2-Amino isonicotinic acid supplier

Name
2-Aminoisonicotinic acid
EINECS -0
CAS No. 13362-28-2
Article Data9
CAS DataBase
Density 1.417 g/cm³
Solubility
Melting Point 300-302 °C
Formula C₆H₆N₂O₂
Boiling Point 498.5 °C at 760 mmHg
Molecular Weight 138.126
Flash Point 255.3 °C
Transport Information
Appearance light yellow cryst
Safety 26-36-45-36/37/39
Risk Codes 36/37/38-23/24/25
Molecular Structure
Hazard Symbols Xi,T
Synonyms Isonicotinicacid, 2-amino- (6CI,7CI,8CI);2-Aminoisonicotinic acid;2-Aminopyridine-4-carboxylic acid;NSC 127962;
PSA 76.21000
LogP 0.94320

Synthetic route

: 6313-54-8
2-chloroisonicotinic acid,

: 13362-28-2
2-aminoisonicotinic acid

Conditions

Conditions	Yield
With ammonium hydroxide at 190℃;
With ammonia In water at 240℃; for 22h;

: 54221-95-3
2-(acetylamino)isonicotinic acid

: 13362-28-2
2-aminoisonicotinic acid

Conditions

Conditions	Yield
With sodium hydroxide
With sodium hydroxide

: 5327-32-2
2-acetylamino-4-methylpyridine

: 13362-28-2
2-aminoisonicotinic acid

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: aq. KMnO4 / 10 h / 75 °C 2: 10percent NaOH View Scheme
Multi-step reaction with 2 steps 1: KMnO4; H2O 2: aqueous NaOH View Scheme
With potassium permanganate; cetyltrimethylammonium chloride; sodium carbonate In water at 55 - 60℃;

: 695-34-1
2-Amino-4-methylpyridine

: 13362-28-2
2-aminoisonicotinic acid

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: sulfur / 20 h / 140 - 160 °C 2: sodium hydroxide / water / 50 h / Reflux View Scheme
Multi-step reaction with 2 steps 1: acetyl chloride / 10 h / 115 - 120 °C 2: sodium carbonate; cetyltrimethylammonium chloride; potassium permanganate / water / 55 - 60 °C View Scheme

: 2-amino-thioisonicotinic acid dimethylamide

: 13362-28-2
2-aminoisonicotinic acid

Conditions

Conditions	Yield
With sodium hydroxide In water for 50h; Reflux;

: 64-17-5
ethanol

: 13362-28-2
2-aminoisonicotinic acid

: 13362-30-6
2-amino-4-ethoxycarbonyl-pyridine

Conditions

Conditions	Yield
With oxygen In water at 20 - 80℃; for 2h; pH=9; Temperature; pH-value; Reflux;	95.1%
With sulfuric acid

: 67-56-1
methanol

: 13362-28-2
2-aminoisonicotinic acid

: 6937-03-7
methyl 2-aminoisonicotinate

Conditions

Conditions	Yield
With thionyl chloride at 0 - 50℃; for 13h; Inert atmosphere;	89%
With sulfuric acid at 80℃; for 72h;	89%
With sulfuric acid at 80℃; for 72h;	86%

: 13362-28-2
2-aminoisonicotinic acid

: 2-amino-3,4,5,6-tetrahydropyridine-4-carboxylic acid hydrochloride

Conditions

Conditions	Yield
With hydrogenchloride; hydrogen; platinum(IV) oxide In ethanol under 1499.7 Torr; for 2h; Ambient temperature;	88%

: zinc(II) nitrate hexahydrate

: 127-19-5
N,N-dimethyl acetamide

: 13362-28-2
2-aminoisonicotinic acid

: Zn(2-aminoisonicotinate)2*(N,N-dimethylacetamide)

Conditions

Conditions	Yield
In N,N-dimethyl acetamide High Pressure; mixt. sealed in vial, heated at 120°C for 3 d; cooled to room temp.; elem. anal.;	88%

...Expand

: zinc(II) nitrate hexahydrate

: 13362-28-2
2-aminoisonicotinic acid

: 73-24-5
adenine

: 68-12-2, 33513-42-7
N,N-dimethyl-formamide

: 1415717-01-9
[Zn(adenine(1-))(2-aminoisonicotinate)]*(N,N-dimethylformamide)

Conditions

Conditions	Yield
at 120℃; for 72h; Autoclave;	88%

...Expand

: zinc(II) nitrate hexahydrate

: 13362-28-2
2-aminoisonicotinic acid

: 68-12-2, 33513-42-7
N,N-dimethyl-formamide

: Zn(2-aminoisonicotinate)2*(N,N-dimethylformamide)

Conditions

Conditions	Yield
In N,N-dimethyl acetamide High Pressure; mixt. sealed in vial, heated at 120°C for 3 d; cooled to room temp.; elem. anal.;	84.5%

...Expand

: 13362-28-2
2-aminoisonicotinic acid

: 104-94-9
4-methoxy-aniline

: 2-amino-N-(4-methoxyphenyl)isonicotinamide

Conditions

Conditions	Yield
Stage #1: 2-aminoisonicotinic acid With oxalyl dichloride In dichloromethane; N,N-dimethyl-formamide at 20℃; for 0.5h; Stage #2: 4-methoxy-aniline With pyridine; ethylenediamine In ethanol; dichloromethane; N,N-dimethyl-formamide at 20℃; for 2.5h; Reflux; Further stages;	75.5%

: 13362-28-2
2-aminoisonicotinic acid

: 172975-98-3
2-methyl-[1,1′-biphenyl]-3-amine

: 2-bromo-N-(2-methyl-[1,1'-biphenyl]-3-yl)isonicotinamide

Conditions

Conditions	Yield
Stage #1: 2-aminoisonicotinic acid With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In dichloromethane for 1h; Stage #2: 2-methyl-[1,1′-biphenyl]-3-amine In dichloromethane	67.9%

: 4418-61-5
5-aminotetrazole

: 13362-28-2
2-aminoisonicotinic acid

: 557-34-6
zinc diacetate

: C6H5N2O2(1-)*CH2N5(1-)*Zn(2+)

Conditions

Conditions	Yield
In methanol; water at 150℃; for 12h;	65%

...Expand

: (-)-1-(6-(2,2,2-trifluoroethoxy)pyridin-3-yl)ethanamine hydrochloride

: 13362-28-2
2-aminoisonicotinic acid

: 2-amino-N-(1-(6-(2,2,2-trifluoroethoxy)pyridin-3-yl)ethyl)isonicotinamide

Conditions

Conditions	Yield
With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃; for 1h;	63%

: 13362-28-2
2-aminoisonicotinic acid

: 108-24-7
acetic anhydride

: 54221-95-3
2-(acetylamino)isonicotinic acid

Conditions

Conditions	Yield
With sulfuric acid In water at 90℃;	60%

: 13362-28-2
2-aminoisonicotinic acid

: 506-59-2
N,N-dimethylammonium chloride

: C8H11N3O

Conditions

Conditions	Yield
Stage #1: 2-aminoisonicotinic acid; N,N-dimethylammonium chloride With triethylamine In N,N-dimethyl-formamide at 10℃; for 0.166667h; Stage #2: With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 20℃;	55.2%

: 109-86-4
2-methoxy-ethanol

: 13362-28-2
2-aminoisonicotinic acid

: (2-methoxyethyl)-2-aminoisonicotinoate

Conditions

Conditions	Yield
With sulfuric acid at 120 - 140℃; for 48h;	49%

: 6-benzyloxy-1-[(E)-2-(5-benzyloxy-4-methoxy-2-methyl-phenyl)vinyl]-7-methoxy-1,2,3,4-tetrahydroisoquinoline

: 13362-28-2
2-aminoisonicotinic acid

: (2-amino-4-pyridyl)-[6-benzyloxy-1-[(E)-2-(5-benzyloxy-4-methoxy-2-methyl-phenyl)vinyl]-7-methoxy-3,4-dihydro-1H-isoquinolin-2-yl]methanone

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine; HATU In N,N-dimethyl-formamide at 20℃; for 1h;	46%

: 914386-75-7
4-[3-amino-1-(4-fluoro-phenyl)-propyl]-N-methyl-benzamide

: 13362-28-2
2-aminoisonicotinic acid

: 2-Amino-N-[3-(4-fluoro-phenyl)-3-(4-methylcarbamoyl-phenyl)-propyl]-isonicotinamide

Conditions

Conditions	Yield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide	44.2%

: 13362-28-2
2-aminoisonicotinic acid

: (E)-2,2'-(diazene-1,2-diyl)diisonicotinic acid

Conditions

Conditions	Yield
With sodium hypochlorite; sodium hydroxide In water at 0 - 5℃; for 4.25h;	44%

: 13362-28-2
2-aminoisonicotinic acid

: 100-46-9
benzylamine

: 301542-44-9
2-amino-N-benzylisonicotinamide

Conditions

Conditions	Yield
Stage #1: 2-aminoisonicotinic acid With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃; for 0.5h; Stage #2: benzylamine With benzotriazol-1-ol In N,N-dimethyl-formamide at 20℃; for 72h;	43%

: 1032570-74-3
7-methoxy-8-[3-(morpholin-4-yl)propoxy]-2,3-dihydroimidazo[1,2-c]quinazolin-5-amine

: 13362-28-2
2-aminoisonicotinic acid

: 1032568-46-9
2-amino-N-{7-methoxy-8-[3-(morpholin-4-yl)propoxy]-2,3-dihydroimidazo[1,2-c]quinazolin-5-yl}isonicotinamide

Conditions

Conditions	Yield
With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃;	37%
With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃;	37%

: 16867-03-1
2-amino-3-hydroxypyridine

: 13362-28-2
2-aminoisonicotinic acid

: 925438-78-4
4-(oxazolo[4,5-b]pyridin-2-yl)pyridin-2-amine

Conditions

Conditions	Yield
With polyphosphoric acid at 220℃; for 4h;	36%

: 30069-31-9
N-(3-amino-4-methylphenyl)-3-(trifluoromethyl)benzamide

: 13362-28-2
2-aminoisonicotinic acid

: 1186206-76-7
2-amino-N-(2-methyl-5-(3-(trifluoromethyl)benzamido)phenyl)isonicotinamide

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine; HATU In N,N-dimethyl-formamide at 20℃; for 12h;	35%

: 75-77-4
chloro-trimethyl-silane

: 13362-28-2
2-aminoisonicotinic acid

: (2S,4S)-4-Acetylthio-1-(4-nitrobenzyloxycarbonyl)-2-carboxypyrrolidine

: (2S,4S)-1-(4-nitrobenzyloxycarbonyl)-2-(4-carboxy-2-pyridylcarbamoyl)pyrrolidin-4-ylthioacetate

Conditions

Conditions	Yield
With thionyl chloride; N-ethyl-N,N-diisopropylamine; N,N-dimethyl-formamide In dichloromethane	32.5%

...Expand

2-Amino isonicotinic acid Chemical Properties

Molecule structure of 2-Amino isonicotinic acid (CAS NO.13362-28-2):

IUPAC Name: 2-Aminopyridine-4-carboxylic acid
Molecular Weight: 138.12404 g/mol
Molecular Formula: C₆H₆N₂O₂
Density: 1.417 g/cm³
Melting Point: 300-302 °C
Boiling Point: 498.5 °C at 760 mmHg
Flash Point: 255.3 °C
Index of Refraction: 1.649
Molar Refractivity: 35.51 cm³
Molar Volume: 97.4 cm³
Polarizability: 14.07×10^-24 cm³
Surface Tension: 77.7 dyne/cm
Enthalpy of Vaporization: 80.74 kJ/mol
Vapour Pressure: 9.33E-11 mmHg at 25 °C
Storage Temp.: keep cold
H-Bond Donor: 2
H-Bond Acceptor: 4
Rotatable Bond Count: 1
Tautomer Count: 2
Exact Mass: 138.042927
MonoIsotopic Mass: 138.042927
Topological Polar Surface Area: 76.2
Heavy Atom Count: 10
Complexity: 138
Canonical SMILES: C1=CN=C(C=C1C(=O)O)N
InChI: InChI=1S/C6H6N2O2/c7-5-3-4(6(9)10)1-2-8-5/h1-3H,(H2,7,8)(H,9,10)
InChIKey: QMKZZQPPJRWDED-UHFFFAOYSA-N
Product Categories: AMINOACID; Amines;blocks; Carboxes; Pyridines; Pyridine series; pyridine derivative; pharmacetical; Carboxylic Acids; Pyridine; Organic acids; Carboxylic Acids

2-Amino isonicotinic acid Safety Profile

Hazard Codes: Irritant Xi, Toxic T
Risk Statements: 36/37/38-23/24/25
R36/37/38:Irritating to eyes, respiratory system and skin.
R23/24/25:Toxic by inhalation, in contact with skin and if swallowed.
Safety Statements: 26-36-45-36/37/39
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36:Wear suitable protective clothing.
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection.
Hazard Note: Irritant/Keep Cold
HazardClass: IRRITANT

2-Amino isonicotinic acid Specification

2-Amino isonicotinic acid (CAS NO.13362-28-2) is also named as 4-pyridinecarboxylic acid, 2-amino- ; acide 2-aminoisonicotinique ; 2-Amino-4-pyridine carboxylic acid ; 2-Amino-4-pyridinecarboxylic acid ; 2-aminoisonicotinic acid hydrochloride ; 2-aminopyridine-4-carboxylic acid . 2-Amino isonicotinic acid (CAS NO.13362-28-2) is light yellow crystal.

Product Name

2-Aminoisonicotinic acid

Synthetic route

2-Amino isonicotinic acid Chemical Properties

2-Amino isonicotinic acid Safety Profile

2-Amino isonicotinic acid Specification

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