1-Aziridine ethanol supplier

Name
1-Aziridineethanol
EINECS
CAS No. 1072-52-2
Article Data4
CAS DataBase
Density 1,088 g/cm3
Solubility
Melting Point
Formula C4H9 N O
Boiling Point 167-168°C
Molecular Weight 87.1216
Flash Point 67°C
Transport Information
Appearance CLEAR COLOURLESS LIQUID
Safety Poison by ingestion, skin contact, and intravenous routes. A skin and eye irritant. Questionable carcinogen with experimental neoplastigenic data. Mutation data reported. When heated to decomposition it emits toxic fumes of NO_x.
Risk Codes R23/24/25;R33;
Molecular Structure
Hazard Symbols Irritant to skin and eyes.
Synonyms 1-(2-Hydroxyethyl)ethylenimine;1-(2-Hydroxylethyl)aziridine; 2-(Aziridin-1-yl)ethanol;N-(2-Hydroxyethyl)aziridine; N-(2-Hydroxyethyl)ethylenimine; N-(b-Hydroxyethyl)aziridine; NSC50209
PSA 23.24000
LogP -0.76780

Synthetic route

: 75-21-8
oxirane

: 151-56-4
ethyleneimine

: 1072-52-2
2-(1-aziridine)ethanol

: 141-43-5
ethanolamine

A: 151-56-4
ethyleneimine

B: 1072-52-2
2-(1-aziridine)ethanol

C: 290-37-9
1,4-pyrazine

Conditions

Conditions	Yield
With (Cs2O)5.5-(P2O5)1.8/SiO2 at 420℃; Temperature;

...Expand

: 1072-52-2
2-(1-aziridine)ethanol

: 557-20-0
diethylzinc

: C2H5(1-)*Zn(2+)*C2H4NC2H4O(1-)=[(C2H5)Zn(C2H4NC2H4O)]

Conditions

Conditions	Yield
In toluene Et2Zn and 1-aziridineethanol (1 equiv.) were reacted in toluene;	99%

: 1072-52-2
2-(1-aziridine)ethanol

: methyl (E)-5-[4-(2,2-dimethylpropanoyloxy)phenyl]-5-(4-hydroxyphenyl)-4-phenyl-pent-4-enoate

: (E)-methyl 5-(4-(2-(aziridin-1-yl)ethoxy)phenyl)-4-phenyl-5-(4-(pivaloyloxy)phenyl)pent-4-enoate

Conditions

Conditions	Yield
With di-isopropyl azodicarboxylate; triphenylphosphine In dichloromethane at 0 - 20℃; Mitsunobu Displacement;	99%

: 1072-52-2
2-(1-aziridine)ethanol

: 680199-30-8
2-chloro-3,5-dinitro-N-[2-(tetrahydro-2H-pyran-2-yloxy)ethyl]benzamide

: 944088-69-1
2-[(2-chloroethyl)(2-hydroxyethyl)amino]-3,5-dinitro-N-[2-(tetrahydro-2H-pyran-2-yloxy)ethyl]benzamide

Conditions

Conditions	Yield
With lithium chloride In various solvent(s) cooling;	97%
In 3-methyl-butan-2-one at 5 - 20℃; Product distribution / selectivity;	97%

: 1072-52-2
2-(1-aziridine)ethanol

: 71-48-7, 917-69-1, 5931-89-5, 55881-15-7, 68931-68-0, 68931-69-1, 93029-27-7
cobalt(II) acetate

: 1214883-04-1
trans-(bis[(acetato-κO)-(2-(1-aziridinyl)ethanol-κ2-N,O)])cobalt(II)

Conditions

Conditions	Yield
In dichloromethane (Ar); Schlenk techniques; 2-(1-azirinyl)ethanol added to CH2Cl2 soln. ofCo(OAc)2; stirred at 21°C for 18 h; evapn.; dried in vac.; elem. anal.;	96%

: 1072-52-2
2-(1-aziridine)ethanol

: 7646-79-9
cobalt(II) chloride

: cis-(bis[chlorido-(2-(1-aziridinyl)ethanol-κ2-N,O)])cobalt(II)

Conditions

Conditions	Yield
In dichloromethane (Ar); Schlenk techniques; 2-(1-azirinyl)ethanol added to CH2Cl2 soln. ofCoCl2; stirred at 21°C for 18 h; evapn.; dried in vac.; stirred in dry acetone; decanted; dried in vac.; elem. anal.;	95%

: 1072-52-2
2-(1-aziridine)ethanol

: 88303-65-5
<2-<(2-hydroxyethyl)amino>ethyl>hydrazine

Conditions

Conditions	Yield
With hydrazine In water at 113℃; for 44h;	94%
With hydrazine hydrate In water for 48h; Heating;	60%

: 1072-52-2
2-(1-aziridine)ethanol

: 7789-45-9
copper(ll) bromide

: 1313430-51-1
tetrakis(μ3-(2-aziridin-1-ylethanolato-κ2N,O)bromidocopper(II))

Conditions

Conditions	Yield
In dichloromethane byproducts: HBr; (Ar); addn. of 1.2 equiv. of aziridine deriv. to suspn. of copper compd.in CH2Cl2, stirring for 18 h at room temp.; evapn., stirring in acetone overnight at room temp., decantation, dryingvac., elem. anal.;	93%

: 1072-52-2
2-(1-aziridine)ethanol

: 6266-51-9
2-chloro-3,5-dinitrobenzamide

: 2-[(2-chloroethyl)(2-hydroxyethyl)amino]-3,5-dinitrobenzamide

Conditions

Conditions	Yield
With lithium chloride In tetrahydrofuran cooling;	92%
In tetrahydrofuran at 5 - 20℃;	92%

: 1072-52-2
2-(1-aziridine)ethanol

: (OC)4Re(η(3)-C3H5)

: 618885-13-5
trans-bis[(μ2-O(η(2)-N,O)-2-aziridinylethoxy)tricarbonyl-rhenium(I)]

Conditions

Conditions	Yield
In octane byproducts: C3H6, CO; all manipulations under Ar atm.; Re complex and 1 equiv. of aminoalc. dissolved in octane and refluxed for 2 h; solvent evapd., residue washed with pentane, dried in vac., elem. anal.;	92%

: 1072-52-2
2-(1-aziridine)ethanol

: 944088-64-6
di(tert-butyl) 2-[(2-chloro-3,5-dinitrobenzoyl)amino]ethyl phosphate

: 944088-77-1
di(tert-butyl) 2-({2-[(2-chloroethyl)(2-hydroxyethyl)amino]-3,5-dinitrobenzoyl}amino)ethyl phosphate

Conditions

Conditions	Yield
With triethylamine In 1,4-dioxane at 20℃;	90%

: 1072-52-2
2-(1-aziridine)ethanol

: 680199-30-8
2-chloro-3,5-dinitro-N-[2-(tetrahydro-2H-pyran-2-yloxy)ethyl]benzamide

: 944088-70-4
2-[(2-bromoethyl)(2-hydroxyethyl)amino]-3,5-dinitro-N-[2-(tetrahydro-2H-pyran-2-yloxy)ethyl]benzamide

Conditions

Conditions	Yield
With lithium bromide In 3-methyl-butan-2-one at 5 - 20℃; Product distribution / selectivity;	90%
With lithium bromide In various solvent(s) cooling;	80%

: 1072-52-2
2-(1-aziridine)ethanol

: 29655-46-7
N-benzyloxycarbonyl-2-(4-hydroxyphenyl)ethylamine

: benzyl 4-(2-(aziridin-1-yl)ethoxy)phenethylcarbamate

Conditions

Conditions	Yield
With di-isopropyl azodicarboxylate; triphenylphosphine In tetrahydrofuran at -5 - 20℃; Inert atmosphere;	89%

: 1072-52-2
2-(1-aziridine)ethanol

: 14243-64-2
(triphenylphosphine)gold(I) chloride

: 2923-28-6
silver trifluoromethanesulfonate

: 852989-12-9
[N-hydroxyethylaziridine-triphenylphosphanegold(I)]-trifluoromethylsulfonate

Conditions

Conditions	Yield
In dichloromethane byproducts: AgCl; (Ar); Ag salt was added to soln. of Au complex (1 equiv.) in CH2Cl2; soln. was stirred for 15 min; centrifuged; soln. was decanted; aziridine (1equiv.) was added; soln. was stirred for 1 h; solvent evapd.; stirred in hexane; filtered; dried (vac.); elem. anal.;	88%

...Expand

: 1072-52-2
2-(1-aziridine)ethanol

: 6266-51-9
2-chloro-3,5-dinitrobenzamide

: 944088-67-9
2-[(2-bromoethyl)(2-hydroxyethyl)amino]-3,5-dinitrobenzamide

Conditions

Conditions	Yield
With lithium bromide In various solvent(s) cooling;	87%
With lithium bromide In 3-methyl-butan-2-one at 5 - 20℃;	87%

: 1072-52-2
2-(1-aziridine)ethanol

: ((4-ethylpiperazin-1-yl)(5-fluoro-4-(methylsulfonyl)-2-nitrophenyl)methanone)

: (5-((2-bromoethyl)(2-hydroxyethyl)amino)-4-(methylsulfonyl)-2-nitrophenyl)(4-ethylpiperazin-1-yl)methanone

Conditions

Conditions	Yield
With lithium bromide In N,N-dimethyl-formamide at -5 - 0℃;	87%

: 1072-52-2
2-(1-aziridine)ethanol

: 680199-30-8
2-chloro-3,5-dinitro-N-[2-(tetrahydro-2H-pyran-2-yloxy)ethyl]benzamide

: 944088-71-5
2-[(2-hydroxyethyl)(2-iodoethyl)amino]-3,5-dinitro-N-[2-(tetrahydro-2H-pyran-2-yloxy)ethyl]benzamide

Conditions

Conditions	Yield
With sodium iodide In 3-methyl-butan-2-one at 5 - 20℃;	82%
With sodium iodide In various solvent(s) cooling;	63%

: 1072-52-2
2-(1-aziridine)ethanol

: 2-bromo-3,5-dinitro-N-[2-(tetrahydro-2H-pyran-2-yloxy)ethyl]benzamide

: 944088-70-4
2-[(2-bromoethyl)(2-hydroxyethyl)amino]-3,5-dinitro-N-[2-(tetrahydro-2H-pyran-2-yloxy)ethyl]benzamide

Conditions

Conditions	Yield
sodium bromide In tetrahydrofuran for 44h; Product distribution / selectivity;	81%

: 1072-52-2
2-(1-aziridine)ethanol

: 16940-66-2
sodium tetrahydroborate

: 22557-95-5
(HOC2H4)(CH2)2NBH3

Conditions

Conditions	Yield
With acetic acid In tetrahydrofuran filtration of filtrate, evapn., dissolving in THF, pptn. with hexane;;	76%

: 1072-52-2
2-(1-aziridine)ethanol

: 124-38-9
carbon dioxide

: 3356-88-5
N-(2'-hydroxyethyl)-2-oxazolidone

Conditions

Conditions	Yield
With 2,2':6,2''-terpyridine In methanol at 110℃; for 20h; Autoclave;	71%
With 1,3-bis(tert-butyl)-imidazolium-2-carboxylate In isopropyl alcohol at 90℃; under 37503.8 Torr; for 20h; Inert atmosphere; Autoclave;	40 %Spectr.

: 1072-52-2
2-(1-aziridine)ethanol

: 6266-51-9
2-chloro-3,5-dinitrobenzamide

: 944088-68-0
2-[(2-hydroxyethyl)(2-iodoethyl)amino]-3,5-dinitrobenzamide

Conditions

Conditions	Yield
With sodium iodide In various solvent(s) cooling;	70%
With sodium iodide In 3-methyl-butan-2-one at 5 - 20℃;	70%

: 1072-52-2
2-(1-aziridine)ethanol

: 421-83-0
trifluoromethane sulfonyl chloride

: 112599-15-2
2-(1-aziridinyl)ethyl trifluoromethanesulfonate

Conditions

Conditions	Yield
With sodium hydride In tetrahydrofuran at -80℃; for 4h;	65%

: 1072-52-2
2-(1-aziridine)ethanol

: 87363-66-4
tert-butyl 2-chloro-3,5-dinitrobenzoate

: 944088-72-6
tert-butyl 2-[(2-hydroxyethyl)(2-chloroethyl)amino]-3,5-dinitrobenzoate

Conditions

Conditions	Yield
With lithium chloride In N,N-dimethyl-formamide cooling;	63%
With lithium chloride In N,N-dimethyl-formamide at 20℃; for 16h;	63%

: 1072-52-2
2-(1-aziridine)ethanol

: 177035-51-7
methyl 3-chloro-2,6-dinitrobenzoate

: methyl 3-[(2-chloroethyl)(2-hydroxyethyl)amino]-2,6-dinitrobenzoate

Conditions

Conditions	Yield
With lithium chloride In N,N-dimethyl-formamide cooling;	63%
With lithium chloride In N,N-dimethyl-formamide at 20℃; for 6h;	63%

: 1072-52-2
2-(1-aziridine)ethanol

: 110-85-0
piperazine

: 134699-02-8
1-(5-hydroxy-3-azapentyl)piperazine

Conditions

Conditions	Yield
With hydrogenchloride In water at 50℃; for 3h;	60%

: 1072-52-2
2-(1-aziridine)ethanol

: 12128-23-3
tricarbonylcyclopentadienylmolybdenum(II) chloride

: 7732-18-5
water

: 1,1-dicarbonyl-(η(5)-cyclopentadienyl)-2-hydroxyethylmolybda(1)-aza(2)-cyclopentan(5)-one

B: [(N-hydroxyethyl-aziridine)(η(5)-cyclopentadienyl)Mo(CO)2]Cl

Conditions

Conditions	Yield
In acetone byproducts: HOCl; Ar atmosphere, addn. of aziridine to soln. of of Mo complex with stirring, 60°C (1 h), cooling to room temp.; reductn. of volume (vacuum); elem. anal.;	A 60% B 0%

...Expand

: 1072-52-2
2-(1-aziridine)ethanol

: 627-93-0
hexanedioic acid dimethyl ester

: 6498-84-6
di[2-(1-aziridinyl)ethyl]adipate

Conditions

Conditions	Yield
Stage #1: 2-(1-aziridine)ethanol With sodium hydride for 0.5h; Stage #2: hexanedioic acid dimethyl ester for 1h; Heating / reflux;	60%

: 1072-52-2
2-(1-aziridine)ethanol

: 87363-66-4
tert-butyl 2-chloro-3,5-dinitrobenzoate

: 1236199-90-8
C15H20BrN3O7

Conditions

Conditions	Yield
With lithium bromide In N,N-dimethyl-formamide at 0 - 20℃;	60%

: 1072-52-2
2-(1-aziridine)ethanol

: 944088-75-9
methyl 3-[(2-hydroxyethyl)(2-iodoethyl)amino]-2,6-dinitrobenzoate

Conditions

Conditions	Yield
Stage #1: methyl 3-chloro-2,6-dinitrobenzoate With sodium iodide In N,N-dimethyl-formamide at 20℃; for 0.0833333h; Stage #2: 2-(1-aziridine)ethanol In N,N-dimethyl-formamide at 0 - 30℃; for 16h;	58%

: 1072-52-2
2-(1-aziridine)ethanol

: 177035-51-7
methyl 3-chloro-2,6-dinitrobenzoate

: 944088-75-9
methyl 3-[(2-hydroxyethyl)(2-iodoethyl)amino]-2,6-dinitrobenzoate

Conditions

Conditions	Yield
With sodium iodide In N,N-dimethyl-formamide cooling;	58%

: 1072-52-2
2-(1-aziridine)ethanol

: 18162-48-6
tert-butyldimethylsilyl chloride

: 192657-68-4
1-[2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-aziridine

Conditions

Conditions	Yield
With sodium hydride In tetrahydrofuran at 0 - 20℃;	56%
With n-butyllithium In tetrahydrofuran; hexane at -78 - 20℃; for 15h;

1-Aziridine ethanol Chemical Properties

Chemical Name: 1-Aziridineethanol
IUPAC NAME: 2-(Aziridin-1-yl)ethanol
CAS No.: 1072-52-2
EINECS: 87.12
RTECS: CM7000000
Molecular Formula: C₄H₉NO
Molecular Weight: 87.12 g/mol
Density: 1.097 g/cm³
Flash Point: 67.2 °C
Boiling Point: 168 °C at 760 mmHg
Following is the structure of 1-Aziridine ethanol (CAS No.1072-52-2):

Product Categories about 1-Aziridine ethanol (CAS No.1072-52-2) are Aziridines ; Simple 3-Membered Ring Compounds
The chemical synonymous of 1-Aziridine ethanol (CAS No.1072-52-2) are 2-(Aziridinyl)Ethanol ; 1-(2-Hydroxyethyl)Ethyleneimine ; 1-(2-Hydroxyethyl)Ethylenimine ; 1-Aziridneethanol ; 1-Aziridineethanol ; Hea ; N-[2-Hydroxyethyl]Aziridine ; N-(2-Hydroxyethyl)Ethyleneimine

1-Aziridine ethanol Toxicity Data With Reference

1.	skn-rbt 545 mg open MOD	UCDS** Union Carbide Data Sheet. (Industrial Medicine and Toxicology Dept., Union Carbide Corp., 270 Park Ave., New York, NY 10017) 11/17/64 .
2.	eye-rbt 1090 mg SEV	UCDS** Union Carbide Data Sheet. (Industrial Medicine and Toxicology Dept., Union Carbide Corp., 270 Park Ave., New York, NY 10017) 11/17/64 .
3.	mmo-sat 1 µg/plate	ENMUDM Environmental Mutagenesis. 5 (Suppl 1)(1983),3.
4.	sln-oin-dmg-orl 50 ppm	ENMUDM Environmental Mutagenesis. 7 (1985),325.
5.	orl-rat LD50:74 mg/kg	JIHTAB Journal of Industrial Hygiene and Toxicology. 31 (1949),60.
6.	ivn-mus LD50:56 mg/kg	CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010) NX#03613 .
7.	skn-rbt LD50:71 µL/kg	UCDS** Union Carbide Data Sheet. (Industrial Medicine and Toxicology Dept., Union Carbide Corp., 270 Park Ave., New York, NY 10017) 11/17/64 .

1-Aziridine ethanol Consensus Reports

IARC Cancer Review: Group 3 IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 7 (1987),p. 56.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) ; Animal Limited Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 9 (1975),p. 47.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) . Reported in EPA TSCA Inventory.

1-Aziridine ethanol Safety Profile

Poison by ingestion, skin contact, and intravenous routes. A skin and eye irritant. Questionable carcinogen with experimental neoplastigenic data. Mutation data reported. When heated to decomposition it emits toxic fumes of NO_x.
Hazard Codes: Toxic T
Risk Statements about 1-Aziridine ethanol (CAS No.1072-52-2):
R34:Causes burns.
Safety Statements about 1-Aziridine ethanol (CAS No.1072-52-2):
S23:Do not breathe vapour.
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection.

Product Name

1-Aziridineethanol

Synthetic route

1-Aziridine ethanol Chemical Properties

1-Aziridine ethanol Toxicity Data With Reference

1-Aziridine ethanol Consensus Reports

1-Aziridine ethanol Safety Profile

Related Products

Hot Products