1-Propanesulfonyl chloride supplier

Name
1-Propanesulfonyl chloride
EINECS 233-414-7
CAS No. 10147-36-1
Article Data28
CAS DataBase
Density 1.29 g/cm³
Solubility Decomposes in hot water.
Melting Point -46oC
Formula C₃H₇ClO₂S
Boiling Point 192.6 °C at 760 mmHg
Molecular Weight 142.606
Flash Point 64.9 °C
Transport Information UN 3265 8/PG 2
Appearance clear liquid
Safety 26-36/37/39-45
Risk Codes 14-34-36
Molecular Structure
Hazard Symbols C
Synonyms Propanesulfonylchloride (6CI);Propylsulfonyl chloride;n-Propanesulfonyl chloride;n-Propylsulphonyl chloride;
PSA 42.52000
LogP 2.04580

Synthetic route

: 629-19-6
Dipropyl disulfide

: 10147-36-1
n-propanesulfonyl chloride

Conditions

Conditions	Yield
With chloro-trimethyl-silane; potassium nitrate In dichloromethane at 50℃; for 4h;	98%

: 4251-16-5
propyl thiocyanate

: 10147-36-1
n-propanesulfonyl chloride

Conditions

Conditions	Yield
With water; chlorine at 5℃;
Stage #1: propyl thiocyanate With water; acetic acid at 50℃; for 0.5h; Stage #2: With sulfuryl dichloride at 50℃; for 0.5h;
With water; chlorine at 5℃;

: 74-98-6
propane

A: 10147-37-2
2-propanesulfonyl chloride

B: 10147-36-1
n-propanesulfonyl chloride

Conditions

Conditions	Yield
With tetrachloromethane; sulfur dioxide; chlorine Irradiation.mit UV-Licht;

: 5284-66-2
propanesulfonic acid

: 10147-36-1
n-propanesulfonyl chloride

Conditions

Conditions	Yield
With phosphorus pentachloride
With sulfuryl dichloride In N,N-dimethyl-formamide at 100 - 105℃; for 3h; Yield given;
With triethylamine In acetone at 80℃; for 0.333333h; microwave irradiation;

: 107-03-9
1-thiopropane

: 10147-36-1
n-propanesulfonyl chloride

Conditions

Conditions	Yield
With chlorine; acetic acid

: 4253-91-2
dipropyl sulfoxide

: 10147-36-1
n-propanesulfonyl chloride

Conditions

Conditions	Yield
With water; chlorine In water at 25 - 30℃; for 1.5h;

: 106-94-5
propyl bromide

: 10147-36-1
n-propanesulfonyl chloride

Conditions

Conditions	Yield
(i) aq. (NH4)2SO3, (ii) PCl5; Multistep reaction;

: 14533-63-2
1-propanesulfonic acid sodium salt

: 10147-36-1
n-propanesulfonyl chloride

Conditions

Conditions	Yield
With chlorine-triphenylphosphine In acetonitrile for 15h; Ambient temperature;

: 4251-16-5
propyl thiocyanate

: 7732-18-5
water

: 7782-50-5
chlorine

: 10147-36-1
n-propanesulfonyl chloride

...Expand

: thiosulfuric acid S-propyl ester

: 7782-50-5
chlorine

: 64-19-7
acetic acid

: 10147-36-1
n-propanesulfonyl chloride

Conditions

Conditions	Yield
Natrium-Salz reagiert;

...Expand

ammonium-: ammonium-

: 10147-36-1
n-propanesulfonyl chloride

Conditions

Conditions	Yield
With phosphorus pentachloride

potassium salt of/the/ propane-α-sulfonic acid: potassium salt of/the/ propane-α-sulfonic acid

: 10147-36-1
n-propanesulfonyl chloride

Conditions

Conditions	Yield
With phosphorus pentachloride

S-propyl-isothiourea hydrochloride: S-propyl-isothiourea hydrochloride

: 10147-36-1
n-propanesulfonyl chloride

Conditions

Conditions	Yield
With water; chlorine at 10 - 15℃;

: 10147-36-1
n-propanesulfonyl chloride

: 24243-71-8
propane-1-sulfonamide

Conditions

Conditions	Yield
With ammonia In diethyl ether at 0℃; for 0.166667h;	100%
With ammonia In toluene at -78℃; for 1h;	83.1%
With ammonia In tetrahydrofuran at 20℃; for 0.3h;	59.5%

: 10147-36-1
n-propanesulfonyl chloride

: 2592-95-2
benzotriazol-1-ol

: 637031-27-7
1-hydroxybenzotriazol propanesulfonate

Conditions

Conditions	Yield
With potassium carbonate In dichloromethane at 0℃; for 1h;	100%

: 10147-36-1
n-propanesulfonyl chloride

: 99-03-6
1-(3-aminophenyl)ethanone

: 844679-65-8
N-(3-acetylphenyl)-1-propane-sulfonamide

Conditions

Conditions	Yield
With pyridine In dichloromethane at 20℃; for 20h;	100%

: 10147-36-1
n-propanesulfonyl chloride

: 51304-58-6
4-cyano-4-phenylpiperidine hydrochloride

: 852029-75-5
4-phenyl-1-(propylsulfonyl)piperidine-4-carbonitrile

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In dichloromethane at 0℃; for 2h;	100%

: 10147-36-1
n-propanesulfonyl chloride

: 57260-71-6
1-t-Butoxycarbonylpiperazine

: 913952-86-0
tert-butyl 4-(propylsulfonyl)piperazine-1-carboxylate

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 25℃; for 3h; Inert atmosphere;	100%
With triethylamine In dichloromethane at 0 - 20℃;	90%
With triethylamine In dichloromethane
With triethylamine In tert-butyl methyl ether at 20℃; for 2h;	13.5 g

: 10147-36-1
n-propanesulfonyl chloride

: 119-32-4
4-Methyl-3-nitroanilin

: 1269421-29-5
N-(4-methyl-3-nitrophenyl)-N-(propylsulfonyl)propane-1-sulfonamide

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 0 - 20℃; for 2h;	100%
With triethylamine In dichloromethane at 0 - 20℃;	100%

: 10147-36-1
n-propanesulfonyl chloride

: 14282-58-7
3,4-dihydroxy-2,5-dicarboxylic acid thiophene

: 3,4-bis(propanesulfonyloxy)thiophene

Conditions

Conditions	Yield
Stage #1: 3,4-dihydroxy-2,5-dicarboxylic acid thiophene With pyridine at 5 - 25℃; for 1h; Inert atmosphere; Stage #2: n-propanesulfonyl chloride With triethylamine at 7 - 25℃; for 18h; Inert atmosphere;	100%

: 10147-36-1
n-propanesulfonyl chloride

: 94838-55-8
tert-butyl (4-aminobenzyl)carbamate

: 401573-20-4
tert-butyl N-[(4-propylsulfonylamino)benzyl]carbamate

Conditions

Conditions	Yield
With pyridine at 20℃; for 16h;	99%
With pyridine In dichloromethane at 20℃;

: 4-(3-aminophenyl)-N-benzyl-trans-3,4-dimethylpiperidine

: 10147-36-1
n-propanesulfonyl chloride

: (+/-)-N-benzyl-trans-3,4-dimethyl-4-(3-propanesulfonylaminophenyl)piperidine

Conditions

Conditions	Yield
In pyridine	99%

: 921627-90-9
N-cyclohexyl-1-(2,4-dichlorophenyl)-5-(4-hydroxyphenyl)-4-methyl-1H-pyrazole-3-carboxamide

: 10147-36-1
n-propanesulfonyl chloride

: 4-[3-[(cyclohexylamino)carbonyl]-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazol-5-yl]phenyl propane-1-sulfonate

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 0 - 20℃;	99%

: 10147-36-1
n-propanesulfonyl chloride

: 121-71-1
3-Hydroxyacetophenone

: 937079-67-9
3-acetylphenyl propane-1-sulfonate

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 0 - 20℃; for 5h;	99%

: 10147-36-1
n-propanesulfonyl chloride

: N-(5-amino-2-methylphenyl)-5-methylisoxazole-4-carboxamide

: 5-methylisoxazole-4-carboxylic acid [2-methyl-5-(propane-1-sulfonylamino)phenyl]amide

Conditions

Conditions	Yield
In dichloromethane at 20℃;	99%
With pyridine In dichloromethane at 20℃;	47%

: 4395-98-6
4-cyanopiperidine

: 10147-36-1
n-propanesulfonyl chloride

: N-1-propanesulfonyl-4-cyanopiperidine

Conditions

Conditions	Yield
With dmap; triethylamine In dichloromethane at 0 - 20℃; for 2.5h;	99%

: 10147-36-1
n-propanesulfonyl chloride

: 59557-91-4
4-bromo-2-methoxyaniline

: N- (4-bromo-2-methoxyphenyl)propane-1-sulfonamide

Conditions

Conditions	Yield
With pyridine In dichloromethane at 20℃; for 16h; Inert atmosphere;	99%
With pyridine In dichloromethane at 20℃; for 16h; Inert atmosphere;	99%

: 863639-54-7
1-(2,4-dichlorophenyl)-5-(4-hydroxyphenyl)-1H-pyrazole-3-carboxylic acid ethyl ester

: 10147-36-1
n-propanesulfonyl chloride

: 863639-55-8
1-(2,4-dichlorophenyl)-5-[4-(propane-1-sulfonyloxy)-phenyl]-1H-pyrazole-3-carboxylic acid ethyl ester

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 0℃; for 1h;	98%
With triethylamine In dichloromethane at 0℃; for 1h;	98%

: 10147-36-1
n-propanesulfonyl chloride

: (R)-(6-(4-chlorophenyl)-8-methoxy-1-methyl-4H-benzo[f][1,2,4]-triazolo[4,3-a][1,4]diazepin-4-yl)methanol

: (R)-(6-(4-chlorophenyl)-8-methoxy-1-methyl-4H-benzo[f][1,2,4]triazolo[4,3-a][1,4]diazepin-4-yl)methyl propane-1-sulfonate

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 0 - 20℃; for 3h;	98%

: 211693-73-1
2-amino-3,4-difluoronitro-benzene

: 10147-36-1
n-propanesulfonyl chloride

: N-(2,3-difluoro-6-nitrophenyl)-N-(propylsulfonyl)propane-1-sulfonamide

Conditions

Conditions	Yield
Stage #1: 2-amino-3,4-difluoronitro-benzene With sodium hydride In tetrahydrofuran; mineral oil at 20℃; for 0.5h; Stage #2: n-propanesulfonyl chloride In tetrahydrofuran; mineral oil at 20℃;	98%

: 10147-36-1
n-propanesulfonyl chloride

: 39165-62-3
sodium propane-1-sulfinate

Conditions

Conditions	Yield
With sodium carbonate; sodium sulfite In water for 1h; Reflux;	97%
With sodium hydrogencarbonate; sodium sulfite In water at 80℃; for 4h;	87%
With sodium carbonate; sodium sulfite In water at 80℃; for 1h;
With sodium hydrogencarbonate; sodium sulfite In water at 80℃; for 4h;

: 10147-36-1
n-propanesulfonyl chloride

: 212195-36-3
(4S,5S)-4-(biphenyl-4-yl)-2,2-dimethyl-1,3-dioxan-5-amine

: 518358-60-6
N-[(4S,5S)-4-(biphenyl-4-yl)-2,2-dimethyl-1,3-dioxan-5-yl]propane-1-sulfonamide

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 20℃;	97%
With triethylamine In dichloromethane for 2h; 0 deg C to r.t.;

: 10147-36-1
n-propanesulfonyl chloride

: 1268830-74-5
methyl 2-chloro-3-amino-6-fluorobenzoate

: 1268830-75-6
methyl 2-chloro-6-fluoro-3-(propylsulfonamido)benzoate

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 0 - 20℃; for 3.33333h;	97%
With triethylamine In dichloromethane at 20℃; for 2h;	97%
Stage #1: methyl 3-amino-2-chloro-6-fluorobenzoate With triethylamine In dichloromethane at 0℃; for 1.33333h; Stage #2: n-propanesulfonyl chloride In dichloromethane at 20℃; for 2h;	97%

: 10147-36-1
n-propanesulfonyl chloride

: tert-butyl N-(1-amino-3-bicyclo[1.1.1]pentanyl)carbamate

: tert-butyl (3-(propylsulfonamido)bicyclo[1.1.1]pentan-1-yl)carbamate

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 0 - 20℃; for 3h;	97%

: 1000590-77-1
2,4-dichloro-3-iodoaniline

: 10147-36-1
n-propanesulfonyl chloride

: N-(2,4-dichloro-3-iodophenyl)propane-1-sulfonamide

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 0 - 20℃; for 1h;	97%

: 10147-36-1
n-propanesulfonyl chloride

: 1239589-52-6
(6-aminospiro[3.3]hept-2-yl)carbamic acid tert-butyl ester

: C15H28N2O4S

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 0 - 20℃; Inert atmosphere;	97%

: 10147-36-1
n-propanesulfonyl chloride

: 131581-40-3
1,1-difluoro-2-(2-naphthyl)ethene

: (E)-2-[2-fluoro-2-(propylsulfonyl)vinyl]naphthalene

Conditions

Conditions	Yield
Stage #1: n-propanesulfonyl chloride With sodium hydrogencarbonate; sodium sulfite In water at 80℃; for 12h; Inert atmosphere; Stage #2: 1,1-difluoro-2-(2-naphthyl)ethene In dimethyl sulfoxide at 40℃; for 48h; Inert atmosphere;	97%

: 10147-36-1
n-propanesulfonyl chloride

: 100-46-9
benzylamine

: 207574-06-9
N-benzylpropane-1-sulfonamide

Conditions

Conditions	Yield
In ethyl acetate at 0 - 20℃; for 1h;	96%
In tetrahydrofuran at 0 - 20℃;	89%
With triethylamine In acetonitrile at 0 - 20℃; Yield given;

: 617-89-0
furan-2-ylmethanamine

: 10147-36-1
n-propanesulfonyl chloride

: N-(2-furylmethyl)-1-propanesulfonylamide

Conditions

Conditions	Yield
With dmap; triethylamine In tetrahydrofuran a) 0 deg C, 3 h, b) RT, 12 h;	96%

: 10147-36-1
n-propanesulfonyl chloride

: 39478-78-9
5-bromo-2-methylaniline

: N-(5-bromo-2-methylphenyl)propane-1-sulfonamide

Conditions

Conditions	Yield
With pyridine; dmap In dichloromethane at 20℃; for 16h;	96%
With pyridine; dmap In dichloromethane at 20℃; for 40h; Inert atmosphere;	96%

: 10147-36-1
n-propanesulfonyl chloride

: (S)-7-(2-hydroxy-ethoxy)-8,8-dimethyl-7,8-dihydro-6H-pyrano[3,2-g]chromen-2-one

: propane-1-sulfonic acid (S)-2-(2,2-dimethyl-8-oxo-3,4-dihydro-2H,8H-pyrano[3,2-g]chromen-3-yloxy)ethyl ester

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 20℃; for 3h;	96%

: 10147-36-1
n-propanesulfonyl chloride

: (1s,3s)-N1-methyl-N1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)cyclobutane-1,3-diamine phosphoric acid

: N-((1S,3S)-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)cyclobutyl)propane-1-sulfonamide

Conditions

Conditions	Yield
With sodium hydroxide In 2-methyltetrahydrofuran; water at 10 - 20℃; pH=2;	96%

1-Propanesulfonyl chloride Chemical Properties

IUPAC Name: Propane-1-sulfonyl chloride
Systematic of 1-Propanesulfonyl chloride (CAS NO.10147-36-1): EINECS 233-414-7 ; Propanesulphonyl chloride
CAS NO: 10147-36-1
Molecular Formula of 1-Propanesulfonyl chloride (CAS NO.10147-36-1): C₃H₇ClO₂S
Molecular Weight: 142.6045
Molecular Structure:

H bond acceptors: 2
Freely Rotating Bonds: 2
Polar Surface Area: 42.52 Å²
Index of Refraction: 1.448
Molar Refractivity: 29.58 cm³
Molar Volume: 110.4 cm³
Surface Tension: 37.3 dyne/cm
Density of 1-Propanesulfonyl chloride (CAS NO.10147-36-1): 1.29 g/cm³
Flash Point: 64.9 °C
Enthalpy of Vaporization: 41.13 kJ/mol
Boiling Point: 192.6 °C at 760 mmHg
Vapour Pressure: 0.675 mmHg at 25°C

1-Propanesulfonyl chloride Safety Profile

Hazard Codes: Corrosive C
Risk Statements: 14-34-36
R14: Reacts violently with water.
R34: Causes burns.
R36: Irritating to eyes.
Safety Statements: 26-36/37/39-45
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36/37/39: Wear suitable protective clothing, gloves and eye/face protection.
S45: In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
RIDADR: UN 3265 8/PG 2
WGK Germany: 3
F: 10-19-21
HazardClass: 8
PackingGroup: III

Product Name

1-Propanesulfonyl chloride

Synthetic route

1-Propanesulfonyl chloride Chemical Properties

1-Propanesulfonyl chloride Safety Profile

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