2-Bromo-4-methylphenol supplier

Name
2-Bromo-4-methylphenol
EINECS 229-595-7
CAS No. 6627-55-0
Article Data101
CAS DataBase
Density 1.554 g/cm³
Solubility Slightly soluble in water.
Melting Point 213-214 °C
Formula C₇H₇BrO
Boiling Point 213.478 °C at 760 mmHg
Molecular Weight 187.036
Flash Point 82.909 °C
Transport Information
Appearance clear colourless to pale yellow liquid
Safety 26-36/37/39
Risk Codes 21/22-36/37/38
Molecular Structure
Hazard Symbols Xn
Synonyms p-Cresol,2-bromo- (6CI,7CI,8CI);2-Bromo-4-cresol;2-Bromo-4-methylphenol;2-Bromo-p-cresol;3-Bromo-4-hydroxytoluene;NSC 60115;
PSA 20.23000
LogP 2.46310

Synthetic route

: 106-44-5
p-cresol

: 6627-55-0
2-bromo-p-cresol

Conditions

Conditions	Yield
With hydrogen bromide; acetic acid In dimethyl sulfoxide at 20℃; for 2h;	100%
With Oxone; potassium bromide In methanol at 20℃; for 4h;	99%
With N-Bromosuccinimide; sulfonic acid functionalized silica In diethyl ether; acetonitrile at 20℃; for 0.166667h;	99%

: 22002-45-5
2-bromo-4-methylanisole

: 6627-55-0
2-bromo-p-cresol

Conditions

Conditions	Yield
Stage #1: 2-bromo-4-methylanisole With boron tribromide In dichloromethane at -78 - 20℃; Inert atmosphere; Stage #2: With water; sodium hydrogencarbonate In dichloromethane Inert atmosphere;	99%
With boron tribromide In dichloromethane at -78 - 20℃; for 2h;

: 25458-49-5
1-(methoxymethoxy)-4-methylbenzene

: 6627-55-0
2-bromo-p-cresol

Conditions

Conditions	Yield
With tris(2,2'-bipyridyl)ruthenium dichloride; carbon tetrabromide In acetonitrile at 20℃; Irradiation;	97%

: 106-44-5
p-cresol

A: 6627-55-0
2-bromo-p-cresol

B: 2432-14-6
3,5-dibromo-4-hydroxytoluene

Conditions

Conditions	Yield
With dihydrogen peroxide; bromine In dichloromethane at 0℃; for 8h;	A 96% B 0.9%
Stage #1: p-cresol With toluene-4-sulfonic acid In methanol for 0.166667h; Stage #2: With N-Bromosuccinimide In methanol for 0.416667h;	A 92% B n/a
With bromine In 1,2-dichloro-ethane at 20 - 25℃; for 7h;	A n/a B 90%

: 106-44-5
p-cresol

A: 6627-55-0
2-bromo-p-cresol

B: 60710-39-6
3-bromo-p-cresol

Conditions

Conditions	Yield
With bromine In various solvent(s) other reaction time;	A n/a B 90%
With trifluorormethanesulfonic acid; bromine In various solvent(s) for 0.166667h; Product distribution; Mechanism; other reaction time;	A 40% B 60%
With bromine In various solvent(s) for 0.166667h; other reaction time;	A 40% B 60%

: 591-17-3
meta-bromotoluene

A: 6627-55-0
2-bromo-p-cresol

B: 2362-12-1
4-Bromo-2-methylphenol

Conditions

Conditions	Yield
With wild type cytochrome P450 CYP102A1 variants RLYF/A330P; oxygen; NADPH Reagent/catalyst; Enzymatic reaction;	A 14% B 82%
With water; lithium perchlorate; acetic acid; 2,3-dicyano-5,6-dichloro-p-benzoquinone In acetonitrile for 48h; Irradiation; Inert atmosphere; Electrolysis; Overall yield = 50 percent; Overall yield = 37.4 mg; chemoselective reaction;

: 17902-32-8
trimethyl(4-methylphenoxy)silane

: 6627-55-0
2-bromo-p-cresol

Conditions

Conditions	Yield
With tris(2,2'-bipyridyl)ruthenium dichloride; carbon tetrabromide In acetonitrile at 20℃; Irradiation;	69%

: 589-92-4
1-methylcyclohexan-4-one

: 6627-55-0
2-bromo-p-cresol

Conditions

Conditions	Yield
With diethyl dibromomalonate at 100℃; for 48h; Bromination; aromatization;	51%

: 583-68-6
2-bromo-p-toluidine

: 6627-55-0
2-bromo-p-cresol

Conditions

Conditions	Yield
With sulfuric acid Diazotization.Eintragen der Diazoniumsalz-Loesung in ein Gemisch von wss. H2SO4 und Na2SO4 bei 130-135grad;
Diazotization.Einleiten von Wasserdampf in die Diazoniumsalzloesung;

: 65849-33-4
(2-Brom-4-methylphenyl)-benzoat

: 6627-55-0
2-bromo-p-cresol

Conditions

Conditions	Yield
With potassium hydroxide

: 1121-70-6
sodium 4-methylphenoxide

A: 6627-55-0
2-bromo-p-cresol

B: 2432-14-6
3,5-dibromo-4-hydroxytoluene

Conditions

Conditions	Yield
With carbon disulfide; bromine

: 106-44-5
p-cresol

A: 6627-55-0
2-bromo-p-cresol

B: 2432-14-6
3,5-dibromo-4-hydroxytoluene

C: 60710-39-6
3-bromo-p-cresol

D: 344249-21-4
2,5-dibromo-p-cresol

Conditions

Conditions	Yield
With trifluorormethanesulfonic acid; bromine for 0.333333h;	A 84 % Chromat. B 3 % Chromat. C 1 % Chromat. D 1 % Chromat.

...Expand

: 106-44-5
p-cresol

A: 6627-55-0
2-bromo-p-cresol

B: 2432-14-6
3,5-dibromo-4-hydroxytoluene

C: 60710-39-6
3-bromo-p-cresol

D: 344249-21-4
2,5-dibromo-p-cresol

E: 2,3-dibromo-4-methylphenol

Conditions

Conditions	Yield
With trifluorormethanesulfonic acid; bromine for 0.333333h; Product distribution; further reaction times;	A 24 % Chromat. B 10 % Chromat. C 18 % Chromat. D 16 % Chromat. E 1 % Chromat.

...Expand

: 106-44-5
p-cresol

A: 6627-55-0
2-bromo-p-cresol

B: 2432-14-6
3,5-dibromo-4-hydroxytoluene

C: 60710-39-6
3-bromo-p-cresol

D: 2,3-dibromo-4-methylphenol

Conditions

Conditions	Yield
With trifluorormethanesulfonic acid; bromine for 0.333333h; Further byproducts given;	A 24 % Chromat. B 10 % Chromat. C 18 % Chromat. D 2 % Chromat.

...Expand

: 106-44-5
p-cresol

A: 6627-55-0
2-bromo-p-cresol

B: 60710-39-6
3-bromo-p-cresol

C: 344249-21-4
2,5-dibromo-p-cresol

D: 2,3-dibromo-4-methylphenol

Conditions

Conditions	Yield
With trifluorormethanesulfonic acid; bromine for 0.333333h; Further byproducts given;	A 8 % Chromat. B 61 % Chromat. C 15 % Chromat. D 2 % Chromat.

...Expand

: 60710-39-6
3-bromo-p-cresol

A: 106-44-5
p-cresol

B: 6627-55-0
2-bromo-p-cresol

Conditions

Conditions	Yield
With trifluorormethanesulfonic acid Product distribution;

: 106-44-5
p-cresol

: 67-66-3
chloroform

: 7726-95-6
bromine

: 6627-55-0
2-bromo-p-cresol

...Expand

: 106-44-5
p-cresol

: 7726-95-6
bromine

natrium carbonate: natrium carbonate

: 6627-55-0
2-bromo-p-cresol

...Expand

3.5-dibromo-1-nitro-2-methoxy-1-methyl-cyclohexen-(2)-one-(4): 3.5-dibromo-1-nitro-2-methoxy-1-methyl-cyclohexen-(2)-one-(4)

: 6627-55-0
2-bromo-p-cresol

Conditions

Conditions	Yield
With hydrogenchloride; acetic acid; zinc

5-bromo-4-hydroxy-toluene-sulfonic acid-(3): 5-bromo-4-hydroxy-toluene-sulfonic acid-(3)

: 6627-55-0
2-bromo-p-cresol

Conditions

Conditions	Yield
With overheated steam; sulfuric acid at 150℃; under 160 Torr;

: 7647-01-0
hydrogenchloride

: 859818-05-6
2,6-dibromo-5-methoxy-4-methyl-4-nitro-cyclohex-2-enone

: 64-19-7
acetic acid

zinc: zinc

: 6627-55-0
2-bromo-p-cresol

...Expand

: 7647-01-0
hydrogenchloride

: 859179-90-1
5-ethoxy-2,6-dibromo-4-methyl-4-nitro-cyclohex-2-enone

: 64-19-7
acetic acid

zinc: zinc

: 6627-55-0
2-bromo-p-cresol

...Expand

: 39953-10-1
2,4,6-tribromo-4-methylcyclohexa-2,5-dienone

: 6627-55-0
2-bromo-p-cresol

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: trifluoromethanesulfonic acid / CH2Cl2 / 0 °C 2: 54percent HI / H2O / 3 h / Heating 3: 84 percent Chromat. / bromine, triflic acid / 0.33 h View Scheme
Multi-step reaction with 3 steps 1: trifluoromethanesulfonic acid / CH2Cl2 / 0 °C 2: 54percent HI / H2O / 3 h / Heating 3: 24 percent Chromat. / bromine, triflic acid / 0.33 h View Scheme
Multi-step reaction with 3 steps 1: trifluoromethanesulfonic acid / CH2Cl2 / 0 °C 2: 54percent HI / H2O / 3 h / Heating 3: 8 percent Chromat. / bromine, triflic acid / 0.33 h View Scheme

: 2432-14-6
3,5-dibromo-4-hydroxytoluene

: 6627-55-0
2-bromo-p-cresol

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1: 4.6 percent / bromine, potassium bromide, pyridine / H2O; diethyl ether / 0.17 h / -5 °C 2: trifluoromethanesulfonic acid / CH2Cl2 / 0 °C 3: 54percent HI / H2O / 3 h / Heating 4: 84 percent Chromat. / bromine, triflic acid / 0.33 h View Scheme
Multi-step reaction with 4 steps 1: 4.6 percent / bromine, potassium bromide, pyridine / H2O; diethyl ether / 0.17 h / -5 °C 2: trifluoromethanesulfonic acid / CH2Cl2 / 0 °C 3: 54percent HI / H2O / 3 h / Heating 4: 24 percent Chromat. / bromine, triflic acid / 0.33 h View Scheme
Multi-step reaction with 4 steps 1: 4.6 percent / bromine, potassium bromide, pyridine / H2O; diethyl ether / 0.17 h / -5 °C 2: trifluoromethanesulfonic acid / CH2Cl2 / 0 °C 3: 54percent HI / H2O / 3 h / Heating 4: 8 percent Chromat. / bromine, triflic acid / 0.33 h View Scheme

: 36776-51-9
2,3,6-tribromo-4-methyl-phenol

: 6627-55-0
2-bromo-p-cresol

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 54percent HI / H2O / 3 h / Heating 2: 84 percent Chromat. / bromine, triflic acid / 0.33 h View Scheme
Multi-step reaction with 2 steps 1: 54percent HI / H2O / 3 h / Heating 2: 24 percent Chromat. / bromine, triflic acid / 0.33 h View Scheme
Multi-step reaction with 2 steps 1: 54percent HI / H2O / 3 h / Heating 2: 8 percent Chromat. / bromine, triflic acid / 0.33 h View Scheme

: 614-34-6
p-cresyl benzoate

: 6627-55-0
2-bromo-p-cresol

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: phosphorus (V)-bromide / 100 °C 2: ethanolic KOH View Scheme

: 2120-18-5
2-bromo-4-methyl-1-(2-propen-1-yloxy)benzene

A: 6627-55-0
2-bromo-p-cresol

B: 99187-38-9
2-bromo-4-methyl-1-propoxybenzene

Conditions

Conditions	Yield
With sodium tetrahydroborate; ruthenium(III) chloride monohydrate In N-Methylformamide; water at 0℃; for 1h;

: 6627-55-0
2-bromo-p-cresol

: 100-39-0
benzyl bromide

: 2830-53-7
1-(benzyloxy)-2-bromo-4-methylbenzene

Conditions

Conditions	Yield
With potassium carbonate In acetone for 20h; Heating;	100%
With sodium hydride In tetrahydrofuran; N,N-dimethyl-formamide	91%
With potassium carbonate In acetone for 4h; Reflux;	90%

: 6627-55-0
2-bromo-p-cresol

: 1493-27-2
ortho-nitrofluorobenzene

: 856382-90-6
2-bromo-4-methyl-1-(2-nitrophenoxy)benzene

Conditions

Conditions	Yield
With potassium carbonate In dimethyl sulfoxide at 95℃; for 24h; Inert atmosphere;	100%
With potassium carbonate In dimethyl sulfoxide at 95℃; for 21h;	95%

: 6627-55-0
2-bromo-p-cresol

: 106-95-6
allyl bromide

: 2120-18-5
2-bromo-4-methyl-1-(2-propen-1-yloxy)benzene

Conditions

Conditions	Yield
With potassium carbonate In acetone at 20℃;	99%
With potassium carbonate In acetone
With potassium carbonate In acetone at 66℃; for 12h;
With potassium carbonate Inert atmosphere;
With potassium carbonate

: 6627-55-0
2-bromo-p-cresol

: 511286-63-8
(4S) 3,4-dibenzyl[1,2,3]oxathiazolidine-2,2-dioxide

: benzyl [(S)-1-benzyl-2-(2-bromo-4-methylphenoxy)ethyl]amine

Conditions

Conditions	Yield
Stage #1: 2-bromo-p-cresol; (4S) 3,4-dibenzyl[1,2,3]oxathiazolidine-2,2-dioxide With sodium hydride In N,N-dimethyl-formamide at 20℃; for 22h; Stage #2: With hydrogenchloride In N,N-dimethyl-formamide at 20℃; for 3h; Further stages.;	99%

: 5292-43-3
bromoacetic acid tert-butyl ester

: 6627-55-0
2-bromo-p-cresol

: 1240286-85-4
tert-butyl (2-bromo-4-methylphenoxy)acetate

Conditions

Conditions	Yield
Stage #1: 2-bromo-p-cresol With potassium carbonate In acetone for 0.166667h; Stage #2: bromoacetic acid tert-butyl ester In acetone at 65℃; for 18h;	99%
With potassium carbonate In N,N-dimethyl-formamide at 60℃; for 12h;
Stage #1: 2-bromo-p-cresol With potassium carbonate In acetone for 0.166667h; Stage #2: bromoacetic acid tert-butyl ester In acetone at 65℃; for 18h;

: 6627-55-0
2-bromo-p-cresol

: 115-11-7
isobutene

: 960309-86-8
1-tert-butoxy-2-bromo-4-methylbenzene

Conditions

Conditions	Yield
With trifluorormethanesulfonic acid In dichloromethane at -78℃; for 4h;	99%

: 6627-55-0
2-bromo-p-cresol

: 106-96-7
propargyl bromide

: 1020991-05-2
2-bromo-4-methyl-1-(prop-2-yn-1-yloxy)benzene

Conditions

Conditions	Yield
With potassium carbonate In toluene; acetonitrile at 60℃; for 16h;	99%
With potassium carbonate In acetone at 80℃; for 5h;	74%
With potassium carbonate In N,N-dimethyl-formamide at 20℃; Inert atmosphere;
With potassium carbonate; sodium iodide In acetone for 6h; Reflux;
With potassium carbonate In acetone for 24h; Reflux; Inert atmosphere;

: 6627-55-0
2-bromo-p-cresol

: 1105712-07-9
(S)-tert-butyl 4-benzyl 1,2,3-oxathiazolidine-3-carboxylate 2,2-dioxide

: 1441005-72-6
C21H26BrNO3

Conditions

Conditions	Yield
Stage #1: 2-bromo-p-cresol; (S)-tert-butyl 4-benzyl-1,2,3-oxathiazolidine-3-carboxylate 2,2-dioxide With sodium hydride In N,N-dimethyl-formamide Stage #2: With hydrogenchloride In water; N,N-dimethyl-formamide	99%

: 6627-55-0
2-bromo-p-cresol

: 2633-66-1
2-mesitylmagnesium bromide

: 1448442-52-1
2',4',5,6'-tetramethyl-[1,1'-biphenyl]-2-ol

Conditions

Conditions	Yield
Stage #1: 2-bromo-p-cresol With sodium hydride In tetrahydrofuran at 0 - 22℃; for 0.166667h; Kumada Cross-Coupling; Reflux; Stage #2: 2-mesitylmagnesium bromide With palladium(II) acetylacetonate for 12h; Reflux;	99%

: 6627-55-0
2-bromo-p-cresol

: 144432-80-4
2-(biphenyl-4-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

: 1310321-62-0
5-methyl[1,1':4',1''-terphenyl]-2-ol

Conditions

Conditions	Yield
With tetrabutylammomium bromide; palladium diacetate; sodium carbonate In water at 20 - 150℃; for 0.166667h; Suzuki Coupling; Sealed tube; Microwave irradiation;	99%

: 764-01-2
methyl propargyl alcohol

: 6627-55-0
2-bromo-p-cresol

: 2-bromo-1-(but-2-yn-1-yloxy)-4-methylbenzene

Conditions

Conditions	Yield
With di-isopropyl azodicarboxylate; triphenylphosphine In tetrahydrofuran at 0 - 20℃; for 0.5h; Mitsunobu Displacement; Inert atmosphere;	99%

: 6627-55-0
2-bromo-p-cresol

: 180639-95-6
2-bromo-4-methyl-6-iodophenol

Conditions

Conditions	Yield
With iodine; silver sulfate In ethanol at 20℃;	98%
With ammonia; iodine; potassium iodide In methanol; water at 60℃;	96%
With N-iodomorpholine-hydrogen iodide; potassium carbonate In water at 20℃; for 3h; Inert atmosphere;	94.9%
With ammonium hydroxide; iodine; potassium iodide
With iodine; silver sulfate In ethanol at 20℃;

: 6627-55-0
2-bromo-p-cresol

: 74-88-4
methyl iodide

: 22002-45-5
2-bromo-4-methylanisole

Conditions

Conditions	Yield
With potassium carbonate In acetone at 50℃; for 12h; Methylation;	98%
With potassium carbonate In N,N-dimethyl-formamide for 18h;	94%
With potassium carbonate	84%
With potassium carbonate In N,N-dimethyl-formamide for 24h; Reflux;

: 459817-82-4
2,2-dioxo-[1,2,3]oxathiazolidine-3-carboxylic acid tert-butyl ester

: 6627-55-0
2-bromo-p-cresol

: 1441005-46-4
C14H20BrNO3

Conditions

Conditions	Yield
Stage #1: 2,2-dioxo-[1,2,3]oxathiazolidine-3-carboxylic acid tert-butyl ester; 2-bromo-p-cresol With sodium hydride In N,N-dimethyl-formamide Stage #2: With hydrogenchloride In water; N,N-dimethyl-formamide	98%

: 6627-55-0
2-bromo-p-cresol

: 1209467-60-6
(4R)-1,2,3-oxathiazolidine-3-carboxylic acid, 4-phenyl 1,1-dimethylethyl ester-2,2-dioxide

: 1441005-63-5
C20H24BrNO3

Conditions

Conditions	Yield
Stage #1: 2-bromo-p-cresol; (4R)-1,2,3-oxathiazolidine-3-carboxylic acid, 4-phenyl 1,1-dimethylethyl ester-2,2-dioxide With sodium hydride In N,N-dimethyl-formamide Stage #2: With hydrogenchloride In water; N,N-dimethyl-formamide	98%

: 6627-55-0
2-bromo-p-cresol

: 124-41-4
sodium methylate

: 93-51-6
2-Methoxy-4-methylphenol

Conditions

Conditions	Yield
With Methyl formate; copper(l) chloride In methanol at 110℃; for 2h; Autoclave;	98%
In methanol at 200℃; under 120012 Torr; for 0.0333333h; Temperature; Pressure; Time; Autoclave;	13.38 g

: 108-77-0
1,3,5-trichloro-2,4,6-triazine

: 6627-55-0
2-bromo-p-cresol

: 2-(2-bromo-4-methylphenoxy)-4,6-dichloro-1,3,5-triazine

Conditions

Conditions	Yield
With tetra(n-butyl)ammonium hydrogensulfate; sodium hydroxide at 0 - 20℃; for 38h;	98%

: 6627-55-0
2-bromo-p-cresol

: 107-30-2
chloromethyl methyl ether

: 104750-60-9
2-bromo-1-(methoxymethoxy)-4-methylbenzene

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In dichloromethane for 5h; Ambient temperature;	97%
With potassium carbonate In acetone at 20℃;	93%
With potassium carbonate In acetone at 40℃; for 1h;	90%

: 6627-55-0
2-bromo-p-cresol

: 115943-93-6
2-deuterio-4-methylphenol

Conditions

Conditions	Yield
Stage #1: 2-bromo-p-cresol With n-butyllithium In diethyl ether; hexane at -78 - 20℃; for 3h; Inert atmosphere; Stage #2: With water-d2 In diethyl ether; hexane at 20℃; for 4h;	97%
Stage #1: 2-bromo-p-cresol With n-butyllithium In diethyl ether; hexane at 0 - 20℃; for 1.08333h; Inert atmosphere; Stage #2: With water-d2 In diethyl ether; hexane at 0℃; for 1h; Inert atmosphere;	72%
Stage #1: 2-bromo-p-cresol With n-butyllithium In tetrahydrofuran; toluene at 10℃; for 4h; Inert atmosphere; Stage #2: With water-d2 In tetrahydrofuran; toluene Inert atmosphere;

: 6627-55-0
2-bromo-p-cresol

: 439948-91-1
(S)-4-Methyl-2,2-dioxo-[1,2,3]oxathiazolidine-3-carboxylic acid tert-butyl ester

: 1441005-57-7
C15H22BrNO3

Conditions

Conditions	Yield
Stage #1: 2-bromo-p-cresol; (S)-4-Methyl-2,2-dioxo-[1,2,3]oxathiazolidine-3-carboxylic acid tert-butyl ester With sodium hydride In N,N-dimethyl-formamide Stage #2: With hydrogenchloride In water; N,N-dimethyl-formamide	97%

: 98437-23-1
benzo[b]thiophene-2-boronic acid

: 6627-55-0
2-bromo-p-cresol

: 2-(benzo[b]thiophen-2-yl)-4-methylphenol

Conditions

Conditions	Yield
With bis(tri-t-butylphosphine)palladium(0); potassium carbonate In tetrahydrofuran; water at 80℃; for 24h; Suzuki-Miyaura Coupling; Inert atmosphere;	97%

: 6627-55-0
2-bromo-p-cresol

: 132559-91-2
4-bromo-6-methyl-2H-pyran-2-one

: 1259312-84-9
4-(2-bromo-4-methylphenoxy)-6-methyl-2-pyrone

Conditions

Conditions	Yield
With potassium carbonate In acetone at 60℃; for 16h;	96.1%

: 6627-55-0
2-bromo-p-cresol

: 115314-14-2
(2s)-(+)-glycidyl 3-nitrobenzenesulfonate

: 1351163-91-1
(2S)-2-[(2-bromo-4-methylphenoxy)methyl]oxirane

Conditions

Conditions	Yield
With caesium carbonate In N,N-dimethyl-formamide at 20℃; for 1h; Inert atmosphere;	96%

: 6627-55-0
2-bromo-p-cresol

: 612-24-8
o-nitrobenzonitrile

: 5-methyl-2-(2-nitrophenyl)-1,3-benzothiazole

Conditions

Conditions	Yield
With p-nitrobenzenesulfonic acid; cis-dichlorobis(triphenylphosphine)molybdenum; 1-ethyl-3-methylimidazolium tetrafluoroborate; bis-[(trifluoroacetoxy)iodo]benzene; 4,4'-di-tert-butyl-2,2'-bipyridine In N,N-dimethyl-formamide at 90℃; for 10h; Reagent/catalyst; Inert atmosphere;	95.4%

: 6627-55-0
2-bromo-p-cresol

: 540-51-2
2-bromoethanol

: 2-(2-bromo-4-methylphenoxy)ethan-1-ol

Conditions

Conditions	Yield
Stage #1: 2-bromo-p-cresol With potassium carbonate In N,N-dimethyl-formamide at 60℃; for 1h; Inert atmosphere; Stage #2: 2-bromoethanol In N,N-dimethyl-formamide at 120℃; Inert atmosphere;	95%
Stage #1: 2-bromo-p-cresol With potassium carbonate In N,N-dimethyl-formamide at 60℃; for 1h; Stage #2: 2-bromoethanol In N,N-dimethyl-formamide at 60 - 120℃; for 12h;	89%

: 6627-55-0
2-bromo-p-cresol

: 1972-28-7
diethylazodicarboxylate

: 1-(3-bromo-1-methyl-4-oxocyclohexa-2,5-dien-1-yl)hydrazine-1,2-dicarboxylic acid diethyl ester

Conditions

Conditions	Yield
With silver(l) oxide In water for 0.5h; Cooling with ice;	95%
With silver(l) oxide In water at 0℃; for 0.5h; Sealed tube;	95%

2-Bromo-4-methylphenol Chemical Properties

The Molecular formula of 2-Bromo-4-methylphenol(6627-55-0): C₇H₇BrO
The Molecular Weight of 2-Bromo-4-methylphenol(6627-55-0): 187.03
The Molecular Structure of 2-Bromo-4-methylphenol(6627-55-0):

EINECS: 229-595-7
Melting point: 213-214 °C
Boiling Point: 213.5 °C at 760 mmHg
Flash Point: 82.9 °C
Index of Refraction: 1.59
Molar Refractivity: 40.64 cm³
Molar Volume: 120.3 cm³
Polarizability: 16.11 10^-24cm³
Surface Tension: 44.3 dyne/cm
Density: 1.554 g/cm³
Enthalpy of Vaporization: 46.81 kJ/mol
Vapour Pressure: 0.112 mmHg at 25°C
IUPAC Name: 2-bromo-4-methylphenol
Synonyms: 3-BROMO-4-HYDROXY-BENZYLIC ALCOHOL3-Bromo-4-hydroxytoluene;2-bromo-p-creso;2-BROMO-P-CRESOL;p-Cresol, 2-bromo-;2-Bromo-p-methylphenol; ;AKOS BBB/368;2-BROMO-4-METHYLPHENOL;

2-Bromo-4-methylphenol Uses

2-Bromo-4-methylphenol(6627-55-0) is used for organic synthesis intermediates.

2-Bromo-4-methylphenol Toxicity Data With Reference

The TOXICITY information of 2-Bromo-4-methylphenol(6627-55-0):
1.mouse LD50 intraperitoneal 195mg/kg (195mg/kg) Journal of Medicinal Chemistry. Vol. 18, Pg. 868, 1975.

2-Bromo-4-methylphenol Safety Profile

The Hazard Codes of 2-Bromo-4-methylphenol(6627-55-0):

Xi,Xn
Hazard Note: Irritant
The Risk Statements information of 2-Bromo-4-methylphenol(6627-55-0):
21/22: Harmful in contact with skin and if swallowed
36/37/38: Irritating to eyes, respiratory system and skin
The Safety Statements information of 2-Bromo-4-methylphenol(6627-55-0):
26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
24/25: Avoid contact with skin and eyes
36/37/39: Wear suitable protective clothing, gloves and eye/face protection
37/39: Wear suitable gloves and eye/face protection
WGK Germany: 3
RTECS: GO6868200

Product Name

2-Bromo-4-methylphenol

Synthetic route

2-Bromo-4-methylphenol Chemical Properties

2-Bromo-4-methylphenol Uses

2-Bromo-4-methylphenol Toxicity Data With Reference

2-Bromo-4-methylphenol Safety Profile

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