1-Dodecanol supplier | CasNO.112-53-8

Name
1-Dodecanol
EINECS 203-982-0
CAS No. 112-53-8
Article Data331
CAS DataBase
Density 0.831 g/cm³
Solubility insoluble in water
Melting Point 22-27 °C
Formula C₁₂H₂₆O
Boiling Point 258 °C at 760 mmHg
Molecular Weight 186.338
Flash Point 115.4 °C
Transport Information UN 3077 9/PG 3
Appearance white low melting crystalline solid
Safety 61-37/39-29-26-60-36
Risk Codes 38-50-50/53-36/38-36/37/38
Molecular Structure
Hazard Symbols Xi,N
Synonyms Dodecyl alcohol;Lauryl Alcohol;Dodecyl Alcohol;1-Dodecanol;Alcohol C12,Dodecyl alcohol,Lauryl alcohol;
PSA 20.23000
LogP 3.89960

Synthetic route

: 63588-79-4
2-(dodecyloxy)tetrahydro-2H-pyran

: 112-53-8
1-dodecyl alcohol

Conditions

Conditions	Yield
With aniline-terephthalaldehyde resin p-toluenesulfonic acid salt In methanol at 20℃; for 3.5h; Reagent/catalyst;	100%
With tris-(4-bromophenyl)aminium hexachloroantimonate In methanol at 20℃; for 2h;	99%
bis(trimethylsilyl)sulphate In methanol; 1,2-dichloro-ethane for 1.5h; Ambient temperature;	98%

: 145800-64-2
Dodecanol triethylsilyl ether

: 112-53-8
1-dodecyl alcohol

Conditions

Conditions	Yield
With 7,7',8,8'-tetracyanoquinodimethane In water; acetonitrile for 5h; Ambient temperature;	100%
With MCM-41 In methanol for 2h; Ambient temperature;	99%
With mesoporous silica MCM-41 In methanol at 20℃; for 2h;	99%

: 114058-22-9
tert-butyldimethylsilyl ether of dodecan-1-ol

: 112-53-8
1-dodecyl alcohol

Conditions

Conditions	Yield
With polymer-supported dicyanoketene acetal; water In acetonitrile at 20℃; for 24h; Hydrolysis;	100%
With aniline-terephthalaldehyde resin p-toluenesulfonic acid salt In methanol at 20℃; for 1h; Reagent/catalyst;	100%
With high p-toluenesulfonate content diphenylamine and terephthalaldehyde resin In methanol at 20℃; for 1h; Reagent/catalyst;	100%

: 28303-42-6
1-dodecanyl formate

: 112-53-8
1-dodecyl alcohol

Conditions

Conditions	Yield
With hydrogenchloride In acetone at 20℃; for 0.25h;	100%

: 6221-88-1
dodecyl trimethylsilyl ether

: 112-53-8
1-dodecyl alcohol

Conditions

Conditions	Yield
With MCM-41 In methanol for 2h; Ambient temperature;	100%
With mesoporous silica MCM-41 In methanol at 20℃; for 2h;	100%
With polymer-supported dicyanoketene acetal; water In acetonitrile at 20℃; for 1h; Hydrolysis;	98%

: 69064-46-6
dodec-2-yn-1-ol

A: 112-53-8
1-dodecyl alcohol

B: 69064-36-4
(Z)-dodec-2-en-1-ol

Conditions

Conditions	Yield
With hydrogen; copper-palladium; silica gel In ethanol at 25℃; under 760 Torr; Kinetics;	A n/a B 100%

: 910660-86-5
bis-(4,4,5,5,6,6,7,7,8,8,9,9,9-tridecafluoro-nonyl)-thiocarbamic acid O-dodecyl ester

A: N,N-bis-(4,4,5,5,6,6,7,7,8,8,9,9,9-tridecafluoro-nonyl)-hydroxylamine

B: 112-53-8
1-dodecyl alcohol

Conditions

Conditions	Yield
With 3-chloro-benzenecarboperoxoic acid In dichloromethane at -78℃; for 1h;	A n/a B 100%

: dodecyl 2-((2-methoxyphenyl)ethynyl)benzoate

: 112-53-8
1-dodecyl alcohol

Conditions

Conditions	Yield
With (triphenylphosphine)gold(I) chloride; silver trifluoromethanesulfonate In ethanol; benzene at 20℃; for 1h;	100%

: 111-82-0
methyl n-dodecanoate

: 112-53-8
1-dodecyl alcohol

Conditions

Conditions	Yield
With C32H36ClNO2P2Ru; potassium tert-butylate; hydrogen In neat (no solvent) at 120℃; under 38002.6 Torr; for 20h; Autoclave; Green chemistry;	99%
With hydrogen In hexane at 200℃; under 15001.5 Torr; for 8h; Reagent/catalyst;	99.8%
Stage #1: methyl n-dodecanoate With phenylsilane; fac-[Mn-(xantphos)(CO)3Br] at 120℃; for 12h; Inert atmosphere; Stage #2: With water; sodium hydroxide In methanol at 20℃; Inert atmosphere;	97%

: 106-33-2
ethyl laurate

: 112-53-8
1-dodecyl alcohol

Conditions

Conditions	Yield
With methanol; Na/SiO2 In tetrahydrofuran at 0 - 25℃; Bouveault-Blanc reduction; Inert atmosphere;	99.5%
With potassium borohydride; hafnium tetrachloride In tetrahydrofuran at 40℃; for 9.6h; Inert atmosphere; Cooling with ice;	95%
With ethandithiol; sodium tetrahydroborate In tetrahydrofuran for 24h; Heating;	94%

: 112-54-9
Dodecanal

: 112-53-8
1-dodecyl alcohol

Conditions

Conditions	Yield
With aluminium trichloride; diphenylstibane In tetrahydrofuran for 3h; Ambient temperature;	99%
Stage #1: Dodecanal With phenylsilane; potassium tert-butylate In toluene at 20℃; for 0.5h; Inert atmosphere; Stage #2: With water; sodium hydroxide In toluene at 0 - 20℃;	99%
With LaNi5 hydride In tetrahydrofuran; methanol 1) 0 deg C, 4 h, 2) r.t., 14 h;	98%

: 765-14-0
1-(vinyloxy)dodecane

: 112-53-8
1-dodecyl alcohol

Conditions

Conditions	Yield
With water; dichloro bis(acetonitrile) palladium(II) at 40℃; for 1h;	99%
With water; dichloro bis(acetonitrile) palladium(II) In tetrahydrofuran at 40℃; for 1h;	98%

: 16308-67-1
dodecyl allyl carbonate

: 75-33-2
2-propanethiol

A: 112-53-8
1-dodecyl alcohol

B: 50996-72-0
allylisopropyl sulfide

C: 124-38-9
carbon dioxide

Conditions

Conditions	Yield
With Roussin's red salt ester; tetrabutylammomium bromide; potassium hydride In tetrahydrofuran; ethanol at 40℃;	A 99% B n/a C n/a

...Expand

: 112-41-4
1-dodecene

: 112-53-8
1-dodecyl alcohol

Conditions

Conditions	Yield
Stage #1: 1-dodecene With PyBH2I In dichloromethane at 20℃; Stage #2: With sodium hydroxide; dihydrogen peroxide In methanol; dichloromethane at 0 - 20℃;	98%
Stage #1: 1-dodecene With sodium tetrahydroborate; ethyl iodide In 1,2-dimethoxyethane at 25℃; for 20h; Stage #2: With dihydrogen peroxide; sodium hydroxide In water at 0 - 25℃; for 0.333333h; Solvent; Reagent/catalyst;	96%
Stage #1: 1-dodecene With borane-THF In tetrahydrofuran; water at 0 - 20℃; for 7h; Inert atmosphere; Stage #2: With dihydrogen peroxide; sodium hydroxide In tetrahydrofuran; water at 0 - 20℃; for 6.5h; Inert atmosphere;	95%

: 92403-99-1
Acetic acid dodecyloxymethyl ester

: 112-53-8
1-dodecyl alcohol

Conditions

Conditions	Yield
With potassium carbonate In methanol; water	98%

: C33H44O3

: 112-53-8
1-dodecyl alcohol

Conditions

Conditions	Yield
With tetra-N-butylammonium tribromide In methanol for 0.41h;	98%

: 195874-65-8
N-Dodecyloxy-selenobenzimidic acid phenyl ester

: 112-53-8
1-dodecyl alcohol

Conditions

Conditions	Yield
With 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride In benzene for 2h; Heating;	97%

: dodecyl triisopropylsilyl ether

: 112-53-8
1-dodecyl alcohol

Conditions

Conditions	Yield
With 2,5-bis(perfluorobutyl)-1,4-benzoquinone In water; acetonitrile at 50℃; for 6h; Reagent/catalyst;	97%
With low-loading and alkylated polystyrene-supported-SO3H In water at 100℃; for 12h;	94%

: 538-24-9
tridodecanoylglycerol

: 112-53-8
1-dodecyl alcohol

Conditions

Conditions	Yield
With C24H38Cl2N3PRu; hydrogen; sodium methylate In isopropyl alcohol at 100℃; under 38002.6 Torr; for 2h; Autoclave;	97%
With 5 wt% Re/TiO2; hydrogen In neat (no solvent) at 230℃; under 37503.8 Torr; for 30h; Autoclave;	81%

: 143-07-7
lauric acid

: 112-53-8
1-dodecyl alcohol

Conditions

Conditions	Yield
With potassium borohydride; hafnium tetrachloride In tetrahydrofuran at 40℃; for 15.3h; Inert atmosphere; Cooling with ice;	96%
With indium(III) bromide; 1,1,3,3-Tetramethyldisiloxane In chloroform at 60℃; for 1h; Inert atmosphere;	95%
With 1,1,3,3-Tetramethyldisiloxane; copper(II) bis(trifluoromethanesulfonate) In toluene at 80℃; for 16h; sealed tube;	95%

: 34458-41-8
dodecyl methoxymethyl ether

: 112-53-8
1-dodecyl alcohol

Conditions

Conditions	Yield
With low-loading and alkylated polystyrene-supported-SO3H In water at 100℃; for 24h;	96%
With dimethylboron bromide; triethylamine 1) CH2Cl2, 1,2-dichloroethane, -78 deg C, 1h, 2) RT, 1h; Yield given. Multistep reaction;

: dodecyl tert-butyldiphenylsilyl ether

: 112-53-8
1-dodecyl alcohol

Conditions

Conditions	Yield
With low-loading and alkylated polystyrene-supported-SO3H In water at 100℃; for 24h;	96%
With acetyl chloride In methanol at 20℃; for 4h;	95%
With tetra-N-butylammonium tribromide In methanol; dichloromethane for 6h; Heating;	94%
With acetonyltriphenylphosphonium bromide In methanol; dichloromethane for 5h;	88%
With 2,5-bis(perfluorohexyl)-3,6-dichloro-1,4-benzoquinone In water; acetonitrile at 50℃; for 6h;	84%

: 10157-76-3
dodecyl 4-methylbenzenesulphonate

: 112-53-8
1-dodecyl alcohol

Conditions

Conditions	Yield
With tetraethylammonium perchlorate; triethylamine In dimethyl sulfoxide at 20℃; for 6h; Electrolysis; Green chemistry;	96%

: 87770-95-4
1-Methylsulfanylmethoxy-dodecane

: 112-53-8
1-dodecyl alcohol

Conditions

Conditions	Yield
With dimethylboron bromide In dichloromethane; 1,2-dichloro-ethane 1.) -78 deg C, 1 h 2.) warming up to 0 deg C, 1 h;	95%
With dimethylboron bromide; triethylamine 1) CH2Cl2, 1,2-dichloroethane, -78 deg C, 1h, 2) 0 deg C, 1h; Yield given. Multistep reaction;
Multi-step reaction with 2 steps 1: 1) Me2BBr, 2) Et3N / 1) CH2Cl2, 1,2-dichloroethane, -78 deg C, 1h, 2) RT, 1h 2: 1) Me2BBr, 2) Et3N / 1) CH2Cl2, 1,2-dichloroethane, -78 deg C, 1h, 2) RT, 1h View Scheme

: 4292-19-7
1-Iodododecane

: 112-53-8
1-dodecyl alcohol

Conditions

Conditions	Yield
In N,N,N,N,N,N-hexamethylphosphoric triamide; water at 100℃; for 2.5h;	94%

: 143-15-7
1-dodecylbromide

: 112-53-8
1-dodecyl alcohol

Conditions

Conditions	Yield
In N,N,N,N,N,N-hexamethylphosphoric triamide; water at 100℃; for 5.5h;	94%
With oxygen; triethylamine; sodium iodide In acetonitrile at 32℃; for 24h; Schlenk technique; UV-irradiation;	50%

: 121505-91-7
1-((dodecyloxy)methyl)-4-methoxybenzene

: 112-53-8
1-dodecyl alcohol

Conditions

Conditions	Yield
With boron trifluoride diethyl etherate; sodium cyanoborohydride In tetrahydrofuran for 10h; Heating;	94%
With t-butyl bromide In acetonitrile for 1h; Solvent; Temperature; Reflux; chemoselective reaction;	92%
With N,N,N,N-tetraethylammonium tetrafluoroborate In methanol Electrochemical reaction;	90%

: 3352-87-2
N,N-diethyldodecanamide

: 112-53-8
1-dodecyl alcohol

Conditions

Conditions	Yield
With n-butyllithium; ammonia borane In tetrahydrofuran; hexane at 23℃; for 1.3h;	94%

: 39695-18-6
((dodecyloxy)methyl)benzene

: 112-53-8
1-dodecyl alcohol

Conditions

Conditions	Yield
With Ti-HMS; hydrogen; 5% Pd on active carbon In methanol under 760 Torr; for 6h; Ambient temperature;	94%
Stage #1: ((dodecyloxy)methyl)benzene With Bromotrichloromethane; (4,4'-di-tert-butyl-2,2'-dipyridyl)-bis-(2-phenylpyridine(-1H))-iridium(III) hexafluorophosphate In dichloromethane at 20℃; for 12h; Inert atmosphere; Irradiation; Stage #2: With methanol In dichloromethane Inert atmosphere;	66%

: 64-18-6
formic acid

: 112-53-8
1-dodecyl alcohol

: 28303-42-6
1-dodecanyl formate

Conditions

Conditions	Yield
toluene-4-sulfonic acid at 85℃; for 4h; Esterification;	100%
With 2-methyl-1-butylimidazolium trifluoroacetate In neat (no solvent) at 70℃; for 1h;	96%
Stage #1: formic acid With acetic anhydride at 40℃; for 2h; Stage #2: 1-dodecyl alcohol at 0 - 20℃; for 15.25h;	94%
With hydrogenchloride

: 112-53-8
1-dodecyl alcohol

: 143-07-7
lauric acid

Conditions

Conditions	Yield
With air; sodium nitrite In trifluoroacetic acid at 0 - 20℃; for 5h;	100%
With Iron(III) nitrate nonahydrate; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; potassium chloride; oxygen In 1,2-dichloro-ethane at 25℃; for 12h;	100%
With Iron(III) nitrate nonahydrate; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; potassium chloride; oxygen In 1,2-dichloro-ethane at 20℃; for 12h; Reagent/catalyst; Schlenk technique;	100%

: 112-53-8
1-dodecyl alcohol

: 112-54-9
Dodecanal

Conditions

Conditions	Yield
With 2,6-dimethylpyridine; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical at 20℃; for 0.5h; electrolysis;	100%
Stage #1: 1-dodecyl alcohol With oxalyl dichloride; dimethyl sulfoxide In dichloromethane at -78℃; for 0.25h; Oxidation; Stage #2: With triethylamine at -78 - 20℃; for 0.166667h;	100%
With iodosylbenzene; Cl-CH2-PS supported 5-amino-1,10-phenanthroline-Ru In acetonitrile at 60℃; for 6h;	100%

: 112-53-8
1-dodecyl alcohol

: 124-63-0
methanesulfonyl chloride

: 51323-71-8
dodecyl mesylate

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 0℃; for 0.25h;	100%
With triethylamine In dichloromethane at 0℃; for 3h; Inert atmosphere;	99%
With triethylamine In dichloromethane at 0℃; for 12h;	93%

: 15761-38-3
L-N-Boc-Ala

: 112-53-8
1-dodecyl alcohol

: 124212-36-8
N-tert-butoxycarbonyl-L-alanine dodecyl ester

Conditions

Conditions	Yield
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 0 - 20℃;	100%
papain on XAD-7 In dichloromethane at 37℃; for 18h;	55%

: 112-53-8
1-dodecyl alcohol

: 148160-26-3
3-tert-butoxycarbonyl-2-chloro-1,3,2-oxazaphospholidine

: 148160-28-5
3-tert-butoxycarbonyl-2-dodecyloxy-1,3,2-oxazaphospholidine

Conditions

Conditions	Yield
With triethylamine In dichloromethane -60 deg C to r.t., 1 h;	100%

: 112-53-8
1-dodecyl alcohol

: 22082-71-9
2-chloro-3-methyl-1,3,2-oxazaphospholidine

: 129274-35-7
2-Dodecyloxy-3-methyl-1,3,2-oxazaphosphacyclopentane

Conditions

Conditions	Yield
With triethylamine In dichloromethane for 1h; -30 - -40 deg C to RT;	100%

: 112-53-8
1-dodecyl alcohol

: 67105-49-1
3-tert-2-chloro-1,3,2-oxazaphosphacyclopentane

: 139715-61-0
3-tert-butyl-2-dodecyloxy-1,3,2-oxazaphosphacyclopentane

Conditions

Conditions	Yield
With triethylamine In dichloromethane for 1h; -60 deg C to rt;	100%

: 112-53-8
1-dodecyl alcohol

: 109-94-4
formic acid ethyl ester

: 28303-42-6
1-dodecanyl formate

Conditions

Conditions	Yield
cerium (IV) sulfate; silica gel for 1h; Heating;	100%

: 112-53-8
1-dodecyl alcohol

: 32315-10-9
bis(trichloromethyl) carbonate

: 24460-74-0
n-dodecyl chloroformate

Conditions

Conditions	Yield
With pyridine In tetrachloromethane at -15 - 20℃;	100%
With pyridine In tetrahydrofuran for 2h;
With pyridine In chloroform for 2h; ice cooling;

: 112-53-8
1-dodecyl alcohol

: 79-08-3
bromoacetic acid

: 3674-07-5
dodecyl bromoacetate

Conditions

Conditions	Yield
With 2,6-di-tert-butyl-4-methyl-phenol; toluene-4-sulfonic acid In toluene for 7h; Reflux;	100%
With toluene-4-sulfonic acid; 1-octyl-3-methylimidazolium tetrafluoroborate at 80℃; for 1h;	98%
With toluene-4-sulfonic acid In 5,5-dimethyl-1,3-cyclohexadiene	95%

: 112-53-8
1-dodecyl alcohol

: 33639-77-9
perbenzyl fucosyl bromide

: (3S,4R,5R,6S)-3,4,5-Tris-benzyloxy-2-dodecyloxy-6-methyl-tetrahydro-pyran

Conditions

Conditions	Yield
With 4 A molecular sieve; tetra-(n-butyl)ammonium iodide; N-ethyl-N,N-diisopropylamine for 4h; Substitution;	100%

: 112-53-8
1-dodecyl alcohol

: 250691-61-3
(2S,3S,4R,5R,6S)-3,4,5-Tris-benzyloxy-2-iodo-6-methyl-tetrahydro-pyran

: (3S,4R,5R,6S)-3,4,5-Tris-benzyloxy-2-dodecyloxy-6-methyl-tetrahydro-pyran

Conditions

Conditions	Yield
With 4 A molecular sieve; tetra-(n-butyl)ammonium iodide; N-ethyl-N,N-diisopropylamine for 4h; Substitution;	100%

: 112-53-8
1-dodecyl alcohol

: 6214-59-1
3-(thymine-1-yl)propionic acid

: dodecyl 3-(thymin-1-yl)propionate

Conditions

Conditions	Yield
With dicyclohexyl-carbodiimide In pyridine at 0 - 20℃; for 48h;	100%

: 112-53-8
1-dodecyl alcohol

: 6340-79-0
4-(4-bromophenyl)-4-oxo-butyric acid

: 375826-30-5
dodecyl 4-(4-bromophenyl)-4-oxobutanoate

Conditions

Conditions	Yield
With dmap; dicyclohexyl-carbodiimide In dichloromethane at 20℃;	100%
With dmap; dicyclohexyl-carbodiimide In dichloromethane at 20℃;	99%

: 112-53-8
1-dodecyl alcohol

: 124072-61-3
N-t-butoxycarbonyl-N-methyl-β-alanine

: 654651-62-4
Boc-MeβAla-O-n-dodecyl

Conditions

Conditions	Yield
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 0 - 20℃;	100%

: 112-53-8
1-dodecyl alcohol

: 57-10-3
1-hexadecylcarboxylic acid

: 42232-29-1
dodecyl hexadecanoic acid ester

Conditions

Conditions	Yield
With zirconium(IV) oxychloride In 1,3,5-trimethyl-benzene at 162℃; for 24h;	100%
With toluene-4-sulfonic acid In benzene for 30h; Reflux;	100%
iron(III) chloride In 1,3,5-trimethyl-benzene at 162℃; for 24h;	99%

: 910660-81-0
C15H12ClF18NS

: 112-53-8
1-dodecyl alcohol

: 910660-85-4
bis-(4,4,5,5,6,6,7,7,7-nonafluoro-heptyl)-thiocarbamic acid O-dodecyl ester

Conditions

Conditions	Yield
With sodium hydride In tetrahydrofuran at 20℃; for 12h;	100%

: 910660-82-1
C19H12ClF26NS

: 112-53-8
1-dodecyl alcohol

: 910660-86-5
bis-(4,4,5,5,6,6,7,7,8,8,9,9,9-tridecafluoro-nonyl)-thiocarbamic acid O-dodecyl ester

Conditions

Conditions	Yield
With sodium hydride In tetrahydrofuran at 20℃; for 12h;	100%

: 112-53-8
1-dodecyl alcohol

: 91424-40-7
3-(tert-butyldimethylsilyloxy)glutaric anhydride

: 916441-89-9
3-(tert-butyldimethylsilyloxy)-5-oxo-5-(dodecyloxy)pentanoic acid

Conditions

Conditions	Yield
In toluene Heating;	100%
In toluene for 24h; Reflux;	95%

: 112-53-8
1-dodecyl alcohol

: 149-87-1
Pyroglutamic acid

: 66183-71-9
ethyl 2-oxopyrrolidine-5-carboxylate

: 75444-31-4
2-pyrrolidone-5-carboxylic acid n-dodecyl ester

Conditions

Conditions	Yield
Novozym 435 at 60℃; under 15.0015 Torr; for 24h; Enzymatic reaction;	100%

...Expand

: 112-53-8
1-dodecyl alcohol

: 1170721-83-1
C29H38O6

: C41H62O6

Conditions

Conditions	Yield
With triphenylphosphine; diethylazodicarboxylate In tetrahydrofuran at 20℃; Mitsunobu reaction;	100%

1-Dodecanol Consensus Reports

Reported in EPA TSCA Inventory.

1-Dodecanol Specification

The IUPAC name of Dodecyl alcohol is dodecan-1-ol. With the CAS registry number 112-53-8, it is also named as 1-Hydroxydodecane. The product's categories are Industrial / Fine Chemicals; 1-Alkanols; Biochemistry; Higher Fatty Acids & Higher Alcohols; Monofunctional & alpha, Omega-Bifunctional Alkanes; Monofunctional Alkanes; Saturated Higher Alcohols, and the other registry numbers are 1322-35-6; 68855-55-0; 8014-32-2; 8032-08-4; 8032-09-5; 8032-10-8. Besides, it is white low melting crystalline solid, which reacts with oxoacids and carboxylic acids to form esters plus water. In addition, its molecular formula is C₁₂H₂₆O and molecular weight is 186.33.

The other characteristics of 1-Dodecanol can be summarized as:
(1)EINECS: 203-982-0; (2)ACD/LogP: 5.13; (3)# of Rule of 5 Violations: 1; (4)ACD/LogD (pH 5.5): 5.13; (5)ACD/LogD (pH 7.4): 5.13; (6)ACD/BCF (pH 5.5): 4631.99; (7)ACD/BCF (pH 7.4): 4631.99; (8)ACD/KOC (pH 5.5): 14640.28; (9)ACD/KOC (pH 7.4): 14640.28; (10)#H bond acceptors: 1; (11)#H bond donors: 1; (12)#Freely Rotating Bonds: 11; (13)Index of Refraction: 1.44; (14)Molar Refractivity: 59.17 cm³; (15)Molar Volume: 224.1 cm³; (16)Surface Tension: 30.4 dyne/cm; (17)Density: 0.831 g/cm³; (18)Flash Point: 115.4 °C; (19)Melting point: 22-27 °C; (20)Enthalpy of Vaporization: 57.56 kJ/mol; (21)Boiling Point: 258 °C at 760 mmHg; (22)Vapour Pressure: 0.00209 mmHg at 25 °C.

Preparation of 1-Dodecanol:
This chemical can be obtained from palm kernel or coconut oil fatty acids and methyl esters by reduction. Furthermore, it is produced by dodecanoic acid.

This reaction needs NaBH₄, CF₃COOH, catechol and tetrahydrofuran at the temperature of 25 °C for 4 hours. The yield is 91 %.

Uses of 1-Dodecanol:
This chemical can be used to make surfactants, lubricating oils, and pharmaceuticals. It is also used as an emollient in cosmetics. Besides, it can react with formaldehyde to get 1-chloromethoxy-dodecane.

This reaction needs Me₃SiCl. The yield is 98 %.

Safety information of 1-Dodecanol:
When you are using 1-Dodecanol, please be cautious about it as the following: it irritates to eyes, respiratory system and skin. In case of contact with eyes, please rinse immediately with plenty of water and seek medical advice. And you should wear suitable protective clothing, gloves and eye/face protection. Moreover, please do not empty into drains. It is also very toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment. This material and its container must be disposed of as hazardous waste. Additionally, please avoid release to the environment, and refer to special instructions / safety data sheets.

People can use the following data to convert to the molecule structure.
(1)Canonical SMILES: CCCCCCCCCCCCO
(2)InChI: InChI=1S/C12H26O/c1-2-3-4-5-6-7-8-9-10-11-12-13/h13H,2-12H2,1H3
(3)InChIKey: LQZZUXJYWNFBMV-UHFFFAOYSA-N

The toxicity data of 1-Dodecanol is as follows:

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
guinea pig	LD50	skin	> 10mL/kg (10mL/kg)		Food and Cosmetics Toxicology. Vol. 11, Pg. 95, 1973.
rat	LD50	oral	> 12800mg/kg (12800mg/kg)		Medizin und Ernaehrung. Vol. 8, Pg. 244, 1967.

Product Name

1-Dodecanol

Synthetic route

1-Dodecanol Consensus Reports

1-Dodecanol Specification

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