Product Name

  • Name

    2-Acetylfluorene

  • EINECS 212-310-5
  • CAS No. 781-73-7
  • Article Data45
  • CAS DataBase
  • Density 1.157 g/cm3
  • Solubility water: 1 g/L (20 °C)
  • Melting Point 128-129 °C(lit.)
  • Formula C15H12O
  • Boiling Point 381.4 °C at 760 mmHg
  • Molecular Weight 208.26
  • Flash Point 169 °C
  • Transport Information
  • Appearance light yellow crystalline powder
  • Safety 24/25
  • Risk Codes
  • Molecular Structure Molecular Structure of 781-73-7 (2-Acetylfluorene)
  • Hazard Symbols
  • Synonyms Ketone,fluoren-2-yl methyl (6CI,7CI,8CI);1-(9H-Fluoren-2-yl)ethanone;2-Acetyl-9H-fluorene;2-Fluorenyl methylketone;NSC 12351;
  • PSA 17.07000
  • LogP 3.46040

Synthetic route

2',3',4',5',6'-pentamethylacetophenone
2040-01-9

2',3',4',5',6'-pentamethylacetophenone

A

1-(9H-fluoren-2-yl)ethanone

1-(9H-fluoren-2-yl)ethanone

B

pentamethylbenzene,
700-12-9

pentamethylbenzene,

Conditions
ConditionsYield
trifluoroacetic acid for 10h; Heating;A 44%
B 99%
2-(4-acetylphenyl)benzyl chloride
228263-51-2

2-(4-acetylphenyl)benzyl chloride

1-(9H-fluoren-2-yl)ethanone
781-73-7

1-(9H-fluoren-2-yl)ethanone

Conditions
ConditionsYield
With bis-triphenylphosphine-palladium(II) chloride; caesium carbonate; Trimethylacetic acid In tetrahydrofuran at 25℃; for 18h; Glovebox; Schlenk technique; Inert atmosphere;94%
With palladium diacetate; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl In 1,2-dimethoxyethane at 100℃; for 12h; Inert atmosphere;48%
N-Acetylimidazole
2466-76-4

N-Acetylimidazole

9H-fluorene
86-73-7

9H-fluorene

1-(9H-fluoren-2-yl)ethanone
781-73-7

1-(9H-fluoren-2-yl)ethanone

Conditions
ConditionsYield
With trifluoroacetic acid for 5h; Heating;89%
9H-fluorene
86-73-7

9H-fluorene

acetic acid
64-19-7

acetic acid

1-(9H-fluoren-2-yl)ethanone
781-73-7

1-(9H-fluoren-2-yl)ethanone

Conditions
ConditionsYield
With N-trifluoroacetylimidazole; trifluoroacetic acid for 10h; Heating;82%
With pyridin-2-yl trifluoromethanesulfonate; trifluoroacetic acid for 5h; Heating;81%
2-acetoxypyridine
3847-19-6

2-acetoxypyridine

9H-fluorene
86-73-7

9H-fluorene

1-(9H-fluoren-2-yl)ethanone
781-73-7

1-(9H-fluoren-2-yl)ethanone

Conditions
ConditionsYield
With trifluoroacetic acid for 5h; Heating;80%
9H-fluorene
86-73-7

9H-fluorene

acetyl chloride
75-36-5

acetyl chloride

1-(9H-fluoren-2-yl)ethanone
781-73-7

1-(9H-fluoren-2-yl)ethanone

Conditions
ConditionsYield
With aluminum (III) chloride In 1,2-dichloro-ethane at 0℃; for 1h; Friedel Crafts acylation;79%
With carbon disulfide; aluminium trichloride
With aluminium trichloride; nitrobenzene
aluminium trichloride
7446-70-0

aluminium trichloride

9H-fluorene
86-73-7

9H-fluorene

acetic anhydride
108-24-7

acetic anhydride

nitrobenzene
98-95-3

nitrobenzene

1-(9H-fluoren-2-yl)ethanone
781-73-7

1-(9H-fluoren-2-yl)ethanone

Conditions
ConditionsYield
anfangs unter Kuehlung;
anfangs unter Kuehlung;
carbon disulfide
75-15-0

carbon disulfide

aluminium trichloride
7446-70-0

aluminium trichloride

9H-fluorene
86-73-7

9H-fluorene

acetyl chloride
75-36-5

acetyl chloride

1-(9H-fluoren-2-yl)ethanone
781-73-7

1-(9H-fluoren-2-yl)ethanone

Conditions
ConditionsYield
at 5 - 10℃;
aluminium trichloride
7446-70-0

aluminium trichloride

9H-fluorene
86-73-7

9H-fluorene

nitrobenzene
98-95-3

nitrobenzene

acetyl chloride
75-36-5

acetyl chloride

1-(9H-fluoren-2-yl)ethanone
781-73-7

1-(9H-fluoren-2-yl)ethanone

Conditions
ConditionsYield
at 5 - 10℃;
aluminium trichloride
7446-70-0

aluminium trichloride

9H-fluorene
86-73-7

9H-fluorene

acetic anhydride
108-24-7

acetic anhydride

boiling carbon disulfide

boiling carbon disulfide

1-(9H-fluoren-2-yl)ethanone
781-73-7

1-(9H-fluoren-2-yl)ethanone

Conditions
ConditionsYield
anfangs unter Kuehlung;
2-acetylfluoren-9-one
42136-05-0

2-acetylfluoren-9-one

A

9H-fluorene
86-73-7

9H-fluorene

B

1-(9H-fluoren-2-yl)ethanone
781-73-7

1-(9H-fluoren-2-yl)ethanone

Conditions
ConditionsYield
With bromine In acetic acidA n/a
B 77.0 g (74 wt.% as calculated for fluorene)
2-phenylbenzyl chloride
38580-83-5

2-phenylbenzyl chloride

2-(4-acetylphenyl)benzyl chloride
228263-51-2

2-(4-acetylphenyl)benzyl chloride

A

9H-fluorene
86-73-7

9H-fluorene

B

1-(9H-fluoren-2-yl)ethanone
781-73-7

1-(9H-fluoren-2-yl)ethanone

Conditions
ConditionsYield
With palladium diacetate; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl In 1,2-dimethoxyethane at 100℃; for 3h; Inert atmosphere;
C17H16O

C17H16O

1-(9H-fluoren-2-yl)ethanone
781-73-7

1-(9H-fluoren-2-yl)ethanone

Conditions
ConditionsYield
With hydrogenchloride In water
1-(2'-aminobiphenyl-4-yl)ethanone
31477-49-3

1-(2'-aminobiphenyl-4-yl)ethanone

1-(9H-fluoren-2-yl)ethanone
781-73-7

1-(9H-fluoren-2-yl)ethanone

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: hydrogenchloride; sodium nitrite / water / 1 h / Cooling
1.2: 20 °C
2.1: palladium diacetate; potassium hydrogencarbonate; potassium acetate; isopropyl alcohol / water; N,N-dimethyl-formamide; N,N-dimethyl acetamide / 10 h / 75 °C / Schlenk technique; Inert atmosphere
View Scheme
2-iodophenylamine
615-43-0

2-iodophenylamine

1-(9H-fluoren-2-yl)ethanone
781-73-7

1-(9H-fluoren-2-yl)ethanone

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: potassium carbonate; palladium diacetate / acetone; water / 65 °C / Sealed tube; Inert atmosphere
2.1: hydrogenchloride; sodium nitrite / water / 1 h / Cooling
2.2: 20 °C
3.1: palladium diacetate; potassium hydrogencarbonate; potassium acetate; isopropyl alcohol / water; N,N-dimethyl-formamide; N,N-dimethyl acetamide / 10 h / 75 °C / Schlenk technique; Inert atmosphere
View Scheme
4-acetylphenylboronic acid
149104-90-5

4-acetylphenylboronic acid

1-(9H-fluoren-2-yl)ethanone
781-73-7

1-(9H-fluoren-2-yl)ethanone

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: potassium carbonate; palladium diacetate / acetone; water / 65 °C / Sealed tube; Inert atmosphere
2.1: hydrogenchloride; sodium nitrite / water / 1 h / Cooling
2.2: 20 °C
3.1: palladium diacetate; potassium hydrogencarbonate; potassium acetate; isopropyl alcohol / water; N,N-dimethyl-formamide; N,N-dimethyl acetamide / 10 h / 75 °C / Schlenk technique; Inert atmosphere
View Scheme
Multi-step reaction with 3 steps
1: palladium diacetate; potassium phosphate; johnphos / tetrahydrofuran / 50 °C / Inert atmosphere
2: triethylamine; methanesulfonyl chloride / dichloromethane / 0 - 25 °C
3: bis-triphenylphosphine-palladium(II) chloride; caesium carbonate; Trimethylacetic acid / tetrahydrofuran / 18 h / 25 °C / Glovebox; Schlenk technique; Inert atmosphere
View Scheme
C17H14O

C17H14O

1-(9H-fluoren-2-yl)ethanone
781-73-7

1-(9H-fluoren-2-yl)ethanone

Conditions
ConditionsYield
With β-lactoglobulin from milk In aq. phosphate buffer; ethanol at 37℃; for 96h; pH=7.4; Catalytic behavior; Darkness; Enzymatic reaction;
o-bromobenzyl alcohol
18982-54-2

o-bromobenzyl alcohol

1-(9H-fluoren-2-yl)ethanone
781-73-7

1-(9H-fluoren-2-yl)ethanone

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: palladium diacetate; potassium phosphate; johnphos / tetrahydrofuran / 50 °C / Inert atmosphere
2: triethylamine; methanesulfonyl chloride / dichloromethane / 0 - 25 °C
3: bis-triphenylphosphine-palladium(II) chloride; caesium carbonate; Trimethylacetic acid / tetrahydrofuran / 18 h / 25 °C / Glovebox; Schlenk technique; Inert atmosphere
View Scheme
2-(4-acetylphenyl)benzyl alcohol

2-(4-acetylphenyl)benzyl alcohol

1-(9H-fluoren-2-yl)ethanone
781-73-7

1-(9H-fluoren-2-yl)ethanone

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: triethylamine; methanesulfonyl chloride / dichloromethane / 0 - 25 °C
2: bis-triphenylphosphine-palladium(II) chloride; caesium carbonate; Trimethylacetic acid / tetrahydrofuran / 18 h / 25 °C / Glovebox; Schlenk technique; Inert atmosphere
View Scheme
1-(9H-fluoren-2-yl)ethanone
781-73-7

1-(9H-fluoren-2-yl)ethanone

2-Acetylfluorene oxime
110827-07-1

2-Acetylfluorene oxime

Conditions
ConditionsYield
With hydroxylamine hydrochloride; sodium acetate In ethanol; water at 95℃;100%
With hydroxylamine hydrochloride; sodium acetate In ethanol; water at 100℃;
With pyridine; hydroxylamine hydrochloride In ethanol at 60℃; for 1h;
With hydroxylamine hydrochloride; sodium acetate In ethanol; water
With hydroxylamine hydrochloride; sodium acetate In ethanol at 90℃; for 2h; Sealed tube; Inert atmosphere;
1-(9H-fluoren-2-yl)ethanone
781-73-7

1-(9H-fluoren-2-yl)ethanone

1-fluoren-2-yl-ethanone oxime
110827-07-1

1-fluoren-2-yl-ethanone oxime

Conditions
ConditionsYield
With hydroxylamine hydrochloride; sodium acetate In water for 1h; Heating;99%
1-(9H-fluoren-2-yl)ethanone
781-73-7

1-(9H-fluoren-2-yl)ethanone

(S)-1-(9H-fluoren-2-yl)ethan-1-ol

(S)-1-(9H-fluoren-2-yl)ethan-1-ol

Conditions
ConditionsYield
With bis(1,5-cyclooctadiene)diiridium(I) dichloride; C53H73FeN2O2PS; hydrogen; lithium tert-butoxide In isopropyl alcohol at 25 - 30℃; under 22801.5 Torr; for 12h; Autoclave; enantioselective reaction;99%
1-(9H-fluoren-2-yl)ethanone
781-73-7

1-(9H-fluoren-2-yl)ethanone

fluorenone-2-carboxylic acid
784-50-9

fluorenone-2-carboxylic acid

Conditions
ConditionsYield
With sodium dichromate In acetic acid Oxidation; Heating;98.5%
With potassium hydroxide; water; bromine at 90℃; for 0.5h;78%
With sodium dichromate; acetic anhydride In acetic acid for 2h; Heating;56%
With potassium hypochlorite
With sodium hydroxide; sodium hypochlorite
1-(9H-fluoren-2-yl)ethanone
781-73-7

1-(9H-fluoren-2-yl)ethanone

4-methoxy-benzaldehyde
123-11-5

4-methoxy-benzaldehyde

3-(9H-fluoren-2-yl)-3-oxopropanenitrile
197250-39-8

3-(9H-fluoren-2-yl)-3-oxopropanenitrile

2,6-di(9H-fluoren-2-yl)-4-(4-methoxyphenyl)nicotinonitrile

2,6-di(9H-fluoren-2-yl)-4-(4-methoxyphenyl)nicotinonitrile

Conditions
ConditionsYield
With ammonium acetate; acetic acid Reflux;98%
1-(9H-fluoren-2-yl)ethanone
781-73-7

1-(9H-fluoren-2-yl)ethanone

2-bromo-1-(9H-fluoren-2-yl)ethanone
39696-13-4

2-bromo-1-(9H-fluoren-2-yl)ethanone

Conditions
ConditionsYield
With bromine In 1,4-dioxane; diethyl ether for 0.5h;97%
With diethyl ether; bromine at 0℃;
With chloroform; hydrogen bromide; bromine; acetic acid
1-(9H-fluoren-2-yl)ethanone
781-73-7

1-(9H-fluoren-2-yl)ethanone

benzaldehyde
100-52-7

benzaldehyde

3-(9H-fluoren-2-yl)-3-oxopropanenitrile
197250-39-8

3-(9H-fluoren-2-yl)-3-oxopropanenitrile

2,6-di(9H-fluoren-2-yl)-4-phenylnicotinonitrile

2,6-di(9H-fluoren-2-yl)-4-phenylnicotinonitrile

Conditions
ConditionsYield
With ammonium acetate; acetic acid Reflux;97%
1-(9H-fluoren-2-yl)ethanone
781-73-7

1-(9H-fluoren-2-yl)ethanone

3-nitro-benzaldehyde
99-61-6

3-nitro-benzaldehyde

dimedone
126-81-8

dimedone

2-(9H-fluoren-2-yl)-7,8-dihydro-7,7-dimethyl-4-(3-nitrophenyl)quinolin-5(6H)-one
1446491-13-9

2-(9H-fluoren-2-yl)-7,8-dihydro-7,7-dimethyl-4-(3-nitrophenyl)quinolin-5(6H)-one

Conditions
ConditionsYield
With dihydrogen peroxide; ammonium carbonate In water at 20℃; Green chemistry;96%
1-(9H-fluoren-2-yl)ethanone
781-73-7

1-(9H-fluoren-2-yl)ethanone

allyl bromide
106-95-6

allyl bromide

2-(9H-fluoren-7-yl)pent-4-en-2-ol
1015254-28-0

2-(9H-fluoren-7-yl)pent-4-en-2-ol

Conditions
ConditionsYield
Stage #1: 1-(9H-fluoren-2-yl)ethanone; allyl bromide With magnesium at 20℃; for 0.116667h; Neat (no solvent);
Stage #2: With ammonium chloride Saturated solution;
95%
With copper; zinc at 20℃; for 0.216667h; Barbier-type reaction;93%
1-(9H-fluoren-2-yl)ethanone
781-73-7

1-(9H-fluoren-2-yl)ethanone

dimedone
126-81-8

dimedone

4-bromo-benzaldehyde
1122-91-4

4-bromo-benzaldehyde

4-(4-bromophenyl)-2-(9H-fluoren-2-yl)-7,8-dihydro-7,7-dimethylquinolin-5(6H)-one
1446491-12-8

4-(4-bromophenyl)-2-(9H-fluoren-2-yl)-7,8-dihydro-7,7-dimethylquinolin-5(6H)-one

Conditions
ConditionsYield
With dihydrogen peroxide; ammonium carbonate In water at 20℃; Green chemistry;95%
1-(9H-fluoren-2-yl)ethanone
781-73-7

1-(9H-fluoren-2-yl)ethanone

4-chlorobenzaldehyde
104-88-1

4-chlorobenzaldehyde

dimedone
126-81-8

dimedone

4-(4-chlorophenyl)-2-(9H-fluoren-2-yl)-7,8-dihydro-7,7-dimethylquinolin-5(6H)-one
1446491-11-7

4-(4-chlorophenyl)-2-(9H-fluoren-2-yl)-7,8-dihydro-7,7-dimethylquinolin-5(6H)-one

Conditions
ConditionsYield
With dihydrogen peroxide; ammonium carbonate In water at 20℃; Green chemistry;94%
With ammonium acetate; oxygen In ethanol for 4h; Catalytic behavior; Reflux;94%
1-(9H-fluoren-2-yl)ethanone
781-73-7

1-(9H-fluoren-2-yl)ethanone

3-oxo-3-(pyren-1-yl)propanenitrile

3-oxo-3-(pyren-1-yl)propanenitrile

4-methoxy-benzaldehyde
123-11-5

4-methoxy-benzaldehyde

6-(9H-fluoren-2-yl)-4-(4-methoxyphenyl)-2-(pyren-1-yl)nicotinonitrile

6-(9H-fluoren-2-yl)-4-(4-methoxyphenyl)-2-(pyren-1-yl)nicotinonitrile

Conditions
ConditionsYield
With ammonium acetate; acetic acid Reflux;94%
1-(9H-fluoren-2-yl)ethanone
781-73-7

1-(9H-fluoren-2-yl)ethanone

3-oxo-3-(pyren-1-yl)propanenitrile

3-oxo-3-(pyren-1-yl)propanenitrile

4-nitrobenzaldehdye
555-16-8

4-nitrobenzaldehdye

6-(9H-fluoren-2-yl)-4-(4-nitrophenyl)-2-(pyren-1-yl)nicotinonitrile

6-(9H-fluoren-2-yl)-4-(4-nitrophenyl)-2-(pyren-1-yl)nicotinonitrile

Conditions
ConditionsYield
With ammonium acetate; acetic acid Reflux;94%
1H-indene-1,3(2H)-dione
606-23-5

1H-indene-1,3(2H)-dione

1-(9H-fluoren-2-yl)ethanone
781-73-7

1-(9H-fluoren-2-yl)ethanone

4-chlorobenzaldehyde
104-88-1

4-chlorobenzaldehyde

4-(4-chlorophenyl)-2-(9H-fluoren-2-yl)-indeno[1,2-b]pyridin-5-one
1221745-70-5

4-(4-chlorophenyl)-2-(9H-fluoren-2-yl)-indeno[1,2-b]pyridin-5-one

Conditions
ConditionsYield
With ammonium acetate; L-proline In ethanol at 20℃; for 2.5h;93%
piperidine
110-89-4

piperidine

2-thioxo-4-thiazolidinone
141-84-4

2-thioxo-4-thiazolidinone

1-(9H-fluoren-2-yl)ethanone
781-73-7

1-(9H-fluoren-2-yl)ethanone

5-[1-(9H-fluoren-2-yl)-ethylidene]-2-piperidin-1-yl-thiazol-4-one

5-[1-(9H-fluoren-2-yl)-ethylidene]-2-piperidin-1-yl-thiazol-4-one

Conditions
ConditionsYield
With 3-[(pyridin-3-yl)methyl]mercaptopropylsilica In ethanol; water for 1.08333h; Reflux; diastereoselective reaction;93%
para-tert-butylphenol
98-54-4

para-tert-butylphenol

1-(9H-fluoren-2-yl)ethanone
781-73-7

1-(9H-fluoren-2-yl)ethanone

malononitrile
109-77-3

malononitrile

7-(4-tert-butylphenoxy)-5-amino-2,4-di(9H-fluoren-2-yl)-1,2-dihydro-2-methyl-1,6naphthyridine-8-carbonitrile

7-(4-tert-butylphenoxy)-5-amino-2,4-di(9H-fluoren-2-yl)-1,2-dihydro-2-methyl-1,6naphthyridine-8-carbonitrile

Conditions
ConditionsYield
With triethylamine In water at 100℃; for 4h;93%
1H-indene-1,3(2H)-dione
606-23-5

1H-indene-1,3(2H)-dione

1-(9H-fluoren-2-yl)ethanone
781-73-7

1-(9H-fluoren-2-yl)ethanone

4-bromo-benzaldehyde
1122-91-4

4-bromo-benzaldehyde

4-(4-bromophenyl)-2-(9H-fluoren-2-yl)-indeno[1,2-b]pyridin-5-one
1221745-69-2

4-(4-bromophenyl)-2-(9H-fluoren-2-yl)-indeno[1,2-b]pyridin-5-one

Conditions
ConditionsYield
With ammonium acetate; L-proline In ethanol at 20℃; for 2.5h;92%
tryptamine
61-54-1

tryptamine

1-(9H-fluoren-2-yl)ethanone
781-73-7

1-(9H-fluoren-2-yl)ethanone

(9H-fluoren-2-yl)(9H-pyrido[3,4-b]indol-1-yl)methanone

(9H-fluoren-2-yl)(9H-pyrido[3,4-b]indol-1-yl)methanone

Conditions
ConditionsYield
With dihydrogen peroxide; iodine In water; dimethyl sulfoxide at 110℃;92%
1-(9H-fluoren-2-yl)ethanone
781-73-7

1-(9H-fluoren-2-yl)ethanone

thiophenol
108-98-5

thiophenol

malononitrile
109-77-3

malononitrile

2-amino-3-(9H-fluoren-2-yl)-3-methyl-5-(phenylthio)-3H-pyrrole-4-carbonitrile

2-amino-3-(9H-fluoren-2-yl)-3-methyl-5-(phenylthio)-3H-pyrrole-4-carbonitrile

Conditions
ConditionsYield
With triethylamine In water at 100℃; for 3h;92%
1-(9H-fluoren-2-yl)ethanone
781-73-7

1-(9H-fluoren-2-yl)ethanone

2-ethylfluorene
1207-20-1

2-ethylfluorene

Conditions
ConditionsYield
With sodium hypophosphite monohydrate; 5%-palladium/activated carbon; hypophosphorous acid In water at 100℃;91%
Wolff-Kishner reduction;80%
With potassium hydroxide; hydrazine In ethylene glycol 1.) 130-140 deg C 2 h, 2.) reflux 4 h;75%
1-(9H-fluoren-2-yl)ethanone
781-73-7

1-(9H-fluoren-2-yl)ethanone

2-acetylfluoren-9-one
42136-05-0

2-acetylfluoren-9-one

Conditions
ConditionsYield
With copper(II) choride dihydrate; 4,7-bis(2-(2-(2-methoxyethoxy)ethoxy)ethoxy)-1,10-phenanthroline; oxygen; sodium hydroxide In water at 50℃; under 2250.23 Torr; for 16h; Schlenk technique;91%
With C30H44N2O8; oxygen; iron(II) sulfate; sodium fluoride In water at 100℃; under 1500.15 Torr; for 9h;91%
With oxygen; lithium hexamethyldisilazane In tetrahydrofuran at 60℃; under 760.051 Torr; for 12h; Sealed tube; Green chemistry; chemoselective reaction;87%
1-(9H-fluoren-2-yl)ethanone
781-73-7

1-(9H-fluoren-2-yl)ethanone

tert-butyldimethylsilyl cyanide
56522-24-8

tert-butyldimethylsilyl cyanide

C22H27NOSi
1365529-71-0

C22H27NOSi

Conditions
ConditionsYield
With tin ion-exchanged montmorillonite In dichloromethane at 25℃; for 0.25h; Inert atmosphere;91%
1-(9H-fluoren-2-yl)ethanone
781-73-7

1-(9H-fluoren-2-yl)ethanone

acetic acid
64-19-7

acetic acid

2-acetoxyfluorene
2443-56-3

2-acetoxyfluorene

Conditions
ConditionsYield
With sodium hydrogen sulfate monohydrate; dihydrogen peroxide In water; toluene at 60℃; for 24h;91%
1-(9H-fluoren-2-yl)ethanone
781-73-7

1-(9H-fluoren-2-yl)ethanone

3-oxo-3-(pyren-1-yl)propanenitrile

3-oxo-3-(pyren-1-yl)propanenitrile

4-cyanobenzaldehyde
105-07-7

4-cyanobenzaldehyde

4-(4-cyanophenyl)-6-(9H-fluoren-2-yl)-2-(pyren-1-yl)nicotinonitrile

4-(4-cyanophenyl)-6-(9H-fluoren-2-yl)-2-(pyren-1-yl)nicotinonitrile

Conditions
ConditionsYield
With ammonium acetate; acetic acid Reflux;91%
1-(9H-fluoren-2-yl)ethanone
781-73-7

1-(9H-fluoren-2-yl)ethanone

(R)-1-(9H-fluoren-2-yl)ethan-1-ol

(R)-1-(9H-fluoren-2-yl)ethan-1-ol

Conditions
ConditionsYield
With C37H40MnN2O2P2(1+)*Br(1-); sodium t-butanolate In isopropyl alcohol at 50℃; for 3h; Inert atmosphere; Schlenk technique; enantioselective reaction;91%
1-bromo-butane
109-65-9

1-bromo-butane

1-(9H-fluoren-2-yl)ethanone
781-73-7

1-(9H-fluoren-2-yl)ethanone

1-(9,9-di-n-butylfluorene-2-yl)-ethanone
883751-49-3

1-(9,9-di-n-butylfluorene-2-yl)-ethanone

Conditions
ConditionsYield
Stage #1: 1-(9H-fluoren-2-yl)ethanone With potassium iodide; potassium hydroxide In dimethyl sulfoxide at 15℃; Inert atmosphere;
Stage #2: 1-bromo-butane In dimethyl sulfoxide at 15℃; for 3h;
90.8%
1-(9H-fluoren-2-yl)ethanone
781-73-7

1-(9H-fluoren-2-yl)ethanone

propargyl bromide
106-96-7

propargyl bromide

2-(9H-fluoren-7-yl)pent-4-yn-2-ol
1193092-71-5

2-(9H-fluoren-7-yl)pent-4-yn-2-ol

Conditions
ConditionsYield
Stage #1: 1-(9H-fluoren-2-yl)ethanone; propargyl bromide With zinc/copper couple at -16 - -14℃; for 0.5h; Barbier type reaction; Neat (no solvent);
Stage #2: With ammonium chloride regioselective reaction;
90%
1H-indene-1,3(2H)-dione
606-23-5

1H-indene-1,3(2H)-dione

1-(9H-fluoren-2-yl)ethanone
781-73-7

1-(9H-fluoren-2-yl)ethanone

benzaldehyde
100-52-7

benzaldehyde

4-phenyl-2-(9H-fluoren-2-yl)-indeno[1,2-b]pyridin-5-one
1221745-73-8

4-phenyl-2-(9H-fluoren-2-yl)-indeno[1,2-b]pyridin-5-one

Conditions
ConditionsYield
With ammonium acetate; L-proline In ethanol at 20℃; for 3h;90%

2-Acetylfluorene Chemical Properties

IUPAC Name: 2-Acetylfluorene
The MF of 2-Acetylfluorene (781-73-7) is C15H12O.

                      
The MW of 2-Acetylfluorene (781-73-7) is 208.26.
Synonyms of 2-Acetylfluorene (781-73-7): 1-(9H-fluoren-2-yl)ethan-1-one ; Ethanone, 1- (9H-fluoren-2-yl)- ; 2-Acetofluorene ; 2-Fluorenyl methyl ketone 
Product Categories: Fluorene Derivatives;Fluorenes, Flurenones;Fluorenes;Fluorenes & Fluorenones;C15 to C38;Carbonyl Compounds;Ketones
Form: light yellow crystalline powder
Index of Refraction: 1.627 
EINECS: 212-310-5
Density: 1.157 g/ml 
Flash Point: 169 °C 
Boiling Point: 381.4 °C
Melting Point: 128-129 °C
Water Solubility: 1 g/L (20 ºC)
BRN: 1871711

2-Acetylfluorene Uses

   2-Acetylfluorene (781-73-7) is used in organic synthesis.

2-Acetylfluorene Production

In the presence of anhydrous aluminum chloride, fluorene with acetic anhydride occurs Friedel-Crafts reaction of 2 - acetyl-fluorene.

2-Acetylfluorene Toxicity Data With Reference

1.    

dnr-esc 80 mg/L

    MUREAV    Mutation Research. 119 (1983),135.

2-Acetylfluorene Safety Profile

Mutation data reported. A flammable liquid. When heated to decomposition it emits acrid smoke and irritating vapors.
Safety information of 2-Acetylfluorene (781-73-7):
Safety Statements 
24/25  Avoid contact with skin and eyes
WGK Germany  3
RTECS  OB3800000

2-Acetylfluorene Standards and Recommendations

DOT Classification:  3; Label: Flammable Liquid

2-Acetylfluorene Specification

Store in a cool, dry place. Keep container closed when not in use.Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Avoid contact with eyes, skin, and clothing. Avoid ingestion and inhalation.

Post buying leads

About|Contact|Cas|Product Name|Molecular|Country|Encyclopedia

Message|New Cas|MSDS|Service|Advertisement|CAS DataBase|Article Data|Manufacturers | Chemical Catalog

©2008 LookChem.com,License: ICP

NO.:Zhejiang16009103

complaints:service@lookchem.com Desktop View