2,3-Epoxypropyltrimethylammonium chloride supplier

Name
2,3-Epoxypropyltrimethylammonium chloride
EINECS 221-221-0
CAS No. 3033-77-0
Article Data11
CAS DataBase
Density 1.13 g/mL at 20 °C(lit.)
Solubility 852g/L at 20℃
Melting Point 137-139 °C
Formula C₆H₁₄ClNO
Boiling Point
Molecular Weight 151.636
Flash Point 170 °C
Transport Information
Appearance solid
Safety 53-14-26-36/37/39-45
Risk Codes 45-21/22-41-43-48/22
Molecular Structure
Hazard Symbols T
Synonyms (2,3-Epoxypropyl)trimethylammoniumchloride (7CI);Oxiranemethanaminium, N,N,N-trimethyl-, chloride (9CI);(b,g-Epoxypropyl)trimethylammonium chloride;1,2-Epoxy-3-(trimethylammonio)propyl chloride;1-(Trimethylammonio)-2,3-epoxypropane chloride;Catiomaster G;ETA (oniumcompound);G-MAC;Glycidyltrimethylammonium chloride;Glytac A;GlytacA 100;N-Glycidyl-N,N,N-trimethylammonium chloride;N-Glycidyltrimethylammoniumchloride;QUAB 151;Raisacat 151;Trimethylglycidylammonium chloride;Weisstex E 100;Wildye PTC;[(Trimethylammonio)methyl]oxiranechloride;
PSA 12.53000
LogP -2.90460

Synthetic route

: 106-89-8
epichlorohydrin

: 75-50-3
trimethylamine

: 3033-77-0
glycidyltrimethylammonium chloride

Conditions

Conditions	Yield
With ethanol at 100℃;
at 120℃;
In water at 20℃;
In chloroform; toluene at 20℃; Solvent; Temperature; Autoclave;	405.5 g

: N-(3-chloro-2-hydroxypropyl)trimethylammonium chloride

: 3033-77-0
glycidyltrimethylammonium chloride

Conditions

Conditions	Yield
With sodium hydroxide In water at 20℃; for 0.5h;
With sodium hydroxide In water
With sodium hydroxide at 13 - 15℃; for 1.16667h;
With sodium hydroxide

: 106-89-8
epichlorohydrin

: 3033-77-0
glycidyltrimethylammonium chloride

: 99-20-7
TREHALOSE

: 3033-77-0
glycidyltrimethylammonium chloride

: C24H50N2O13(2+)*2Cl(1-)

Conditions

Conditions	Yield
With sodium chloride; sodium hydroxide In isopropyl alcohol at 20 - 40℃; for 7h; pH=11;	96%

: cobalt(II) molybdate

: 3033-77-0
glycidyltrimethylammonium chloride

: glycidyltrimethylammonium cobalt(III) molybdate

Conditions

Conditions	Yield
In water for 0.166667h;	90%

: molybdenum vanadate

: 7732-18-5
water

: 3033-77-0
glycidyltrimethylammonium chloride

: penta(glycidyltrimethylammonium)phosphomolybdic vanadate

Conditions

Conditions	Yield
for 0.166667h;	90%

...Expand

: ammonium molybdate tetrahydrate

: 3033-77-0
glycidyltrimethylammonium chloride

: glycidyltrimethylammonium pentaammonium molybdate

Conditions

Conditions	Yield
In water for 0.166667h;	90%

: sodium molybdate

: 3033-77-0
glycidyltrimethylammonium chloride

: penta(glycidyltrimethylammonium) molybdate

Conditions

Conditions	Yield
In water for 0.166667h;	90%

: 3033-77-0
glycidyltrimethylammonium chloride

deacetylated chitosan: deacetylated chitosan

N-[(2-hydroxy-3-trimethylammonium)propyl]chitosan chloride: N-[(2-hydroxy-3-trimethylammonium)propyl]chitosan chloride

Conditions

Conditions	Yield
In water for 10h;	87.8%

: 3033-77-0
glycidyltrimethylammonium chloride

: 124-40-3
dimethyl amine

: 3-(dimethylamino)-2-hydroxy-N,N,N-trimethylpropan-1-aminium chloride

Conditions

Conditions	Yield
In water at 60℃;	87%

: C17H6Br2Cl2N4O2

: 3033-77-0
glycidyltrimethylammonium chloride

: 68960-97-4
1,14-diamino-3,6,9,12-tetraoxatetradecane

: C33H43Br2ClN7O7(1+)*Cl(1-)

Conditions

Conditions	Yield
Stage #1: C17H6Br2Cl2N4O2; 1,14-diamino-3,6,9,12-tetraoxatetradecane With sodium carbonate at 35 - 40℃; for 2h; pH=5-6; Stage #2: glycidyltrimethylammonium chloride With hydrogenchloride at 85℃; pH=4;	82.46%

...Expand

: 459-80-3
geranic acid

: 3033-77-0
glycidyltrimethylammonium chloride

: C16H30NO3(1+)*Cl(1-)

Conditions

Conditions	Yield
With sodium hydrogencarbonate In isopropyl alcohol; acetone at 80℃; for 16h;	79%

: 112-80-1
cis-Octadecenoic acid

: 3033-77-0
glycidyltrimethylammonium chloride

: (Z)-2-hydroxy-3-[(1-oxo-9-octadecenyl)oxy]propyltrimethylammonium chloride

Conditions

Conditions	Yield
With sodium hydrogencarbonate In isopropyl alcohol; acetone at 80℃; for 16h;	79%

: 6522-75-4
1-(4,6-dichloro-[1,3,5]triazin-2-ylamino)-anthraquinone

: 3033-77-0
glycidyltrimethylammonium chloride

: 68960-97-4
1,14-diamino-3,6,9,12-tetraoxatetradecane

: C33H45ClN7O7(1+)*Cl(1-)

Conditions

Conditions	Yield
Stage #1: 1-(4,6-dichloro-[1,3,5]triazin-2-ylamino)-anthraquinone; 1,14-diamino-3,6,9,12-tetraoxatetradecane With sodium carbonate at 35 - 40℃; for 2h; pH=5-6; Stage #2: glycidyltrimethylammonium chloride With hydrogenchloride at 85℃; pH=4;	79%

...Expand

: 1119-23-9
3-hydroxyethylammonium-n-propanesulfonate

: 3033-77-0
glycidyltrimethylammonium chloride

: 1379044-59-3
N-(2-hydroxy-3-trimethylammoniumpropyl)-N-(2-hydroxyethyl)homotaurine inner salt

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In ethanol; water at 5 - 20℃; for 21h;	76%

: 3033-77-0
glycidyltrimethylammonium chloride

: 501-52-0
3-Phenylpropionic acid

: C15H24NO3(1+)*Cl(1-)

Conditions

Conditions	Yield
With sodium hydrogencarbonate In isopropyl alcohol; acetone at 80℃; for 16h;	76%

: 14389-86-7
2-benzyloxybenzoic acid

: 3033-77-0
glycidyltrimethylammonium chloride

: C20H26NO4(1+)*Cl(1-)

Conditions

Conditions	Yield
With sodium hydrogencarbonate In isopropyl alcohol; acetone at 80℃; for 16h;	73%

: 503-74-2
3-methylbutyric acid

: 3033-77-0
glycidyltrimethylammonium chloride

: C11H24NO3(1+)*Cl(1-)

Conditions

Conditions	Yield
With sodium hydrogencarbonate In isopropyl alcohol; acetone at 80℃; for 16h;	70%

: 3033-77-0
glycidyltrimethylammonium chloride

: 17465-86-0
cyclomaltooctaose

: C54H94NO41(1+)*Cl(1-)

Conditions

Conditions	Yield
With sodium hydroxide In water at 60℃; for 2h;	60%

: 71-30-7
Cytosine

: 3033-77-0
glycidyltrimethylammonium chloride

: [3-(4-Amino-2-oxo-2H-pyrimidin-1-yl)-2-hydroxy-propyl]-trimethyl-ammonium; chloride

Conditions

Conditions	Yield
With caesium carbonate In N,N-dimethyl-formamide at 120℃; for 16h;	57%

: 3033-77-0
glycidyltrimethylammonium chloride

: 30754-24-6
heptakis(6-amino-6-deoxy)-β-cyclodextrin

: heptakis-[6-deoxy-6-(2-hydroxy-3-trimethylammonion-propyl)amino]-beta-cyclomaltoheptaose

Conditions

Conditions	Yield
In aq. buffer at 50℃; for 24h; pH=10;	51%

: 50979-18-5
guanidine sulfamate

: 3033-77-0
glycidyltrimethylammonium chloride

: C7H19N4O(1+)*Cl(1-)*H3NO3S

Conditions

Conditions	Yield
With water; 4-pyrrolidin-1-ylpyridine at 45℃; for 2h; Temperature;	50.5%

: 3033-77-0
glycidyltrimethylammonium chloride

: 65-85-0
benzoic acid

: C13H20NO3(1+)*Cl(1-)

Conditions

Conditions	Yield
With sodium hydrogencarbonate In isopropyl alcohol; acetone at 60℃; for 16h;	26%

: 3033-77-0
glycidyltrimethylammonium chloride

: 142-62-1
hexanoic acid

: C12H26NO3(1+)*Cl(1-)

Conditions

Conditions	Yield
With sodium hydrogencarbonate In isopropyl alcohol; acetone at 60℃; for 16h;	25%

: 3033-77-0
glycidyltrimethylammonium chloride

: 10016-20-3
alpha cyclodextrin

: C42H74NO31(1+)*Cl(1-)

Conditions

Conditions	Yield
With sodium hydroxide at 50℃;	23%

: 35717-98-7
bis(2-propyl)-p-toluenesulfonyloxymethylphosphonate

: 3033-77-0
glycidyltrimethylammonium chloride

: 66224-66-6, 66224-67-7, 66224-68-8, 66224-69-9, 134434-48-3, 134434-49-4, 134454-76-5, 134461-75-9
adenine

: 9-(2-(phosphonomethoxy)-3-(trimethylammonio)propyl)adenine

Conditions

Conditions	Yield
Multistep reaction;

...Expand

: 35717-98-7
bis(2-propyl)-p-toluenesulfonyloxymethylphosphonate

: 3033-77-0
glycidyltrimethylammonium chloride

: 1904-98-9
2,6-diaminopurine

: 9-(2-(phosphonomethoxy)-3-(trimethylammonio)propyl)-2,6-diaminopurine

Conditions

Conditions	Yield
Multistep reaction;

...Expand

: 67-56-1
methanol

: 3033-77-0
glycidyltrimethylammonium chloride

: 7585-39-9
β‐cyclodextrin

A: [3-((3R,4S,5S,6R)-4,5-Dihydroxy-6-hydroxymethyl-2-methoxy-tetrahydro-pyran-3-yloxy)-2-hydroxy-propyl]-trimethyl-ammonium; chloride

B: [3-((2R,3R,4S,5R)-3,5-Dihydroxy-2-hydroxymethyl-6-methoxy-tetrahydro-pyran-4-yloxy)-2-hydroxy-propyl]-trimethyl-ammonium; chloride

C: [2-Hydroxy-3-((2R,3S,4S,5R)-3,4,5-trihydroxy-6-methoxy-tetrahydro-pyran-2-ylmethoxy)-propyl]-trimethyl-ammonium; chloride

Conditions

Conditions	Yield
With sodium hydroxide Product distribution; var. conditions; also degradation of γ-cyclodextrin;

...Expand

: 35717-98-7
bis(2-propyl)-p-toluenesulfonyloxymethylphosphonate

: 3033-77-0
glycidyltrimethylammonium chloride

: 4637-24-5
N,N-dimethyl-formamide dimethyl acetal

: 66224-66-6, 66224-67-7, 66224-68-8, 66224-69-9, 134434-48-3, 134434-49-4, 134454-76-5, 134461-75-9
adenine

A: 9-(2-(phosphonomethoxy)-3-(trimethylammonio)propyl)adenine

B: 3-[2-(phosphonomethoxy)-3-(trimethylammonio)propyl]adenine

Conditions

Conditions	Yield
With ammonium hydroxide; trimethylsilyl bromide; sodium hydride; triethylamine Yield given. Multistep reaction;
With ammonium hydroxide; trimethylsilyl bromide; sodium hydride; triethylamine Multistep reaction;

...Expand

: 35717-98-7
bis(2-propyl)-p-toluenesulfonyloxymethylphosphonate

: 3033-77-0
glycidyltrimethylammonium chloride

: 4637-24-5
N,N-dimethyl-formamide dimethyl acetal

: 66224-66-6, 66224-67-7, 66224-68-8, 66224-69-9, 134434-48-3, 134434-49-4, 134454-76-5, 134461-75-9
adenine

A: [3-(6-Amino-purin-9-yl)-2-(diisopropoxy-phosphorylmethoxy)-propyl]-trimethyl-ammonium; chloride

B: [3-(6-Amino-purin-3-yl)-2-(diisopropoxy-phosphorylmethoxy)-propyl]-trimethyl-ammonium; chloride

Conditions

Conditions	Yield
With ammonium hydroxide; sodium hydride Multistep reaction. Title compound not separated from byproducts;

...Expand

: 35717-98-7
bis(2-propyl)-p-toluenesulfonyloxymethylphosphonate

: 3033-77-0
glycidyltrimethylammonium chloride

: 4637-24-5
N,N-dimethyl-formamide dimethyl acetal

: 66224-66-6, 66224-67-7, 66224-68-8, 66224-69-9, 134434-48-3, 134434-49-4, 134454-76-5, 134461-75-9
adenine

A: {2-(Diisopropoxy-phosphorylmethoxy)-3-[6-(dimethylamino-methyleneamino)-purin-3-yl]-propyl}-trimethyl-ammonium; chloride

B: {2-(Diisopropoxy-phosphorylmethoxy)-3-[6-(dimethylamino-methyleneamino)-purin-9-yl]-propyl}-trimethyl-ammonium; chloride

Conditions

Conditions	Yield
With sodium hydride Multistep reaction. Title compound not separated from byproducts;

...Expand

: 3033-77-0
glycidyltrimethylammonium chloride

: 4637-24-5
N,N-dimethyl-formamide dimethyl acetal

: 66224-66-6, 66224-67-7, 66224-68-8, 66224-69-9, 134434-48-3, 134434-49-4, 134454-76-5, 134461-75-9
adenine

A: {3-[6-(Dimethylamino-methyleneamino)-purin-9-yl]-2-hydroxy-propyl}-trimethyl-ammonium; chloride

B: {3-[6-(Dimethylamino-methyleneamino)-purin-3-yl]-2-hydroxy-propyl}-trimethyl-ammonium; chloride

Conditions

Conditions	Yield
With 1.) CsCO3 1.) DMF, 120 deg C, 16 h, 2.) DMF, 20 deg C, 24 h; Multistep reaction. Title compound not separated from byproducts;

...Expand

2,3-Epoxypropyltrimethylammonium chloride Chemical Properties

Glycidyl trimethyl ammonium chloride(3033-77-0)'s molecular formula is C₆H₁₄NOCl and its formula weight is 151.6.
The density of glycidyl trimethyl ammonium chloride(3033-77-0) is 1.13 g/mL at 20 °C(lit.)
Its flash point is 170°C.
The molecular structure of glycidyl trimethyl ammonium chloride(3033-77-0):

2,3-Epoxypropyltrimethylammonium chloride Uses

Glycidyl trimethyl ammonium chloride(3033-77-0) is used in organic synthesis, the paper industry, water treatment industry, etc.

2,3-Epoxypropyltrimethylammonium chloride Toxicity Data With Reference

1.	mmo-klp 2 mmol/L	MUREAV Mutation Research. 89 (1981),269.
2.	cyt-rat:lvr 10 mg/L	MUREAV Mutation Research. 153 (1985),57.
3.	scu-mus LD50:90 mg/kg	JCSOA9 Journal of the Chemical Society .(London, England.: )1947,176.

2,3-Epoxypropyltrimethylammonium chloride Consensus Reports

Reported in EPA TSCA Inventory.

2,3-Epoxypropyltrimethylammonium chloride Safety Profile

Suspected carcinogen. Poison by subcutaneous route. Mutation data reported. When heated to decomposition it emits toxic fumes of Cl⁻, NH₃, and NO_x. See also AMMONIUM CHLORIDE.

2,3-Epoxypropyltrimethylammonium chloride Standards and Recommendations

DFG MAK: Confirmed Animal Carcinogen, Suspected Human Carcinogen

Product Name

2,3-Epoxypropyltrimethylammonium chloride

Synthetic route

2,3-Epoxypropyltrimethylammonium chloride Chemical Properties

2,3-Epoxypropyltrimethylammonium chloride Uses

2,3-Epoxypropyltrimethylammonium chloride Toxicity Data With Reference

2,3-Epoxypropyltrimethylammonium chloride Consensus Reports

2,3-Epoxypropyltrimethylammonium chloride Safety Profile

2,3-Epoxypropyltrimethylammonium chloride Standards and Recommendations

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