2-Aminoethyldiisopropylamine supplier

Name
2-Aminoethyldiisopropylamine
EINECS 204-447-4
CAS No. 121-05-1
Article Data18
CAS DataBase
Density 0.837 g/cm³
Solubility Fully miscible in water.
Melting Point 52°C (estimate)
Formula C₈H₂₀N₂
Boiling Point 162.8 °C at 760 mmHg
Molecular Weight 144.26
Flash Point 49.3 °C
Transport Information UN 2734
Appearance
Safety S23;S28
Risk Codes R10;R37/38
Molecular Structure
Hazard Symbols Xi
Synonyms 1,2-Ethanediamine,N,N-bis(1-methylethyl)- (9CI);Ethylenediamine, N,N-diisopropyl- (6CI,7CI,8CI);2-(Diisopropylamino)ethanamine;2-(Diisopropylamino)ethylamine;N,N-Bis(1-methylethyl)-1,2-ethanediamine;N,N-Diisopropyl-1,2-ethanediamine;N,N-Diisopropylethylenediamine;N-(N,N-Diisopropylamino)ethylamine;[2-(Diisopropylamino)ethan-1-yl]amine;
PSA 29.26000
LogP 1.76420

Synthetic route

: 54714-49-7
N,N-(diisopropylamino)acetonitrile

: 121-05-1
N',N'-diisopropyl-ethane-1,2-diamine

Conditions

Conditions	Yield
With lithium aluminium tetrahydride; nickel dichloride In tetrahydrofuran at 5 - 65℃; for 5h; Solvent; Reagent/catalyst; Temperature;	83.7%

: 1211469-53-2
C9H21N3O

: 121-05-1
N',N'-diisopropyl-ethane-1,2-diamine

Conditions

Conditions	Yield
With hydrogenchloride; sodium nitrate In water at 0 - 80℃; for 7h; Curtius rearrangement;	82%

: 2-(diisopropylamino)ethyl chloride hydrochloride

: 121-05-1
N',N'-diisopropyl-ethane-1,2-diamine

Conditions

Conditions	Yield
With ammonium hydroxide In water at 5 - 10℃; for 8h; Autoclave; Large scale;	51.7%

: 85262-27-7
N-(2-diisopropylaminoethyl)phthalimide

: 121-05-1
N',N'-diisopropyl-ethane-1,2-diamine

Conditions

Conditions	Yield
With hydrogen bromide
With hydrogenchloride
With hydrazine

: 27453-38-9
methyl (3-diisopropylamino)-propionate

: 121-05-1
N',N'-diisopropyl-ethane-1,2-diamine

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: hydrazine hydrate / ethanol / 12 h / 20 °C / Reflux 2: hydrogenchloride; sodium nitrate / water / 7 h / 0 - 80 °C View Scheme

: 108-18-9
diisopropylamine

: 121-05-1
N',N'-diisopropyl-ethane-1,2-diamine

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: iron(III) chloride hexahydrate / water / 15 h / 20 °C 2: hydrazine hydrate / ethanol / 12 h / 20 °C / Reflux 3: hydrogenchloride; sodium nitrate / water / 7 h / 0 - 80 °C View Scheme

: 121-05-1
N',N'-diisopropyl-ethane-1,2-diamine

: 24066-82-8
ethyl 2-isothiocyanatoacetate

: 3-(2-diisopropylamino-ethyl)-2-thioxo-imidazolidin-4-one

Conditions

Conditions	Yield
In chloroform for 4h;	99.8%

: 121-05-1
N',N'-diisopropyl-ethane-1,2-diamine

: 5464-11-9
2-methylthio-2-imidazoline hydroiodide

: 2-(2-(diisopropylamino)ethylamino)-4,5-dihydro-1H-imidazole

Conditions

Conditions	Yield
Stage #1: N',N'-diisopropyl-ethane-1,2-diamine; 2-methylthio-2-imidazoline hydroiodide In tetrahydrofuran at 40℃; for 24h; Stage #2: With sodium hydroxide In water at 20℃;	99%

: 98-01-1
furfural

: 121-05-1
N',N'-diisopropyl-ethane-1,2-diamine

: N1-(furan-2-ylmethylene)-N2,N2-diisopropylethane-1,2-diamine

Conditions

Conditions	Yield
With magnesium sulfate In dichloromethane at 20℃; Inert atmosphere; Darkness;	99%

: 121-05-1
N',N'-diisopropyl-ethane-1,2-diamine

: 5-norbornene-exo-2,3-dicarboxylic anhydride

: N-(2-aminoethyldiisopropylamine)-5-norbornene-exo-2,3-dicarboxylic acid imide

Conditions

Conditions	Yield
With triethylamine Reflux;	99%

: 121-05-1
N',N'-diisopropyl-ethane-1,2-diamine

: 95-92-1
oxalic acid diethyl ester

: 25148-95-2
N1,N2-bis(2-(diisopropylamino)ethyl)oxalamide

Conditions

Conditions	Yield
at 130℃;	99%

: 626-19-7
Isophthalaldehyde

: 121-05-1
N',N'-diisopropyl-ethane-1,2-diamine

: bis[diisopropylaminoethyl]-N,N‘-m-xylylenediimine

Conditions

Conditions	Yield
In ethanol	99%

: 877997-99-4
2-[(2-hydroxy-4,5-dimethoxybenzoyl)amino]-1,3-thiazole-4-carboxylic acid methyl ester

: 121-05-1
N',N'-diisopropyl-ethane-1,2-diamine

: 2-[N-(4,5-dimethoxy-2-hydroxybenzoyl)amino]-4-[(2-diisopropyl-aminoethyl)aminocarbonyl]-1,3-thiazole hydrochloride

Conditions

Conditions	Yield
Stage #1: 2-[(2-hydroxy-4,5-dimethoxybenzoyl)amino]-1,3-thiazole-4-carboxylic acid methyl ester; N',N'-diisopropyl-ethane-1,2-diamine In toluene at 100℃; for 5h; Stage #2: With hydrogenchloride In water; isopropyl alcohol	97%
Stage #1: 2-[(2-hydroxy-4,5-dimethoxybenzoyl)amino]-1,3-thiazole-4-carboxylic acid methyl ester; N',N'-diisopropyl-ethane-1,2-diamine In 1,4-dioxane at 75℃; for 6h; Inert atmosphere; Stage #2: With hydrogenchloride In methanol; water	96.3%

: 877997-99-4
2-[(2-hydroxy-4,5-dimethoxybenzoyl)amino]-1,3-thiazole-4-carboxylic acid methyl ester

: 121-05-1
N',N'-diisopropyl-ethane-1,2-diamine

: N-[2-(diisopropylamino)ethyl]-2-[(2-hydroxy-4,5-dimethoxybenzoyl)amino]-1,3-thiazole-4-carboxamide hydrochloride

Conditions

Conditions	Yield
Stage #1: 2-[(2-hydroxy-4,5-dimethoxybenzoyl)amino]-1,3-thiazole-4-carboxylic acid methyl ester; N',N'-diisopropyl-ethane-1,2-diamine In toluene at 70 - 100℃; for 5h; Inert atmosphere; Stage #2: With hydrogenchloride In water	97%

: 206882-11-3
2-[N-(3-cyanobenzoyl)amino]-4-methoxycarbonyl-1,3-thiazole.hydrochloride

: 121-05-1
N',N'-diisopropyl-ethane-1,2-diamine

: 75-24-1
trimethylaluminum

: 107-06-2
1,2-dichloro-ethane

: 206881-85-8
2-[N-(3-Cyanobenzoyl)amino]-4-[(2-diisopropylaminoethyl)aminocarbonyl]-1,3-thiazolehydrochloride

Conditions

Conditions	Yield
With hydrogenchloride In toluene	95.4%

...Expand

: 121-05-1
N',N'-diisopropyl-ethane-1,2-diamine

: 67217-55-4
mono-6-deoxy-6-(p-tolylsulphonyl)-β-cyclodextrin

: 1393337-75-1
6-deoxy-6-N,N'-diisopropyl-aminoethylamino-bcyclodextrin

Conditions

Conditions	Yield
at 85℃; for 0.5h; Microwave irradiation;	95%

: 121-05-1
N',N'-diisopropyl-ethane-1,2-diamine

: 5111-07-9, 51744-55-9
purpurin-18-methyl ester

: purpurin-18-N-(N-isopropylamino)ethylimide

Conditions

Conditions	Yield
In toluene for 2h; Inert atmosphere; Reflux;	94%

: 75-79-6
Methyltrichlorosilane

: 121-05-1
N',N'-diisopropyl-ethane-1,2-diamine

: C25H60N6Si

Conditions

Conditions	Yield
With triethylamine In hexane at 20℃; for 24h;	93%

: 121-05-1
N',N'-diisopropyl-ethane-1,2-diamine

: C16H20N2O6S

: N-[2-(diisopropylamino)ethyl]-2-[(2,4,5-trimethoxybenzoyl)amino]-1,3-thiazole-4-carboxamide hydrochloride

Conditions

Conditions	Yield
Stage #1: N',N'-diisopropyl-ethane-1,2-diamine; C16H20N2O6S In N,N-dimethyl acetamide at 120℃; for 8h; Inert atmosphere; Stage #2: With hydrogenchloride In water at 20℃; for 4h; pH=1 - 2; Inert atmosphere;	93%

: 87-51-4
indole-3-acetic acid

: 121-05-1
N',N'-diisopropyl-ethane-1,2-diamine

: N-(2-(diisopropylamino)ethyl)-2-(1H-indol-3-yl)acetamide

Conditions

Conditions	Yield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃; for 12h;	92.2%

: 121-05-1
N',N'-diisopropyl-ethane-1,2-diamine

: 2-N-phthalimide-4-methoxycarbonyl-1,3-thiazole

: C20H24N4O3S

Conditions

Conditions	Yield
at 100℃; for 6h;	91.5%

: 121-05-1
N',N'-diisopropyl-ethane-1,2-diamine

: 24335-35-1
2,4-dichloro-1,3-di-tert-butyl-1,3,2,4-diazadiphosphetidine

: 1343408-39-8
C24H56N6P2

Conditions

Conditions	Yield
With triethylamine In tetrahydrofuran for 24h; Inert atmosphere; Reflux;	91%

: 121-05-1
N',N'-diisopropyl-ethane-1,2-diamine

: 100-52-7
benzaldehyde

: N1-benzylidene-N2,N2-diisopropylethane-1,2-diamine

Conditions

Conditions	Yield
With sodium sulfate In diethyl ether at 20℃; for 2h; Reflux;	91%
With magnesium sulfate In diethyl ether at 20℃;	76%
In ethanol for 24h;

: 121-05-1
N',N'-diisopropyl-ethane-1,2-diamine

: 99009-49-1
1-chloro-7-hydroxy-4-nitro-9(10H)-acridinone

: 174275-52-6
1-(2-Diisopropylamino-ethylamino)-7-hydroxy-4-nitro-10H-acridin-9-one

Conditions

Conditions	Yield
In N,N-dimethyl-formamide at 80℃; for 0.5h;	90%

: 121-05-1
N',N'-diisopropyl-ethane-1,2-diamine

: 52447-23-1
heptadecafluorononanic acid chloride

: 2,2,3,3,4,4,5,5,6,6,7,7,8,8,8-pentadecafluoro-octanoic acid (2-diisopropylamino-ethyl)-amide

Conditions

Conditions	Yield
With triethylamine In dichloromethane for 0.5h;	90%

: 121-05-1
N',N'-diisopropyl-ethane-1,2-diamine

: 1951-36-6
2,5-dihydroxyterephthaldeyde

: 2,5-bis-[(2-diisopropylamino-ethylimino)-methyl]-benzene-1,4-diol

Conditions

Conditions	Yield
In dichloromethane for 1h; Heating;	90%

: 1121-60-4
pyridine-2-carbaldehyde

: 121-05-1
N',N'-diisopropyl-ethane-1,2-diamine

: PyCH2NH(CH2)2N(iPr)2

Conditions

Conditions	Yield
Stage #1: pyridine-2-carbaldehyde; N',N'-diisopropyl-ethane-1,2-diamine for 1h; Inert atmosphere; Stage #2: With methanol; sodium tetrahydroborate for 1h; Inert atmosphere;	90%

: 2-[(2-hydroxy-4,5-dimethoxybenzoyl)amino]-1,3-thiazole-4-carboxylic acid ethyl ester

: 121-05-1
N',N'-diisopropyl-ethane-1,2-diamine

: Acotiamide

Conditions

Conditions	Yield
at 120℃; for 3h; Inert atmosphere;	89.1%
at 70 - 105℃; for 13h; Temperature; Inert atmosphere; Large scale;

: 220866-33-1
4-chloro-2-oxo-1-phenyl-1,2-dihydro-quinoline-3-carboxylic acid ethyl ester

: 121-05-1
N',N'-diisopropyl-ethane-1,2-diamine

: ethyl 4-(2-diisopropylaminoethylamino)-2-oxo-1-phenyl-1,2-dihydroquinoline-3-carboxylate

Conditions

Conditions	Yield
In tetrahydrofuran; water	87.3%

: 67-52-7
BARBITURIC ACID

: 50-99-7
D-glucose

: 121-05-1
N',N'-diisopropyl-ethane-1,2-diamine

: C22H34N6O9

Conditions

Conditions	Yield
With toluene-4-sulfonic acid In ethanol at 50℃; for 12h;	87%

...Expand

: 121-05-1
N',N'-diisopropyl-ethane-1,2-diamine

: 56043-45-9, 13829-06-6
N,N,N',N'-tetramethylchlorformamidinium chloride

: 428514-99-2
2-[2-(diisopropylamino)ethyl]-1,1,3,3-tetramethylguanidine

Conditions

Conditions	Yield
Stage #1: N',N'-diisopropyl-ethane-1,2-diamine; N,N,N',N'-tetramethylchlorformamidinium chloride With triethylamine In acetonitrile for 3h; Inert atmosphere; Reflux; Stage #2: With sodium hydroxide In water; acetonitrile Inert atmosphere; Stage #3: With potassium hydroxide In water Inert atmosphere;	86%

: 121-05-1
N',N'-diisopropyl-ethane-1,2-diamine

: 2043-61-0
cyclohexanecarbaldehyde

: 2-cyclohexylmethylene-N,N-diisopropylethylen-1-amine

Conditions

Conditions	Yield
With sodium sulfate In diethyl ether at 20℃; for 2h; Reflux;	86%

: 121-05-1
N',N'-diisopropyl-ethane-1,2-diamine

: 37091-73-9
2-chloro-1,3-dimethylimidazolinium chloride

: 1309596-51-7
N1-(1,3-dimethylimidazolidin-2-yliden)-N2,N2-diisopropylethan-1,2-diamine

Conditions

Conditions	Yield
Stage #1: N',N'-diisopropyl-ethane-1,2-diamine; 2-chloro-1,3-dimethylimidazolinium chloride With triethylamine In acetonitrile for 3h; Inert atmosphere; Reflux; Stage #2: With sodium hydroxide In water; acetonitrile Inert atmosphere; Stage #3: With potassium hydroxide In water Inert atmosphere;	85%

: 121-05-1
N',N'-diisopropyl-ethane-1,2-diamine

: 90-02-8
salicylaldehyde

: 2-(((2-(di-isopropylamino)ethyl)imino)methyl)phenol

Conditions

Conditions	Yield
In methanol for 3h; Reflux;	85%

: ethyl 2-[N-(2-hydroxy-4,5-dimethoxybenzoyl)amino]-1,3-thiazole-4-carboxylate acetate

: 121-05-1
N',N'-diisopropyl-ethane-1,2-diamine

: Acotiamide

Conditions

Conditions	Yield
With dicyclohexyl-carbodiimide In neat (no solvent) at 20 - 120℃; for 1h; Solvent; Temperature; Inert atmosphere; Large scale;	83%
In toluene at 70 - 110℃; for 4h; Large scale;	82%

2-Aminoethyldiisopropylamine Chemical Properties

Molecular Structure of 2-Aminoethyldiisopropylamine (CAS NO.121-05-1):

IUPAC Name: N,N-di(propan-2-yl)ethane-1,2-diamine
Empirical Formula: C₈H₂₀N₂
Molecular Weight: 144.2578
EINECS: 204-447-4
H bond acceptors: 2
H bond donors: 2
Freely Rotating Bonds: 5
Polar Surface Area: 6.48 Å²
Index of Refraction: 1.449
Molar Refractivity: 46.28 cm³Molar Volume: 172.2 cm³
Surface Tension: 29 dyne/cm
Density: 0.837 g/cm³
Flash Point: 49.3 °C
Enthalpy of Vaporization: 39.93 kJ/mol
Boiling Point: 162.8 °C at 760 mmHg
Vapour Pressure: 2.13 mmHg at 25°C
InChI
InChI=1/C8H20N2/c1-7(2)10(6-5-9)8(3)4/h7-8H,5-6,9H2,1-4H3
Smiles
N(CCN)(C(C)C)C(C)C

2-Aminoethyldiisopropylamine Toxicity Data With Reference

ipr-mus LD50:200 mg/kg

NTIS** National Technical Information Service. (Springfield, VA 22161) (Formerly U.S. Clearinghouse for Scientific and Technical Information) AD277-689 .

2-Aminoethyldiisopropylamine Consensus Reports

Reported in EPA TSCA Inventory.

2-Aminoethyldiisopropylamine Safety Profile

Poison by intraperitoneal route. When heated to decomposition it emits toxic vapors of NO_x.
Hazard Codes: Corrosive C, Irritant Xi
Risk Statements: 10-34-37/38
R10:Flammable.
R34:Causes burns.
R37/38:Irritating to respiratory system and skin.
Safety Statements: 16-26-27-36/37/39-45-28-23
S16:Keep away from sources of ignition.
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S27:Take off immediately all contaminated clothing.
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection.
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
S28:After contact with skin, wash immediately with plenty of soap-suds.
S23:Do not breathe vapour.
RIDADR: UN 2733 3/PG 3
WGK Germany: 3
RTECS: KV4200000
HazardClass: 8
PackingGroup: II

2-Aminoethyldiisopropylamine Specification

2-Aminoethyldiisopropylamine , with CAS number of 121-05-1, can be called 2-(Diisopropylamino)ethanamine ; N,N-Bis(1-methylethyl)-1,2-ethanediamine ; N,N-Diisopropyl-1,2-ethanediamine ; N,N-Diisopropylethylenediamine ; N-(N,N-Diisopropylamino)ethylamine ; [2-(Diisopropylamino)ethan-1-yl]amine .

Product Name

2-Aminoethyldiisopropylamine

Synthetic route

2-Aminoethyldiisopropylamine Chemical Properties

2-Aminoethyldiisopropylamine Toxicity Data With Reference

2-Aminoethyldiisopropylamine Consensus Reports

2-Aminoethyldiisopropylamine Safety Profile

2-Aminoethyldiisopropylamine Specification

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