Product Name

  • Name

    1-Phenylcyclopentanecarboxylic acid

  • EINECS 201-037-7
  • CAS No. 77-55-4
  • Article Data31
  • CAS DataBase
  • Density 1.162 g/cm3
  • Solubility
  • Melting Point 157-161 °C
  • Formula C12H14O2
  • Boiling Point 338.8 °C at 760 mmHg
  • Molecular Weight 190.242
  • Flash Point 157.1 °C
  • Transport Information
  • Appearance Cream to grey-brown powder
  • Safety 37/39-26-45-36/37/39-27
  • Risk Codes 36/37/38-34
  • Molecular Structure Molecular Structure of 77-55-4 (1-Phenylcyclopentanecarboxylic acid)
  • Hazard Symbols IrritantXi,CorrosiveC
  • Synonyms 1-Phenylcyclopentane-1-carboxylicacid;NSC 19462;
  • PSA 37.30000
  • LogP 2.58300

Synthetic route

2-allyl-2-phenylpent-4-enoic acid

2-allyl-2-phenylpent-4-enoic acid

1-phenyl-1-cyclopentanecarboxylic acid
77-55-4

1-phenyl-1-cyclopentanecarboxylic acid

Conditions
ConditionsYield
Stage #1: 2-allyl-2-phenylpent-4-enoic acid With tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride In tetrahydrofuran at 40℃; for 0.5h; Inert atmosphere;
Stage #2: With formic acid; sodium hydride In tetrahydrofuran at 80℃; for 24h; Inert atmosphere;
97%
C13H14O2

C13H14O2

1-phenyl-1-cyclopentanecarboxylic acid
77-55-4

1-phenyl-1-cyclopentanecarboxylic acid

Conditions
ConditionsYield
With dihydrogen peroxide In water; ethyl acetate at 20℃; for 12h; Green chemistry; regioselective reaction;92%
With dihydrogen peroxide In ethyl acetate at 20℃; regioselective reaction;92%
1-phenyl-1-cyclopentanecarboxaldehyde
21573-69-3

1-phenyl-1-cyclopentanecarboxaldehyde

1-phenyl-1-cyclopentanecarboxylic acid
77-55-4

1-phenyl-1-cyclopentanecarboxylic acid

Conditions
ConditionsYield
With potassium sulfite; copper(l) chloride; potassium bromide In cyclohexane at 160℃; for 8h; Temperature;91%
With silver(l) oxide
1-phenyl-1-cyclopentanecarbonitrile
77-57-6

1-phenyl-1-cyclopentanecarbonitrile

1-phenyl-1-cyclopentanecarboxylic acid
77-55-4

1-phenyl-1-cyclopentanecarboxylic acid

Conditions
ConditionsYield
With potassium hydroxide In ethanol for 96h; Heating;68%
With sulfuric acid
With potassium hydroxide at 200℃;
1-phenyl-N-(quinolin-8-yl)cyclopentanecarboxamide
908520-36-5

1-phenyl-N-(quinolin-8-yl)cyclopentanecarboxamide

1-phenyl-1-cyclopentanecarboxylic acid
77-55-4

1-phenyl-1-cyclopentanecarboxylic acid

Conditions
ConditionsYield
Stage #1: 1-phenyl-N-(quinolin-8-yl)cyclopentanecarboxamide With ozone In dichloromethane at -78℃; Inert atmosphere;
Stage #2: With lithium hydroxide monohydrate; dihydrogen peroxide In tetrahydrofuran; water at 20℃; for 48h; Inert atmosphere;
53%
1,4-dibromo-butane
110-52-1

1,4-dibromo-butane

t-butyl phenylacetate
16537-09-0

t-butyl phenylacetate

1-phenyl-1-cyclopentanecarboxylic acid
77-55-4

1-phenyl-1-cyclopentanecarboxylic acid

Conditions
ConditionsYield
(i) aq. NaOH, Cl, DMSO, (ii) aq. H2SO4, AcOH; Multistep reaction;
formic acid
64-18-6

formic acid

1-phenylcyclopentanol
10487-96-4

1-phenylcyclopentanol

1-phenyl-1-cyclopentanecarboxylic acid
77-55-4

1-phenyl-1-cyclopentanecarboxylic acid

Conditions
ConditionsYield
With sulfuric acid at 20 - 25℃; for 2h;
1-Methyl-1-(1-phenyl-cyclopentanecarbonyloxymethyl)-pyrrolidinium; chloride

1-Methyl-1-(1-phenyl-cyclopentanecarbonyloxymethyl)-pyrrolidinium; chloride

1-phenyl-1-cyclopentanecarboxylic acid
77-55-4

1-phenyl-1-cyclopentanecarboxylic acid

Conditions
ConditionsYield
In water at 37℃; Rate constant; pH 7.4;
1,4-dibromo-butane
110-52-1

1,4-dibromo-butane

diethyl ether
60-29-7

diethyl ether

sodium compound of phenylacetonitrile

sodium compound of phenylacetonitrile

A

1-phenyl-1-cyclopentanecarboxylic acid
77-55-4

1-phenyl-1-cyclopentanecarboxylic acid

B

amide of 1-phenyl-cyclopentane-carboxylic acid-(1)

amide of 1-phenyl-cyclopentane-carboxylic acid-(1)

Conditions
ConditionsYield
und folgender Hydrolyse des Reaktionsprodukts mit alkoh.KOH;
1,4-dibromo-butane
110-52-1

1,4-dibromo-butane

sodium-compound of phenylacetonitrile

sodium-compound of phenylacetonitrile

A

1-phenyl-1-cyclopentanecarboxylic acid
77-55-4

1-phenyl-1-cyclopentanecarboxylic acid

B

1-phenyl-cyclopentane-carboxylic acid-(1)-amide

1-phenyl-cyclopentane-carboxylic acid-(1)-amide

Conditions
ConditionsYield
With diethyl ether Behandeln des Reaktionsprodukts mit aethanol. Kalilauge;
phenylacetonitrile
140-29-4

phenylacetonitrile

1-phenyl-1-cyclopentanecarboxylic acid
77-55-4

1-phenyl-1-cyclopentanecarboxylic acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: NaNH2
2: methanol. KOH / 200 °C
View Scheme
Multi-step reaction with 2 steps
1: NaOH
2: aqueous KOH / 130 - 140 °C
View Scheme
Multi-step reaction with 2 steps
1: NaNH2
2: KOH; diethylene glycol / 190 °C
View Scheme
phenylacetonitrile
140-29-4

phenylacetonitrile

n-butyl halide

n-butyl halide

1-phenyl-1-cyclopentanecarboxylic acid
77-55-4

1-phenyl-1-cyclopentanecarboxylic acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: liq. NH3, NaNH2
2: KOH / bis-(2-hydroxy-ethyl) ether
View Scheme
Multi-step reaction with 2 steps
1: NaNH2
2: (acid hydrolysis)
View Scheme
2-(hydroxymethylene)cyclohexanone
823-45-0

2-(hydroxymethylene)cyclohexanone

1-phenyl-1-cyclopentanecarboxylic acid
77-55-4

1-phenyl-1-cyclopentanecarboxylic acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: toluene / 0.17 h / 20 °C / Inert atmosphere
1.2: 12 h / Inert atmosphere
2.1: dihydrogen peroxide / ethyl acetate; water / 12 h / 20 °C / Green chemistry
View Scheme
cyclohexanone
108-94-1

cyclohexanone

1-phenyl-1-cyclopentanecarboxylic acid
77-55-4

1-phenyl-1-cyclopentanecarboxylic acid

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: sodium hydride / mineral oil; methanol; toluene / 12 h / 0 - 20 °C / Inert atmosphere
2.1: toluene / 0.17 h / 20 °C / Inert atmosphere
2.2: 12 h / Inert atmosphere
3.1: dihydrogen peroxide / ethyl acetate; water / 12 h / 20 °C / Green chemistry
View Scheme
benzeneacetic acid methyl ester
101-41-7

benzeneacetic acid methyl ester

1-phenyl-1-cyclopentanecarboxylic acid
77-55-4

1-phenyl-1-cyclopentanecarboxylic acid

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: sodium iodide; sodium hydride / tetrahydrofuran
2.1: sodium hydroxide; water / ethanol / 90 °C
3.1: tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride / tetrahydrofuran / 0.5 h / 40 °C / Inert atmosphere
3.2: 24 h / 80 °C / Inert atmosphere
View Scheme
Multi-step reaction with 2 steps
1.1: sodium hydride / tetrahydrofuran; mineral oil / 0 °C
1.2: 1,4-halobutane / 18.17 h / 0 - 50 °C
2.1: sodium hydroxide / methanol; water / 3 h / Reflux
View Scheme
methyl 2-phenyl-2-(prop-2-enyl)pent-4-enoate
242482-24-2

methyl 2-phenyl-2-(prop-2-enyl)pent-4-enoate

1-phenyl-1-cyclopentanecarboxylic acid
77-55-4

1-phenyl-1-cyclopentanecarboxylic acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: sodium hydroxide; water / ethanol / 90 °C
2.1: tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride / tetrahydrofuran / 0.5 h / 40 °C / Inert atmosphere
2.2: 24 h / 80 °C / Inert atmosphere
View Scheme
1-phenyl-1-cyclopentanecarboxylic acid methyl ester
4535-96-0

1-phenyl-1-cyclopentanecarboxylic acid methyl ester

1-phenyl-1-cyclopentanecarboxylic acid
77-55-4

1-phenyl-1-cyclopentanecarboxylic acid

Conditions
ConditionsYield
With sodium hydroxide In methanol; water for 3h; Reflux;
1-phenyl-1-cyclopentanecarboxylic acid
77-55-4

1-phenyl-1-cyclopentanecarboxylic acid

1-phenyl-1-cyclopentanecarboxylic acid methyl ester
4535-96-0

1-phenyl-1-cyclopentanecarboxylic acid methyl ester

Conditions
ConditionsYield
In diethyl ether at 20℃; for 24h;98%
1-phenyl-1-cyclopentanecarboxylic acid
77-55-4

1-phenyl-1-cyclopentanecarboxylic acid

potassium phenyltrifluoborate

potassium phenyltrifluoborate

C18H18O2

C18H18O2

Conditions
ConditionsYield
With dipotassium hydrogenphosphate; oxygen; palladium diacetate; p-benzoquinone In tetr-butanol at 100℃; under 22801.5 Torr; for 48h;98%
methanol
67-56-1

methanol

1-phenyl-1-cyclopentanecarboxylic acid
77-55-4

1-phenyl-1-cyclopentanecarboxylic acid

1-phenyl-1-cyclopentanecarboxylic acid methyl ester
4535-96-0

1-phenyl-1-cyclopentanecarboxylic acid methyl ester

Conditions
ConditionsYield
With thionyl chloride at 20℃; for 17h; Cooling with ice; Inert atmosphere;97%
With hydrogenchloride for 2h; Heating;88%
sulfuric acid Heating / reflux;
1-phenyl-1-cyclopentanecarboxylic acid
77-55-4

1-phenyl-1-cyclopentanecarboxylic acid

phenyl(2,4,6-triisopropylphenyl)iodonium trifluoromethanesulfonate
312727-69-8

phenyl(2,4,6-triisopropylphenyl)iodonium trifluoromethanesulfonate

2,4,6-triisopropylphenyl 1-phenylcyclopentane-1-carboxylate

2,4,6-triisopropylphenyl 1-phenylcyclopentane-1-carboxylate

Conditions
ConditionsYield
With potassium tert-butylate In toluene at 0℃; for 1.25h; Reflux;94%
1-phenyl-1-cyclopentanecarboxylic acid
77-55-4

1-phenyl-1-cyclopentanecarboxylic acid

1-hydroxymethyl-1-phenylcyclopentane
59115-90-1

1-hydroxymethyl-1-phenylcyclopentane

Conditions
ConditionsYield
With lithium aluminium tetrahydride In tetrahydrofuran at 0 - 20℃; for 18h; Reflux;93%
With borane-THF In tetrahydrofuran for 2h; Ambient temperature;75%
Multi-step reaction with 2 steps
1: 88 percent / HCl / 2 h / Heating
2: 88 percent / LiAlH4 / tetrahydrofuran / 3 h / Heating
View Scheme
N-(3-phenylpropyl)-6-amino-4a-(3-methoxyphenyl)-8a-methyloctahydroisoquinoline

N-(3-phenylpropyl)-6-amino-4a-(3-methoxyphenyl)-8a-methyloctahydroisoquinoline

1-phenyl-1-cyclopentanecarboxylic acid
77-55-4

1-phenyl-1-cyclopentanecarboxylic acid

1-phenylcyclopentanecarboxylic acid [4a-(3-methoxyphenyl)-8a-methyl-2-(3-phenylpropyl)octahydroisoquinolin-6-yl]amide

1-phenylcyclopentanecarboxylic acid [4a-(3-methoxyphenyl)-8a-methyl-2-(3-phenylpropyl)octahydroisoquinolin-6-yl]amide

Conditions
ConditionsYield
With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine In tetrahydrofuran at 20℃; for 2h;92%
tert-butyl (1S,4R,5R,7S)-7-amino-5-(3-isopropoxyphenyl)-4-methyl-2-azabicyclo[3.3.1]nonane-2-carboxylate
911422-98-5

tert-butyl (1S,4R,5R,7S)-7-amino-5-(3-isopropoxyphenyl)-4-methyl-2-azabicyclo[3.3.1]nonane-2-carboxylate

1-phenyl-1-cyclopentanecarboxylic acid
77-55-4

1-phenyl-1-cyclopentanecarboxylic acid

tert-butyl (1S,4R,5R,7S)-5-(3-isopropoxyphenyl)-4-methyl-7-{[(1-phenyl-1-cyclopentyl)carbonyl]amino}-2-azabicyclo[3.3.1]nonane-2-carboxylate
911423-02-4

tert-butyl (1S,4R,5R,7S)-5-(3-isopropoxyphenyl)-4-methyl-7-{[(1-phenyl-1-cyclopentyl)carbonyl]amino}-2-azabicyclo[3.3.1]nonane-2-carboxylate

Conditions
ConditionsYield
With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine In tetrahydrofuran at 20℃; for 4h;92%
cis-N-(3-phenylpropyl)-6-amino-4a-(3-methoxyphenyl)-8a-methyloctahydroisoquinoline

cis-N-(3-phenylpropyl)-6-amino-4a-(3-methoxyphenyl)-8a-methyloctahydroisoquinoline

1-phenyl-1-cyclopentanecarboxylic acid
77-55-4

1-phenyl-1-cyclopentanecarboxylic acid

1-phenylcyclopentanecarboxylic acid cis-[4a-(3-methoxyphenyl)-8a-methyl-2-(3-phenylpropyl)octahydroisoquinolin-6-yl]amide

1-phenylcyclopentanecarboxylic acid cis-[4a-(3-methoxyphenyl)-8a-methyl-2-(3-phenylpropyl)octahydroisoquinolin-6-yl]amide

Conditions
ConditionsYield
With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine In tetrahydrofuran at 20℃; for 2h;92%
phenylglyoxylic acid ethyl ester
1603-79-8

phenylglyoxylic acid ethyl ester

1-phenyl-1-cyclopentanecarboxylic acid
77-55-4

1-phenyl-1-cyclopentanecarboxylic acid

ethyl 2-hydroxy-2-phenyl-2-(1-phenylcyclopentyl)acetate

ethyl 2-hydroxy-2-phenyl-2-(1-phenylcyclopentyl)acetate

Conditions
ConditionsYield
With (4s,6s)-2,4,5,6-tetra(9H-carbazol-9-yl)isophthalonitrile; caesium carbonate In dimethyl sulfoxide at 40℃; for 1h; Glovebox; Inert atmosphere; Irradiation;91%
1-phenyl-1-cyclopentanecarboxylic acid
77-55-4

1-phenyl-1-cyclopentanecarboxylic acid

1-(4-iodophenyl)cyclopentanecarboxylic acid
135569-28-7

1-(4-iodophenyl)cyclopentanecarboxylic acid

Conditions
ConditionsYield
With sodium iodate; sulfuric acid; iodine at 20 - 70℃; for 72h;89%
1-phenyl-1-cyclopentanecarboxylic acid
77-55-4

1-phenyl-1-cyclopentanecarboxylic acid

1-(4-nitro-phenyl)-cyclopentanecarboxylic acid
52648-77-8

1-(4-nitro-phenyl)-cyclopentanecarboxylic acid

Conditions
ConditionsYield
With sulfuric acid; nitric acid at 0 - 20℃; for 3h;87%
With sulfuric acid; nitric acid In acetic anhydride at 10℃; for 3h; Yield given;
1-phenyl-1-cyclopentanecarboxylic acid
77-55-4

1-phenyl-1-cyclopentanecarboxylic acid

phenethylamine
64-04-0

phenethylamine

N-phenethyl-1-phenylcyclopentane-1-carboxamide

N-phenethyl-1-phenylcyclopentane-1-carboxamide

Conditions
ConditionsYield
With C36H24B4N2O3 In toluene at 80℃; for 14h; Molecular sieve;86%
With oxygen; potassium carbonate; eosin y In toluene at 20℃; Irradiation; Green chemistry;86%
4-ethoxycarbonylpyrazole
37622-90-5

4-ethoxycarbonylpyrazole

1-phenyl-1-cyclopentanecarboxylic acid
77-55-4

1-phenyl-1-cyclopentanecarboxylic acid

ethyl 1-(1-phenylcyclopentyl)-1H-pyrazole-4-carboxylate

ethyl 1-(1-phenylcyclopentyl)-1H-pyrazole-4-carboxylate

Conditions
ConditionsYield
With 2,4,6-trimethyl-pyridine; tert-butylammonium hexafluorophosphate(V) In dichloromethane for 2.5h; Molecular sieve; Electrochemical reaction;86%
1-phenyl-1-cyclopentanecarboxylic acid
77-55-4

1-phenyl-1-cyclopentanecarboxylic acid

cyclopentylbenzene
700-88-9

cyclopentylbenzene

Conditions
ConditionsYield
With 2,6-dimethylpyridine; 4,4'-dichlorodiphenyl disulfide; 10-methyl-9-(2,4,6-trimethylphenyl) acridinium tetrafluoroborate In 1,2-dichloro-ethane at 20℃; for 14h; Irradiation; Inert atmosphere;82%
1-phenyl-1-cyclopentanecarboxylic acid
77-55-4

1-phenyl-1-cyclopentanecarboxylic acid

4-methoxycarbonylphenyl bromide
619-42-1

4-methoxycarbonylphenyl bromide

methyl 4-((1-phenylcyclopentane-1-carbonyl)oxy)benzoate

methyl 4-((1-phenylcyclopentane-1-carbonyl)oxy)benzoate

Conditions
ConditionsYield
With nickel(II) bromide dimethoxyethane; 4,4'-Dimethoxy-2,2'-bipyridin; tetrabutylammomium bromide; potassium carbonate In N,N-dimethyl acetamide at 20℃; for 10h; Inert atmosphere; Glovebox; Electrolysis;82%
1-phenyl-1-cyclopentanecarboxylic acid
77-55-4

1-phenyl-1-cyclopentanecarboxylic acid

carbon monoxide
201230-82-2

carbon monoxide

1-(2-carboxyphenyl)cyclopentanecarboxylic acid
41058-64-4

1-(2-carboxyphenyl)cyclopentanecarboxylic acid

Conditions
ConditionsYield
With dipotassium hydrogenphosphate; sodium acetate; palladium diacetate; silver carbonate In 1,4-dioxane at 150℃; under 760.051 Torr; for 18h;80%
1-phenyl-1-cyclopentanecarboxylic acid
77-55-4

1-phenyl-1-cyclopentanecarboxylic acid

9-(3-amino-3,5-dideoxy-β-D-xylofuranosyl)-N6-cyclopentyladenine
423774-22-5

9-(3-amino-3,5-dideoxy-β-D-xylofuranosyl)-N6-cyclopentyladenine

9-(3,5-dideoxy-3-{[(1-phenylcyclopentyl)carbonyl]amino}-β-D-xylofuranosyl)-N6-cyclopentyladenine

9-(3,5-dideoxy-3-{[(1-phenylcyclopentyl)carbonyl]amino}-β-D-xylofuranosyl)-N6-cyclopentyladenine

Conditions
ConditionsYield
With benzotriazol-1-ol; diisopropyl-carbodiimide In dichloromethane at 20℃; for 2h;79%
(+)-(1S,4R,5R,7S)-5-(3-isopropoxyphenyl)-2,4-dimethyl-2-azabicyclo[3.3.1]nonan-7-amine

(+)-(1S,4R,5R,7S)-5-(3-isopropoxyphenyl)-2,4-dimethyl-2-azabicyclo[3.3.1]nonan-7-amine

1-phenyl-1-cyclopentanecarboxylic acid
77-55-4

1-phenyl-1-cyclopentanecarboxylic acid

N-[(1S,4R,5R,7S)-5-(3-isopropoxyphenyl)-2,4-dimethyl-2-azabicyclo[3.3.1]non-7-yl]-1-phenylcyclopentanecarboxamide

N-[(1S,4R,5R,7S)-5-(3-isopropoxyphenyl)-2,4-dimethyl-2-azabicyclo[3.3.1]non-7-yl]-1-phenylcyclopentanecarboxamide

Conditions
ConditionsYield
With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine In tetrahydrofuran at 20℃;78%
1-phenyl-1-cyclopentanecarboxylic acid
77-55-4

1-phenyl-1-cyclopentanecarboxylic acid

4-methylphenyl methylsulfide
623-13-2

4-methylphenyl methylsulfide

(p-tolylthio)methyl 1-phenylcyclopentane-1-carboxylate

(p-tolylthio)methyl 1-phenylcyclopentane-1-carboxylate

Conditions
ConditionsYield
With tetrabutylammonium tetrafluoroborate In methanol; acetonitrile at 20℃; for 6h; Inert atmosphere; Electrochemical reaction;77%
8-amino quinoline
578-66-5

8-amino quinoline

1-phenyl-1-cyclopentanecarboxylic acid
77-55-4

1-phenyl-1-cyclopentanecarboxylic acid

1-phenyl-N-(quinolin-8-yl)cyclopentanecarboxamide
908520-36-5

1-phenyl-N-(quinolin-8-yl)cyclopentanecarboxamide

Conditions
ConditionsYield
With thionyl chloride; oxalyl dichloride In dichloromethane; N,N-dimethyl-formamide at 20℃; for 2h; Inert atmosphere; Schlenk technique;76%
1-phenyl-1-cyclopentanecarboxylic acid
77-55-4

1-phenyl-1-cyclopentanecarboxylic acid

spiro-2-one

spiro-2-one

Conditions
ConditionsYield
With [bis(acetoxy)iodo]benzene; potassium acetate; palladium diacetate; N-acetylglycine In tert-butyl alcohol at 100℃; for 12h; Solvent; Reagent/catalyst; Temperature; Time; Sealed tube;69%
1-phenyl-1-cyclopentanecarboxylic acid
77-55-4

1-phenyl-1-cyclopentanecarboxylic acid

6-(1-methyl-1H-pyrazol-4-yl)-4-(6-(piperazin-1-yl)pyridin-3-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile dihydrochloride

6-(1-methyl-1H-pyrazol-4-yl)-4-(6-(piperazin-1-yl)pyridin-3-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile dihydrochloride

6-(1-methyl-1H-pyrazol-4-yl)-4-(6-(4-(1-phenylcyclopentanecarbonyl)piperazin-1-yl)pyridin-3-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile

6-(1-methyl-1H-pyrazol-4-yl)-4-(6-(4-(1-phenylcyclopentanecarbonyl)piperazin-1-yl)pyridin-3-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile

Conditions
ConditionsYield
Stage #1: 1-phenyl-1-cyclopentanecarboxylic acid With N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In N,N-dimethyl acetamide at 20℃; for 0.416667h;
Stage #2: 6-(1-methyl-1H-pyrazol-4-yl)-4-(6-(piperazin-1-yl)pyridin-3-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile dihydrochloride With N-ethyl-N,N-diisopropylamine In N,N-dimethyl acetamide
68%
1-phenyl-1-cyclopentanecarboxylic acid
77-55-4

1-phenyl-1-cyclopentanecarboxylic acid

methyllithium
917-54-4

methyllithium

1-(1-phenylcyclopentyl)ethan-1-one
4046-09-7

1-(1-phenylcyclopentyl)ethan-1-one

Conditions
ConditionsYield
In diethyl ether 1.) 0 deg C; 2.) 2 h, reflux;67%
In diethyl ether Heating;
1-phenyl-1-cyclopentanecarboxylic acid
77-55-4

1-phenyl-1-cyclopentanecarboxylic acid

1,1'-Diphenyl-1,1'-bicyclopentyl
59358-70-2

1,1'-Diphenyl-1,1'-bicyclopentyl

Conditions
ConditionsYield
With C44H32N4(2+)*2F6P(1-); sodium hydroxide In water; acetonitrile at 20℃; for 18h; Irradiation;65%
Multi-step reaction with 2 steps
2: sodium; toluene
View Scheme
1-phenyl-1-cyclopentanecarboxylic acid
77-55-4

1-phenyl-1-cyclopentanecarboxylic acid

monomethyl monopotassium malonate
38330-80-2

monomethyl monopotassium malonate

3-oxo-3-(1-phenyl-cyclopentyl)-propionic acid methyl ester
880352-58-9

3-oxo-3-(1-phenyl-cyclopentyl)-propionic acid methyl ester

Conditions
ConditionsYield
Stage #1: 1-phenyl-1-cyclopentanecarboxylic acid With 1,1'-carbonyldiimidazole In tetrahydrofuran at 20℃; for 2h;
Stage #2: monomethyl monopotassium malonate With magnesium chloride In tetrahydrofuran at 50℃;
65%
1-phenyl-1-cyclopentanecarboxylic acid
77-55-4

1-phenyl-1-cyclopentanecarboxylic acid

1-Phenyl-3-buten-1-ol
80735-94-0

1-Phenyl-3-buten-1-ol

allyl 1-phenylcyclopentanecarboxylate

allyl 1-phenylcyclopentanecarboxylate

Conditions
ConditionsYield
With palladium diacetate; silver carbonate In 1,2-dichloro-benzene at 100℃; for 24h; Inert atmosphere;65%

1-Phenylcyclopentanecarboxylic acid Chemical Properties

IUPAC Name: 1-phenylcyclopentane-1-carboxylic acid
The MF of 1-Phenylcyclopentanecarboxylic acid(77-55-4): C12H14O2
The MW of 1-Phenylcyclopentanecarboxylic acid(77-55-4): 190.24
EINECS: 201-037-7
mp: 159-161 °C(lit.)
Density: 1.162 g/cm3 
Flash Point: 157.1 °C 
Boiling Point: 338.8 °C at 760 mmHg 
Index of Refraction: 1.568 
Appearance: Cream to gray brown.
Solubility in water: Soluble
Categories: C11 to C12;Carbonyl Compounds;Carboxylic Acids
Synonyms: rarechem al bo 1511;phenylcyclopentanecarboxylic acid;akos bc-0226;1-Phenylcyclopentanecarboxylic acid;1-phenylcyclopentane-1-carboxylic acid;1-phenylcyclopentanecarboxylic acid;asischem d50957;1-Phenylcyclopentanecarboxylic acid 99%
the structure of 1-Phenylcyclopentanecarboxylic acid(77-55-4):
 

1-Phenylcyclopentanecarboxylic acid Safety Profile

Hazard Codes: Xi,C
Risk Statements: 36/37/38-34
36/37/38:  Irritating to eyes, respiratory system and skin 
34:  Causes burns 
Safety Statements: 37/39-26-45-36/37/39-27
37/39:  Wear suitable gloves and eye/face protection 
26:  In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 
45:  In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) 
36/37/39:  Wear suitable protective clothing, gloves and eye/face protection 
27:  Take off immediately all contaminated clothing  
WGK Germany: 3

1-Phenylcyclopentanecarboxylic acid Specification

1. First Aid Measures
Ingestion:
If victim is conscious and alert, give 2-4 cupfuls of milk or water. Get medical aid immediately.
Inhalation:
Get medical aid immediately. Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen.
Skin:
Get medical aid. Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Remove contaminated clothing and shoes.
Eyes:
Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid immediately.
2. Handling and Storage
Storage:
Store in a cool, dry place. Keep container closed when not in use.
Handling:
Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Avoid contact with eyes, skin, and clothing. Avoid ingestion and inhalation.
 

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