2-Chloro-4'-hydroxyacetophenone supplier

Name
2-CHLORO-4'-HYDROXYACETOPHENONE
EINECS 228-613-0
CAS No. 6305-04-0
Article Data24
CAS DataBase
Density 1.304 g/cm3
Solubility
Melting Point 145-146 °C
Formula C8H7 Cl O2
Boiling Point 337.1 ºC at 760 mmHg
Molecular Weight 170.595
Flash Point 157.7 ºC
Transport Information
Appearance
Safety A poison by ingestion. A severe skin and eye irritant. When heated to decomposition it emits toxic vapors of Cl⁻.
Risk Codes
Molecular Structure
Hazard Symbols
Synonyms Acetophenone,2-chloro-4'-hydroxy- (6CI,7CI); 2-Chloro-1-(4-hydroxyphenyl)ethanone;2-Chloro-4'-hydroxyacetophenone; 4-Hydroxy-a-chloroacetophenone; 4-Hydroxyphenacyl chloride;4'-Hydroxy-2-chloroacetophenone; Chlorophenacyle; NSC 41671;p-(Chloroacetyl)phenol; p-Hydroxyphenacyl chloride; w-Chloro-4-hydroxyacetophenone
PSA 37.30000
LogP 1.81370

Synthetic route

: 99-93-4
4-Hydroxyacetophenone

: 6305-04-0
p-hydroxyphenacyl chloride

Conditions

Conditions	Yield
With N,N,N-trimethylbenzenemethanaminium dichloroiodate In methanol; 1,2-dichloro-ethane for 10h; Heating;	95%
With 2,2,3,4,5,6-hexachloro-cyclohexa-2,4-dien-1-one In ethanol for 5h; Heating;	77%
With hydrogenchloride; ammonium nitrate; iodine; oxygen In water; acetonitrile at 60℃; for 22h; Green chemistry; chemoselective reaction;	64%
With N-chloro-succinimide; toluene-4-sulfonic acid In acetonitrile at 40℃;	45%

: 79-04-9
chloroacetyl chloride

: 108-95-2
phenol

: 6305-04-0
p-hydroxyphenacyl chloride

Conditions

Conditions	Yield
With aluminum (III) chloride In dichloromethane at 0 - 30℃; for 7h; Solvent;	94%
With aluminium trichloride In various solvent(s) at 70℃; for 5h;	50%
Stage #1: chloroacetyl chloride; phenol; aluminum (III) chloride In 1,2-dichloro-ethane at 0 - 65℃; for 13h; Stage #2: With hydrogenchloride In dichloromethane; water	15%

: 868746-76-3
2-chloro-1-(4-chloroacetoxy-phenyl)-ethanone

: 6305-04-0
p-hydroxyphenacyl chloride

Conditions

Conditions	Yield
With sodium hydroxide In methanol; water at 0 - 20℃; for 0.5h;	85%

: 620-73-5
phenyl chloroacetate

A: 53074-73-0
2-(2-chloroacetyl)phenol

B: 6305-04-0
p-hydroxyphenacyl chloride

Conditions

Conditions	Yield
With beryllium(II) chloride at 130 - 140℃;
With aluminium trichloride at 120℃;

: 620-73-5
phenyl chloroacetate

: 6305-04-0
p-hydroxyphenacyl chloride

Conditions

Conditions	Yield
With aluminium trichloride

: 100-66-3
methoxybenzene

: 79-04-9
chloroacetyl chloride

A: 53074-73-0
2-(2-chloroacetyl)phenol

B: 6305-04-0
p-hydroxyphenacyl chloride

Conditions

Conditions	Yield
With aluminium trichloride; 1,1,2,2-tetrachloroethane
With aluminium trichloride; 1,1,2,2-tetrachloroethane

...Expand

: 100-66-3
methoxybenzene

: 79-04-9
chloroacetyl chloride

: 6305-04-0
p-hydroxyphenacyl chloride

Conditions

Conditions	Yield
With aluminium trichloride; Petroleum ether
With aluminium trichloride
With carbon disulfide; aluminium trichloride
With aluminium trichloride

: Dimethyl-<4-hydroxy-phenacyl>-sulfoniumchlorid

: 6305-04-0
p-hydroxyphenacyl chloride

Conditions

Conditions	Yield
at 110℃;

: 620-73-5
phenyl chloroacetate

: 7446-70-0
aluminium trichloride

A: 6305-04-0
p-hydroxyphenacyl chloride

B ω-chloro-2-oxy-acetophenone: ω-chloro-2-oxy-acetophenone

Conditions

Conditions	Yield
at 120℃;

...Expand

: 620-73-5
phenyl chloroacetate

A: 6305-04-0
p-hydroxyphenacyl chloride

B ω-chloro-2-oxy-acetophenone: ω-chloro-2-oxy-acetophenone

Conditions

Conditions	Yield
With aluminium trichloride at 120℃;

: 620-73-5
phenyl chloroacetate

A: 6305-04-0
p-hydroxyphenacyl chloride

B 2-chloro-1-<2-hydroxy-phenyl>-ethanone-(1): 2-chloro-1-<2-hydroxy-phenyl>-ethanone-(1)

Conditions

Conditions	Yield
With beryllium(II) chloride at 130 - 140℃;

: α,α-dichloro-4-hydroxyacetophenone

A: 6305-04-0
p-hydroxyphenacyl chloride

B: 99-93-4
4-Hydroxyacetophenone

Conditions

Conditions	Yield
With indium(I) bromide In tetrahydrofuran at 20℃; for 24h;

: 2196-99-8
2-chloro-1-(4-methoxyphenyl)ethanone

: 6305-04-0
p-hydroxyphenacyl chloride

Conditions

Conditions	Yield
With aluminium trichloride In n-heptane for 2.5h; Heating;	9.5 g

: 100-66-3
methoxybenzene

enanthoyl chloride: enanthoyl chloride

: 6305-04-0
p-hydroxyphenacyl chloride

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: AlCl3 / heptane / 1.5 h / 35 °C 2: 9.5 g / AlCl3 / heptane / 2.5 h / Heating View Scheme

: 118-93-4
o-hydroxyacetophenone

palladium/charcoal: palladium/charcoal

: 6305-04-0
p-hydroxyphenacyl chloride

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: HCl / methanol / 10 °C 2: 110 °C View Scheme

: 6305-04-0
p-hydroxyphenacyl chloride

: 100-39-0
benzyl bromide

: 63365-56-0
1-(4-(benzyloxy)phenyl)-2-chloroethane-1-one

Conditions

Conditions	Yield
Stage #1: p-hydroxyphenacyl chloride With potassium carbonate In N,N-dimethyl-formamide at 20 - 30℃; for 0.5h; Stage #2: benzyl bromide In N,N-dimethyl-formamide at 30 - 40℃; for 4h; Solvent; Reagent/catalyst;	97.5%

: 6305-04-0
p-hydroxyphenacyl chloride

: 18162-48-6
tert-butyldimethylsilyl chloride

: 130798-41-3
1-(4-(tert-butyldimethylsilyloxy)phenyl)-2-chloroethanone

Conditions

Conditions	Yield
With 1H-imidazole In N,N-dimethyl-formamide at 23℃; for 0.05h;	97%

: 6305-04-0
p-hydroxyphenacyl chloride

: 3290-99-1
4-methoxybenzoic acid hydrazide

: 3-(4-methoxyphenyl)-6-(4-hydroxyphenyl)-1,2,4-triazine

Conditions

Conditions	Yield
With ammonium propionate; propionic acid at 190℃; for 30h;	92%

: 1450-76-6
1-(2-hydroxy-5-nitrophenyl)ethanone

: 6305-04-0
p-hydroxyphenacyl chloride

: 141645-21-8
2-(4-hydroxy benzoyl) 3-methyl 5-nitro benzofuran

Conditions

Conditions	Yield
With 1,8-diazabicyclo[5.4.0]undec-7-ene In dichloromethane at 20℃; for 4h; Solvent; Molecular sieve; Inert atmosphere;	91.1%

: 917-64-6
methyl magnesium iodide

: 6305-04-0
p-hydroxyphenacyl chloride

A: 770-39-8
4-methoxyphenylacetone

B: 98815-43-1
1-[(4-hydroxy)phenyl]-2-methyl-2-propanol

C: 98815-45-3
1-chloro-2-(4-hydroxyphenyl)propan-2-ol

Conditions

Conditions	Yield
In tetrahydrofuran at 20℃; for 2h; Title compound not separated from byproducts;	A 5% B 90% C n/a

...Expand

: 917-64-6
methyl magnesium iodide

: 6305-04-0
p-hydroxyphenacyl chloride

A: 770-39-8
4-methoxyphenylacetone

B: 98815-45-3
1-chloro-2-(4-hydroxyphenyl)propan-2-ol

Conditions

Conditions	Yield
In tetrahydrofuran at 20℃; for 2h; Title compound not separated from byproducts;	A 90% B 90%

...Expand

: 6305-04-0
p-hydroxyphenacyl chloride

: 124-41-4
sodium methylate

: 32136-81-5
alpha-methoxy-4-hydroxyacetophenone

Conditions

Conditions	Yield
In methanol for 24h; Ambient temperature;	90%
In methanol pH=8; pH-value;	18.3 g

: 6921-64-8
4'-hydroxy-2'-methylacetophenone

: 6305-04-0
p-hydroxyphenacyl chloride

: (3,6-dimethylbenzofuran-2-yl)(4-hydroxyphenyl)methanone

Conditions

Conditions	Yield
With 1,8-diazabicyclo[5.4.0]undec-7-ene In dichloromethane at 20℃; for 3h; Solvent; Molecular sieve; Inert atmosphere;	88.54%

: 7338-80-9
6-(phenylmethyl)-3,4-dihydro-3-thioxo-1,2,4-triazin-5(2H)-one

: 6305-04-0
p-hydroxyphenacyl chloride

: 6-benzyl-3-(4-hydroxyphenyl)-7H-thiazolo[3,2-b]-1,2,4-triazin-7-one

Conditions

Conditions	Yield
With sodium acetate; acetic acid Reflux;	85%
With sodium acetate In acetic acid Reflux;	79.2%
With sodium acetate; acetic acid

: 552-41-0
1-(2-hydroxy-4-methoxyphenyl)ethanone

: 6305-04-0
p-hydroxyphenacyl chloride

: (4-hydroxyphenyl)(6-methoxy-3-methylbenzofuran-2-yl)methanone

Conditions

Conditions	Yield
With 1,8-diazabicyclo[5.4.0]undec-7-ene In dichloromethane at 20℃; for 3h; Solvent; Molecular sieve; Inert atmosphere;	81%

: 6305-04-0
p-hydroxyphenacyl chloride

: 112517-73-4
6-[(4-methoxyphenyl)methyl]-3,4-dihydro-3-thioxo-1,2,4-triazin-5(2H)-one

: 3-(4-hydroxyphenyl)-6-(4-methoxybenzyl)-7H-thiazolo-[3,2-b][1,2,4]triazin-7-one

Conditions

Conditions	Yield
With sodium acetate In acetic acid Reflux;	80.1%
With sodium acetate; acetic acid Reflux;	64%
With sodium acetate In acetic acid Reflux;	62.7%
With sodium acetate; acetic acid
With sodium acetate In acetic acid Reflux;

: 6305-04-0
p-hydroxyphenacyl chloride

: 143540-96-9
5-p-Tolyloxymethyl-2,4-dihydro-[1,2,4]triazole-3-thione

: 4-(2-p-Tolyloxymethyl-thiazolo[3,2-b][1,2,4]triazol-6-yl)-phenol

Conditions

Conditions	Yield
In propan-1-ol for 20h; Heating;	75%

: 6305-04-0
p-hydroxyphenacyl chloride

A: 156-38-7
4-hydroxyphenylacetate

B: 108791-64-6
1,4-bis(4-hydroxyphenyl)butan-1,4-dione

C: 99-93-4
4-Hydroxyacetophenone

Conditions

Conditions	Yield
With methyloxirane In water; acetonitrile for 4h; Irradiation;	A 75% B 10% C 5%

...Expand

: 6305-04-0
p-hydroxyphenacyl chloride

: 75-31-0
isopropylamine

: 69716-74-1
1-(4-hydroxy-phenyl)-2-isopropylamino-ethanone; hydrochloride

Conditions

Conditions	Yield
Stage #1: p-hydroxyphenacyl chloride; isopropylamine In methanol at 20℃; for 3h; Stage #2: With hydrogenchloride In methanol; water	75%

: 6305-04-0
p-hydroxyphenacyl chloride

: 93703-24-3
3-methyl-8-bromoxanthine

: 1192215-81-8
8-bromo-3,7-dihydro-7-[2-(4-hydroxyphenyl)-2-oxoethyl]-3-methyl-1H-purine-2,6-dione

Conditions

Conditions	Yield
Stage #1: 3-methyl-8-bromoxanthine With N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 25℃; for 0.0833333h; Inert atmosphere; Stage #2: p-hydroxyphenacyl chloride In N,N-dimethyl-formamide at 25℃; Inert atmosphere;	74%

: 6305-04-0
p-hydroxyphenacyl chloride

: 30186-18-6
4'-bromo-2'-hydroxyacetophenone

: (6-bromo-3-methylbenzofuran-2-yl)(4-hydroxyphenyl)methanone

Conditions

Conditions	Yield
With 1,8-diazabicyclo[5.4.0]undec-7-ene In dichloromethane at 20℃; for 3h; Solvent; Molecular sieve; Inert atmosphere;	73.2%

: 6305-04-0
p-hydroxyphenacyl chloride

: 202475-60-3
WHI-P131

: 1-(4-hydroxyphenyl)-2-(4-((6,7-dimethoxyquinazolin-4-yl)amino)phenoxy)ethanone

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 18h;	73%

: 6305-04-0
p-hydroxyphenacyl chloride

: 143540-95-8
5-o-Tolyloxymethyl-2,4-dihydro-[1,2,4]triazole-3-thione

: 4-(2-o-Tolyloxymethyl-thiazolo[3,2-b][1,2,4]triazol-6-yl)-phenol

Conditions

Conditions	Yield
In propan-1-ol for 20h; Heating;	72%

: 6305-04-0
p-hydroxyphenacyl chloride

: 118-93-4
o-hydroxyacetophenone

: 32730-17-9
(4-hydroxy-phenyl)-(3-methyl-benzofuran-2-yl)-methanone

Conditions

Conditions	Yield
With 1,8-diazabicyclo[5.4.0]undec-7-ene In dichloromethane at 20℃; for 4h; Solvent; Molecular sieve; Inert atmosphere;	72%

: 6305-04-0
p-hydroxyphenacyl chloride

: 78171-88-7
5-Phenoxymethyl-2,4-dihydro-[1,2,4]triazole-3-thione

: 4-(2-Phenoxymethyl-thiazolo[3,2-b][1,2,4]triazol-6-yl)-phenol

Conditions

Conditions	Yield
In propan-1-ol for 20h; Heating;	70%

: 6305-04-0
p-hydroxyphenacyl chloride

: 372164-14-2
5-m-Tolyloxymethyl-2,4-dihydro-[1,2,4]triazole-3-thione

: 4-(2-m-Tolyloxymethyl-thiazolo[3,2-b][1,2,4]triazol-6-yl)-phenol

Conditions

Conditions	Yield
In propan-1-ol for 20h; Heating;	70%

: 6305-04-0
p-hydroxyphenacyl chloride

: 33401-57-9
6-(4-chlorobenzyl)-3-thioxo-3,4-dihydro-[1,2,4]-triazin-5(2H)-one

: 6-(4-chlorobenzyl)-3-(4-hydroxyphenyl)-7H-thiazolo[3,2-b]-1,2,4-triazin-7-one

Conditions

Conditions	Yield
With sodium acetate; acetic acid Reflux;	65%
With sodium acetate In acetic acid Reflux;	65.4%
With sodium acetate; acetic acid

: 447-00-7
6-phenyl-1,2,4-triazine-3(2H)-thione-5(4H)-one

: 6305-04-0
p-hydroxyphenacyl chloride

: 1186078-85-2
3-(4-hydroxyphenyl)-6-phenyl-7H-thiazolo[3,2-b][1,2,4]triazin-7-one

Conditions

Conditions	Yield
With acetic acid for 12h; Reflux;	60%

: 6305-04-0
p-hydroxyphenacyl chloride

: 64-19-7
acetic acid

: 20816-46-0
α,α-dimethyl-p-hydroxyphenacyl acetate

Conditions

Conditions	Yield
With triethylamine In acetonitrile for 3h; Heating;	50%
With triethylamine In acetonitrile for 3h; Heating;	40%

: 6305-04-0
p-hydroxyphenacyl chloride

: C11H11N3O2S

: 3-(4-hydroxyphenyl)-6-(4-ethoxyphenyl)-7H-thiazolo[3,2-b]-1,2,4-triazin-7-one

Conditions

Conditions	Yield
With sodium acetate In acetic acid Reflux;	42.8%

: 6305-04-0
p-hydroxyphenacyl chloride

: 76-93-7
Benzilic acid

: 2-(4-hydroxyphenyl)-2-oxoethyl 2,2-diphenyl-2-hydroxyacetate

Conditions

Conditions	Yield
With sodium hydroxide; sodium iodide for 3.5h; Heating;	38%

: 6305-04-0
p-hydroxyphenacyl chloride

: 79-19-6
thiosemicarbazide

: 74495-46-8
2-amino-5-(p-hydroxyphenyl)-1,3,4-thiadiazine hydrochloride

Conditions

Conditions	Yield
In ethanol Heating;	27%

2-Chloro-4'-hydroxyacetophenone Chemical Properties

IUPAC Name: 2-Chlor-1-(4-hydroxyphenyl)ethanon
The MF of 2-Chlor-1-(4-hydroxyphenyl)ethanon (6305-04-0) is C₈H₇ClO₂.

The MW of 2-Chlor-1-(4-hydroxyphenyl)ethanon (6305-04-0) is 170.59298.
Synonyms of 2-Chlor-1-(4-hydroxyphenyl)ethanon (6305-04-0): 2-Chloro-1-(4-hydroxyphenyl)ethanone ; Ethanone, 2-chloro-1- (4-hydroxyphenyl)- ; 2-Chloro-1-(4-hydroxyphenyl)ethan-1-one ; 2-Chloro-4'-hydroxyacetophenone
Index of Refraction: 1.571
EINECS: 228-613-0
Density: 1.304 g/ml
Flash Point: 157.7 °C
Boiling Point: 337.1 °C

2-Chloro-4'-hydroxyacetophenone Toxicity Data With Reference

1.	skn-rbt 500 mg SEV	JACTDZ Journal of the American College of Toxicology. 12 (1993),581.
2.	eye-rbt 10 mg SEV	JACTDZ Journal of the American College of Toxicology. 12 (1993),581.
3.	orl-rat LD50:230 mg/kg	JACTDZ Journal of the American College of Toxicology. 12 (1993),581.
4.	skn-rbt LD50:>8 g/kg	JACTDZ Journal of the American College of Toxicology. 12 (1993),581.

2-Chloro-4'-hydroxyacetophenone Safety Profile

A poison by ingestion. A severe skin and eye irritant. When heated to decomposition it emits toxic vapors of Cl⁻.

Product Name

2-CHLORO-4'-HYDROXYACETOPHENONE

Synthetic route

2-Chloro-4'-hydroxyacetophenone Chemical Properties

2-Chloro-4'-hydroxyacetophenone Toxicity Data With Reference

2-Chloro-4'-hydroxyacetophenone Safety Profile

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