1-Dimethylamino-2-propanol supplier

Name
1-Dimethylamino-2-propanol
EINECS 203-556-4
CAS No. 108-16-7
Article Data28
CAS DataBase
Density 0.888 g/cm³
Solubility miscible with water
Melting Point -85 °C
Formula C₅H₁₃NO
Boiling Point 123.999 °C at 760 mmHg
Molecular Weight 103.164
Flash Point 25.556 °C
Transport Information UN 2734 8/PG 2
Appearance light yellow liquid
Safety 26-36/37/39-45-36-23
Risk Codes 10-22-34
Molecular Structure
Hazard Symbols C
Synonyms 1-(Dimethylamino)-2-propanol;1-Methyl-2-(dimethylamino)ethanol;2-(Dimethylamino)-1-methyl-1-ethanol;2-(Dimethylamino)-1-methylethanol;3-(Dimethylamino)-2-propanol;Bisomer Amine D 700;DL-1-(Dimethylamino)-2-propanol;Dimepranol;Dimethyl(2-hydroxypropyl)amine;Dimethylisopropanolamine;N,N-Dimethyl-2-hydroxy-1-propanamine;N,N-Dimethyl-2-hydroxypropylamine;N,N-Dimethylamino-2-propanol;N,N-Dimethylisopropanolamine;NSC 3163;
PSA 23.47000
LogP -0.07120

Synthetic route

: 124-40-3
dimethyl amine

: 75-56-9, 16033-71-9
methyloxirane

: 108-16-7
1-methyl-2-N,N-dimethylaminoethanol

Conditions

Conditions	Yield
With diisopropanolamine at 70℃; under 5250.53 Torr; for 3h; Reagent/catalyst; Pressure; Temperature;	99.6%
With methanol at 60℃;
In ethanol Heating;

: 50-00-0
formaldehyd

: 78-96-6, 1674-56-2
3-amino-2-propanol

: 108-16-7
1-methyl-2-N,N-dimethylaminoethanol

Conditions

Conditions	Yield
With formic acid for 24h; Heating;	60%

: 5909-67-1
tetramethyldiamidothiophosphoric acid

: 75-56-9, 16033-71-9
methyloxirane

A: 108-16-7
1-methyl-2-N,N-dimethylaminoethanol

B: 5843-26-5
tetramethylphosphorodiamidous acid

C: 83296-07-5
2-oxo-2-dimethylamino-4-methyl-1,3,2-thiaoxaphospholane

Conditions

Conditions	Yield
In 1,4-dioxane at 100 - 110℃; for 4h;	A n/a B n/a C 20%

...Expand

: 1207286-38-1
1,1-dimethyl-1-(2-hydroxypropyl)amine benzoylformimide

A: 108-16-7
1-methyl-2-N,N-dimethylaminoethanol

B: 860223-18-3
2,3-dihydroxy-2,3-diphenyl-succinic acid diamide

Conditions

Conditions	Yield
In methanol at 20 - 30℃; for 0.833333h; UV-irradiation;	A n/a B 10%

: 19686-73-8
1-bromo-2-propanol

: 124-40-3
dimethyl amine

: 108-16-7
1-methyl-2-N,N-dimethylaminoethanol

Conditions

Conditions	Yield
With benzene at 125℃;

: 124-40-3
dimethyl amine

: 127-00-4
1-Chloro-2-propanol

: 108-16-7
1-methyl-2-N,N-dimethylaminoethanol

Conditions

Conditions	Yield
With sodium hydroxide at 40℃;
With toluene at 95 - 100℃;
at 100℃;
With sodium hydroxide at 40℃;

: 50-00-0
formaldehyd

: 64-18-6
formic acid

: 78-96-6, 1674-56-2
3-amino-2-propanol

: 108-16-7
1-methyl-2-N,N-dimethylaminoethanol

Conditions

Conditions	Yield
With water

...Expand

: 15364-56-4
dimethylaminoacetone

: 108-16-7
1-methyl-2-N,N-dimethylaminoethanol

Conditions

Conditions	Yield
With lithium aluminium tetrahydride In diethyl ether
(reduction);

: 124763-29-7
C13H18(125)INO3

A: 108-16-7
1-methyl-2-N,N-dimethylaminoethanol

B: p-(125I)iodophenoxyacetic acid

Conditions

Conditions	Yield
With phosphate buffer at 37℃; for 0.0833333h; chemical stability to hydrolysis; var.: time;

Ru[(-)-BINAP](OCOCH3)2: Ru[(-)-BINAP](OCOCH3)2

: 15364-56-4
dimethylaminoacetone

: 108-16-7
1-methyl-2-N,N-dimethylaminoethanol

Conditions

Conditions	Yield
With nitrogen In methanol; dichloromethane

: 1207286-38-1
1,1-dimethyl-1-(2-hydroxypropyl)amine benzoylformimide

A: 108-16-7
1-methyl-2-N,N-dimethylaminoethanol

B: 4461-33-0
benzoyl isocyanate

Conditions

Conditions	Yield
Kinetics; Temperature; Solvent; Curtius rearrangement; Pyrolysis;

: 50-99-7
D-glucose

: 124-40-3
dimethyl amine

A: 108-01-0
2-(N,N-dimethylamino)ethanol

B: 108-16-7
1-methyl-2-N,N-dimethylaminoethanol

C: 110-18-9
N,N,N,N,-tetramethylethylenediamine

D: 1822-45-3
1,2-bis(dimethylamino)propane

E: 15364-56-4
dimethylaminoacetone

F: 68-12-2, 33513-42-7
N,N-dimethyl-formamide

Conditions

Conditions	Yield
With 5 wt% ruthenium/carbon; hydrogen In water at 124.84℃; under 37503.8 Torr; for 1h; Catalytic behavior; Pressure; Temperature;

...Expand

: 50-99-7
D-glucose

: 124-40-3
dimethyl amine

A: 108-01-0
2-(N,N-dimethylamino)ethanol

B: 108-16-7
1-methyl-2-N,N-dimethylaminoethanol

C: 110-18-9
N,N,N,N,-tetramethylethylenediamine

D: 1822-45-3
1,2-bis(dimethylamino)propane

E: 68-12-2, 33513-42-7
N,N-dimethyl-formamide

Conditions

Conditions	Yield
With 5 wt% ruthenium/carbon; hydrogen In water at 124.84℃; under 37503.8 Torr; for 1h;

...Expand

: 50-99-7
D-glucose

: 124-40-3
dimethyl amine

A: 108-01-0
2-(N,N-dimethylamino)ethanol

B: 108-16-7
1-methyl-2-N,N-dimethylaminoethanol

C: 110-18-9
N,N,N,N,-tetramethylethylenediamine

D: 1822-45-3
1,2-bis(dimethylamino)propane

E: 15364-56-4
dimethylaminoacetone

Conditions

Conditions	Yield
With 5 wt% ruthenium/carbon; hydrogen In water at 124.84℃; under 56255.6 Torr; for 1h;

...Expand

: 470-23-5
D-fructose

: 124-40-3
dimethyl amine

A: 108-01-0
2-(N,N-dimethylamino)ethanol

B: 108-16-7
1-methyl-2-N,N-dimethylaminoethanol

C: 110-18-9
N,N,N,N,-tetramethylethylenediamine

D: 1822-45-3
1,2-bis(dimethylamino)propane

E: 15364-56-4
dimethylaminoacetone

Conditions

Conditions	Yield
With 5 wt% ruthenium/carbon; hydrogen In water at 124.84℃; under 56255.6 Torr; for 1h;

...Expand

: 108-16-7
1-methyl-2-N,N-dimethylaminoethanol

: 1184-54-9, 18213-24-6
copper(II) methoxide

: 128000-75-9, 185827-91-2
Cu(OCH(CH3)CH2N(CH3)2)2

Conditions

Conditions	Yield
(Ar); room temp.;	100%
In not given prepd. by the alcohol-exchange procedure described by Singh, J. V.; Baranwal, B. P.; Mehrotra, R. C.; T. Anorg. Allg. Chem. 1981, 477, 235; sublimation, crystn. from hexane;	75%

: 108-16-7
1-methyl-2-N,N-dimethylaminoethanol

: bis(dimethylamino-2-propoxy)nickel

: 67-63-0
isopropyl alcohol

: lithium chloride

: 2Li(1+)*2(CH3)2CHOH*2NiCl(OCH(CH3)CH2N(CH3)2)2(1-)=[Li((CH3)2CHOH)NiCl(OCH(CH3)CH2N(CH3)2)2]2

Conditions

Conditions	Yield
In toluene N2-atmosphere; refluxing; evapn.; elem. anal.;	100%

...Expand

: bis(bis(trimethylsilyl)amido)zinc(II)

: 108-16-7
1-methyl-2-N,N-dimethylaminoethanol

: zinc(II) 1-(dimethylamino)propan-2-olate

Conditions

Conditions	Yield
In hexane byproducts: HN(Si(CH3)3)2; under dry N2; alcohol added to soln. of Zn-compd., exothermic reaction, refluxed for 2h,; volatiles removed in vac., distn. (170°C bath, 10**-4 Torr; elem. anal.;	97%

: 108-16-7
1-methyl-2-N,N-dimethylaminoethanol

: 4584-49-0
(2-chloropropyl)dimethylamine hydrochloride

Conditions

Conditions	Yield
With thionyl chloride In chloroform at 0 - 20℃; for 1h; Reflux;	95%
With thionyl chloride In chloroform	95%
With thionyl chloride In chloroform Reflux; Cooling with ice;

: 108-16-7
1-methyl-2-N,N-dimethylaminoethanol

: 1115-99-7
triethyl gallium

: 811786-08-0
[(C2H5)2Ga(OCH(CH3)CH2N(CH3)2)]2

Conditions

Conditions	Yield
In dichloromethane (N2); using Schlenk techniques; addn. dropwise of HOCH(CH3)CH2NMe2 (1 equiv.) to soln. of Et3Ga (1 equiv.) in CH2Cl2 at -78°C with stirring for 0.5 h; slow warming to room temp., stirring for 5 h; removal of solvent in vac., redissolving in toluene and cooling to -20°C; as solid; elem. anal.;	95%
In hexane (N2); using Schlenk techniques; treatment of HOCH(CH3)CH2NMe2 (1 equiv.)with Et3Ga (1 equiv.) in hexane at room temp.;

: 108-16-7
1-methyl-2-N,N-dimethylaminoethanol

: 55147-78-9
bis(bis(trimethylsilyl)amido)tin(II)

: 2C5H12NO(1-)*Sn(2+)

Conditions

Conditions	Yield
With trimethyl orthoformate In hexane at 20℃; for 19h; Cooling with ice;	95%

: 108-16-7
1-methyl-2-N,N-dimethylaminoethanol

: 1115-99-7
triethyl gallium

: 811786-08-0
((C2H5)2Ga(OCH(CH3)CH2N(CH3)2))2

Conditions

Conditions	Yield
In toluene byproducts: ethane; under N2; ligand added dropwise to soln. of Et3Ga (molar ratio 1:1) in toluene at -78°C with stirring over 0.5 h; warmed slowly to room temp.; stirred for 24 h; solvent removed in vac.; crystd. by standing at room temp. for several d; elem. anal.;	92%

: 108-16-7
1-methyl-2-N,N-dimethylaminoethanol

: 111-83-1
1-bromo-octane

: C13H30NO(1+)*Br(1-)

Conditions

Conditions	Yield
In propan-1-ol at 85℃; for 18.5h;	91%

: 108-16-7
1-methyl-2-N,N-dimethylaminoethanol

: tin(IV) tert-butoxide

: C18H42N2O4Sn

Conditions

Conditions	Yield
In pentane at 20℃; for 1h; Schlenk technique; Inert atmosphere;	91%

: 16853-85-3
lithium aluminium tetrahydride

: 108-16-7
1-methyl-2-N,N-dimethylaminoethanol

: lithium bis(2-dimethylamino-1-methyl-ethanolato)dihydridoaluminate

Conditions

Conditions	Yield
In tetrahydrofuran byproducts: H2; all manipulations under N2; soln. of org. compd. added to stirred soln. of LiAlH4 in ratio of 2:1 at -25°C, stirred for 1 h at ambient temp.; pentane added, crystd. at -20°C, filtered, solvents removed from filtrate, oily product crystd. by washing with pentane; elem. anal.;	90.4%

: 108-16-7
1-methyl-2-N,N-dimethylaminoethanol

: 7114-39-8
[1,3,2]dioxaphospholan-2-yl-dimethyl-amine

: 148173-67-5
2-<(2-dimethylamino-1-methyl)ethoxy>-1,3,2-dioxaphospholane

Conditions

Conditions	Yield
at 130℃; for 0.0833333h;	87%

: 108-16-7
1-methyl-2-N,N-dimethylaminoethanol

: 24566-90-3
octyl chloromethyl ether

: (2-hydroxy-propyl)-dimethyl-octyloxymethyl-ammonium; chloride

Conditions

Conditions	Yield
In hexane at 20℃; Menschutkin's reaction;	87%
In hexane for 0.166667h; Menschutkin reaction;

: 108-16-7
1-methyl-2-N,N-dimethylaminoethanol

: 24566-92-5
1-chloromethoxy-decane

: decyloxymethyl-(2-hydroxy-propyl)-dimethyl-ammonium; chloride

Conditions

Conditions	Yield
In hexane at 20℃; Menschutkin's reaction;	87%
In hexane for 0.166667h; Menschutkin reaction;

: 108-16-7
1-methyl-2-N,N-dimethylaminoethanol

: 24566-91-4
1-chloromethoxy-nonane

: (2-hydroxy-propyl)-dimethyl-nonyloxymethyl-ammonium; chloride

Conditions

Conditions	Yield
In hexane at 20℃; Menschutkin's reaction;	86%
In hexane for 0.166667h; Menschutkin reaction;

: 108-16-7
1-methyl-2-N,N-dimethylaminoethanol

: 2351-69-1
1-(chloromethoxy)butane

: butoxymethyl-(2-hydroxy-propyl)-dimethyl-ammonium; chloride

Conditions

Conditions	Yield
In hexane at 20℃; Menschutkin's reaction;	86%

: 108-16-7
1-methyl-2-N,N-dimethylaminoethanol

: hexaamminenickel (II) chloride

: bis(dimethylamino-2-propoxy)nickel

Conditions

Conditions	Yield
With Na In toluene byproducts: NaCl; N2-atmosphere; 80°C (2 h), Ni-complex addn., refluxing (2 h); decanting, crystn. on concg. (-15°C, overnight), filtering, washing (hexane), drying; elem. anal.;	86%

: 108-16-7
1-methyl-2-N,N-dimethylaminoethanol

: 7646-85-7
zinc(II) chloride

: 862103-96-6
[Chloro-(rac-1-dimethylaminoisopropanolato)-zink(II)]4

Conditions

Conditions	Yield
In methanol rac-1-dimethylaminoisopropanol slowly added dropwise to ZnCl2 soln. in MeOH under stirring; stirred for 2 days; heated for 2 h under reflux; cooled slowly to -5°C; left standing for 3 days; washed with n-haxane; recrystallized from MeOH; dried in vacuum; elem. anal.;	86%

: 108-16-7
1-methyl-2-N,N-dimethylaminoethanol

: 19416-65-0
1-chloromethoxy-pentane

: (2-hydroxy-propyl)-dimethyl-pentyloxymethyl-ammonium; chloride

Conditions

Conditions	Yield
In hexane at 20℃; Menschutkin's reaction;	85%

: 108-16-7
1-methyl-2-N,N-dimethylaminoethanol

: 13497-64-8
octadecyl chloromethyl ether

: (2-hydroxy-propyl)-dimethyl-octadecyloxymethyl-ammonium; chloride

Conditions

Conditions	Yield
In hexane at 20℃; Menschutkin's reaction;	85%
In hexane for 0.166667h; Menschutkin reaction;

: 108-16-7
1-methyl-2-N,N-dimethylaminoethanol

: 13497-62-6
1-(chloromethoxy)tetradecane

: (2-hydroxy-propyl)-dimethyl-tetradecyloxymethyl-ammonium; chloride

Conditions

Conditions	Yield
In hexane at 20℃; Menschutkin's reaction;	85%
In hexane for 0.166667h; Menschutkin reaction;

: 108-16-7
1-methyl-2-N,N-dimethylaminoethanol

: 682-00-8
tributyltin ethoxide

: 42017-19-6
(C4H9)3SnOCH(CH3)CH2N(CH3)2

Conditions

Conditions	Yield
In benzene byproducts: C2H5OH; 1:1; azeotropic removal of C2H5OH;	85%
byproducts: C2H5OH; equimolar amts. of educts, heated; remove alc.;	85%
byproducts: C2H5OH; equimolar amts. of educts, heated; remove alc.;	85%
In benzene byproducts: C2H5OH; 1:1; azeotropic removal of C2H5OH;	85%

: 108-16-7
1-methyl-2-N,N-dimethylaminoethanol

: 1067-52-3
tributyltin methoxide

: 42017-19-6
(C4H9)3SnOCH(CH3)CH2N(CH3)2

Conditions

Conditions	Yield
byproducts: CH3OH; equimolar amts. of educts, heated; remove alc.;	85%
byproducts: CH3OH; equimolar amts. of educts, heated; remove alc.;	85%

: 108-16-7
1-methyl-2-N,N-dimethylaminoethanol

: 39979-92-5
hexyloxymethyl chloride

: hexyloxymethyl-(2-hydroxy-propyl)-dimethyl-ammonium; chloride

Conditions

Conditions	Yield
In hexane at 20℃; Menschutkin's reaction;	84%
In hexane for 0.166667h; Menschutkin reaction;	83.5%

: 108-16-7
1-methyl-2-N,N-dimethylaminoethanol

: 13497-63-7
1-chloromethoxy-hexadecane

: hexadecyloxymethyl-(2-hydroxy-propyl)-dimethyl-ammonium; chloride

Conditions

Conditions	Yield
In hexane at 20℃; Menschutkin's reaction;	84%
In hexane for 0.166667h; Menschutkin reaction;

: 108-16-7
1-methyl-2-N,N-dimethylaminoethanol

: 24566-93-6
chloromethyl undecyl ether

: (2-hydroxypropyl)dimethyl(undecyloxymethyl)ammonium chloride

Conditions

Conditions	Yield
In hexane at 20℃; Menschutkin's reaction;	84%
In hexane for 0.166667h; Menschutkin reaction;

: 108-16-7
1-methyl-2-N,N-dimethylaminoethanol

: 20769-85-1
2-bromoisobutyric acid bromide

: C9H18BrNO2

Conditions

Conditions	Yield
With dmap; triethylamine In dichloromethane at 20℃; for 24h;	84%
With dmap; triethanolamine In dichloromethane at 20℃; Inert atmosphere; Cooling with ice;

: 108-16-7
1-methyl-2-N,N-dimethylaminoethanol

: 1641-40-3
pyrocatechol phosphorochloridite

: 150786-14-4
1-methyl-2-(dimethylamino)ethyl o-phenylene phosphite

Conditions

Conditions	Yield
With triethylamine In benzene Heating;	83%

: 108-16-7
1-methyl-2-N,N-dimethylaminoethanol

: 3587-57-3
chloromethyl propyl ether

: (2-hydroxy-propyl)-dimethyl-propoxymethyl-ammonium; chloride

Conditions

Conditions	Yield
In hexane at 20℃; Menschutkin's reaction;	83%

1-Dimethylamino-2-propanol Chemical Properties

IUPAC Name: 1-Dimethylamino-2-propanol
The MF of 1-Dimethylamino-2-propanol (108-16-7) is C₅H₁₃NO.

The MW of 1-Dimethylamino-2-propanol (108-16-7) is 103.16.
Synonyms of 1-Dimethylamino-2-propanol (108-16-7): 1-(Dimethylamino)-2-propano ; 1,1-Dimethylaminopropan-2-ol ; 1-Dimethylaminopropan-2-ol ; 1-N,N-Dimethylin-2-propanolamine ; 2-Propanol,1,1-(dimethylamino)- ; Dimethyl(2-hydroxypropyl)amine
Stability: Stable. Flammable. Incompatible with strong oxidizing agents, amines, acids
Form: light yellow liquid
Index of Refraction: 1.436
EINECS: 203-556-4
Density: 0.887 g/ml
Flash Point: 25.6 °C
Boiling Point: 124 °C
Melting Point: -85 °C
Storage temp: Flammables area
Water Solubility: miscible

1-Dimethylamino-2-propanol Uses

1-Dimethylamino-2-propanol (108-16-7) is used for the pharmaceutical industry, also used as a stabilizer of acrylonitrile polymer.

1-Dimethylamino-2-propanol Production

Hydrochloric acid---Sodium hydroxide---Diethyl ether---Formaldehyde---Formic acid---Amino-2-propanol

1-Dimethylamino-2-propanol Toxicity Data With Reference

1.	skn-rbt 10 mg/24H MLD	AMIHBC AMA Archives of Industrial Hygiene and Occupational Medicine. 10 (1954),61.
2.	skn-rbt 500 mg MOD	FCTOD7 Food and Chemical Toxicology. 20 (1982),563.
3.	eye-rbt 250 µg SEV	AMIHBC AMA Archives of Industrial Hygiene and Occupational Medicine. 10 (1954),61.
4.	eye-rbt 100 mg/4S rns SEV	FCTOD7 Food and Chemical Toxicology. 20 (1982),573.
5.	orl-rat LD50:1890 mg/kg	AMIHBC AMA Archives of Industrial Hygiene and Occupational Medicine. 10 (1954),61.

1-Dimethylamino-2-propanol Consensus Reports

Reported in EPA TSCA Inventory.

1-Dimethylamino-2-propanol Safety Profile

Moderately toxic by ingestion. A skin and severe eye irritant. Used in boiler water condensate corrosion control. Dangerous fire hazard when exposed to heat or flame. Can react vigorously with oxidizers. To fight fire, use foam, CO₂, dry chemical. When heated to decomposition it emits toxic fumes of NO_x. See also AMINES.Safety information of 1-Dimethylamino-2-propanol (108-16-7):
Hazard Codes C
Risk Statements
10 Flammable
22 Harmful if swallowed
34 Causes burns
Safety Statements
26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
36/37/39 Wear suitable protective clothing, gloves and eye/face protection
45 In case of accident or if you feel unwell, seek medical advice immediately (show label where possible)
23 Do not breathe gas/fumes/vapor/spray (appropriate wording to be specified by the manufacturer)
RIDADR UN 2734 8/PG 2
WGK Germany 1
RTECS UB3150000
F 10-34
HazardClass 8
PackingGroup II
HS Code 29221980

Product Name

1-Dimethylamino-2-propanol

Synthetic route

1-Dimethylamino-2-propanol Chemical Properties

1-Dimethylamino-2-propanol Uses

1-Dimethylamino-2-propanol Production

1-Dimethylamino-2-propanol Toxicity Data With Reference

1-Dimethylamino-2-propanol Consensus Reports

1-Dimethylamino-2-propanol Safety Profile

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