2,3-Dimethoxybenzylamine supplier

Name
2,3-Dimethoxybenzylamine
EINECS 224-515-7
CAS No. 4393-09-3
Article Data9
CAS DataBase
Density 1.062 g/cm³
Solubility
Melting Point 229-230 °C(Solv: N,N-dimethylformamide (68-12-2))
Formula C₉H₁₃NO₂
Boiling Point 269.8 °C at 760 mmHg
Molecular Weight 167.208
Flash Point 113.5 °C
Transport Information
Appearance Colorless to light yellow liquid
Safety 26-37/39
Risk Codes 36/37/38
Molecular Structure
Hazard Symbols Xi
Synonyms (2,3-Dimethoxyphenyl)methanamine;2,3-Dimethoxybenzylamine;Benzylamine, 2,3-dimethoxy-;[(2,3-Dimethoxyphenyl)methyl]amine;o-Veratrylamine;
PSA 44.48000
LogP 1.86280

Synthetic route

: 5470-95-1
oxime of 2,3-dimethoxy-benzaldehyde

: 4393-09-3
2,3-dimethoxybenzyl amine

Conditions

Conditions	Yield
With sodium amalgam; acetic acid at 40 - 50℃;
With lithium aluminium tetrahydride

: 5653-62-3
2,3-dimethoxybenzonitrile

: 4393-09-3
2,3-dimethoxybenzyl amine

Conditions

Conditions	Yield
With sodium hydroxide; hydrogen; sodium chloride; platinum(IV) oxide 1.) ethanol, chloroform, 40 psi, 3 h; Yield given. Multistep reaction;

: 86-51-1
2,3-dimethyoxybenzaldehyde

: 4393-09-3
2,3-dimethoxybenzyl amine

Conditions

Conditions	Yield
Stage #1: 2,3-dimethyoxybenzaldehyde In trimethyl orthoformate at 25℃; Stage #2: With lithium borohydride In tetrahydrofuran at 65℃; for 5h; Stage #3: With trifluoroacetic acid In dichloromethane at 25℃; for 5h;

: C9H12NO2Pol

: 4393-09-3
2,3-dimethoxybenzyl amine

Conditions

Conditions	Yield
With trifluoroacetic acid In dichloromethane at 25℃; for 5h; ((9-(amino)xanthen-2-yl)oxy)butanoic acid handle, p-methylbenzhydrylamine resin (H2N-XAL-MBHA resin);

: C9H10NO2Pol

: 4393-09-3
2,3-dimethoxybenzyl amine

Conditions

Conditions	Yield
Stage #1: C9H10NO2Pol With lithium borohydride In tetrahydrofuran at 65℃; for 5h; Stage #2: With trifluoroacetic acid In dichloromethane at 25℃; for 5h;

: 69912-63-6
boc-β-methoxyalanine dicyclohexylamine

: 4393-09-3
2,3-dimethoxybenzyl amine

: tert-butyl (S)-(1-((2,3-dimethoxybenzyl)amino)-3-methoxy-1-oxopropan-2-yl)carbamate

Conditions

Conditions	Yield
In ethyl acetate	100%

: 4393-09-3
2,3-dimethoxybenzyl amine

: 71989-31-6
Fmoc-Pro-OH

: 866824-06-8
2-(2,3-dimethoxy-benzylcarbamoyl)-pyrrolidine-1-carboxylic acid 9H-fluoren-9-ylmethyl ester

Conditions

Conditions	Yield
Stage #1: Fmoc-Pro-OH With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In acetonitrile at 20℃; for 0.333333h; Stage #2: 2,3-dimethoxybenzyl amine In acetonitrile at 20℃;	99%

: 4393-09-3
2,3-dimethoxybenzyl amine

α-bromoacetophenone: α-bromoacetophenone

: 2-(2,3-dimethoxyphenyl)-5-phenyloxazole

Conditions

Conditions	Yield
With iodine; potassium carbonate In N,N-dimethyl-formamide for 18h; Heating;	99%

: 209961-35-3
8-(2,3-dimethoxy-benzoylamino)-octanoic acid

: 4393-09-3
2,3-dimethoxybenzyl amine

: 773156-68-6
N-[7-(2,3-dimethoxy-benzylcarbamoyl)-heptyl]-2,3-dimethoxy-benzamide

Conditions

Conditions	Yield
Stage #1: 8-(2,3-dimethoxy-benzoylamino)-octanoic acid With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In acetonitrile for 0.5h; Stage #2: 2,3-dimethoxybenzyl amine In acetonitrile	96%

: 4393-09-3
2,3-dimethoxybenzyl amine

: 71989-16-7
Fmoc-Asn-OH

: 857064-44-9
[2-carbamoyl-1-(2,3-dimethoxy-benzylcarbamoyl)-ethyl]-carbamic acid 9H-fluoren-9-ylmethyl ester

Conditions

Conditions	Yield
Stage #1: Fmoc-Asn-OH With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In acetonitrile at 20℃; for 0.333333h; Stage #2: 2,3-dimethoxybenzyl amine In acetonitrile at 20℃;	95%

: 4393-09-3
2,3-dimethoxybenzyl amine

: 613-54-7
2-Bromo-2'-acetonaphthone

: 2-(2,3-dimethoxyphenyl)-5-(naphthalen-2-yl)oxazole

Conditions

Conditions	Yield
With iodine; potassium carbonate In N,N-dimethyl-formamide for 18h; Heating;	95%

: 945031-68-5
(R)-6-oxo-1,2-dithia-5-azacyclodecane-4-carboxylic acid

: 4393-09-3
2,3-dimethoxybenzyl amine

: (R)-N-(2,3-dimethoxybenzyl)-6-oxo-1,2,5-dithiazecane-4-carboxamide

Conditions

Conditions	Yield
Stage #1: (R)-6-oxo-1,2-dithia-5-azacyclodecane-4-carboxylic acid With N-ethyl-N,N-diisopropylamine; 1,1'-carbonyldiimidazole In tetrahydrofuran at 20℃; for 0.5h; Stage #2: 2,3-dimethoxybenzyl amine In tetrahydrofuran at 20℃; for 18h; Further stages.;	94%

: 4393-09-3
2,3-dimethoxybenzyl amine

: 108-24-7
acetic anhydride

: 861523-11-7
N-(2,3-dimethoxybenzyl)acetamide

Conditions

Conditions	Yield
With dmap; triethylamine In dichloromethane at 20℃; for 12h; Inert atmosphere;	93%

: 4393-09-3
2,3-dimethoxybenzyl amine

: 5000-65-7
2-bromo-3'-methoxyacetophenone

: 2-(2,3-dimethoxyphenyl)-5-(3-methoxyphenyl)oxazole

Conditions

Conditions	Yield
With iodine; potassium carbonate In N,N-dimethyl-formamide for 18h; Heating;	93%

: 85-44-9
phthalic anhydride

: 4393-09-3
2,3-dimethoxybenzyl amine

: N-(2,3-dimethoxybenzyl)phthalamide

Conditions

Conditions	Yield
In dichloromethane	90%

: 4393-09-3
2,3-dimethoxybenzyl amine

: 71989-14-5
Fmoc-(tBu)Asp-OH

: 773156-70-0
N-(2,3-dimethoxy-benzyl)-3-(9H-fluoren-9-ylmethoxycarbonylamino)-succinamic acid tert-butyl ester

Conditions

Conditions	Yield
Stage #1: Fmoc-(tBu)Asp-OH With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In dichloromethane; N,N-dimethyl-formamide for 2h; Stage #2: 2,3-dimethoxybenzyl amine In dichloromethane; N,N-dimethyl-formamide	90%

: 4393-09-3
2,3-dimethoxybenzyl amine

: 2632-13-5
2-Bromo-4'-methoxyacetophenone

: 2-(2,3-dimethoxyphenyl)-5-(4-methoxyphenyl)oxazole

Conditions

Conditions	Yield
With iodine; potassium carbonate In N,N-dimethyl-formamide for 18h; Heating;	90%

: 4530-20-5
BOC-glycine

: 4393-09-3
2,3-dimethoxybenzyl amine

: 591207-56-6
N-t-butoxycarbonylglycine(2,3-dimethoxybenzyl)amide

Conditions

Conditions	Yield
Stage #1: BOC-glycine With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In dichloromethane; N,N-dimethyl-formamide for 1h; Stage #2: 2,3-dimethoxybenzyl amine In dichloromethane; N,N-dimethyl-formamide	88%

: Fmoc-His(Mtt)-OH

: 4393-09-3
2,3-dimethoxybenzyl amine

: {1-(2,3-dimethoxy-benzylcarbamoyl)-2-[1-(2,2,2-triphenyl-ethyl)-1H-imidazol-2-yl]-ethyl}-carbamic acid 9H-fluoren-9-ylmethyl ester

Conditions

Conditions	Yield
Stage #1: Fmoc-His(Mtt)-OH With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In acetonitrile at 20℃; for 0.333333h; Stage #2: 2,3-dimethoxybenzyl amine In acetonitrile at 20℃;	87%

: 4393-09-3
2,3-dimethoxybenzyl amine

: 71989-20-3
N2-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-glutamine

: 857064-45-0
[3-carbamoyl-1-(2,3-dimethoxy-benzylcarbamoyl)-propyl]-carbamic acid 9H-fluoren-9-ylmethyl ester

Conditions

Conditions	Yield
Stage #1: N2-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-glutamine With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In acetonitrile at 20℃; for 0.333333h; Stage #2: 2,3-dimethoxybenzyl amine In acetonitrile at 20℃;	87%

: 98-98-6
2-Picolinic acid

: 4393-09-3
2,3-dimethoxybenzyl amine

: N-(2,3-dimethoxybenzyl)pyridine-2-amide

Conditions

Conditions	Yield
Inert atmosphere;	84%
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃; for 24h;

: 4393-09-3
2,3-dimethoxybenzyl amine

: 187808-48-6
methyl 5-(N,N-dimethylamino)-2,4-pentadienoate

: methyl 5-(2,3-dimethoxybenzylamino)-2,4-pentadienoate

Conditions

Conditions	Yield
In tetrahydrofuran for 85h; Heating;	83%

: 495-69-2
Hippuric Acid

: 4393-09-3
2,3-dimethoxybenzyl amine

: N-benzoylglycine(2,3-dimethoxybenzyl)amide

Conditions

Conditions	Yield
Stage #1: Hippuric Acid With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In dichloromethane; N,N-dimethyl-formamide for 1h; Stage #2: 2,3-dimethoxybenzyl amine In dichloromethane; N,N-dimethyl-formamide	82%

: 4393-09-3
2,3-dimethoxybenzyl amine

: 77128-72-4
N-(9-fluorenylmethoxycarbonyl)-O-methyl-L-tyrosine

: 857064-46-1
[1-(2,3-dimethoxy-benzylcarbamoyl)-2-(4-methoxy-phenyl)-ethyl]-carbamic acid 9H-fluoren-9-ylmethyl ester

Conditions

Conditions	Yield
Stage #1: N-(9-fluorenylmethoxycarbonyl)-O-methyl-L-tyrosine With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In acetonitrile at 20℃; for 0.333333h; Stage #2: 2,3-dimethoxybenzyl amine In acetonitrile at 20℃;	82%

: 4001-73-4
2-Bromobenzamide

: 4393-09-3
2,3-dimethoxybenzyl amine

: 2-(2,3-dimethoxyphenyl)quinazolin-4(3H)-one

Conditions

Conditions	Yield
With potassium carbonate; dimethyl sulfoxide at 80℃; for 2h;	82%

: 4393-09-3
2,3-dimethoxybenzyl amine

: 590-17-0
cyanomethyl bromide

: 2-((2,3-dimethoxybenzyl)amino)acetonitrile

Conditions

Conditions	Yield
Stage #1: 2,3-dimethoxybenzyl amine With triethylamine In tetrahydrofuran at 0℃; for 0.25h; Stage #2: cyanomethyl bromide In tetrahydrofuran at 0 - 20℃; for 16h;	82%

: 4393-09-3
2,3-dimethoxybenzyl amine

: 4-{3,5-bis-[3-carboxy-1,1-bis-(2-carboxy-ethyl)-propylcarbamoyl]-benzoylamino}-4-(2-carboxy-ethyl)-heptanedioic acid

: C120H150N12O30

Conditions

Conditions	Yield
With benzotriazol-1-ol; dicyclohexyl-carbodiimide In N,N-dimethyl-formamide for 48h;	81%

: 4393-09-3
2,3-dimethoxybenzyl amine

: 51012-65-8
2-bromo-1-o-tolylethanone

: 2-(2,3-dimethoxyphenyl)-5-(2-methylphenyl)oxazole

Conditions

Conditions	Yield
With iodine; potassium carbonate In N,N-dimethyl-formamide for 18h; Heating;	80%

: 371224-33-8
8-chloro-2,2-dimethyl-5-pyrrolidin-1-yl-1,4-dihydro-2H-pyrano[4'',3":4',5']pyrido[3',2':4,5]thieno[3,2-d]pyrimidine

: 4393-09-3
2,3-dimethoxybenzyl amine

: 889657-56-1
N-(2,3-dimethoxybenzyl)-5-(pyrrolidin-1-yl)-2,2-dimethyl-1,4-dihydro-2H-pyrano[4'',3'':4',5']pyrido[3',2':4,5]thieno[3,2-d]pyrimidine-8-amine

Conditions

Conditions	Yield
In ethanol for 24h; Heating / reflux;	79%

: 4393-09-3
2,3-dimethoxybenzyl amine

: 78217-83-1
N-2,3-Dimethoxybenzoyl-glycine

: 2-(2,3-Dimethoxyphenyl)carbonyl amino-N-(2,3-dimethoxybenzyl) acetamide

Conditions

Conditions	Yield
Stage #1: N-2,3-Dimethoxybenzoyl-glycine With 1-hydroxy-pyrrolidine-2,5-dione; dicyclohexyl-carbodiimide In 1,4-dioxane at 20℃; for 16h; Stage #2: 2,3-dimethoxybenzyl amine With sodium hydrogencarbonate In water for 20h;	77%

: 123-99-9
azelaic acid

: 4393-09-3
2,3-dimethoxybenzyl amine

: azelic acid bis(2,3-dimethoxybenzylamide)

Conditions

Conditions	Yield
Stage #1: azelaic acid With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In acetonitrile for 0.25h; Stage #2: 2,3-dimethoxybenzyl amine In acetonitrile for 2h;	77%

: 2426-84-8
4-(benzyloxy)-5-methoxy-2-nitrobenzaldehyde

: 4393-09-3
2,3-dimethoxybenzyl amine

: N-(4-benzyloxy-5-methoxy-2-nitrobenzyl)-1-(2,3-dimethoxyphenyl)methanamine

Conditions

Conditions	Yield
With sodium tris(acetoxy)borohydride In chloroform for 48h; Reflux;	76%

: 4385-56-2
2-(4-hydroxy-3,5-dimethoxyphenyl)acetic acid

: 4393-09-3
2,3-dimethoxybenzyl amine

: N-(2,3-dimethoxybenzyl)-2-(4-hydroxy-3,5-dimethoxyphenyl)acetamide

Conditions

Conditions	Yield
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃; for 10h;	75%

: 1204-21-3
2-bromo-2',5'-dimethoxyacetophenone

: 4393-09-3
2,3-dimethoxybenzyl amine

: 2-(2,3-dimethoxyphenyl)-5-(2,5-dimethoxyphenyl)oxazole

Conditions

Conditions	Yield
With iodine; potassium carbonate In N,N-dimethyl-formamide for 18h; Heating;	75%

: 7596-88-5
N-dodecanoylglycine

: 4393-09-3
2,3-dimethoxybenzyl amine

: N-dodecanoylglycine(2,3-dimethoxybenzyl)amide

Conditions

Conditions	Yield
Stage #1: N-dodecanoylglycine With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In dichloromethane; N,N-dimethyl-formamide for 1h; Stage #2: 2,3-dimethoxybenzyl amine In dichloromethane; N,N-dimethyl-formamide	74%

2,3-Dimethoxybenzylamine Specification

The cas register number of 2,3-Dimethoxybenzylamine is 4393-09-3. It also can be called as Benzenemethanamine,2,3-dimethoxy- and the IUPAC Name about this chemical is (2,3-dimethoxyphenyl)methanamine. It belongs to the following product categories, such as Anilines, Aromatic Amines and Nitro Compounds, Amine, Amines, C9 to C10, Nitrogen Compounds and so on.

Physical properties about 2,3-Dimethoxybenzylamine are: (1)ACD/LogP: 0.83; (2)ACD/LogD (pH 5.5): -2.17; (3)ACD/LogD (pH 7.4): -0.95; (4)ACD/BCF (pH 5.5): 1; (5)ACD/BCF (pH 7.4): 1; (6)ACD/KOC (pH 5.5): 1; (7)ACD/KOC (pH 7.4): 1.13; (8)#H bond acceptors: 3; (9)#H bond donors: 2; (10)#Freely Rotating Bonds: 4; (11)Polar Surface Area: 21.7Å²; (12)Index of Refraction: 1.522; (13)Molar Refractivity: 48.06 cm³; (14)Molar Volume: 157.4 cm³; (15)Polarizability: 19.05x10^-24cm³; (16)Surface Tension: 36.3 dyne/cm; (17)Enthalpy of Vaporization: 50.8 kJ/mol; (18)Vapour Pressure: 0.00709 mmHg at 25°C.

When you are using this chemical, please be cautious about it as the following:
This chemical is irritating to eyes, respiratory system and skin. When you are using it, wear suitable gloves and eye/face protection. In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.

You can still convert the following datas into molecular structure:
(1)Canonical SMILES: COC1=CC=CC(=C1OC)CN
(2)InChI: InChI=1S/C9H13NO2/c1-11-8-5-3-4-7(6-10)9(8)12-2/h3-5H,6,10H2,1-2H3
(3)InChIKey: LVMPWFJVYMXSNY-UHFFFAOYSA-N

Product Name

2,3-Dimethoxybenzylamine

Synthetic route

2,3-Dimethoxybenzylamine Specification

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