2-Methyl-1,3-dioxolane supplier

Name
2-METHYL-1,3-DIOXOLANE
EINECS 207-841-4
CAS No. 497-26-7
Article Data73
CAS DataBase
Density 0.97g/cm³
Solubility very soluble SOLVENT

Melting Point

Formula C4H8 O2

Boiling Point 82 - 83 C

Molecular Weight 88.1063

Flash Point -2 C

Transport Information HAZARD

Appearance clear liquid

Safety Moderately toxic by ingestion. Mildly toxic by inhalation. A skin and eye irritant. When heated to decomposition it emits acrid smoke and irritating fumes.

Risk Codes 11-36

Molecular Structure

Hazard Symbols 2 (Packing Group: II) UN NO.

Synonyms 2-Methyl-1,3-dioxacyclopentane;2-Methyl-1,3-dioxolane;2-Methyldioxolane;Methyl dioxolane;NSC 5209;

PSA 18.46000

LogP 0.37920

Synthetic route

107-21-1
ethylene glycol

75-07-0
acetaldehyde

497-26-7
2-methyl-1,3-dioxolane

Conditions

Conditions Yield

With chloro-trimethyl-silane at 20℃; for 0.416667h; 97%

With toluene-4-sulfonic acid 1.)cooling, 1 h 2.)20 deg C, 20 h; 57%

With C6H12Bi6O28S6 for 4h; Reflux; 10%

64-17-5
ethanol

107-21-1
ethylene glycol

497-26-7
2-methyl-1,3-dioxolane

Conditions

Conditions Yield

With iron(III) chloride hexahydrate; sodium nitrite at 50℃; for 24h; Temperature; Time; UV-irradiation; 67%

4360-63-8
2-bromomethyl-1,3-dioxolane

24398-88-7
ethyl 3-bromobenzoate

A

497-26-7
2-methyl-1,3-dioxolane

B

4405-17-8
di(1,3-dioxolan-2-yl)methane

C

93-89-0
benzoic acid ethyl ester

D

898776-72-2
ethyl 3-((1,3-dioxolan-2-yl)methyl)benzoate

E

3,3'-dicarbethoxybiphenyl

Conditions

Conditions Yield

With pyridine; 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; 1,10-Phenanthroline; NiI2*3.5H2O; sodium iodide; zinc at 20 - 60℃; for 19h; chemoselective reaction; A n/a
B n/a
C n/a
D 66%
E n/a

...Expand

110-80-5
2-ethoxy-ethanol

546-67-8
lead(IV) tetraacetate

A

497-26-7
2-methyl-1,3-dioxolane

B

111-15-9
2-ethoxyethyl acetate

C

141-78-6
ethyl acetate

Conditions

Conditions Yield

In chlorobenzene at 140℃; for 0.5h; A 27%
B 63%
C 10%

...Expand

110-80-5
2-ethoxy-ethanol

A

497-26-7
2-methyl-1,3-dioxolane

B

111-15-9
2-ethoxyethyl acetate

C

141-78-6
ethyl acetate

Conditions

Conditions Yield

With lead(IV) acetate In chlorobenzene at 140℃; for 0.5h; glass tube; A 27%
B 63%
C 10%

...Expand

764-48-7
2-hydroxyethyl vinyl ether

497-26-7
2-methyl-1,3-dioxolane

Conditions

Conditions Yield

With potassium hydroxide at 120℃; Product distribution; cyclization, various alkalis; 51%

With sulfuric acid

107-21-1
ethylene glycol

A

497-26-7
2-methyl-1,3-dioxolane

B

123-91-1
1,4-dioxane

C

75-07-0
acetaldehyde

D

111-46-6
diethylene glycol

Conditions

Conditions Yield

With tungsten trioxide on silica; hydrogen In water at 340℃; Temperature; Inert atmosphere; A 38.8%
B 28.7%
C 44.9%
D n/a

...Expand

110-80-5
2-ethoxy-ethanol

A

497-26-7
2-methyl-1,3-dioxolane

B

628-35-3
ethylene glycol monoformate

C

22056-82-2
ethoxyacetaldehyde

D

109-94-4
formic acid ethyl ester

Conditions

Conditions Yield

With air; methyl nitrite; nitrogen(II) oxide at 23.85℃; under 750 Torr; for 2h; Oxidation; UV-irradiation; Further byproducts given; A 3.4%
B 36%
C 24%
D 43%

...Expand

107-21-1
ethylene glycol

A

497-26-7
2-methyl-1,3-dioxolane

B

111-46-6
diethylene glycol

Conditions

Conditions Yield

With synthetic silica ge at 150℃; for 24h; Kinetics; Autoclave; Green chemistry; A 40%
B 9%

107-21-1
ethylene glycol

74-86-2
acetylene

A

497-26-7
2-methyl-1,3-dioxolane

B

764-78-3
ethylene glycol divinyl ether

C

764-48-7
2-hydroxyethyl vinyl ether

Conditions

Conditions Yield

With sodium hydroxide; cesium fluoride at 138 - 142℃; under 10297.1 Torr; for 3.5h; A 4%
B 11%
C 26%

...Expand

107-21-1
ethylene glycol

497-26-7
2-methyl-1,3-dioxolane

Conditions

Conditions Yield

With silica gel In neat (no solvent) at 150℃; under 1147.61 Torr; for 7h; Autoclave; 19%

With silica gel at 150℃; for 7h; Kinetics; Reagent/catalyst; Autoclave; Green chemistry; 19%

56-23-5
tetrachloromethane

764-48-7
2-hydroxyethyl vinyl ether

497-26-7
2-methyl-1,3-dioxolane

65850-74-0
2-(ethoxyethoxy)-ethanol

497-26-7
2-methyl-1,3-dioxolane

Conditions

Conditions Yield

at 210℃;

108-05-4
vinyl acetate

107-21-1
ethylene glycol

497-26-7
2-methyl-1,3-dioxolane

Conditions

Conditions Yield

With boron trifluoride diethyl etherate; mercury(II) oxide

111-34-2
-butyl vinyl ether

107-21-1
ethylene glycol

497-26-7
2-methyl-1,3-dioxolane

Conditions

Conditions Yield

With hydrogenchloride

107-21-1
ethylene glycol

5435-44-9, 22243-66-9
(E)-3-Ureido-but-2-enoic acid ethyl ester

A

497-26-7
2-methyl-1,3-dioxolane

B

123-91-1
1,4-dioxane

C

75-07-0
acetaldehyde

...Expand

107-21-1
ethylene glycol

74-86-2
acetylene

497-26-7
2-methyl-1,3-dioxolane

107-21-1
ethylene glycol

123-63-7
paracetaldehyde

497-26-7
2-methyl-1,3-dioxolane

Conditions

Conditions Yield

With sulfuric acid at 100℃;

With cation exchanger Unter Entfernen des entstehenden Wassers;

89583-60-8
1,2-bis-(1-chloro-ethoxy)-ethane

A

497-26-7
2-methyl-1,3-dioxolane

B

764-78-3
ethylene glycol divinyl ether

Conditions

Conditions Yield

With N,N-diethylaniline

4845-50-5
2,3-dihydroxy-1,4-dioxane

A

497-26-7
2-methyl-1,3-dioxolane

B

543-75-9
1,4-dioxene

Conditions

Conditions Yield

With toluene-4-sulfonic acid 1.) ethylene glycol, 100 deg C, 15 min; 2.) ethylene glycol; Multistep reaction;

764-48-7
2-hydroxyethyl vinyl ether

A

497-26-7
2-methyl-1,3-dioxolane

B

34557-54-5
methane

C

74-84-0
ethane

D

74-98-6
propane

E

127-08-2
potassium acetate

F

74-86-2
acetylene

Conditions

Conditions Yield

With potassium hydroxide at 170℃; Product distribution; other hydroxides (Na, Li);

...Expand

929-37-3
2-[2-(ethenyloxy)ethoxy]ethan-1-ol

A

497-26-7
2-methyl-1,3-dioxolane

B

64-17-5
ethanol

C

764-48-7
2-hydroxyethyl vinyl ether

Conditions

Conditions Yield

With potassium hydroxide at 170 - 250℃; Product distribution;

...Expand

201230-82-2
carbon monoxide

A

497-26-7
2-methyl-1,3-dioxolane

B

64-17-5
ethanol

C

75-07-0
acetaldehyde

D

109-94-4
formic acid ethyl ester

Conditions

Conditions Yield

With hydrogen; Co(CO)8 In various solvent(s) at 200℃; under 237880 Torr; for 6h; Further byproducts given. Title compound not separated from byproducts; A 7 mmol
B 45 mmol
C 3 mmol
D 20 mmol

...Expand

107-21-1
ethylene glycol

67-64-1
acetone

A

497-26-7
2-methyl-1,3-dioxolane

B

2916-31-6
2,2-dimethyl-1,3-dioxolane

C

105-57-7
diethyl acetal

D

64-17-5
ethanol

E

75-07-0
acetaldehyde

F

67-63-0
isopropyl alcohol

Conditions

Conditions Yield

With hydrogenchloride for 30h; Product distribution; Irradiation; reaction without aq. HCl;

...Expand

107-21-1
ethylene glycol

A

646-06-0
1,3-DIOXOLANE

B

497-26-7
2-methyl-1,3-dioxolane

C

5694-68-8
2-hydroxymethyl-1,3-dioxolane

D

64-18-6
formic acid

E

64-19-7
acetic acid

Conditions

Conditions Yield

With iron(III)-acetylacetonate; oxygen In water at 150℃; for 100h; Product distribution; other acetloacetonates, also in basic solution;

...Expand

107-21-1
ethylene glycol

A

497-26-7
2-methyl-1,3-dioxolane

B

123-91-1
1,4-dioxane

C

75-07-0
acetaldehyde

Conditions

Conditions Yield

With Nafion-H at 175℃; for 19h; Product distribution; also in continuous flow reactor charged with Nafion-H or NaHX zeolites, at 175 deg C or 250 deg C, respectively; A 20 % Chromat.
B 71 % Chromat.
C 6 % Chromat.

With sulfuric acid In water at 110 - 140℃; Product distribution; Dehydration; cyclization;

...Expand

111-46-6
diethylene glycol

A

497-26-7
2-methyl-1,3-dioxolane

B

123-91-1
1,4-dioxane

C

543-75-9
1,4-dioxene

D

3041-16-5
p-dioxanone

Conditions

Conditions Yield

With zeolite NaY; copper at 280℃; further catalysts and conditions; Yield given;

With zeolite NaY; copper at 280℃; Product distribution; effect of support on selectivity of dioxene formation; further catalysts and conditions;

...Expand

534-15-6
1,1-dimethoxyethane

107-21-1
ethylene glycol

A

497-26-7
2-methyl-1,3-dioxolane

B

67-56-1
methanol

C

78706-61-3
acetaldehyde-[bis-(2-hydroxy-ethyl)-acetal]

D

2-(1-methoxy-ethoxy)-ethanol

Conditions

Conditions Yield

In dimethylsulfoxide-d6 at 25℃; for 24h; Product distribution; Further Variations:; reagent ratios; transacetalization;

...Expand

75-07-0
acetaldehyde

ethylene glycol (excess)

ethylene glycol (excess)

497-26-7
2-methyl-1,3-dioxolane

497-26-7
2-methyl-1,3-dioxolane

623-43-8, 4358-59-2, 18707-60-3, 130981-57-6
methyl crotonate

1332861-28-5
methyl 3-(2-methyl-1,3-dioxolan-2-yl)butanoate

Conditions

Conditions Yield

With (Bu4N)2S2O8 In 1,2-dichloro-ethane at 70℃; for 2.5h; Inert atmosphere; regioselective reaction; 99%

497-26-7
2-methyl-1,3-dioxolane

107-21-1
ethylene glycol

Conditions

Conditions Yield

With water under 76.0051 - 760.051 Torr; Reflux; 99%

With water; silica gel In neat (no solvent) at 150℃; under 1147.61 Torr; for 24h; Autoclave; 10%

497-26-7
2-methyl-1,3-dioxolane

4360-63-8
2-bromomethyl-1,3-dioxolane

Conditions

Conditions Yield

With bromine; di-tert-butyldicyclohexano-18-crown-18 In benzene at 20℃; for 0.166667h; Bromination; 96%

With 1,4-Dioxane Dibromide In tetrachloromethane at 29.9℃; Rate constant; Thermodynamic data; Mechanism; ΔH(excit.), ΔS(excit.), ΔG(excit.), lg A; further temp., kinetics;

497-26-7
2-methyl-1,3-dioxolane

624-48-6
dimethyl cis-but-2-ene-1,4-dioate

102277-14-5
2-(2-methyl-1,3-dioxolan-2-yl)butanedioic acid 1,4-dimethyl ester

Conditions

Conditions Yield

With (Bu4N)2S2O8 In 1,2-dichloro-ethane at 70℃; for 0.333333h; Inert atmosphere; regioselective reaction; 96%

With di-tert-butyl peroxide at 20℃; for 0.5h; Inert atmosphere; UV-irradiation; 95%

With di-tert-butyl peroxide at 20℃; under 50 Torr; for 3h; Sonication; Inert atmosphere; Photolysis;

497-26-7
2-methyl-1,3-dioxolane

183889-12-5
N-(4-acetylamino-phenyl)-glycine ethyl ester

C16H22N2O5

Conditions

Conditions Yield

With tert.-butylhydroperoxide; copper (I) acetate In water; 1,2-dichloro-ethane at 60℃; for 16h; Inert atmosphere; 92%

497-26-7
2-methyl-1,3-dioxolane

542-59-6
2-hydroxyethyl acetate

Conditions

Conditions Yield

With 3,3-dimethyldioxirane In acetone at 25℃; Kinetics; 91%

With 3,3-dimethyldioxirane In acetone at 25℃; 91%

With dinitrogen tetraoxide at 0℃; for 2h; var. reag.: O2 with Co(II)salt and 18-crown-6; O3 or hydroperoxides; 84%

497-26-7
2-methyl-1,3-dioxolane

105122-15-4
(5S)-5-(tert-butyldimethylsilanyloxymethyl)-5H-furan-2-one

1370642-61-7
5-O-(tert-butyldimethylsilyloxymethyl)-4-C-(2-methyl-1,3-dioxolane)-tetrahydrofuran-2-one

Conditions

Conditions Yield

With benzophenone for 2h; Inert atmosphere; 87%

497-26-7
2-methyl-1,3-dioxolane

(S)-methyl 3-methyl-2-(2-(phenylamino)acetamido)butanoate

C18H26N2O5

Conditions

Conditions Yield

With tert.-butylhydroperoxide; copper (I) acetate In water; 1,2-dichloro-ethane at 60℃; for 16h; Inert atmosphere; 85%

497-26-7
2-methyl-1,3-dioxolane

Ph-Gly-Pro-Val-OMe

C23H33N3O6

Conditions

Conditions Yield

With tert.-butylhydroperoxide; copper (I) acetate In water; 1,2-dichloro-ethane at 60℃; for 16h; Inert atmosphere; 85%

497-26-7
2-methyl-1,3-dioxolane

C16H21NO5

C20H27NO7

Conditions

Conditions Yield

With tert.-butylhydroperoxide; copper (I) acetate In water; 1,2-dichloro-ethane at 60℃; for 16h; Inert atmosphere; 84%

497-26-7
2-methyl-1,3-dioxolane

Ph-Gly-Ala-OBn

C22H26N2O5

Conditions

Conditions Yield

With tert.-butylhydroperoxide; copper (I) acetate In water; 1,2-dichloro-ethane at 60℃; for 16h; Inert atmosphere; 84%

497-26-7
2-methyl-1,3-dioxolane

40555-08-6
ethyl 2,3-dideoxy-6-O-trityl-α-D-glycero-hex-2-enopyranosid-4-ulose

(2R,5S,6S)-6-Ethoxy-5-(2-methyl-[1,3]dioxolan-2-yl)-2-trityloxymethyl-dihydro-pyran-3-one

Conditions

Conditions Yield

With trans-di-O-tert-butyl hyponitrite In acetonitrile for 1h; Heating; other substrates, other reactants; 83%

With trans-di-O-tert-butyl hyponitrite In acetonitrile for 1h; Heating; 83%

497-26-7
2-methyl-1,3-dioxolane

78-94-4
methyl vinyl ketone

A

5735-97-7
(2-methyl-[1,3]dioxolan-2-yl)-acetic acid

B

18871-63-1
3,3-ethylenedioxybutanal

Conditions

Conditions Yield

With oxygen; N-hydroxyphthalimide; cobalt(II) acetate at 25℃; A 83%
B 4%

...Expand

497-26-7
2-methyl-1,3-dioxolane

685-83-6
bis(diethylamino)chlorophosphine

(1-(2-chloroethoxy)ethyl)phosphonic acid bis(diethylamide)

Conditions

Conditions Yield

With zinc trifluoromethanesulfonate In tetrahydrofuran at 130℃; for 24h; Microwave irradiation; Inert atmosphere; Sealed tube; 83%

497-26-7
2-methyl-1,3-dioxolane

292638-85-8
acrylic acid methyl ester

163458-23-9
Methyl (+/-)-2-hydroxy-3-(2-methyl-1,3-dioxolan-2-yl)propanoate

Conditions

Conditions Yield

With N-hydroxyphthalimide; oxygen; cobalt(II) acetate at 20℃; for 3h; 81%

With oxygen; N-hydroxyphthalimide; cobalt(II) acetate at 25℃; for 3h; 81%

With 4,9-(benzene-1,2-diyl)-2,4-dihydroxy-3a,4,9,9a-tetrahydro-1H-benzo[f]isoindole-1,3(2H)-dione; oxygen; cobalt(II) acetate at 20℃; under 760.051 Torr; for 5h; 60%

497-26-7
2-methyl-1,3-dioxolane

4-benzyl-3-(tert-butylperoxy)-3,4-dihydro-2H-benzo[b][1,4]oxazin-2-one

4-benzyl-3-(2-methyl-1,3-dioxolan-2-yl)-3,4-dihydro-2H-benzo[b][1,4]oxazin-2-one

Conditions

Conditions Yield

With copper diacetate In 1,2-dichloro-ethane at 60℃; for 6h; Inert atmosphere; 81%

497-26-7
2-methyl-1,3-dioxolane

A

29776-97-4
1,2-ethanediol acetate formate

B

4219-47-0
ethylene glycol mono caprylate

Conditions

Conditions Yield

With oxygen; zinc(II) chloride; CoCl2 In 1,2-dimethoxyethane at 55℃; for 41h; A 79%
B 80%

497-26-7
2-methyl-1,3-dioxolane

623-91-6
diethyl Fumarate

60636-60-4
(2-methyl-[1,3]dioxolan-2-yl)-succinic acid diethyl ester

Conditions

Conditions Yield

With N-hydroxyphthalimide; dibenzoyl peroxide In toluene at 80℃; for 1h; 80%

497-26-7
2-methyl-1,3-dioxolane

1121-66-0
2-Cyclohepten-1-one

1332861-29-6
C11H18O3

Conditions

Conditions Yield

With (Bu4N)2S2O8 In 1,2-dichloro-ethane at 70℃; for 1.5h; Inert atmosphere; regioselective reaction; 80%

497-26-7
2-methyl-1,3-dioxolane

2216-92-4
N-phenylglycine ethyl ester

C14H19NO4

Conditions

Conditions Yield

With tert.-butylhydroperoxide; copper (I) acetate In water; 1,2-dichloro-ethane at 60℃; for 16h; Catalytic behavior; Reagent/catalyst; Inert atmosphere; 80%

497-26-7
2-methyl-1,3-dioxolane

930-30-3
cyclopent-2-enone

3-(2-methyl-1,3-dioxolan-2-yl)cyclopentanone

Conditions

Conditions Yield

With benzophenone In acetonitrile for 2.5h; Irradiation; 78%

With (Bu4N)2S2O8 In 1,2-dichloro-ethane at 70℃; for 0.5h; Inert atmosphere; regioselective reaction; 60%

497-26-7
2-methyl-1,3-dioxolane

107-13-1
acrylonitrile

2-hydroxy-3-(2-methyl-1,3-dioxolan-2-yl)propanenitrile

Conditions

Conditions Yield

With oxygen; N-hydroxyphthalimide; cobalt(II) acetate at 25℃; for 16h; 77%

With 4,9-(benzene-1,2-diyl)-2,4-dihydroxy-3a,4,9,9a-tetrahydro-1H-benzo[f]isoindole-1,3(2H)-dione; oxygen; cobalt(II) acetate at 20℃; under 760.051 Torr; 58%

497-26-7
2-methyl-1,3-dioxolane

498-66-8
norbornene

623-91-6
diethyl Fumarate

A

60636-60-4
(2-methyl-[1,3]dioxolan-2-yl)-succinic acid diethyl ester

2-(1R,2R,4S)-Bicyclo[2.2.1]hept-2-yl-3-(2-methyl-[1,3]dioxolan-2-yl)-succinic acid diethyl ester

Conditions

Conditions Yield

With N-hydroxyphthalimide; dibenzoyl peroxide In toluene at 80℃; for 15h; A 12%
B 77%

...Expand

497-26-7
2-methyl-1,3-dioxolane

119-61-9
benzophenone

59995-47-0, 59995-49-2, 61305-27-9, 61740-29-2
4-Hydroxycyclopent-2-enone

(+/-)-trans-3-hydroxy-4-(2-methyl-1,3-dioxolan-2-yl)cyclopentanone

(+/-)-cis-3-hydroxy-4-(2-methyl-1,3-dioxolan-2-yl)cyclopentanone

(2SR,3RS,4RS)-4-hydroxy-2-(diphenylhydroxymethyl)-3-(2-methyl-1,3-dioxolan-2-yl)cyclopentanone

Conditions

Conditions Yield

In acetonitrile for 2h; Irradiation; A 75%
B n/a
C 7.5%

...Expand

497-26-7
2-methyl-1,3-dioxolane

Ph-Gly-Pro-Phe-Val-OMe

C32H42N4O7

Conditions

Conditions Yield

With tert.-butylhydroperoxide; copper (I) acetate In water; 1,2-dichloro-ethane at 60℃; for 16h; Inert atmosphere; 75%

497-26-7
2-methyl-1,3-dioxolane

Eto-Gly-Phe-Gly-oet

C19H26N2O7

Conditions

Conditions Yield

With tert.-butylhydroperoxide; copper (I) acetate In water; 1,2-dichloro-ethane at 60℃; for 16h; Inert atmosphere; 75%

497-26-7
2-methyl-1,3-dioxolane

2700-22-3
Benzylidenemalononitrile

2-((2-methyl-1,3-dioxolan-2-yl)(phenyl)methyl)malononitrile

Conditions

Conditions Yield

With pyrene-1,6-dione at 50℃; for 24h; Irradiation; 75%

497-26-7
2-methyl-1,3-dioxolane

5535-48-8
PVS

56161-54-7
2-methyl-2-(2-(phenylsulfonyl)ethyl)-1,3-dioxolane

Conditions

Conditions Yield

With tetrabutylammonium decatungstate ammonium salt; sodium hydrogencarbonate In acetonitrile for 20h; Catalytic behavior; Reagent/catalyst; Solvent; UV-irradiation; Inert atmosphere; 74%

With (Bu4N)2S2O8 In 1,2-dichloro-ethane at 70℃; for 1.5h; Inert atmosphere; regioselective reaction; 48%

497-26-7
2-methyl-1,3-dioxolane

C15H19NO5

C19H25NO7

Conditions

Conditions Yield

With tert.-butylhydroperoxide; copper (I) acetate In water; 1,2-dichloro-ethane at 60℃; for 16h; Inert atmosphere; 74%

2-Methyl-1,3-dioxolane Chemical Properties

Product Name: 2-Methyl-1,3-dioxolane (CAS NO.497-26-7)

Molecular Formula: C₄H₈O₂
Molecular Weight: 88.11g/mol
Mol File: 497-26-7.mol
Einecs: 207-841-4
Appearance: Clear colorless liquid
Boiling point: 82.4 °C at 760 mmHg
Storage Temperature: Flammables area
Flash Point: 4 °C
Density: 0.97 g/cm³
Refractive index: n20/D 1.398(lit.)
Sensitive: Moisture Sensitive
Surface Tension: 27.9 dyne/cm
Enthalpy of Vaporization: 30.96 kJ/mol
Vapour Pressure: 87.6 mmHg at 25°C
XLogP3-AA: 0.2
H-Bond Donor: 0
H-Bond Acceptor: 2
Product Categories: Dioxanes & Dioxolanes; Dioxolanes

2-Methyl-1,3-dioxolane Toxicity Data With Reference

1.
skn-rbt 500 mg/24H MLD
    85JCAE    Prehled Prumyslove Toxikologie; Organicke Latky Marhold, J.,Prague, Czechoslovakia.: Avicenum,1986,797.

2.
eye-rbt 20 mg/24H MOD
    85JCAE    Prehled Prumyslove Toxikologie; Organicke Latky Marhold, J.,Prague, Czechoslovakia.: Avicenum,1986,797.

3.
orl-rat LD50:2900 mg/kg
    GISAAA    Gigiena i Sanitariya. 47 (8)(1982),89.

4.
ihl-rat LC50:80 g/m3
    GISAAA    Gigiena i Sanitariya. 39 (11)(1974),94.

5.
orl-mus LD50:3500 mg/kg
    GISAAA    Gigiena i Sanitariya. 39 (11)(1974),94.

6.
ihl-mus LC50:59 g/m3
    GISAAA    Gigiena i Sanitariya. 39 (11)(1974),94.

2-Methyl-1,3-dioxolane Consensus Reports

Reported in EPA TSCA Inventory.

2-Methyl-1,3-dioxolane Safety Profile

Moderately toxic by ingestion. Mildly toxic by inhalation. A skin and eye irritant. When heated to decomposition it emits acrid smoke and irritating fumes.
Safety Information of 2-Methyl-1,3-dioxolane (CAS NO.497-26-7):
Hazard Codes: F,Xi
Risk Statements: 11-36
11: Highly Flammable
36: Irritating to the eyes
Safety Statements: 16-26
16: Keep away from sources of ignition - No smoking
26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice

2-Methyl-1,3-dioxolane Specification

2-Methyl-1,3-dioxolane ,its CAS NO. is 497-26-7,the synonyms is 2-Methyl-1,3-dioxacyclopentane ; 2-Methyl-3-dioxolane ; 2-Methyldioxolane ; Acetaldehyde ethylene acetal ; 2-Methyl-1,3-dioxolane ; Methyldioxolane .

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Conditions	Yield
With chloro-trimethyl-silane at 20℃; for 0.416667h;	97%
With toluene-4-sulfonic acid 1.)cooling, 1 h 2.)20 deg C, 20 h;	57%
With C6H12Bi6O28S6 for 4h; Reflux;	10%

Conditions	Yield
With potassium hydroxide at 120℃; Product distribution; cyclization, various alkalis;	51%
With sulfuric acid

Conditions	Yield
With silica gel In neat (no solvent) at 150℃; under 1147.61 Torr; for 7h; Autoclave;	19%
With silica gel at 150℃; for 7h; Kinetics; Reagent/catalyst; Autoclave; Green chemistry;	19%

Conditions	Yield
With sulfuric acid at 100℃;
With cation exchanger Unter Entfernen des entstehenden Wassers;

Conditions	Yield
With Nafion-H at 175℃; for 19h; Product distribution; also in continuous flow reactor charged with Nafion-H or NaHX zeolites, at 175 deg C or 250 deg C, respectively;	A 20 % Chromat. B 71 % Chromat. C 6 % Chromat.
With sulfuric acid In water at 110 - 140℃; Product distribution; Dehydration; cyclization;

Conditions	Yield
With zeolite NaY; copper at 280℃; further catalysts and conditions; Yield given;
With zeolite NaY; copper at 280℃; Product distribution; effect of support on selectivity of dioxene formation; further catalysts and conditions;

Conditions	Yield
With water under 76.0051 - 760.051 Torr; Reflux;	99%
With water; silica gel In neat (no solvent) at 150℃; under 1147.61 Torr; for 24h; Autoclave;	10%

Conditions	Yield
With bromine; di-tert-butyldicyclohexano-18-crown-18 In benzene at 20℃; for 0.166667h; Bromination;	96%
With 1,4-Dioxane Dibromide In tetrachloromethane at 29.9℃; Rate constant; Thermodynamic data; Mechanism; ΔH(excit.), ΔS(excit.), ΔG(excit.), lg A; further temp., kinetics;

Conditions	Yield
With (Bu4N)2S2O8 In 1,2-dichloro-ethane at 70℃; for 0.333333h; Inert atmosphere; regioselective reaction;	96%
With di-tert-butyl peroxide at 20℃; for 0.5h; Inert atmosphere; UV-irradiation;	95%
With di-tert-butyl peroxide at 20℃; under 50 Torr; for 3h; Sonication; Inert atmosphere; Photolysis;

Conditions	Yield
With 3,3-dimethyldioxirane In acetone at 25℃; Kinetics;	91%
With 3,3-dimethyldioxirane In acetone at 25℃;	91%
With dinitrogen tetraoxide at 0℃; for 2h; var. reag.: O2 with Co(II)salt and 18-crown-6; O3 or hydroperoxides;	84%

Conditions	Yield
With trans-di-O-tert-butyl hyponitrite In acetonitrile for 1h; Heating; other substrates, other reactants;	83%
With trans-di-O-tert-butyl hyponitrite In acetonitrile for 1h; Heating;	83%

Conditions	Yield
With N-hydroxyphthalimide; oxygen; cobalt(II) acetate at 20℃; for 3h;	81%
With oxygen; N-hydroxyphthalimide; cobalt(II) acetate at 25℃; for 3h;	81%
With 4,9-(benzene-1,2-diyl)-2,4-dihydroxy-3a,4,9,9a-tetrahydro-1H-benzo[f]isoindole-1,3(2H)-dione; oxygen; cobalt(II) acetate at 20℃; under 760.051 Torr; for 5h;	60%

Conditions	Yield
With benzophenone In acetonitrile for 2.5h; Irradiation;	78%
With (Bu4N)2S2O8 In 1,2-dichloro-ethane at 70℃; for 0.5h; Inert atmosphere; regioselective reaction;	60%

Conditions	Yield
With tetrabutylammonium decatungstate ammonium salt; sodium hydrogencarbonate In acetonitrile for 20h; Catalytic behavior; Reagent/catalyst; Solvent; UV-irradiation; Inert atmosphere;	74%
With (Bu4N)2S2O8 In 1,2-dichloro-ethane at 70℃; for 1.5h; Inert atmosphere; regioselective reaction;	48%

1.	skn-rbt 500 mg/24H MLD	85JCAE Prehled Prumyslove Toxikologie; Organicke Latky Marhold, J.,Prague, Czechoslovakia.: Avicenum,1986,797.
2.	eye-rbt 20 mg/24H MOD	85JCAE Prehled Prumyslove Toxikologie; Organicke Latky Marhold, J.,Prague, Czechoslovakia.: Avicenum,1986,797.
3.	orl-rat LD50:2900 mg/kg	GISAAA Gigiena i Sanitariya. 47 (8)(1982),89.
4.	ihl-rat LC50:80 g/m3	GISAAA Gigiena i Sanitariya. 39 (11)(1974),94.
5.	orl-mus LD50:3500 mg/kg	GISAAA Gigiena i Sanitariya. 39 (11)(1974),94.
6.	ihl-mus LC50:59 g/m3	GISAAA Gigiena i Sanitariya. 39 (11)(1974),94.

Product Name

2-METHYL-1,3-DIOXOLANE

Synthetic route

2-Methyl-1,3-dioxolane Chemical Properties

2-Methyl-1,3-dioxolane Toxicity Data With Reference

2-Methyl-1,3-dioxolane Consensus Reports

2-Methyl-1,3-dioxolane Safety Profile

2-Methyl-1,3-dioxolane Specification

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