2-Ethoxyethylamine supplier

Name
2-Ethoxyethylamine
EINECS 203-801-5
CAS No. 110-76-9
Density 0.852 g/cm³
Solubility Completely miscible in water
Melting Point
Formula C₄H₁₁NO
Boiling Point 108.8 °C at 760 mmHg
Molecular Weight 89.1374
Flash Point 17.7 °C
Transport Information UN 2734
Appearance
Safety 26-36/37/39
Risk Codes 10-34
Molecular Structure
Hazard Symbols Xn
Synonyms Ethanolamine ethyl ether;2-Ethoxyethanamine;2-Aminoethyl ethyl ether;Ethylamine,2-ethoxy- (6CI,7CI,8CI);b-Ethoxyethylamine;Ethyl aminoethyl ether;Ethyl2-aminoethyl ether;Ethoxyethylamine;
PSA 35.25000
LogP 0.68190

Synthetic route

: 110-80-5
2-ethoxy-ethanol

: 110-76-9
2-ethoxy-1-ethanamine

Conditions

Conditions	Yield
With copper chromite; ammonia at 200℃;
With phosphoric acid; pumice stone; ammonia at 200 - 240℃;
With ammonia; nickel at 200℃;

: 62957-60-2
2-ethoxyacetonitrile

: 110-76-9
2-ethoxy-1-ethanamine

Conditions

Conditions	Yield
With nickel Hydrogenation;

: 31890-52-5
1-ethoxy-2-nitroethane

: 110-76-9
2-ethoxy-1-ethanamine

Conditions

Conditions	Yield
With ethanol; platinum at 20℃; under 73550.8 Torr; Hydrogenation;
With nickel under 77228.3 Torr; Hydrogenation;

: 141-52-6
sodium ethanolate

: 2576-47-8
2-bromoethylamine hydrobromide

: 110-76-9
2-ethoxy-1-ethanamine

Conditions

Conditions	Yield
at 150 - 160℃;

: 689-98-5
chloroethylamine

: 110-76-9
2-ethoxy-1-ethanamine

Conditions

Conditions	Yield
With ethanol

: 151-56-4
ethyleneimine

: 64-17-5
ethanol

: 110-76-9
2-ethoxy-1-ethanamine

Conditions

Conditions	Yield
(i) BF3-Et2O, (ii) /BRN= 1718733/, (iii) KOH; Multistep reaction;

: 72821-42-2
Butyl-N-β-Ethoxyethylacetimidate

: 110-76-9
2-ethoxy-1-ethanamine

Conditions

Conditions	Yield
With sulfuric acid

: 75-03-6
ethyl iodide

: 141-43-5
ethanolamine

: 110-76-9
2-ethoxy-1-ethanamine

Conditions

Conditions	Yield
(i) Na, (ii) /BRN= 505934/; Multistep reaction;

: 64-17-5
ethanol

aziridinium picrate: aziridinium picrate

: 110-76-9
2-ethoxy-1-ethanamine

: 141-52-6
sodium ethanolate

hydrochloride of β-chloro-ethylamine: hydrochloride of β-chloro-ethylamine

: 110-76-9
2-ethoxy-1-ethanamine

Conditions

Conditions	Yield
at 150 - 160℃;

: 64-17-5
ethanol

N-nitroso-ethylenediamine-N-sulfonic acid: N-nitroso-ethylenediamine-N-sulfonic acid

: 110-76-9
2-ethoxy-1-ethanamine

: 670252-61-6
phenyl N-(4-(1-(ethylamino)carbonyl-1H-5-indolyl)oxy-pyridin-2-yl)carbamate

: 110-76-9
2-ethoxy-1-ethanamine

: N1-ethyl-5-(2-(((2-ethoxyethyl)amino)carbonyl)amino-4-pyridyl)oxy-1H-1-indolecarboxamide

Conditions

Conditions	Yield
In DMF (N,N-dimethyl-formamide) at 20℃; for 1h;	100%

: 110-76-9
2-ethoxy-1-ethanamine

: C53H63N5O12

: C57H72N6O12

Conditions

Conditions	Yield
With 1-hydroxy-7-aza-benzotriazole; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In water; N,N-dimethyl-formamide at 20℃; for 1.5h;	100%

: 110-76-9
2-ethoxy-1-ethanamine

: C57H73N7O12

: C61H82N8O12

Conditions

Conditions	Yield
With 1-hydroxy-7-aza-benzotriazole; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In water; N,N-dimethyl-formamide at 20℃; for 1.5h;	100%

: 110-76-9
2-ethoxy-1-ethanamine

: 690634-09-4
benzotriazole-1-carbothioic acid ((R)-1-phenylethyl)amide

: 1-(2-ethoxyethyl)-3-[(R)-1-phenylethyl]thiourea

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 20℃; for 24h;	99%

: 110-76-9
2-ethoxy-1-ethanamine

: 89506-40-1
2-(2-oxo-2-phenylethyl)-2,3-dihydro-1H-inden-1-one

: 1325642-75-8
1-(2-ethoxyethyl)-2-phenyl-1,4-dihydroindeno[1,2-b]pyrrole

Conditions

Conditions	Yield
With bismuth (III) nitrate pentahydrate In tetrahydrofuran at 100℃; for 18h; Paal-Knorr pyrrole synthesis;	99%

: 110-76-9
2-ethoxy-1-ethanamine

: 1620230-93-4
1,3-dibromo-6,7-dihydro-4H-pyrazino[2,1-a]isoquinolin-4-one

: 1620231-06-2
1-bromo-3-(2-ethoxyethylamino)-6,7-dihydro-4H-pyrazino[2,1-a]isoquinolin-4-one

Conditions

Conditions	Yield
In tetrahydrofuran at 20℃; for 12h;	99%

: 110-76-9
2-ethoxy-1-ethanamine

: 172375-50-7
2-Oxo-2H-furo<2,3-h>-1-benzopyran-3-carbonyl chloride

: 2-Oxo-2H-furo[2,3-h]chromene-3-carboxylic acid (2-ethoxy-ethyl)-amide

Conditions

Conditions	Yield
In tetrahydrofuran for 24h; Ambient temperature;	98%

: 110-76-9
2-ethoxy-1-ethanamine

: 98-61-3
4-iodobenzenesulfonyl chloride

: 600638-57-1
N-(2-ethoxyethyl)-4-iodobenzenesulphonamide

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In dichloromethane at 0℃; for 18h;	98%
With N-ethyl-N,N-diisopropylamine In dichloromethane at 0℃; for 18h;	98%

: 110-76-9
2-ethoxy-1-ethanamine

: 446-35-5
2,4-Difluoronitrobenzene

: 1233231-52-1
N-(2-ethoxyethyl)-5-fluoro-2-nitroaniline

Conditions

Conditions	Yield
With potassium carbonate In 1,4-dioxane at 20℃;	98%
With N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃; for 16h;	499 mg

: 110-76-9
2-ethoxy-1-ethanamine

: 123-54-6
acetylacetone

: 4-((2-ethoxyethyl)amino)pent-3-en-2-one

Conditions

Conditions	Yield
In diethyl ether for 1h; Inert atmosphere; Schlenk technique; Reflux;	98%
In diethyl ether

: 110-76-9
2-ethoxy-1-ethanamine

: cis-3-(9-benzyl-2,3,4,4a,9,9a-hexahydro-1H-carbazol-4a-yl)-propanoic acid

: cis-3-(9-benzyl-2,3,4,4a,9,9a-hexahydro-1H-carbazol-4a-yl)-N-(2-ethoxyethyl)propanamide

Conditions

Conditions	Yield
Stage #1: cis-3-(9-benzyl-2,3,4,4a,9,9a-hexahydro-1H-carbazol-4a-yl)-propanoic acid With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In dichloromethane at 23℃; for 1h; Stage #2: 2-ethoxy-1-ethanamine In dichloromethane at 23℃; for 1h;	98%

: 110-76-9
2-ethoxy-1-ethanamine

: 123-54-6
acetylacetone

: N-(2′-ethoxyethyl)-2-penten-2-ol-4-imine

Conditions

Conditions	Yield
Stage #1: 2-ethoxy-1-ethanamine; acetylacetone In diethyl ether for 1h; Reflux; Stage #2: In diethyl ether at 20℃;	95.7%

: 5470-18-8
2-Chloro-3-nitropyridine

: 110-76-9
2-ethoxy-1-ethanamine

: 118705-43-4
N-(2-ethoxyethyl)-3-nitro-2-pyridinamine

Conditions

Conditions	Yield
at 80℃; for 0.166667h;	95%
With sodium bicarbonate In ethanol	25.5 parts (100%)
With N-ethyl-N,N-diisopropylamine In dimethyl sulfoxide at 80℃; for 0.75h;	567 mg

: 110-76-9
2-ethoxy-1-ethanamine

: 611-70-1
phenyl isopropyl ketone

: 139007-06-0
N-(2-ethoxyethyl)-N-(2-methyl-1-phenyl)-propylideneamine

Conditions

Conditions	Yield
With toluene-4-sulfonic acid In toluene Heating;	95%

: 110-76-9
2-ethoxy-1-ethanamine

: 1588764-64-0
C21H35ClN6O6

: 1588764-68-4
C25H45N7O7

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In acetonitrile at 140℃; for 1.5h; Microwave irradiation;	95%

: 110-76-9
2-ethoxy-1-ethanamine

: 35382-88-8
N-(2-benzoylphenyl)-2,2,2-trichloroacetamide

: 853942-71-9
3-(4-ethoxyethyl)-4-phenyl-4-(trichloromethyl)-3,4-dihydroquinazolin-2(1H)-one

Conditions

Conditions	Yield
In dimethyl sulfoxide at 20℃;	94%
In dimethyl sulfoxide

: 75-15-0
carbon disulfide

: 110-76-9
2-ethoxy-1-ethanamine

: 70-23-5
ethyl Bromopyruvate

: ethyl 3-(ethoxyethyl)-4-hydroxy-2-thioxothiazolidine-4-carboxylate

Conditions

Conditions	Yield
With N-benzyl-trimethylammonium hydroxide In neat (no solvent) at 20℃; for 2.5h; Green chemistry;	94%

...Expand

: 110-76-9
2-ethoxy-1-ethanamine

: 1588764-72-0
C10H12Cl2N4O2

: 1588764-76-4
C14H22ClN5O3

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In acetonitrile at 20℃; for 2h;	93%

: 110-76-9
2-ethoxy-1-ethanamine

: 3-(3-amino-6-chloropyridazin-4-yl)phenol

: 3-(3-amino-6-((2-ethoxyethyl)amino)pyridazin-4-yl)phenol

Conditions

Conditions	Yield
With dicyclohexyl-(2′,4′,6′-triisopropyl-3,6-dimethoxy-[1,1′-biphenyl]-2-yl)phosphine; chloro[2-(dicyclohexylphosphino)-3 ,6-dimethoxy-2’,4’, 6’-triisopropyl- 1,1’-biphenyl] [2-(2-aminoethyl)phenyl]palladium(II); lithium hexamethyldisilazane In tetrahydrofuran at 60℃; for 0.416667h; Buchwald-Hartwig Coupling; Inert atmosphere;	93%

: 16801-19-7
2-[2-(vinyloxy)ethoxymethyl]oxirane

: 110-76-9
2-ethoxy-1-ethanamine

: 271776-66-0
1-(2-vinyloxyethoxy)-3-(2-ethoxyethylamino)propan-2-ol

Conditions

Conditions	Yield
In water at 50℃; for 8h; Addition;	91.7%
at 50 - 60℃; for 8h;	69.7%

: 61049-69-2
3-O-benzylmaltol

: 110-76-9
2-ethoxy-1-ethanamine

: 1-(2'-ethoxyethyl)-2-methyl-3-benzyloxy-4-(1H)-pyridinone

Conditions

Conditions	Yield
In ethanol at 80℃; for 5h; Inert atmosphere; Microwave irradiation;	91%

: 110-76-9
2-ethoxy-1-ethanamine

: 5589-17-3
6,7-diamino-1H,3H-benzo[de]isochromene-1,3-dione

: C16H17N3O3

Conditions

Conditions	Yield
In N,N-dimethyl-formamide at 80℃; for 3h; Temperature; Inert atmosphere;	91%

: 110-76-9
2-ethoxy-1-ethanamine

: 301644-15-5
(3-phenylamino-4,5-dihydro-benzo[g]indazol-2-yl)-acetic acid ethyl ester

: N-(2-ethoxy-ethyl)-2-(3-phenylamino-4,5-dihydro-benzo[g]indazol-2-yl)-acetamide

Conditions

Conditions	Yield
at 100℃; for 4h; Acylation;	90%

: 110-76-9
2-ethoxy-1-ethanamine

: 98-58-8
4-bromobenzenesulfonyl chloride

: 321710-87-6
4-bromo-N-(2-ethoxyethyl)benzenesulfonamide

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In tetrahydrofuran at 0℃; for 0.166667h;	90%

: 5-(2,7-dichloro-4H-benzo[5,6]cyclohepta[1,2-d]thiazol-4-yl)-1-methylpyrimidine-2,4(1H,3H)-dione

: 110-76-9
2-ethoxy-1-ethanamine

: 5-(7-chloro-2-((2-ethoxyethyl)amino)-4H-benzo[5,6]cyclohepta-[1,2-d]thiazol-4-yl)-1-methylpyrimidine-2,4(1H,3H)-dione

Conditions

Conditions	Yield
With triethylamine In 1,4-dioxane Inert atmosphere;	90%

: 16013-85-7
2,6-dicholoro-3-nitropyridine

: 110-76-9
2-ethoxy-1-ethanamine

: 926910-32-9
(6-chloro-3-nitro-pyridin-2-yl)-(2-ethoxy-ethyl)-amine

Conditions

Conditions	Yield
With potassium carbonate In 1,4-dioxane at 50℃; for 6h;	89%
With sodium carbonate In isopropyl alcohol at 0 - 20℃;
With sodium carbonate In isopropyl alcohol at 0 - 20℃; for 17h;

: 110-76-9
2-ethoxy-1-ethanamine

: 6-chloro-4-(4-(trifluoromethyl)phenyl)pyridazin-3-amine

: N3-(2-ethoxyethyl)-5-(4-(trifluoromethyl)phenyl)pyridazine-3,6-diamine

Conditions

Conditions	Yield
With dicyclohexyl-(2′,4′,6′-triisopropyl-3,6-dimethoxy-[1,1′-biphenyl]-2-yl)phosphine; chloro[2-(dicyclohexylphosphino)-3 ,6-dimethoxy-2’,4’, 6’-triisopropyl- 1,1’-biphenyl] [2-(2-aminoethyl)phenyl]palladium(II); lithium hexamethyldisilazane In tetrahydrofuran at 60℃; for 0.416667h; Buchwald-Hartwig Coupling; Inert atmosphere;	88%

: 629-03-8
1 ,6-dibromohexane

: 110-76-9
2-ethoxy-1-ethanamine

: 740043-68-9
N,N'-bis-(2-ethoxy-ethyl)-hexanediyldiamine

Conditions

Conditions	Yield
In neat (no solvent) at 40 - 60℃;	87%
With water
With water

: 110-76-9
2-ethoxy-1-ethanamine

: 88-95-9
Phthaloyl dichloride

: 113336-86-0
3-[(E)-2-Ethoxy-ethylimino]-3H-isobenzofuran-1-one

Conditions

Conditions	Yield
With triethylamine In benzene	87%

: 110-76-9
2-ethoxy-1-ethanamine

: 1620230-92-3
3-bromo-1-ethoxy-6,7-dihydro-4H-pyrazino[2,1-a]isoquinolin-4-one

: 1620231-00-6
1-ethoxy-3-(2-ethoxyethylamino)-6,7-dihydro-4H-pyrazino[2,1-a]isoquinolin-4-one

Conditions

Conditions	Yield
In tetrahydrofuran at 20℃; for 12h;	87%

2-Ethoxyethylamine Chemical Properties

Molecular Structure of 2-Ethoxyethylamine (CAS NO.110-76-9):

IUPAC Name: 2-ethoxyethanamine
CAS: 110-76-9
Empirical Formula: C₄H₁₁NO
Molecular Weight: 89.1362
H bond acceptors: 2
H bond donors: 2
Freely Rotating Bonds: 4
Polar Surface Area: 12.47 Å²
Index of Refraction: 1.409
Molar Refractivity: 25.86 cm³
Molar Volume: 104.6 cm³
Surface Tension: 27.7 dyne/cm
Density: 0.852 g/cm³
Flash Point: 17.7 °C
Enthalpy of Vaporization: 34.76 kJ/mol
Boiling Point: 108.8 °C at 760 mmHg
Vapour Pressure: 25.5 mmHg at 25°C
CAS DataBase Reference: 110-76-9(CAS DataBase Reference)
NIST Chemistry Reference: 2-Ethoxyethylamine(110-76-9)
EPA Substance Registry System: Ethanamine, 2-ethoxy-(110-76-9)
Smiles: O(CCN)CC
InChI: InChI=1/C4H11NO/c1-2-6-4-3-5/h2-5H2,1H3

2-Ethoxyethylamine Safety Profile

Risk Statements: 10-34
R10:Flammable.
R34:Causes burns.
Safety Statements: 26-36/37/39
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection.
RIDADR: 2734

2-Ethoxyethylamine Specification

2-Ethoxyethylamine , with CAS number of 110-76-9, can be called 2-Ethoxyethylamine ; 2-ethoxy-1-ethanamine ; 2-aminoethyl ethyl ether ; o-ethylethanolamine ; 2-aminodiethyl ether ; 2-ethoxy-ethanamin ; 2-ethoxyethanamine ; ethanamine, 2-ethoxy- .

Product Name

2-Ethoxyethylamine

Synthetic route

2-Ethoxyethylamine Chemical Properties

2-Ethoxyethylamine Safety Profile

2-Ethoxyethylamine Specification

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