2-Aminobenzothiazole-6-carboxylic acid supplier

Name
2-Aminobenzothiazole-6-carboxylic acid
EINECS 202-283-8
CAS No. 93-85-6
Article Data25
CAS DataBase
Density 1.604 g/cm³
Solubility
Melting Point 265 °C
Formula C₈H₆N₂O₂
Boiling Point 466.6 °C at 760 mmHg
Molecular Weight 194.214
Flash Point 236 °C
Transport Information
Appearance
Safety 26-37
Risk Codes 36/37/38
Molecular Structure
Hazard Symbols Xi
Synonyms 2-Amino-6-benzothiazolecarboxylicacid;2-Amino-6-carboxybenzothiazole;NSC 39119;
PSA 104.45000
LogP 2.15790

Synthetic route

: 333-20-0
potassium thioacyanate

: 150-13-0
4-amino-benzoic acid

: 93-85-6
2-aminobenzothiazole-6-carboxylic acid

Conditions

Conditions	Yield
With sodium iodide dichloride at 70℃; for 10h;	97%
With bromine In acetic acid for 2h;	68%
Stage #1: potassium thioacyanate; 4-amino-benzoic acid With bromine In methanol Stage #2: With hydrogenchloride In methanol

: 68867-21-0
4-amino-3-thiocyanatobenzonitrile

: 93-85-6
2-aminobenzothiazole-6-carboxylic acid

Conditions

Conditions	Yield
With hydrogenchloride; water at 100℃; for 6h;	59%
With hydrogenchloride; water at 100℃; for 6h;	59%
With hydrogenchloride In water at 100℃; for 6h;	59%

: 540-72-7
sodium thiocyanide

: 150-13-0
4-amino-benzoic acid

: 93-85-6
2-aminobenzothiazole-6-carboxylic acid

Conditions

Conditions	Yield
With bromine In methanol at -10 - -5℃; for 2h;	42%

: 66947-92-0
2-aminobenzo[d]thiazole-6-carboxylic acid methyl ester

: 93-85-6
2-aminobenzothiazole-6-carboxylic acid

Conditions

Conditions	Yield
With sodium hydroxide In ethanol at 20℃; for 4h;	33%

: 20600-51-5
N-(6-methylbenzo[d]thiazol-2-yl)acetamide

: 93-85-6
2-aminobenzothiazole-6-carboxylic acid

Conditions

Conditions	Yield
With potassium permanganate; water; magnesium sulfate Erwaermen des Reaktionsprodukts mit wss. H2SO4;

: 50850-93-6
ethyl 2-aminobenzothiazole-6-carboxylate

: 93-85-6
2-aminobenzothiazole-6-carboxylic acid

Conditions

Conditions	Yield
With hydrogenchloride
With hydrogenchloride Heating;
With LiOH In 1,4-dioxane; water
With LiOH In 1,4-dioxane; water

: 1147550-11-5
ammonium thiocyanate

: 150-13-0
4-amino-benzoic acid

: 93-85-6
2-aminobenzothiazole-6-carboxylic acid

Conditions

Conditions	Yield
With bromine; acetic acid Erhitzen des Reaktionsprodukts mit wss. HCl;

: 15192-76-4
copper(II) thiocyanate

: 150-13-0
4-amino-benzoic acid

: 93-85-6
2-aminobenzothiazole-6-carboxylic acid

Conditions

Conditions	Yield
With acetic acid

: 2536-91-6
6-methylbenzothiazol-2-ylamine

: 93-85-6
2-aminobenzothiazole-6-carboxylic acid

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 2: KMnO4; MgSO4; H2O / Erwaermen des Reaktionsprodukts mit wss. H2SO4 View Scheme

: 23051-16-3
4-thioureidobenzoic acid ethyl ester

: 93-85-6
2-aminobenzothiazole-6-carboxylic acid

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: bromine; chloroform / Behandeln des Reaktionsprodukts mit schwefliger Saeure 2: hydrochloric acid View Scheme

: 94-09-7
p-aminoethylbenzoate

: 93-85-6
2-aminobenzothiazole-6-carboxylic acid

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: (i) Br2, AcOH, (ii) aq. Na2CO3 2: aq. HCl / Heating View Scheme

: ammonium thiocyanate

: 150-13-0
4-amino-benzoic acid

: 93-85-6
2-aminobenzothiazole-6-carboxylic acid

Conditions

Conditions	Yield
With sodium hydroxide; bromine In water; acetic acid

: 150-13-0
4-amino-benzoic acid

: 93-85-6
2-aminobenzothiazole-6-carboxylic acid

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: bromine; acetic acid / water / 0 - 10 °C 2: hydrogenchloride / water / 2 h / Reflux View Scheme
Multi-step reaction with 2 steps 1: bromine / acetic acid / 1 h / 0 - 10 °C 2: hydrogenchloride; water / 2 h / Reflux View Scheme

: 873-74-5
4-Aminobenzonitrile

: 93-85-6
2-aminobenzothiazole-6-carboxylic acid

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: acetic acid / 3.5 h / 20 °C / Cooling with ice 2: hydrogenchloride; water / 6 h / 100 °C View Scheme
Multi-step reaction with 2 steps 1: acetic acid; bromine / 3.5 h / 20 °C / Cooling with ice 2: hydrogenchloride / water / 6 h / 100 °C View Scheme

: 18330-64-8
4-amino-3-thiocyanatobenzoic acid

: 93-85-6
2-aminobenzothiazole-6-carboxylic acid

Conditions

Conditions	Yield
With hydrogenchloride In water for 2h; Reflux;
With hydrogenchloride; water for 2h; Reflux;

: 93-85-6
2-aminobenzothiazole-6-carboxylic acid

: 4-amino-3-mercaptobenzoic acid zinc salt

Conditions

Conditions	Yield
Stage #1: 2-aminobenzothiazole-6-carboxylic acid With potassium hydroxide; water for 3h; Heating / reflux; Stage #2: With hydrogenchloride In water at 20℃; Stage #3: With zinc(II) chloride In water	98%

: 93-85-6
2-aminobenzothiazole-6-carboxylic acid

: 100-46-9
benzylamine

: 2-amino-N-benzylbenzo[d]thiazole-6-carboxamide

Conditions

Conditions	Yield
Stage #1: 2-aminobenzothiazole-6-carboxylic acid With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; triethylamine In N,N-dimethyl-formamide for 0.0333333h; Stage #2: benzylamine In N,N-dimethyl-formamide at 20℃; for 18h;	88%
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 0 - 20℃; for 24h;	65%

: 93-85-6
2-aminobenzothiazole-6-carboxylic acid

: 1280582-87-7
C15H11BrCl2OS

: 1370023-99-6
2-(2,4-dichlorophenyl)-3-[4-(methylsulfanyl)phenyl]imidazo[2,1-b][1,3]benzothiazole-7-carboxylic acid

Conditions

Conditions	Yield
In ethanol Reflux;	85.67%
Stage #1: 2-aminobenzothiazole-6-carboxylic acid; C15H11BrCl2OS In ethanol Reflux; Stage #2: With phosphorus pentoxide In ethanol Reflux;	85.67%

: 27895-95-0
2-bromo-1,2-bis(4-methoxyphenyl)ethanone

: 93-85-6
2-aminobenzothiazole-6-carboxylic acid

: 1280582-32-2
2,3-bis(4-methoxyphenyl)imidazo[2,1-b][1,3]benzothiazole-7-carboxylic acid

Conditions

Conditions	Yield
In ethanol Reflux;	83.55%
Stage #1: 2-bromo-1,2-bis(4-methoxyphenyl)ethanone; 2-aminobenzothiazole-6-carboxylic acid In ethanol Reflux; Stage #2: With phosphorus pentoxide In ethanol Reflux;	83.55%

: 2-bromo-1-(4''-(methylthio)phenyl)-2-(4'-methoxyphenyl)-1-ethanone

: 93-85-6
2-aminobenzothiazole-6-carboxylic acid

: 1370409-52-1
2-(4-methoxyphenyl)-3-[4-(methylsulfanyl) phenyl]imidazo[2,1-b][1,3]benzothiazole-7-carboxylic acid

Conditions

Conditions	Yield
In ethanol Reflux;	82.9%
Stage #1: 2-bromo-1-(4''-(methylthio)phenyl)-2-(4'-methoxyphenyl)-1-ethanone; 2-aminobenzothiazole-6-carboxylic acid In ethanol Reflux; Stage #2: With phosphorus pentoxide In ethanol Reflux;	82.9%

: 93-85-6
2-aminobenzothiazole-6-carboxylic acid

: 79-04-9
chloroacetyl chloride

: 2-(2-chloroacetylamino)benzothiazole-6-carboxylic acid

Conditions

Conditions	Yield
With potassium carbonate In chloroform for 12h; Heating;	81%

: 2971-79-1
isonipecotic acid methyl ester

: 93-85-6
2-aminobenzothiazole-6-carboxylic acid

: methyl 1-(2-aminobenzo[d]thiazole-6-carbonyl)piperidine-4-carboxylate

Conditions

Conditions	Yield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 0 - 20℃; for 24h;	81%

: 93-85-6
2-aminobenzothiazole-6-carboxylic acid

: 1280582-79-7
C15H12BrClO2

: 1370409-59-8
2-(2-chlorophenyl)-3-(4-methoxyphenyl)-2,3-dihydroimidazo[2,1-b][1,3]benzothiazole-7-carboxylic acid

Conditions

Conditions	Yield
In ethanol Reflux;	78.29%
Stage #1: 2-aminobenzothiazole-6-carboxylic acid; C15H12BrClO2 In ethanol Reflux; Stage #2: With phosphorus pentoxide In ethanol Reflux;	78.29%

: 93-85-6
2-aminobenzothiazole-6-carboxylic acid

: 108-24-7
acetic anhydride

: 100817-94-5
2-acetamidobenzo[d]thiazole-6-carboxylic acid

Conditions

Conditions	Yield
With pyridine for 2h; Heating;	76%

: 67-56-1
methanol

: 93-85-6
2-aminobenzothiazole-6-carboxylic acid

: 66947-92-0
2-aminobenzo[d]thiazole-6-carboxylic acid methyl ester

Conditions

Conditions	Yield
With dmap; diazomethyl-trimethyl-silane In tetrahydrofuran; hexane at 20℃;	75%
sulfuric acid

: 18638-99-8
3,4,5-trimethoxybenzylamine

: 93-85-6
2-aminobenzothiazole-6-carboxylic acid

: 2-amino-N-(3,4,5-trimethoxybenzyl)benzo[d]thiazole-6-carboxamide

Conditions

Conditions	Yield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 0 - 20℃; for 24h;	74%

: 93-85-6
2-aminobenzothiazole-6-carboxylic acid

: 1280582-80-0
C15H12BrClOS

: 1370025-25-4
2-(2-chlorophenyl)-3-[4-(methylsulfanyl) phenyl]-2,3-dihydroimidazo[2,1-b][1,3]benzothiazole-7-carboxylic acid

Conditions

Conditions	Yield
In ethanol Reflux;	72.6%
Stage #1: 2-aminobenzothiazole-6-carboxylic acid; C15H12BrClOS In ethanol Reflux; Stage #2: With phosphorus pentoxide In ethanol Reflux;	72.6%

: 93-85-6
2-aminobenzothiazole-6-carboxylic acid

: 2-(aminomethyl)-5-((4-methoxybenzyl)oxy)-4H-pyran-4-one

: 2-amino-N-((5-((4-methoxybenzyl)oxy)-4-oxo-4H-pyran-2-yl)methyl)benzo[d]thiazole-6-carboxamide

Conditions

Conditions	Yield
With 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 20℃;	72.4%

: 93-85-6
2-aminobenzothiazole-6-carboxylic acid

: 67-63-0
isopropyl alcohol

: 134949-38-5
isopropyl 2-aminobenzo[d]thiazole-6-carboxylate

Conditions

Conditions	Yield
With sulfuric acid at 0℃; for 24h; Reflux;	71%

: 93-85-6
2-aminobenzothiazole-6-carboxylic acid

: 91-00-9
Benzhydrylamine

: 2-amino-N-benzhydrylbenzo[d]thiazole-6-carboxamide

Conditions

Conditions	Yield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 0 - 20℃; for 24h;	70%

: 93-85-6
2-aminobenzothiazole-6-carboxylic acid

: 14543-45-4
4-amino-3-mercaptobenzoic acid

Conditions

Conditions	Yield
Stage #1: 2-aminobenzothiazole-6-carboxylic acid With water; potassium hydroxide for 24h; Inert atmosphere; Reflux; Stage #2: With hydrogenchloride In water Cooling with ice;	67.9%
Stage #1: 2-aminobenzothiazole-6-carboxylic acid With water; potassium hydroxide for 24h; Inert atmosphere; Reflux; Stage #2: With hydrogenchloride In water Cooling with ice;	67.9%
With potassium hydroxide In water for 24h; Inert atmosphere; Reflux;	67.9%
With water; potassium hydroxide for 3h; Reflux;	66.1%
With potassium hydroxide In water

: 93-85-6
2-aminobenzothiazole-6-carboxylic acid

: 1280582-84-4
C15H11BrCl2O

: 1370024-36-4
2-(2,4-dichlorophenyl)-3-(4-methylphenyl)imidazo[2,1-b][1,3]benzothiazole-7-carboxylic acid

Conditions

Conditions	Yield
In ethanol Reflux;	66.3%
Stage #1: 2-aminobenzothiazole-6-carboxylic acid; C15H11BrCl2O In ethanol Reflux; Stage #2: With phosphorus pentoxide In ethanol Reflux;	66.3%

: 93-85-6
2-aminobenzothiazole-6-carboxylic acid

: 1280582-86-6
C15H11BrCl2O2

: 1370409-53-2
2-(2,4-dichlorophenyl)-3-(4-methoxyphenyl)imidazo[2,1-b][1,3]benzothiazole-7-carboxylic acid

Conditions

Conditions	Yield
In ethanol Reflux;	65.46%
Stage #1: 2-aminobenzothiazole-6-carboxylic acid; C15H11BrCl2O2 In ethanol Reflux; Stage #2: With phosphorus pentoxide In ethanol Reflux;	65.46%

: 93-85-6
2-aminobenzothiazole-6-carboxylic acid

: 3-[methyl(phenyl)amino]propyl acetate

: 2-[(E)-(4-{[3-(acetyloxy)propyl](methyl)amino}phenyl)diazenyl]-1,3-benzothiazole-6-carboxylic acid

Conditions

Conditions	Yield
Stage #1: 2-aminobenzothiazole-6-carboxylic acid With nitrosylsulfuric acid In acetic acid; propionic acid at 0 - 20℃; for 4.08333h; Stage #2: 3-[methyl(phenyl)amino]propyl acetate With aminosulfonic acid In methanol; water; acetic acid; propionic acid at 0 - 4℃; for 1.08333h;	64%

: 873302-27-3
7‐(4‐bromobutoxy)‐5‐hydroxy‐2‐phenyl‐4H‐chromen‐4‐one

: 93-85-6
2-aminobenzothiazole-6-carboxylic acid

: 2-(4-(5-hydroxy-4-oxo-2-phenyl-4H-chromen-7-yloxy)butylamino)benzo[d]thiazole-6-carboxylic acid

Conditions

Conditions	Yield
In acetonitrile Reflux;	61%

: 93-85-6
2-aminobenzothiazole-6-carboxylic acid

: 102-49-8
3,4-dichlorobenzyl amine

: 2-amino-N-(3,4-dichlorobenzyl)benzo[d]thiazole-6-carboxamide

Conditions

Conditions	Yield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 0 - 20℃; for 24h;	61%

: 93-85-6
2-aminobenzothiazole-6-carboxylic acid

: 100-39-0
benzyl bromide

: benzyl 2-aminobenzo[d]thiazole-6-carboxylate

Conditions

Conditions	Yield
In acetonitrile at 20℃; for 18h;	61%

: 61-54-1
tryptamine

: 93-85-6
2-aminobenzothiazole-6-carboxylic acid

: N-(2-(1H-indol-3-yl)ethyl)-2-aminobenzo[d]thiazole-6-carboxamide

Conditions

Conditions	Yield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 0 - 20℃; for 24h;	59%

: 93-85-6
2-aminobenzothiazole-6-carboxylic acid

: 2ClH*C6H7NO

: 6-(benzo[d]oxazol-2-yl)benzo[d]thiazol-2-amine

Conditions

Conditions	Yield
With Eaton′s Reagent for 8h; Reflux;	56%

: 93-85-6
2-aminobenzothiazole-6-carboxylic acid

: 2632-13-5
2-Bromo-4'-methoxyacetophenone

: 4-(4-methoxyphenyl)-7-thia-2,5-diazatricyclo[6.4.0.02,6] dodeca-1(8),3,5,9,11-pentaene-10-carboxylic acid

Conditions

Conditions	Yield
In 2-methoxy-ethanol at 40 - 140℃; for 43h;	55%

: 93-85-6
2-aminobenzothiazole-6-carboxylic acid

: 18469-52-8
methyl 4-(aminomethyl)benzoate

: methyl 4-((2-aminobenzo[d]thiazole-6-carboxamido)methyl)benzoate

Conditions

Conditions	Yield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 0 - 20℃; for 24h;	53%

: 93-85-6
2-aminobenzothiazole-6-carboxylic acid

: 146651-75-4
tert–butyl (2–aminophenyl)carbamate

: 866000-85-3
{2-[(2-amino-benzothiazole-6-carbonyl)-amino]-phenyl}-carbamic acid tert-butyl ester

Conditions

Conditions	Yield
With BOP; triethylamine In DMF (N,N-dimethyl-formamide) at 20℃;	52%

2-Aminobenzothiazole-6-carboxylic acid Chemical Properties

Molecular structure of 6-Benzothiazolecarboxylicacid, 2-amino- (CAS NO.93-85-6) is:

Product Name: 6-Benzothiazolecarboxylicacid, 2-amino-
CAS Registry Number: 93-85-6
IUPAC Name: 2-amino-1,3-benzothiazole-6-carboxylic acid
Molecular Weight: 194.21044 [g/mol]
Molecular Formula: C₈H₆N₂O₂S
EINECS: 202-283-8
XLogP3: 1.8
H-Bond Donor: 2
H-Bond Acceptor: 4
Melting Point: 265 °C
Surface Tension: 93.4 dyne/cm
Density: 1.604 g/cm³
Flash Point: 236 °C
Enthalpy of Vaporization: 76.75 kJ/mol
Boiling Point: 466.6 °C at 760 mmHg
Vapour Pressure: 1.65E-09 mmHg at 25°C
Product Categories: Benzothiazole

2-Aminobenzothiazole-6-carboxylic acid Safety Profile

Hazard Codes: Xi
HazardClass: IRRITANT

2-Aminobenzothiazole-6-carboxylic acid Specification

6-Benzothiazolecarboxylicacid, 2-amino- , its cas register number is 93-85-6. It also can be called NSC 39119 ; 2-Aminobenzothiazole-6-carboxylic acid .

Product Name

2-Aminobenzothiazole-6-carboxylic acid

Synthetic route

2-Aminobenzothiazole-6-carboxylic acid Chemical Properties

2-Aminobenzothiazole-6-carboxylic acid Safety Profile

2-Aminobenzothiazole-6-carboxylic acid Specification

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