1H-1,2,3-Triazole-1-ethanol supplier

Name
1H-1,2,3 TRIAZOLE-1-ETHANOL
EINECS
CAS No. 74731-63-8
Article Data5
CAS DataBase
Density 1.322 g/cm³
Solubility
Melting Point
Formula C₄H₇N₃O
Boiling Point 270.981 °C at 760 mmHg
Molecular Weight 113.119
Flash Point 117.685 °C
Transport Information
Appearance
Safety
Risk Codes
Molecular Structure
Hazard Symbols
Synonyms 2-(1,2,3-Triazol-1-yl)ethanol;2-(1H-1,2,3-Triazol-1-yl)ethanol;
PSA 50.94000
LogP -0.72960

Synthetic route

: 1517-05-1
2-azidoethanol

: 74-86-2
acetylene

: 74731-63-8
2-(1,2,3-triazol-1-yl)-ethan-1-ol

Conditions

Conditions	Yield
at 110 - 120℃; under 9120 - 10640 Torr;	95%

: 74731-49-0
1-(β-hydroxyethyl)-1,2,3-triazole-4-carboxylic acid

: 74731-63-8
2-(1,2,3-triazol-1-yl)-ethan-1-ol

Conditions

Conditions	Yield
under 5 - 10 Torr; Heating;	64.2%

: 288-36-8
1,2,3-triazole

: 141072-57-3
1-bromoethanol

: 74731-63-8
2-(1,2,3-triazol-1-yl)-ethan-1-ol

Conditions

Conditions	Yield
In ethanol

: 74731-63-8
2-(1,2,3-triazol-1-yl)-ethan-1-ol

: 193002-25-4
7-hydroxy-6-methoxy-3-pivaloyloxymethyl-3,4-dihydroquinazolin-4-one

: 220896-22-0
6-methoxy-3-((pivaloyloxy)methyl)-7-(2-(1,2,3-triazol-1-yl)ethoxy)-3,4-dihydroquinazolin-4-one

Conditions

Conditions	Yield
With triphenylphosphine; diethylazodicarboxylate In dichloromethane at 20℃; for 2h;	97%
With triphenylphosphine; diethylazodicarboxylate In dichloromethane at 20℃; for 1h; Etherification;

: 74731-63-8
2-(1,2,3-triazol-1-yl)-ethan-1-ol

: 193002-25-4
7-hydroxy-6-methoxy-3-pivaloyloxymethyl-3,4-dihydroquinazolin-4-one

: 1972-28-7
diethylazodicarboxylate

: 220896-22-0
6-methoxy-3-((pivaloyloxy)methyl)-7-(2-(1,2,3-triazol-1-yl)ethoxy)-3,4-dihydroquinazolin-4-one

Conditions

Conditions	Yield
With triphenylphosphine In dichloromethane	97%

...Expand

: 4548-45-2
2-chloro-5-nitropyridine

: 74731-63-8
2-(1,2,3-triazol-1-yl)-ethan-1-ol

: 2-(2-(1H-1,2,3-triazol-1-yl)ethoxy)-5-nitropyridine

Conditions

Conditions	Yield
Stage #1: 2-chloro-5-nitropyridine With sodium hydride In tetrahydrofuran at 0℃; for 0.166667h; Stage #2: 2-(1,2,3-triazol-1-yl)-ethan-1-ol In tetrahydrofuran at 0℃; for 2h;	90%

: 74731-63-8
2-(1,2,3-triazol-1-yl)-ethan-1-ol

: 98-59-9
p-toluenesulfonyl chloride

: 263400-92-6
2-(1H-1,2,3-triazol-1-yl)ethyl 4-methyl-1-benzenesulfonate

Conditions

Conditions	Yield
With dmap; triethylamine In dichloromethane at -10 - -4℃;	86%
With dmap; triethylamine In dichloromethane at -4℃;	86%
With dmap; triethylamine In dichloromethane at -10 - -4℃;	86%
Stage #1: 2-(1,2,3-triazol-1-yl)-ethan-1-ol; p-toluenesulfonyl chloride With dmap; triethylamine In dichloromethane; water at -10 - -4℃; for 0.166667h; Stage #2: With hydrogenchloride In dichloromethane; water Stage #3: With sodium hydrogencarbonate In dichloromethane; water	86%
With triethylamine; dmap In dichloromethane at -10 - -4℃;	86%

: 58013-41-5
allyl-(4-chloromethyl-2-methyl-phenyl)-ether

: 74731-63-8
2-(1,2,3-triazol-1-yl)-ethan-1-ol

: 865350-63-6
1-[2-(4-allyloxy-2-methyl-benzyloxy)-ethyl]-1H-[1,2,3]triazole

Conditions

Conditions	Yield
With sodium hydride In DMF (N,N-dimethyl-formamide) at 20℃; for 5h;	86%

: 74731-63-8
2-(1,2,3-triazol-1-yl)-ethan-1-ol

: 107-13-1
acrylonitrile

A: 2-(4'-cyano-2'-oxa-1'-butyl)-1,2,3-triazole

B: 84440-24-4
2-(5'-cyano-3'-oxa-1-pentyl)-1,2,3-triazole

Conditions

Conditions	Yield
With potassium hydroxide In water at 25 - 35℃; for 7h;	A 25% B 78%

...Expand

: 32078-38-9
4-allyloxybenzyl chloride

: 74731-63-8
2-(1,2,3-triazol-1-yl)-ethan-1-ol

: 864156-90-1
1-[2-(4-allyloxy-benzyloxy)-ethyl]-1H-[1,2,3]-triazole

Conditions

Conditions	Yield
With sodium hydride In DMF (N,N-dimethyl-formamide) at -50 - 20℃;	78%
With sodium hydride In DMF (N,N-dimethyl-formamide) at -50 - 20℃;	78%
With sodium hydride In N,N-dimethyl-formamide at -50 - 20℃;	78%
With sodium hydride In N,N-dimethyl-formamide at -50 - 20℃;	78%
With sodium hydride In N,N-dimethyl-formamide at -50 - 20℃;	78%

: 74731-63-8
2-(1,2,3-triazol-1-yl)-ethan-1-ol

A: 41917-22-0
N-vinyl-1,2,3-triazole

B: 59282-97-2
1-(3-oxa-4-pentenyl)-1,2,3-triazole

Conditions

Conditions	Yield
With potassium hydroxide; acetylene In 1,4-dioxane at 175 - 180℃; under 7600 - 9120 Torr; for 1.5h;	A 5.5% B 33.5%

: 74731-63-8
2-(1,2,3-triazol-1-yl)-ethan-1-ol

: 74-86-2
acetylene

A: 41917-22-0
N-vinyl-1,2,3-triazole

B: 59282-97-2
1-(3-oxa-4-pentenyl)-1,2,3-triazole

Conditions

Conditions	Yield
With potassium hydroxide In 1,4-dioxane at 175 - 180℃; under 7600 - 9120 Torr; for 1.5h;	A 5.5% B 33.5%

...Expand

: 352205-91-5
4-chloro-6-cyano-7-hydroxyquinoline

: 74731-63-8
2-(1,2,3-triazol-1-yl)-ethan-1-ol

: 1972-28-7
diethylazodicarboxylate

: 398487-34-8
4-chloro-6-cyano-7-(2-(1,2,3-triazol-1-yl)ethoxy)quinoline

Conditions

Conditions	Yield
With triphenylphosphine In dichloromethane	32%

...Expand

: 3145-86-6
4-nitrobenzyl iodide

: 74731-63-8
2-(1,2,3-triazol-1-yl)-ethan-1-ol

: 791629-24-8
1-[2-(4-nitro-benzyloxy)-ethyl]-1H-[1,2,3]triazole

Conditions

Conditions	Yield
Stage #1: 2-(1,2,3-triazol-1-yl)-ethan-1-ol With sodium hydride In tetrahydrofuran at -50℃; for 0.75h; Stage #2: 4-nitrobenzyl iodide In tetrahydrofuran for 2h; Heating / reflux;	27%

: 111-34-2
-butyl vinyl ether

: 74731-63-8
2-(1,2,3-triazol-1-yl)-ethan-1-ol

: 59282-97-2
1-(3-oxa-4-pentenyl)-1,2,3-triazole

Conditions

Conditions	Yield
With mercury(II) diacetate at 95 - 100℃; for 2h;	6.35%

: 74731-63-8
2-(1,2,3-triazol-1-yl)-ethan-1-ol

: 196603-96-0
4-(4-bromo-2-fluorophenylamino)-7-hydroxy-6-methoxyquinazoline

: N-(4-bromo-2-fluorophenyl)-6-methoxy-7-[2-(1H-1,2,3-triazol-1-yl)ethoxy]quinazoline-4-amine

Conditions

Conditions	Yield
With triphenylphosphine; diethylazodicarboxylate In dichloromethane at 20℃; for 2h; Etherification;

: 74731-63-8
2-(1,2,3-triazol-1-yl)-ethan-1-ol

: 193001-59-1
4-(4-chloro-2-fluorophenylamino)-7-hydroxy-6-methoxyquinazoline

: (4-chloro-2-fluoro-phenyl)-[6-methoxy-7-(2-[1,2,3]triazol-1-yl-ethoxy)-quinazolin-4-yl]-amine

Conditions

Conditions	Yield
With triphenylphosphine; diethylazodicarboxylate In dichloromethane at 20℃; for 3h; Etherification;

: 74731-63-8
2-(1,2,3-triazol-1-yl)-ethan-1-ol

: 257938-40-2
N-(4-bromo-2,6-difluorophenyl)-7-hydroxy-6-methoxy-4-quinazolinylamine

: (4-bromo-2,6-difluoro-phenyl)-[6-methoxy-7-(2-[1,2,3]triazol-1-yl-ethoxy)-quinazolin-4-yl]-amine

Conditions

Conditions	Yield
With triphenylphosphine; diethylazodicarboxylate In dichloromethane at 20℃; for 2h; Etherification;

: 658085-52-0
5-(6-(azidocarbonyl)-5-isopropylpyrrolo[2,1-f][1,2,4]triazin-4-ylamino)-2,4-difluoro-N-methoxybenzamide

: 74731-63-8
2-(1,2,3-triazol-1-yl)-ethan-1-ol

: [4-(2,4-difluoro-5-methoxycarbamoyl-phenylamino)-5-isopropyl-pyrrolo[2,1-f][1,2,4]triazin-6-yl]-carbamic acid 2-[1,2,3]triazol-1-yl-ethyl ester

Conditions

Conditions	Yield
In N,N-dimethyl-formamide at 85℃; for 2h; Curtius rearrangement;

: 580-16-5
6-hydroxyquinoline

: 74731-63-8
2-(1,2,3-triazol-1-yl)-ethan-1-ol

: 476660-01-2
6-[2-(1H-1,2,3-triazol-1-yl)ethoxy]quinoline

Conditions

Conditions	Yield
With triphenylphosphine; diethylazodicarboxylate In tetrahydrofuran

: 865350-66-9
1-allyloxy-3-fluoro-4-chloromethyl-benzene

: 74731-63-8
2-(1,2,3-triazol-1-yl)-ethan-1-ol

: 865350-67-0
1-[2-(4-allyloxy-2-fluoro-benzyloxy)-ethyl]-1H-[1,2,3]triazole

Conditions

Conditions	Yield
With sodium hydride In DMF (N,N-dimethyl-formamide) at -50 - 20℃;

: C33H46N8O7PPol

: 74731-63-8
2-(1,2,3-triazol-1-yl)-ethan-1-ol

: C31H38N10O8PPol

Conditions

Conditions	Yield
With benzotriazol-1-ol In N,N-dimethyl-formamide; acetonitrile at 20℃; for 65h; polystyrene resin;

1H-1,2,3-Triazole-1-ethanol Specification

The CAS register number of 1H-1,2,3-Triazole-1-ethanol is 74731-63-8. It also can be called as 2-(1,2,3-Triazol-1-yl)ethanol and the systematic name about this chemical is 2-(1H-1,2,3-triazol-1-yl)ethanol. The molecular formula about this chemical is C₄H₇N₃O and the molecular weight is 113.12.

Physical properties about 1H-1,2,3-Triazole-1-ethanol are: (1)ACD/LogP: -0.48; (2)#H bond acceptors: 4; (3)#H bond donors: 1; (4)#Freely Rotating Bonds: 3; (5)Polar Surface Area: 50.94 Å²; (6)Index of Refraction: 1.602; (7)Molar Refractivity: 29.342 cm³; (8)Molar Volume: 85.553 cm³; (9)Polarizability: 11.632x10^-24cm³; (10)Surface Tension: 55.293 dyne/cm; (11)Density: 1.322 g/cm³; (12)Flash Point: 117.685 °C; (13)Enthalpy of Vaporization: 53.789 kJ/mol; (14)Boiling Point: 270.981 °C at 760 mmHg; (15)Vapour Pressure: 0.003 mmHg at 25 °C.

You can still convert the following datas into molecular structure:
(1)SMILES: OCCn1nncc1
(2)InChI: InChI=1/C4H7N3O/c8-4-3-7-2-1-5-6-7/h1-2,8H,3-4H2
(3)InChIKey: PKHVUMMJMYKRNO-UHFFFAOYAP
(4)Std. InChI: InChI=1S/C4H7N3O/c8-4-3-7-2-1-5-6-7/h1-2,8H,3-4H2
(5)Std. InChIKey: PKHVUMMJMYKRNO-UHFFFAOYSA-N

Product Name

1H-1,2,3 TRIAZOLE-1-ETHANOL

Synthetic route

1H-1,2,3-Triazole-1-ethanol Specification

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