Conditions | Yield |
---|---|
With 1-methyl-1H-imidazole; copper(l) iodide In toluene at 160℃; for 16h; Product distribution / selectivity; | 100% |
With 1-methyl-1H-imidazole; copper(l) iodide at 140℃; for 16h; Product distribution / selectivity; | 100% |
With 1,3-bis-(diphenylphosphino)propane; sodium carbonate; palladium diacetate In 1-methyl-pyrrolidin-2-one at 130℃; for 16h; Product distribution / selectivity; | 30% |
Conditions | Yield |
---|---|
With trifluorormethanesulfonic acid; trimethylsilylazide In acetonitrile at 25℃; for 0.00138889h; Schmidt Reaction; Flow reactor; | 99% |
Stage #1: pyridine-2-carbaldehyde With hydroxylamine hydrochloride; triethylamine In dichloromethane at 20℃; for 0.0833333h; Stage #2: With potassium hydrogen difluoride; 3-(imidazole-1-sulfonyl)-1-methyl-3H-imidazol-1-ium triflate In water at 20℃; for 3h; | 96% |
With ammonium acetate; phenyltrimethylammonium tribromide In dichloromethane at 20℃; for 17h; Reagent/catalyst; Solvent; Time; | 95% |
t-butyl α-anti-(methoxycarbonyl)oximino-α-(2-pyridyl)acetate
2-Cyanopyridine
Conditions | Yield |
---|---|
With trifluoroacetic acid In dichloromethane at 25℃; for 6h; | 99% |
2-Cyanopyridine
Conditions | Yield |
---|---|
With trifluoroacetic acid In dichloromethane at 25℃; for 36h; | 99% |
Conditions | Yield |
---|---|
With C18H14CuIN4 In acetonitrile at 20℃; for 24h; Inert atmosphere; Sealed tube; UV-irradiation; | 99% |
Conditions | Yield |
---|---|
Stage #1: 2-bromo-pyridine With copper(l) iodide; 1,10-Phenanthroline; potassium iodide In N,N-dimethyl-formamide at 110℃; for 6h; Stage #2: 2-hydroxy-2-methylpropanenitrile With N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 110℃; for 48h; | 98% |
With 1-Butylimidazole; copper(l) iodide; sodium carbonate In o-xylene at 150℃; for 21h; Inert atmosphere; Pressure tube; | 91% |
Conditions | Yield |
---|---|
With triethylamine In acetonitrile at 20℃; for 3h; | 97% |
With trichloro(trifluoromethanesulfonato)titanium(IV) at 80℃; for 10h; Dehydration; | 95% |
With thionyl chloride; polyvinylpyrrolidone In dichloromethane at 20℃; for 0.25h; Dehydration; | 93% |
Conditions | Yield |
---|---|
With 1,1'-bis-(diphenylphosphino)ferrocene; tributyltin chloride; tris(dibenzylideneacetone)dipalladium (0) In acetonitrile at 80℃; for 17h; | 96% |
Conditions | Yield |
---|---|
With ammonia; water; oxygen; V*0.5Sn*7.5Ti*xO at 400℃; for 0.000130556h; Oxidation; | 95% |
With cobalt(II) 5,10,15,20-tetraphenylporphyrin; ammonia; sodium tetrakis[(3,5-di-trifluoromethyl)phenyl]borate at 300℃; for 12h; Temperature; | 95.7% |
With ammonium hydroxide at 370℃; Temperature; Flow reactor; | 86% |
Conditions | Yield |
---|---|
With air; ammonia; water; vanadia; titanium(IV) oxide; tin(IV) oxide at 380℃; for 0.000105556h; Product distribution; var. reagents ratios, temp. and contact time; | A 3% B 95% |
With air; ammonia; water; vanadia; titanium(IV) oxide; tin(IV) oxide at 380℃; for 0.000105556h; | A 3% B 95% |
With air; water; vanadia at 380℃; for 0.000508333h; | A 86% B 3.2% |
trimethylsilyl cyanide
1-Dimethylcarbamoyloxy-pyridinium; chloride
2-Cyanopyridine
Conditions | Yield |
---|---|
In dichloromethane at 27℃; | 95% |
4-chloro-pyridine-2-carbonitrile
2-Cyanopyridine
Conditions | Yield |
---|---|
With sodium tetrahydroborate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; N,N,N,N,-tetramethylethylenediamine In tetrahydrofuran at 25℃; for 2h; Inert atmosphere; | 95% |
With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium tetrahydroborate; N,N,N,N,-tetramethylethylenediamine In tetrahydrofuran at 25℃; for 2h; Inert atmosphere; chemoselective reaction; | 95% |
Conditions | Yield |
---|---|
With potassium hydroxide; ammonium bicarbonate; (Bu4N)2S2O8; copper(II) formate; nikel(II) formate In isopropyl alcohol at 25℃; for 1.5h; | 92% |
With ammonium hydroxide; dihydrogen peroxide In water; acetonitrile at 30℃; for 3h; | 91% |
With copper(l) iodide; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; ammonium hydroxide at 100℃; for 30h; | 88% |
Conditions | Yield |
---|---|
In dimethyl sulfoxide for 0.0333333h; Rosenmund-von Braun reaction; microwave irradiation; | 92% |
2-pyridinyl-1,3,4-oxadiazole
2-Cyanopyridine
Conditions | Yield |
---|---|
With sodium t-butanolate In N,N-dimethyl-formamide at 20℃; for 8h; | 91% |
Conditions | Yield |
---|---|
In methanol at 25℃; for 0.166667h; Product distribution; Mechanism; the similar results with other nucleophiles (sodium benzenesulphinate, sodium methanesulphinate, sodium toluene-p-sulphinate); a series of iminium salts investigated; no 4-cyanopyridine production; | A n/a B 90% |
potassium cyanide
1-Dimethylcarbamoyloxy-pyridinium; chloride
2-Cyanopyridine
Conditions | Yield |
---|---|
In acetonitrile at 27℃; | 90% |
Conditions | Yield |
---|---|
With iodine; triethylamine In dichloromethane at 20℃; for 1h; | 90% |
With manganese(IV) oxide In acetone under 760.051 Torr; for 0.5h; | 83 %Chromat. |
With methylene blue; 1,8-diazabicyclo[5.4.0]undec-7-ene In acetonitrile at 25℃; Sealed tube; Irradiation; | 55.1 mg |
Conditions | Yield |
---|---|
With sodium carbonate In N,N-dimethyl-formamide; acetonitrile at 25℃; for 0.5h; Reagent/catalyst; | 90% |
Conditions | Yield |
---|---|
With ammonia at 210 - 380℃; for 0.00166667h; Temperature; | 89% |
With ethyl phosphodichloridite; 1,8-diazabicyclo[5.4.0]undec-7-ene In dichloromethane at 20℃; for 1h; | 88% |
With uranyl nirate hexahydrate; N-methyl-N-trimethylsilyl-2,2,2-trifluoroacetamide In 1,2-dimethoxyethane at 100℃; for 24h; | 87% |
3,6,6-Trimethyl-4-{[1-pyridin-2-yl-meth-(E)-ylidene]-amino}-4,6-dihydro-1H-cyclopenta[1,2,4]triazine-5,7-dicarboxylic acid dimethyl ester
A
pyridine-2-carbaldehyde
B
2-Cyanopyridine
Conditions | Yield |
---|---|
With sodium methylate In ethanol for 3h; Product distribution; Heating; | A 8% B 88% |
Conditions | Yield |
---|---|
Stage #1: 2-hydroxyiminomethyl-pyridine With 2-chloro-1-methyl-pyridinium iodide In dichloromethane at 20℃; for 0.166667h; Stage #2: With triethylamine In dichloromethane at 20℃; for 1h; | 88% |
With chloranil In acetonitrile Photolysis; | 33 % Chromat. |
2-Cyanopyridine
Conditions | Yield |
---|---|
With iron(III) chloride; 2,6-di-tert-butyl-4-methyl-phenol In toluene at 20℃; for 0.0833333h; Schlenk technique; | 87% |
2,4-Dicyanopyridine
2-Cyanopyridine
Conditions | Yield |
---|---|
With benzophenone In water; isopropyl alcohol for 2h; Irradiation; pH 12; | 86% |
With benzophenone In water; isopropyl alcohol for 1h; Irradiation; pH 12; |
Conditions | Yield |
---|---|
With sodium carbonate In N,N-dimethyl-formamide at 25℃; for 0.5h; Reagent/catalyst; | 86% |
Conditions | Yield |
---|---|
With dmap; 1,1'-bis-(diphenylphosphino)ferrocene; nickel(II) chloride hexahydrate; zinc In acetonitrile at 80℃; for 6h; Schlenk technique; Inert atmosphere; Sealed tube; | 85% |
With dmap; 1,1'-bis-(diphenylphosphino)ferrocene; nickel(II) chloride hexahydrate; zinc In acetonitrile at 80℃; for 6h; Inert atmosphere; Sealed tube; | 85% |
Conditions | Yield |
---|---|
With sodium carbonate In N,N-dimethyl-formamide at 25℃; for 0.5h; | 84% |
Conditions | Yield |
---|---|
With sodium carbonate In N,N-dimethyl-formamide at 25℃; for 0.5h; | 81% |
pyridine N-oxide
trimethylsilyl cyanide
A
2-Cyanopyridine
B
pyridine-4-carbonitrile
Conditions | Yield |
---|---|
With triethylamine In acetonitrile for 12h; Heating; | A 80% B 0.5 % Chromat. |
Conditions | Yield |
---|---|
With dihydrogen peroxide; methyltrioxorhenium(VII) In dichloromethane; water at 20℃; Inert atmosphere; | 100% |
With HOF* CH3CN In chloroform at 0 - 20℃; Oxidation; | 98% |
With dihydrogen peroxide; methyltrioxorhenium(VII) In dichloromethane; water for 24h; Ambient temperature; | 94% |
Conditions | Yield |
---|---|
With hydroxylamine hydrochloride; triethylamine In ethanol for 3h; Reflux; | 100% |
With hydroxylamine hydrochloride; sodium hydroxide In ethanol; water at 0 - 20℃; | 94% |
With hydroxylamine hydrochloride; sodium hydrogencarbonate In methanol for 2h; Heating / reflux; | 93% |
Conditions | Yield |
---|---|
With ammonia; lanthanum(lll) triflate at 200℃; for 24h; in a stainless steel pressure vessel; | 100% |
With sodium hydride at 180℃; | 67% |
With sodium hydride at 160 - 165℃; |
Conditions | Yield |
---|---|
With sodium at 21 - 24℃; for 12h; | 100% |
With hydrogenchloride In dichloromethane at 0℃; | 95.4% |
Stage #1: 2-Cyanopyridine; ethanol With hydrogenchloride Stage #2: With sodium hydroxide | |
Stage #1: 2-Cyanopyridine; ethanol With hydrogenchloride at 5℃; for 18h; Stage #2: With triethylamine In ethanol at 20℃; for 18h; |
Conditions | Yield |
---|---|
With hydrazine hydrate In ethanol at 0 - 40℃; for 16h; | 100% |
With hydrazine hydrate | 90% |
With hydrazine hydrate In ethanol at 20℃; for 48h; Inert atmosphere; | 76% |
Conditions | Yield |
---|---|
Stage #1: methyllithium With cerium(III) chloride In tetrahydrofuran; diethyl ether at -76 - -60℃; Stage #2: 2-Cyanopyridine In tetrahydrofuran; diethyl ether at -76 - 15℃; | 100% |
Stage #1: methyllithium With cerium(III) chloride In tetrahydrofuran; diethyl ether at -78℃; for 1.5h; Inert atmosphere; Schlenk technique; Stage #2: 2-Cyanopyridine In tetrahydrofuran; diethyl ether at -78 - 20℃; for 1.25h; Inert atmosphere; Schlenk technique; | 96% |
Stage #1: methyllithium With cerium(III) chloride heptahydrate In tetrahydrofuran at -78℃; for 2h; Inert atmosphere; Stage #2: 2-Cyanopyridine In tetrahydrofuran at 20℃; Inert atmosphere; | 82% |
Conditions | Yield |
---|---|
With sodium tetrahydroborate In water; dimethyl sulfoxide at 60℃; for 6h; High pressure; Green chemistry; | 99.9% |
With 5%-palladium/activated carbon; ammonia; hydrogen In methanol at 30℃; under 7500.75 Torr; for 8h; Reagent/catalyst; Temperature; Pressure; Autoclave; | 95.11% |
With sodium tetrahydroborate In water at 25℃; for 1h; Sonication; | 80% |
Conditions | Yield |
---|---|
With potassium carbonate In water; dimethyl sulfoxide at 60℃; for 8h; High pressure; Green chemistry; | 99.9% |
With C13H26B(1-)*K(1+) In tetrahydrofuran for 24h; Ambient temperature; | 73% |
Stage #1: 2-Cyanopyridine With diisobutylaluminium hydride In toluene at 20℃; for 0.222222h; Flow reactor; Stage #2: With water; sodium L-tartrate In toluene at 0℃; chemoselective reaction; | 56% |
Conditions | Yield |
---|---|
With manganese(IV) oxide; silica gel In chlorobenzene for 5h; Heating; | 99% |
With cerium(IV) oxide; water at 30℃; for 12h; | 99% |
With manganese(IV) oxide In 1,4-dioxane at 140℃; under 2280.15 Torr; for 1h; Inert atmosphere; | 99% |
Conditions | Yield |
---|---|
With 5%-palladium/activated carbon; hydrogen In ethanol for 72h; Molecular sieve; | 99.7% |
With sodium tetrahydroborate; La0.5Ca0.5CoO3 In methanol at 40℃; under 760.051 Torr; for 0.583333h; chemoselective reaction; | 85% |
With hydrogen; palladium on activated charcoal In ethanol; water for 9h; Ambient temperature; |
2-Cyanopyridine
5-(2-pyridyl)-1H-tetrazole
Conditions | Yield |
---|---|
With sodium azide; water; zinc(II) chloride at 25℃; for 24h; Micellar solution; | 99% |
With sodium azide; zinc(II) chloride In water at 25℃; for 24h; | 99% |
With sodium azide at 60℃; for 4.66667h; | 97% |
Conditions | Yield |
---|---|
With sodium hydroxide for 0.333333h; Ambient temperature; | 99% |
With sodium at 20℃; Cooling with ice; | 74% |
With sodium methylate Ambient temperature; |
Conditions | Yield |
---|---|
With dichlorobis(trimethylphosphine)nickel In tetrahydrofuran; 1-methyl-pyrrolidin-2-one at 70℃; for 12h; Inert atmosphere; | 99% |
2-Cyanopyridine
2-(aminomethyl)pyridine hydrochloride
Conditions | Yield |
---|---|
With hydrogenchloride; hydrogen In 1,4-dioxane; methanol at 60℃; under 375.038 Torr; for 18h; Flow reactor; | 99% |
Stage #1: 2-Cyanopyridine With hydrogen at 130℃; under 750.075 Torr; for 6h; Stage #2: Acidic conditions; chemoselective reaction; | 99% |
Multi-step reaction with 2 steps 1.1: [Ru(BH0PI)(PPh3)2][K(18-crown-6)] / benzene / 0.08 h / 25 °C / Sealed tube 1.2: 18 h / 45 °C / Sealed tube 2.1: hydrogenchloride / water / 2 h / 25 °C View Scheme |
Conditions | Yield |
---|---|
With diammonium sulfide In methanol at 80℃; for 0.25h; microwave irradiation; | 98% |
With dipotassium peroxodisulfate; Thiram; potassium iodide at 100℃; for 12h; Reagent/catalyst; | 94% |
With hydrogenchloride; tiolacetic acid In 1,2-dichloro-ethane Ambient temperature; | 91% |
2-Cyanopyridine
ethylenediamine
4,5-dihydro-2-(pyridin-2-yl)-1H-imidazole
Conditions | Yield |
---|---|
With trichloroisocyanuric acid In neat (no solvent) at 110℃; for 0.133333h; chemoselective reaction; | 98% |
With 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione at 110℃; for 0.5h; chemoselective reaction; | 97% |
With tetraphosphorus decasulfide for 0.166667h; ultrasonication; | 95% |
Conditions | Yield |
---|---|
With tribromomelamine at 100℃; for 0.116667h; Neat (no solvent); | 98% |
With trichloroisocyanuric acid In neat (no solvent) at 110℃; for 0.0166667h; chemoselective reaction; | 98% |
With 1-butyl-3-methylimidazolium tribromide at 100℃; for 0.166667h; | 96% |
With 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione at 110℃; for 0.133333h; chemoselective reaction; | 95% |
In aq. phosphate buffer; dimethyl sulfoxide at 37℃; pH=7.4; |
Conditions | Yield |
---|---|
With water for 11h; Reflux; Green chemistry; | 98% |
With cerium(IV) oxide; water at 160℃; for 5h; Inert atmosphere; | > 99 %Chromat. |
Conditions | Yield |
---|---|
for 0.05h; Ionic liquid; Microwave irradiation; | 98% |
2-Cyanopyridine
Conditions | Yield |
---|---|
With potassium dichromate; sulfuric acid; sodium carbonate In methanol; water at 50℃; pH=0.5; Reagent/catalyst; Temperature; pH-value; Solvent; Large scale; | 97.5% |
Conditions | Yield |
---|---|
In 5,5-dimethyl-1,3-cyclohexadiene at 170℃; for 16h; | 97.4% |
With cyclooctadienyl cobalt at 140 - 190℃; for 2h; Temperature; Autoclave; | 250 g |
Conditions | Yield |
---|---|
With diethyl ether at -20 - 20℃; for 4h; | 97% |
In diethyl ether for 1h; Heating; | 85% |
Stage #1: 2-Cyanopyridine; ethylmagnesium bromide In diethyl ether at -15 - 20℃; for 3h; Inert atmosphere; Stage #2: With hydrogenchloride In diethyl ether; water at 20℃; for 0.25h; Inert atmosphere; | 85% |
The 2-Cyanopyridine is an organic compound with the formula C6H4N2. The IUPAC name of this chemical is pyridine-2-carbonitrile. With the CAS registry number 100-70-9 and EINECS 202-880-3, it is also named as 2-Pyridinecarboxylic acid, nitrile. The product's categories are Pyridine; Pyridines Derivates. It is white to brown low melting crystalline solid which is immiscible with water. Additionally, this chemical should be sealed in the container and stored in the cool and dry place.
The other characteristics of this product can be summarized as: (1)ACD/LogP: 0.51; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): 0.51; (4)ACD/LogD (pH 7.4): 0.51; (5)ACD/BCF (pH 5.5): 1.44; (6)ACD/BCF (pH 7.4): 1.44; (7)ACD/KOC (pH 5.5): 45.22; (8)ACD/KOC (pH 7.4): 45.22; (9)#H bond acceptors: 2; (10)#H bond donors: 0; (11)#Freely Rotating Bonds: 0; (12)Polar Surface Area: 36.68 Å2; (13)Index of Refraction: 1.539; (14)Molar Refractivity: 29.11 cm3; (15)Molar Volume: 92.8 cm3; (16)Surface Tension: 51.4 dyne/cm; (17)Enthalpy of Vaporization: 46.2 kJ/mol; (18)Vapour Pressure: 0.0861 mmHg at 25°C; (19)Exact Mass: 104.037448; (20)MonoIsotopic Mass: 104.037448; (21)Topological Polar Surface Area: 36.7; (22)Heavy Atom Count: 8; (23)Complexity: 111.
Preparation of 2-Cyanopyridine: It can be obtained by pyridine-2-carbaldehyde oxime. This reaction which is a kind of dehydration needs reagent TiCl3(OTf) at temperature of 80 °C. The reaction time is 10 hours. The yield is 95%.
Uses of 2-Cyanopyridine: It is used as intermediate in pharmaceutical, dye and other industries. It also can react with S-Methylcysteinol to get (R)-(-)-4,5-dihydro-4-(methylsulfanylmethyl)-2-(2-pyridyl)oxazole. This reaction needs reagent ZnCl2 and solvent chlorobenzene at temperature of 135 °C. The reaction time is 16 hours. The yield is 36%.
When you are using this chemical, please be cautious about it as the following:
It is not only harmful by inhalation, in contact with skin and if swallowed, but also irritating to eyes, respiratory system and skin. So people should avoid contact with skin and eyes. In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
People can use the following data to convert to the molecule structure.
1. SMILES:N#Cc1ncccc1
2. InChI:InChI=1/C6H4N2/c7-5-6-3-1-2-4-8-6/h1-4H
3. InChIKey:FFNVQNRYTPFDDP-UHFFFAOYAF
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