-propan-2-ol

: 1314127-26-8
4-(cyclopropylmethoxy)-N-(2-{[(2-hydroxy-2-methylpropyl)amino]methyl}-1,4-dimethyl-1H-indol-5-yl)benzamide

Conditions

Conditions	Yield
Stage #1: 4-(cyclopropylmethoxy)-N-(2-formyl-1,4-dimethyl-1H-indol-5-yl)benzamide; 1-Amino-2-methyl-propan-2-ol With acetic acid In 1-methyl-pyrrolidin-2-one at 20℃; for 3h; Stage #2: With sodium tris(acetoxy)borohydride In 1-methyl-pyrrolidin-2-one at 20℃; for 15h; Stage #3: With sodium hydroxide In 1-methyl-pyrrolidin-2-one; water; ethyl acetate at 20℃;	94%

: tricarbonyl[(8-11-η)-(2E,6E,8E,10E)-dodeca-2,6,8,10-tetraenoic acid]iron

: 2854-16-2
1-Amino-2-methyl-propan-2-ol

: C19H25FeNO5

Conditions

Conditions	Yield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃;	94%

: N-(4-chloroquinolin-3-yl)-2-(ethoxy-d5)acetamide

: 2854-16-2
1-Amino-2-methyl-propan-2-ol

: 1-(2-((ethoxy-d5)methyl)-1H-imidazo[4,5-c]quinolin-1-yl)-2-methylpropan-2-ol

Conditions

Conditions	Yield
With toluene-4-sulfonic acid at 125℃; for 15h; Sealed tube;	94%

: 394-41-2
3-fluoro-4-nitrophenol

: 2854-16-2
1-Amino-2-methyl-propan-2-ol

: 69045-82-5
2-fluoro-5-(trifluoromethyl)pyridine

: 2-methyl-1-((2-nitro-5-((5-(trifluoromethyl)pyridin-2-yl)oxy)phenyl)amino)propan-2-ol

Conditions

Conditions	Yield
Stage #1: 3-fluoro-4-nitrophenol; 1-Amino-2-methyl-propan-2-ol With sodium hydrogencarbonate In 1-methyl-pyrrolidin-2-one at 120℃; for 4h; Inert atmosphere; Stage #2: 2-fluoro-5-(trifluoromethyl)pyridine With potassium carbonate In 1-methyl-pyrrolidin-2-one at 100℃; for 4h; Inert atmosphere;	93.5%
Stage #1: 3-fluoro-4-nitrophenol; 1-Amino-2-methyl-propan-2-ol With caesium carbonate; N-ethyl-N,N-diisopropylamine In 1-methyl-pyrrolidin-2-one at 100℃; for 4h; Stage #2: 2-fluoro-5-(trifluoromethyl)pyridine With caesium carbonate In 1-methyl-pyrrolidin-2-one at 100℃; for 3h;	1.53 g
Stage #1: 3-fluoro-4-nitrophenol; 1-Amino-2-methyl-propan-2-ol With N-ethyl-N,N-diisopropylamine In 1-methyl-pyrrolidin-2-one at 100℃; for 4h; Stage #2: 2-fluoro-5-(trifluoromethyl)pyridine With caesium carbonate	1.53 g

...Expand

: 928318-76-7
8-(Cyclopropylmethyl)-2-(2,4-difluorophenyl)-3-(2-(methanesulfonyl)pyrimidin-4-yl)imidazo[1,2-a]pyrazine

: 2854-16-2
1-Amino-2-methyl-propan-2-ol

: 1061668-19-6
1-{4-[8-cyclopropylmethyl-2-(2,4-difluorophenyl)-imidazo[1,2-a]pyrazin-3-yl]-pyrimidin-2-ylamino}-2-methylpropan-2-ol

Conditions

Conditions	Yield
In acetonitrile at 80℃; for 16h;	93%

: 2854-16-2
1-Amino-2-methyl-propan-2-ol

: 103826-56-8
(E)-methyl 4,4-dimethyl-5-oxopent-2-enoate

: 1027960-64-0
(E)-4-(5,5-Dimethyl-oxazolidin-2-yl)-4-methyl-pent-2-enoic acid methyl ester

Conditions

Conditions	Yield
With 4 Angstroem MS In 1,2-dimethoxyethane for 2h; Ambient temperature;	92%

: 18744-21-3
2E,6Z,8E,10E-dodecatetraenoic acid

: 2854-16-2
1-Amino-2-methyl-propan-2-ol

: 97465-69-5, 83883-10-7
hydroxy-α-sanshool

Conditions

Conditions	Yield
With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine In chloroform; acetonitrile at 20℃; for 0.5h;	92%
With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine In dichloromethane at 20℃; for 1h;	82%

: 1314128-01-2
N-(2-formyl-1-methyl-1H-indol-5-yl)-4-(tetrahydrofuran-3-ylmethoxy)benzamide

: 2854-16-2
1-Amino-2-methyl-propan-2-ol

: 1314127-01-9
N-(2-{[(2-hydroxy-2-methylpropyl)amino]methyl}-1-methyl-1H-indol-5-yl)-4-(tetrahydrofuran-3-ylmethoxy)benzamide

Conditions

Conditions	Yield
Stage #1: N-(2-formyl-1-methyl-1H-indol-5-yl)-4-(tetrahydrofuran-3-ylmethoxy)benzamide; 1-Amino-2-methyl-propan-2-ol With acetic acid In 1-methyl-pyrrolidin-2-one at 20℃; for 3h; Stage #2: With sodium tris(acetoxy)borohydride In 1-methyl-pyrrolidin-2-one at 20℃; for 90h; Stage #3: With sodium hydroxide In 1-methyl-pyrrolidin-2-one; water; ethyl acetate at 20℃;	92%

1-Amino-2-methylpropan-2-ol Specification

The 2-Propanol,1-amino-2-methyl-, with the CAS registry number 2854-16-2, has the systematic name and IUPAC name of 1-amino-2-methylpropan-2-ol. It is a kind of irritant chemical, and belongs to the product category of Pharmacetical. And the molecular formula of the chemical is C₄H₁₁NO.

The physical properties of 2-Propanol,1-amino-2-methyl- are as followings: (1)ACD/LogP: -0.61; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): -3.69; (4)ACD/LogD (pH 7.4): -2.97; (5)ACD/BCF (pH 5.5): 1; (6)ACD/BCF (pH 7.4): 1; (7)ACD/KOC (pH 5.5): 1; (8)ACD/KOC (pH 7.4): 1; (9)#H bond acceptors: 2; (10)#H bond donors: 3; (11)#Freely Rotating Bonds: 3; (12)Polar Surface Area: 12.47 Å²; (13)Index of Refraction: 1.447; (14)Molar Refractivity: 25.61 cm³; (15)Molar Volume: 95.7 cm³; (16)Polarizability: 10.15×10^-24cm³; (17)Surface Tension: 34.4 dyne/cm; (18)Density: 0.93 g/cm³; (19)Flash Point: 54.9 °C; (20)Enthalpy of Vaporization: 47.01 kJ/mol; (21)Boiling Point: 167.2 °C at 760 mmHg; (22)Vapour Pressure: 0.566 mmHg at 25°C.

You can still convert the following datas into molecular structure:
(1)SMILES: OC(C)(C)CN
(2)InChI: InChI=1/C4H11NO/c1-4(2,6)3-5/h6H,3,5H2,1-2H3
(3)InChIKey: LXQMHOKEXZETKB-UHFFFAOYAA

The toxicity data is as follows:

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Source
mouse	LCLo	inhalation	1095ppm/18H (1095ppm)	Shell Chemical Company. Unpublished Report. Vol. -, Pg. 1, 1961.
mouse	LD50	oral	2450mg/kg (2450mg/kg)	Shell Chemical Company. Unpublished Report. Vol. -, Pg. 1, 1961.
rabbit	LDLo	skin	1960mg/kg (1960mg/kg)	Shell Chemical Company. Unpublished Report. Vol. -, Pg. 1, 1961.
rat	LDLo	oral	3gm/kg (3000mg/kg)	Shell Chemical Company. Unpublished Report. Vol. -, Pg. 1, 1961.

Product Name

1-Amino-2-methylpropan-2-ol

Synthetic route

1-Amino-2-methylpropan-2-ol Specification

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