2,2'-Bis(trifluoromethyl)benzidine supplier

Name
2,2'-Bis(trifluoromethyl)benzidine
EINECS 671-105-2
CAS No. 341-58-2
Article Data20
CAS DataBase
Density 1.415 g/cm³
Solubility
Melting Point 183 °C
Formula C₁₄H₁₀F₆N₂
Boiling Point 376.9 °C at 760 mmHg
Molecular Weight 320.237
Flash Point 171.4 °C
Transport Information UN 2811
Appearance white crystalline powder
Safety 22-36/37/39-45
Risk Codes 22-45-50/53
Molecular Structure
Hazard Symbols T, Xi
Synonyms m-Tolidine,a,a,a,a',a',a'-hexafluoro- (6CI,8CI);2,2'-Bis(trifluoromethyl)-4,4'-diaminobiphenyl;4,4'-Diamino-2,2'-bis(trifluoromethyl)biphenyl;TFMB;[1,1'-Biphenyl]-4,4'-diamine,2,2'-bis(trifluoromethyl)-;
PSA 52.04000
LogP 5.71800

Synthetic route

: 641-98-5
2,2'-bis-(trifluoromethyl)-4,4'-dinitro-1,1'-biphenyl

: 341-58-2
2,2'-bis(trifluoromethyl)benzidine

Conditions

Conditions	Yield
With ammonium formate; zinc In methanol at 50℃; Temperature; Concentration;	96.83%
With palladium 10% on activated carbon; hydrogen In ethanol at 80℃; under 15001.5 Torr; Catalytic behavior; Pressure; Temperature;	92%
With hydrogenchloride; tin
With hydrogen; palladium on activated charcoal In toluene at 60℃; under 7500.75 Torr; for 6h; Autoclave;

: 351-19-9
1,2-bis(3-(trifluoromethyl)phenyl)hydrazine

: 341-58-2
2,2'-bis(trifluoromethyl)benzidine

Conditions

Conditions	Yield
With sulfuric acid In water; toluene for 5h; Product distribution / selectivity;	95.1%
With hydrogenchloride In water; toluene at 25℃; for 3h; Product distribution / selectivity;	95%
With sulfuric acid In water at -5 - 75℃; under 2280.15 - 3800.26 Torr; for 2h; Temperature; Inert atmosphere;	60%

: 588-00-1
1,2-bis((3-trifluoromethyl)phenyl)diazene

A: 341-58-2
2,2'-bis(trifluoromethyl)benzidine

B: 440-66-4
4,2'-bis-trifluoromethyl-biphenyl-2,4'-diyldiamine

Conditions

Conditions	Yield
With sodium amalgam; ethanol; sulfuric acid

: 98-46-4
3-trifluoromethylnitrobenzene

: 341-58-2
2,2'-bis(trifluoromethyl)benzidine

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: lead; sodium acetate; aqueous ethanol 2: sodium-amalgam; aqueous ethanol; H2SO4 View Scheme

: 344-62-7
N-[2-(trifluoromethyl)phenyl]acetamide

: 341-58-2
2,2'-bis(trifluoromethyl)benzidine

Conditions

Conditions	Yield
Multi-step reaction with 5 steps 1: H2SO4; HNO3 2: aq.-ethanolic NaOH 3: acetic acid; sulfuric acid; aqueous sodium nitrite solution; aqueous potassium iodide solution 4: copper-powder / 300 °C 5: tin; aq.-ethanolic HCl View Scheme

: 121-01-7
4-nitro-2-trifluoromethyl-aniline

: 341-58-2
2,2'-bis(trifluoromethyl)benzidine

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: acetic acid; sulfuric acid; aqueous sodium nitrite solution; aqueous potassium iodide solution 2: copper-powder / 300 °C 3: tin; aq.-ethanolic HCl View Scheme

: 395-68-6
N-(4-nitro-2-(trifluoromethyl)phenyl)acetamide

: 341-58-2
2,2'-bis(trifluoromethyl)benzidine

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1: aq.-ethanolic NaOH 2: acetic acid; sulfuric acid; aqueous sodium nitrite solution; aqueous potassium iodide solution 3: copper-powder / 300 °C 4: tin; aq.-ethanolic HCl View Scheme

: 400-75-9
1-iodo-4-nitro-2-(trifluoromethyl)benzene

: 341-58-2
2,2'-bis(trifluoromethyl)benzidine

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: copper-powder / 300 °C 2: tin; aq.-ethanolic HCl View Scheme

3,3'-bis (trifluoromethyl)-4,4'-hydrazobenzene: 3,3'-bis (trifluoromethyl)-4,4'-hydrazobenzene

: 98-46-4
3-trifluoromethylnitrobenzene

: 7440-66-6
zinc

: 341-58-2
2,2'-bis(trifluoromethyl)benzidine

Conditions

Conditions	Yield
With sodium hydroxide; sulfuric acid; ammonium chloride; ammonia In methanol; acetone; toluene

...Expand

: C22H18F6N2O6

: 341-58-2
2,2'-bis(trifluoromethyl)benzidine

Conditions

Conditions	Yield
With water; sodium hydroxide In dichloromethane for 4h; Solvent; Reflux;	115 g

: C24H22F6N2O6

: 341-58-2
2,2'-bis(trifluoromethyl)benzidine

Conditions

Conditions	Yield
With water; sodium hydroxide In dichloromethane for 4h; Reflux;	126.5 g

: C26H26F6N2O6

: 341-58-2
2,2'-bis(trifluoromethyl)benzidine

Conditions

Conditions	Yield
With water; sodium hydroxide In dichloromethane for 4h; Reflux;	120.7 g

: C22H14F6N2O6

: 341-58-2
2,2'-bis(trifluoromethyl)benzidine

Conditions

Conditions	Yield
With water; sodium hydroxide In dichloromethane for 4h; Reflux;	119.5 g

: C30H18F6N2O6

: 341-58-2
2,2'-bis(trifluoromethyl)benzidine

Conditions

Conditions	Yield
With water; sodium hydroxide In dichloromethane for 4h; Reflux;	81.8 g

: 320-51-4
4-chloro-3-trifluoromethyl-aniline

: 341-58-2
2,2'-bis(trifluoromethyl)benzidine

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1.1: dichloromethane / 0 - 20 °C 2.1: sodium hydroxide / dichloromethane / 0.5 h / 20 °C 2.2: 5 h / 65 °C 3.1: water; sodium hydroxide / dichloromethane / 4 h / Reflux View Scheme

: 15761-39-4
1-(tert-butoxycarbonyl)-L-proline

: 341-58-2
2,2'-bis(trifluoromethyl)benzidine

: (2S,2'S)-di-tert-butyl 2,2'-(((2,2'-bis(trifluoromethyl)-[1,1'-biphenyl]-4,4'-diyl)bis(azanediyl))bis(carbonyl))bis(pyrrolidine-1-carboxylate)

Conditions

Conditions	Yield
With N-(3-dimethylaminopropyl)-N-ethylcarbodiimide In dichloromethane at 20℃; for 2h;	96%
With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃; for 2h;	96%

: 341-58-2
2,2'-bis(trifluoromethyl)benzidine

: 122-04-3
4-nitro-benzoyl chloride

: N,N'-(2,2'-bis(trifluoromethyl)-[1,1'-biphenyl]-4,4'-diyl)bis(4-nitrobenzamide)

Conditions

Conditions	Yield
With pyridine In tetrahydrofuran Cooling with ice;	95.7%
With pyridine In N,N-dimethyl acetamide at 80℃; for 3h;	65.4%

: 341-58-2
2,2'-bis(trifluoromethyl)benzidine

: 104-88-1
4-chlorobenzaldehyde

: (N4Z,N4'Z)-N4,N4'-bis(4-chlorobenzylidene)-2,2'-bis(trifluoromethyl)biphenyl-4,4'-diamine

Conditions

Conditions	Yield
In ethanol at 20℃; for 3h; Reflux;	94.15%

: 341-58-2
2,2'-bis(trifluoromethyl)benzidine

MeCOX: MeCOX

: 4,4'-Diacetylamino-2,2'-bis(trifluoromethyl)biphenyl

Conditions

Conditions	Yield
	94%

: 341-58-2
2,2'-bis(trifluoromethyl)benzidine

: 123-08-0
4-hydroxy-benzaldehyde

: 4,4'-(1Z,1'Z)-(2,2'-bis(trifluoromethyl)biphenyl-4,4'-diyl)bis(azan-1-yl-1-ylidene)bis(methan-1-yl-1-ylidene)diphenol

Conditions

Conditions	Yield
In ethanol at 20℃; for 3h; Reflux;	93.35%

: 118-45-6
4-chlorophthalic anhydride

: 341-58-2
2,2'-bis(trifluoromethyl)benzidine

: C30H12Cl2F6N2O4

Conditions

Conditions	Yield
With 4-hydroxymethyl-1,3-dioxolan-2-one at 180℃; for 14h;	91.8%

: 1121-60-4
pyridine-2-carbaldehyde

: 762-04-9, 123-22-8
Diethyl phosphonate

: 341-58-2
2,2'-bis(trifluoromethyl)benzidine

: tetraethyl (2,2'-bis(trifluoromethyl)biphenyl-4,4'-diyl)bis(azanediyl)bis(pyridin-2-ylmethylene)diphosphonate

Conditions

Conditions	Yield
With water at 45℃; for 0.5h; Sonication; Green chemistry;	91.76%

...Expand

: 762-04-9, 123-22-8
Diethyl phosphonate

: 341-58-2
2,2'-bis(trifluoromethyl)benzidine

: 459-57-4
4-fluorobenzaldehyde

: tetraethyl (2,2'-bis(trifluoromethyl)biphenyl-4,4'-diyl)bis(azanediyl)bis((4-fluorophenyl)methylene)diphosphonate

Conditions

Conditions	Yield
With water at 45℃; for 0.5h; Sonication; Green chemistry;	91.42%

...Expand

: 762-04-9, 123-22-8
Diethyl phosphonate

: 341-58-2
2,2'-bis(trifluoromethyl)benzidine

: 99-61-6
3-nitro-benzaldehyde

: tetraethyl (2,2'-bis(trifluoromethyl)biphenyl-4,4'-diyl)bis(azanediyl)bis((3-nitrophenyl)methylene)diphosphonate

Conditions

Conditions	Yield
With water at 45℃; for 0.5h; Reagent/catalyst; Temperature; Time; Sonication; Green chemistry;	91.07%

...Expand

: 762-04-9, 123-22-8
Diethyl phosphonate

: 341-58-2
2,2'-bis(trifluoromethyl)benzidine

: 104-88-1
4-chlorobenzaldehyde

: tetraethyl (2,2'-bis(trifluoromethyl)biphenyl-4,4'-diyl)bis(azanediyl)bis((4-chlorophenyl)methylene)diphosphonate

Conditions

Conditions	Yield
With water at 45℃; for 0.5h; Sonication; Green chemistry;	90.46%

...Expand

: 762-04-9, 123-22-8
Diethyl phosphonate

: 341-58-2
2,2'-bis(trifluoromethyl)benzidine

: 4748-78-1
4-ethylbenzylaldehyde

: tetraethyl (2,2'-bis(trifluoromethyl)biphenyl-4,4'-diyl)bis(azanediyl)bis((4-ethylphenyl)methylene)diphosphonate

Conditions

Conditions	Yield
With water at 45℃; for 0.5h; Sonication; Green chemistry;	90.35%

...Expand

: 762-04-9, 123-22-8
Diethyl phosphonate

: 341-58-2
2,2'-bis(trifluoromethyl)benzidine

: 100-52-7
benzaldehyde

: tetraethyl (2,2'-bis(trifluoromethyl)biphenyl-4,4'-diyl)bis(azanediyl)bis(phenylmethylene)diphosphonate

Conditions

Conditions	Yield
With water at 45℃; for 0.5h; Sonication; Green chemistry;	89.91%

...Expand

: 762-04-9, 123-22-8
Diethyl phosphonate

: 341-58-2
2,2'-bis(trifluoromethyl)benzidine

: 100-10-7
4-dimethylamino-benzaldehyde

: tetraethyl (2,2'-bis(trifluoromethyl)biphenyl-4,4'-diyl)bis(azanediyl)bis((4-(dimethylamino)phenyl)methylene)diphosphonate

Conditions

Conditions	Yield
With water at 45℃; for 0.5h; Sonication; Green chemistry;	89.17%

...Expand

: 762-04-9, 123-22-8
Diethyl phosphonate

: 341-58-2
2,2'-bis(trifluoromethyl)benzidine

: 123-08-0
4-hydroxy-benzaldehyde

: tetraethyl (2,2'-bis(trifluoromethyl)biphenyl-4,4'-diyl)bis(azanediyl)bis((4-hydroxyphenyl)methylene)diphosphonate

Conditions

Conditions	Yield
With water at 45℃; for 0.5h; Sonication; Green chemistry;	88.23%

...Expand

: 98-03-3
thiophene-2-carbaldehyde

: 762-04-9, 123-22-8
Diethyl phosphonate

: 341-58-2
2,2'-bis(trifluoromethyl)benzidine

: tetraethyl (2,2'-bis(trifluoromethyl)biphenyl-4,4'-diyl)bis(azanediyl)bis(thiophen-2-ylmethylene)diphosphonate

Conditions

Conditions	Yield
With water at 45℃; for 0.5h; Sonication; Green chemistry;	87.79%

...Expand

: 762-04-9, 123-22-8
Diethyl phosphonate

: 341-58-2
2,2'-bis(trifluoromethyl)benzidine

: 123-11-5
4-methoxy-benzaldehyde

: tetraethyl (2,2'-bis(trifluoromethyl)biphenyl-4,4'-diyl)bis(azanediyl)bis((4-methoxyphenyl)methylene)diphosphonate

Conditions

Conditions	Yield
With water at 45℃; for 0.5h; Sonication; Green chemistry;	86.68%

...Expand

: 341-58-2
2,2'-bis(trifluoromethyl)benzidine

: 4,4'-Dibromo-2,2'-bis(trifluoromethyl)biphenyl

Conditions

Conditions	Yield
Stage #1: 2,2'-bis(trifluoromethyl)benzidine With sulfuric acid; sodium nitrite In water at 2 - 65℃; for 1h; Stage #2: With hydrogen bromide; copper(I) bromide at 45℃; Reagent/catalyst;	86%
With tert.-butylnitrite; copper(ll) bromide	60%

: 5466-84-2
4-nitrophthalic anhydride

: 341-58-2
2,2'-bis(trifluoromethyl)benzidine

: C30H12F6N4O8

Conditions

Conditions	Yield
With propionic acid at 150℃; for 10h;	80%

: 341-58-2
2,2'-bis(trifluoromethyl)benzidine

: C19H8F6O7

: C52H18F18N2O10

Conditions

Conditions	Yield
Stage #1: 2,2'-bis(trifluoromethyl)benzidine; C19H8F6O7 In 1-methyl-pyrrolidin-2-one at 90℃; for 1h; Stage #2: With pyridine; acetic anhydride In 1-methyl-pyrrolidin-2-one at 90℃; for 2h; Temperature;	80%

: 341-58-2
2,2'-bis(trifluoromethyl)benzidine

: 89803-70-3
2,2'-bis(trifluoromethyl)-4,4'-diiodobiphenyl

Conditions

Conditions	Yield
Stage #1: 2,2'-bis(trifluoromethyl)benzidine With sulfuric acid; sodium nitrite In water; acetic acid at 5℃; for 1h; Stage #2: With potassium iodide In water for 3h;	78.4%
Stage #1: 2,2'-bis(trifluoromethyl)benzidine With hydrogenchloride; sodium nitrite In water at 0 - 5℃; Stage #2: With iodine; sodium iodide In dichloromethane; water at 5 - 20℃;	75%
With sodium iodide; sulfuric acid; iodine; sodium hydrogensulfite; sodium nitrite In dichloromethane; water	13.3 grams (78%)
Stage #1: 2,2'-bis(trifluoromethyl)benzidine With sulfuric acid; sodium nitrite Stage #2: With iodine; sodium iodide Further stages.;

: 341-58-2
2,2'-bis(trifluoromethyl)benzidine

: 35675-46-8
3-methyl-4-nitro-benzoyl chloride

: C30H20F6N4O6

Conditions

Conditions	Yield
With pyridine In tetrahydrofuran at 20℃; for 12h; Sealed tube; Cooling with ice;	76%

: 341-58-2
2,2'-bis(trifluoromethyl)benzidine

: 2,2′-bis(trifluoromethyl)-4,4′-dihydroxybiphenyl

Conditions

Conditions	Yield
With uranyl nitrate hydrate; water; trifluoroacetic acid for 96h; Irradiation; Inert atmosphere;	75%
Stage #1: 2,2'-bis(trifluoromethyl)benzidine With hydrogenchloride; sodium nitrite In water at -4℃; for 2h; Inert atmosphere; Stage #2: With phosphoric acid In water at 20℃; for 25h; Inert atmosphere; Reflux;	46.9%
Stage #1: 2,2'-bis(trifluoromethyl)benzidine With methanesulfonic acid In water Stage #2: With sodium nitrite In water at 10 - 20℃; for 12h; Stage #3: With sulfuric acid; water at 120℃;

: 341-58-2
2,2'-bis(trifluoromethyl)benzidine

: 3,3',5,5'-tetrabromo-2,2'-bis(trifluoromethyl)-[1,1'-biphenyl]-4,4'-diamine

Conditions

Conditions	Yield
With bromine In methanol at 20℃; for 14h; Reflux;	75%

: 341-58-2
2,2'-bis(trifluoromethyl)benzidine

: 7487-10-7
pyromellitic acid monoanhydride

: C34H10F6N2O10

Conditions

Conditions	Yield
Stage #1: 2,2'-bis(trifluoromethyl)benzidine; pyromellitic acid monoanhydride In 1-methyl-pyrrolidin-2-one; N,N-dimethyl acetamide at 90℃; for 1h; Stage #2: With pyridine; acetic anhydride In 1-methyl-pyrrolidin-2-one; N,N-dimethyl acetamide; toluene at 90℃;	72%
Stage #1: 2,2'-bis(trifluoromethyl)benzidine; pyromellitic acid monoanhydride In 1-methyl-pyrrolidin-2-one at 90℃; for 1h; Stage #2: With pyridine; acetic anhydride In 1-methyl-pyrrolidin-2-one at 90℃; for 2h;

: 27550-59-0
4-hydroxyphthalic anhydride

: 341-58-2
2,2'-bis(trifluoromethyl)benzidine

: C30H14F6N2O6

Conditions

Conditions	Yield
With propionic acid at 150℃; for 10h;	70%

: 341-58-2
2,2'-bis(trifluoromethyl)benzidine

: 552-30-7
trimellitic Anhydride

: 2,2'-bis(trifluoromethyl)-4,4'-bis(trimelletimide)biphenyl

Conditions

Conditions	Yield
With acetic acid Reflux;	56.1%

: 341-58-2
2,2'-bis(trifluoromethyl)benzidine

: 407-25-0
trifluoroacetic anhydride

: 4,4'-bis-(trifluoroacetamido)-2,2'-bis(trifluoromethyl)-5,5'-dinitrobiphenyl

Conditions

Conditions	Yield
With potassium nitrate at 5 - 10℃; for 72h;	51%

2,2'-Bis(trifluoromethyl)benzidine Chemical Properties

The Molecular Structure of 2,2'-Bis-(trifluormethyl) benzidine (CAS NO.341-58-2):

Molecular Formula: C₁₄H₁₀F₆N₂
Molecular Weight: 320.233019 g/mol
IUPAC: 4-[4-amino-2-(trifluoromethyl)phenyl]-3-(trifluoromethyl)aniline
Product Categories: Biphenyls (for High-Performance Polymer Research);Functional Materials;Reagent for High-Performance Polymer ResearchNominal Mass: 320 Da
Average Mass: 320.233 Da
Monoisotopic Mass: 320.074818 Da
Nominal Mass: 320 Da
Average Mass: 320.233 Da
Monoisotopic Mass: 320.074818 Da
Index of Refraction: 1.524
Molar Refractivity: 69.27 cm³
Molar Volume: 226.2 cm³
Surface Tension: 34 dyne/cm
Density: 1.415 g/cm³
Flash Point: 171.4 °C
Enthalpy of Vaporization: 62.46 kJ/mol
Boiling Point: 376.9 °C at 760 mmHg
Vapour Pressure: 7.02E-06 mmHg at 25°C

2,2'-Bis(trifluoromethyl)benzidine Safety Profile

Hazard Codes: Toxic T Irritant Xi
Risk Statements: 22-45-50/53
R22:Harmful if swallowed
R45:May cause cancer
R50/53:Very toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment
Safety Statements: 22-36/37/39-45
S22:Do not breathe dust
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
RIDADR: 2811
Hazard Note: Toxic
HazardClass: IRRITANT-HARMFUL

2,2'-Bis(trifluoromethyl)benzidine Specification

2,2'-Bis-(trifluormethyl) benzidine (CAS NO.341-58-2) is also called as 4,4'-diamino-2,2'-bis(trifluoromethyl)biphenyl ; 22Tfmb ; 2,2'-Di(trifluoromethyl)benzidine ; 2,2'-Bis(trifluoromethyl)-4,4'-diamino biphenyl ; 2,2'-Bis(trifluoromethyl)benzidine 97% .

Product Name

2,2'-Bis(trifluoromethyl)benzidine

Synthetic route

2,2'-Bis(trifluoromethyl)benzidine Chemical Properties

2,2'-Bis(trifluoromethyl)benzidine Safety Profile

2,2'-Bis(trifluoromethyl)benzidine Specification

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