Conditions | Yield |
---|---|
With potassium iodide In acetonitrile at 20℃; for 0.25h; | 95% |
With iodine; triphenylphosphine at 20℃; for 0.133333h; Ionic liquid; | 91% |
With hydrogen iodide at 120℃; for 4h; | 80% |
Conditions | Yield |
---|---|
With N-iodo-succinimide In chlorobenzene for 2h; Irradiation; | A 94% B 1% C n/a |
With N-iodo-succinimide In chlorobenzene for 2h; Product distribution; Irradiation; var. irradiat. times, temps. and light cond.; | A 94% B 1% C n/a |
Conditions | Yield |
---|---|
With hexaethylbisphosphonium bistriiodide Heating; | 88% |
With phosphoric acid; potassium iodide |
Conditions | Yield |
---|---|
In diethyl ether for 2h; Ambient temperature; | A n/a B 85% |
Conditions | Yield |
---|---|
With I*2H2O In toluene at 150℃; Rate constant; | 80% |
With I*2H2O In toluene at 150℃; | 80% |
With sodium iodide In acetone Substitution; | 64% |
1-iodo-butane
Conditions | Yield |
---|---|
With potassium iodide In dichloromethane; water at 20℃; for 0.15h; | 78% |
With potassium iodide In dichloromethane; water at 20℃; for 0.15h; Product distribution; further diphenylalkylsulfonium salts, further K salts and other nucleophiles; | 78% |
Conditions | Yield |
---|---|
With tetrabutylammonium tetrafluoroborate In acetone at 320℃; Product distribution; in a gas chromatograph; other temperature; various concentration of reagent; | A 77% B n/a |
Conditions | Yield |
---|---|
With 2-chloro-4,6-dimethoxy-1 ,3,5-triazine; sodium iodide In acetone Reflux; | 70% |
-butyl vinyl ether
acetyl iodide
A
vinyl acetate
B
1-iodo-butane
C
vinyliodide
D
acetic acid butyl ester
Conditions | Yield |
---|---|
In dichloromethane at 10℃; | A 11.8% B 12.8% C 35.8% D 39.8% |
Conditions | Yield |
---|---|
With iron pentacarbonyl; iodoform In N,N-dimethyl-formamide 1.) 70-90 deg C, 1 h, 2.) 80-90, 1 h; | 37% |
With ethylene glycol; potassium iodide | |
With iodine; iron pentacarbonyl at 85 - 90℃; for 1.5h; further reagent; Yield given; |
Conditions | Yield |
---|---|
With tert-butylhypochlorite; mercury(II) iodide In 1,1,2-Trichloro-1,2,2-trifluoroethane at 47℃; for 8h; Irradiation; Yield given; | A n/a B 35% |
With tert-butylhypochlorite; mercury(II) iodide In 1,1,2-Trichloro-1,2,2-trifluoroethane at 47℃; for 8h; Irradiation; | A n/a B 35% |
Conditions | Yield |
---|---|
Stage #1: diiodomethane; (1Z)-N-(3-ethynylphenyl)-2,2,2-trifluoroethanimidoyl chloride With methyllithium lithium bromide In tetrahydrofuran; diethyl ether at -78℃; for 0.5h; Stage #2: n-butyllithium In tetrahydrofuran; diethyl ether; hexane at -78℃; for 0.5h; | A 25% B 31% |
Conditions | Yield |
---|---|
With phosphoric acid; potassium iodide |
dibutyl hydrogen phosphite
A
1-iodo-butane
B
Phosphoric acid mono-n-butylester
Conditions | Yield |
---|---|
With hydrogen iodide |
Conditions | Yield |
---|---|
With water; potassium iodide | |
With tetra-(n-butyl)ammonium iodide In acetone at 210℃; Product distribution; ina gas chromatograph; |
butyl methyl ether
chloro-acetyl iodide
A
butyl chloroacetate
B
1-iodo-butane
C
methyl iodide
dibutyl ether
acetyl iodide
A
1-iodo-butane
B
acetic acid butyl ester
Conditions | Yield |
---|---|
at 25℃; unter Lichtausschluss; |
dibutyl ether
butyl 2,4,6-trimethylbenzoate
phenylmagnesium iodide
A
1-iodo-butane
B
biphenyl
C
mesitylenecarboxylic acid
Conditions | Yield |
---|---|
anschliessend Behandeln mit wss. Schwefelsaeure; |
1-butyl-3-propyl-imidazolium; iodide
A
1-propyl-1H-imidazole
B
1-Butylimidazole
C
1-iodo-butane
D
1-iodo-propane
Conditions | Yield |
---|---|
at 260 - 300℃; im Vakuum; |
n-butyllithium
ethyl iodide
A
1-iodo-butane
B
ethyllithium
Conditions | Yield |
---|---|
reversible Reaktion; |
Conditions | Yield |
---|---|
With water; dibenzoyl peroxide at 95℃; unter hohem Druck; |
3-ethyl-1-butyl-imidazolium; iodide
A
N-Ethylimidazole
B
1-Butylimidazole
C
1-iodo-butane
D
ethyl iodide
Conditions | Yield |
---|---|
at 260 - 300℃; im Vakuum; |
1-bromo-butane
iodo(trimethylsilyl)methane
A
1-iodo-butane
B
(bromomethyl)trimethylsilane
Conditions | Yield |
---|---|
With triisooctyl amine Equilibrium constant; |
Conditions | Yield |
---|---|
With borane; iodine; sodium methylate 1.) THF, 25 deg C, 1 h, 2.) MeOH, 24 h; Yield given. Multistep reaction; |
Conditions | Yield |
---|---|
With sodium hydroxide; nickel tetraaza macrocycle; water at 25℃; |
n-butyllithium
1-iodo-butane
Conditions | Yield |
---|---|
With tri-n-butylstannylmethyl iodide |
Conditions | Yield |
---|---|
With borane; iodine; sodium methylate 1.) THF, 25 deg C, 1 h, 2.) MeOH, 24 h; Yield given. Multistep reaction; |
n-Butyl chloride
iodo(trimethylsilyl)methane
A
1-iodo-butane
B
Chloromethyltrimethylsilane
Conditions | Yield |
---|---|
With triisooctyl amine Equilibrium constant; |
dibutyl ethylphosphonite
1,1,1,2,2,3,3-heptafluoro-3-iodo-propane
A
1-iodo-butane
B
butyl ethyl(heptafluoropropyl)phosphinate
Conditions | Yield |
---|---|
In octane Rate constant; Kinetics; Thermodynamic data; E (activ.); ΔH(excit.); ΔS(excit.); ΔG(excit.); |
Conditions | Yield |
---|---|
With lithium aluminium tetrahydride In tetrahydrofuran at 25℃; for 1h; Product distribution; var. aralkyl halides, rates of reduction; | 100% |
With sodium ammonium; ammonia | |
With aluminium amalgam |
N-methylcyclohexylamine
1-iodo-butane
1-butyl-1-methylpiperidinium iodide
Conditions | Yield |
---|---|
In chloroform at 60℃; for 6h; | 100% |
In chloroform Heating; |
Conditions | Yield |
---|---|
In tetrahydrofuran at 20℃; for 16h; | 100% |
1-iodo-butane
2,8,9-Trimethyl-2,5,8,9-tetraaza-1-phospha-bicyclo[3.3.3]undecane 1-sulfide
Conditions | Yield |
---|---|
In acetonitrile at 50 - 55℃; for 96h; | 100% |
1-iodo-butane
Conditions | Yield |
---|---|
In [D3]acetonitrile | 100% |
1-iodo-butane
O,O-diethyltrimethylsilylchloromethylphosphonate α-lithie
(1-Chloro-1-trimethylsilanyl-pentyl)-phosphonic acid diethyl ester
Conditions | Yield |
---|---|
In tetrahydrofuran; hexane for 1h; Ambient temperature; | 100% |
1-iodo-butane
1-amino-3-methylbenzene
N-butyl-N-(3-methyl-n-propyl)-m-toluidine
Conditions | Yield |
---|---|
With sodium acetate at 130 - 140℃; for 4h; | 100% |
Conditions | Yield |
---|---|
at 135℃; for 15h; | 100% |
Conditions | Yield |
---|---|
In methanol | 100% |
Conditions | Yield |
---|---|
In methanol | 100% |
1-iodo-butane
Cyclobutanecarboxylic acid
1-butylcyclobutane carboxylic acid
Conditions | Yield |
---|---|
Stage #1: Cyclobutanecarboxylic acid With lithium diethylamide In tetrahydrofuran; n-heptane; ethylbenzene at 0 - 20℃; for 2h; Stage #2: 1-iodo-butane In tetrahydrofuran; n-heptane; ethylbenzene at 20℃; | 100% |
With lithium diisopropyl amide In tetrahydrofuran at 20℃; for 12h; | |
Stage #1: Cyclobutanecarboxylic acid With lithium diisopropyl amide In tetrahydrofuran; hexane at -78 - 20℃; for 1h; Stage #2: 1-iodo-butane In tetrahydrofuran at 0 - 20℃; for 12h; |
1-iodo-butane
4-(6-hydroxy-7-methoxy-4-quinazolinyl)-1-piperazinecarboxylic acid tert-butyl ester
4-(6-butoxy-7-methoxy-4-quinazolinyl)-1-piperazinecarboxylic acid tert-butyl ester
Conditions | Yield |
---|---|
With potassium carbonate In N,N-dimethyl-formamide at 20℃; | 100% |
1-iodo-butane
2-imidazolecarbaldehyde
1-n-butyl-1H-imidazole-2-carbaldehyde
Conditions | Yield |
---|---|
With potassium carbonate In N,N-dimethyl-formamide | 100% |
Stage #1: 2-imidazolecarbaldehyde With potassium carbonate In N,N-dimethyl-formamide Stage #2: 1-iodo-butane | 82% |
With potassium carbonate In DMF (N,N-dimethyl-formamide) at 50℃; for 6h; | |
With potassium carbonate In N,N-dimethyl-formamide at 80℃; |
Conditions | Yield |
---|---|
With potassium carbonate In acetonitrile for 4h; Heating; | 100% |
1-iodo-butane
Conditions | Yield |
---|---|
Stage #1: (4aS,7S,7aR)-nepetalactam With potassium hydride In tetrahydrofuran at 0℃; for 0.5h; Stage #2: 1-iodo-butane In tetrahydrofuran at 0 - 20℃; for 1h; | 100% |
Conditions | Yield |
---|---|
100% |
1-iodo-butane
1,1-dibutyl-2,3,4,5-tetraphenylgermole
Conditions | Yield |
---|---|
In not given | 100% |
1-iodo-butane
2,6-bis(1H-benzo[d]imidazol-1-yl)pyridine
Conditions | Yield |
---|---|
at 160℃; for 30h; Inert atmosphere; Neat (no solvent); Sealed tube; | 100% |
at 160℃; for 30h; |
Conditions | Yield |
---|---|
With 1,8-diazabicyclo[5.4.0]undec-7-ene In tetrahydrofuran at 20℃; for 0.25h; | 100% |
1-vinylimidazole
1-iodo-butane
1-vinyl-3-butyl-3H-imidazol-1-ium iodide
Conditions | Yield |
---|---|
In toluene at 110℃; for 24h; | 100% |
for 5h; Inert atmosphere; Reflux; | 96% |
In tert-butyl methyl ether at 20℃; for 312h; | 83% |
In tetrahydrofuran at 20℃; for 24h; | 31% |
Reflux; |
1-iodo-butane
2-bromo-N-(4-ethylphenyl)benzamide
Conditions | Yield |
---|---|
Stage #1: 2-bromo-N-(4-ethylphenyl)benzamide With sodium hydride In N,N-dimethyl-formamide; mineral oil at 0℃; for 0.5h; Inert atmosphere; Stage #2: 1-iodo-butane In N,N-dimethyl-formamide; mineral oil at 0℃; | 100% |
Stage #1: 2-bromo-N-(4-ethylphenyl)benzamide With sodium hydride In N,N-dimethyl-formamide Stage #2: 1-iodo-butane In N,N-dimethyl-formamide |
1-iodo-butane
2-bromo-N-(4-tert-butylphenyl)benzamide
Conditions | Yield |
---|---|
Stage #1: 2-bromo-N-(4-tert-butylphenyl)benzamide With sodium hydride In N,N-dimethyl-formamide; mineral oil at 0℃; for 0.5h; Inert atmosphere; Stage #2: 1-iodo-butane In N,N-dimethyl-formamide; mineral oil at 0℃; | 100% |
Stage #1: 2-bromo-N-(4-tert-butylphenyl)benzamide With sodium hydride In N,N-dimethyl-formamide Stage #2: 1-iodo-butane In N,N-dimethyl-formamide |
1-iodo-butane
2-bromo-N-(4-methylphenyl)benzamide
Conditions | Yield |
---|---|
Stage #1: 2-bromo-N-(4-methylphenyl)benzamide With sodium hydride In N,N-dimethyl-formamide; mineral oil at 0℃; for 0.5h; Inert atmosphere; Stage #2: 1-iodo-butane In N,N-dimethyl-formamide; mineral oil at 0℃; | 100% |
Stage #1: 2-bromo-N-(4-methylphenyl)benzamide With sodium hydride In N,N-dimethyl-formamide Stage #2: 1-iodo-butane In N,N-dimethyl-formamide |
1-iodo-butane
tert-butyl (3-perfluorooctyl)propoxycarbamate
C20H24F17NO3
Conditions | Yield |
---|---|
With caesium carbonate In acetonitrile at 45℃; for 2h; | 100% |
1-iodo-butane
sodium 1-thio-β-D-glucopyranoside
n-butyl 1-thio-β-D-glucopyranoside
Conditions | Yield |
---|---|
In methanol at 20℃; for 1h; | 100% |
1-iodo-butane
1,3-bis(2,6-diiopropylphenyl)imidazol-2-ylidene borane
1,3-bis-(2,6-diisopropylphenyl)imidazol-2-ylidene boryl iodide
Conditions | Yield |
---|---|
In benzene byproducts: C12H26; 1 equiv of borane and 1 equiv of C4H9I were heated in C6H6 at 180°C for 72 h; filtered; | 100% |
1-iodo-butane
Conditions | Yield |
---|---|
at 100℃; for 5h; | 100% |
for 5h; Reflux; Inert atmosphere; | 99% |
1-iodo-butane
Conditions | Yield |
---|---|
at 100℃; for 5h; | 100% |
1-iodo-butane
Conditions | Yield |
---|---|
at 100℃; for 5h; | 100% |
1-iodo-butane
N-(benzimidazol-1-yl)-1-(4-nitrophenyl)methanimine
N-(3-butylbenzimidazol-3-ium-1-yl)-1-(4-nitrophenyl)methanimine iodide
Conditions | Yield |
---|---|
at 100℃; for 5h; | 100% |
1.Introduction of 1-Iodobutane
1-Iodobutane, with its CAS register No 542-69-8, is a kind of colorless or pale orange clear liquid. It has synonyms of Butyl iodide;1-Iodobutane Butyl iodide;1-Butyliodide;Butane,1-iodo- and 1-Jodbutan [Czech]. 1-Iodobutane should be stored in shady and cool warehouse and mainly used as solvent.
2.Properties of 1-Iodobutane
(1) Freely Rotating Bonds: 2 (2) Polar Surface Area: 0 Å2 (3) Index of Refraction: 1.503 (4) Molar Refractivity: 33.54 cm3
(5) Molar Volume: 113.3 cm3 (6) Polarizability: 13.3 ×10-24cm3 (7) Surface Tension: 29.9 dyne/cm (8) Density: 1.622 g/cm3
(9) Flash Point: 33.3 °C (10) Enthalpy of Vaporization: 34.66 kJ/mol (11) Boiling Point: 130.9 °C at 760 mmHg
(12) Vapour Pressure: 11.7 mmHg at 25°C
3.Structure descriptors of 1-Iodobutane
SMILES:ICCCC
Std. InChI:InChI=1S/C4H9I/c1-2-3-4-5/h2-4H2,1H3
Std. InChIKey:KMGBZBJJOKUPIA-UHFFFAOYSA-N
4.Safety information of 1-Iodobutane
Hazard Codes: Xn
Risk Statements: 10-20-36/37/38-20/22
R10: Flammable.
R20: Harmful by inhalation.
R36/37/38: Irritating to eyes, respiratory system and skin.
R20/22: Harmful by inhalation and if swallowed.
Safety Statements: 16-36-36/37/39-26
S16: Keep away from sources of ignition.
S36: Wear suitable protective clothing.
S36/37/39: Wear suitable protective clothing, gloves and eye/face protection.
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
RIDADR: UN 1993 3/PG 3
WGK Germany: 3
RTECS: EK4400000
F: 8
HazardClass: 3
PackingGroup: III
HS Code: 29033080
5.Toxicity date of 1-Iodobutane
1. | mouseLD50:101 mg/kg | "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982Vol. -, Pg. 30, 1982. | ||
2. | ratLD50:6100mg/m3/4H | "Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969Vol. -, Pg. 756, 1969. | ||
3. | ratLD50:692mg/kg | "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982Vol. -, Pg. 30, 1982. |
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