Conditions | Yield |
---|---|
With dihydrogen peroxide; cobalt(II) acetate; manganese(II) acetate; hexanoic acid at 60℃; for 12h; Temperature; Reagent/catalyst; | 87% |
(i) Br2, KOH, (ii) (hydrolysis); Multistep reaction; | |
Multi-step reaction with 3 steps 1: H2SO4, CrO3 2: H2SO4 3: KMnO4, NaHCO3 View Scheme | |
With nitric acid at 125℃; for 1h; Temperature; High pressure; | |
With oxygen; cobalt(II) acetate; manganese(II) acetate; acetic acid; sodium bromide In water at 133 - 136℃; under 7500.75 - 11251.1 Torr; for 7.5h; Reagent/catalyst; Temperature; Pressure; | 32 g |
2-methyl-3-nitro-benzoic acid methyl ester
4-fluorobenzaldehyde
A
2-[trans-2-(4-fluorophenyl)-vinyl]-3-nitrobenzoic acid
B
2-methyl-3-nitrobenzic acid
Conditions | Yield |
---|---|
With 1,8-diazabicyclo[5.4.0]undec-7-ene In dimethyl sulfoxide at 20 - 50℃; for 12.5h; | A 84% B n/a |
ortho-methylbenzoic acid
A
2-methyl-3-nitrobenzic acid
B
5-nitro-o-toluic acid
Conditions | Yield |
---|---|
With nitric acid at 0℃; | |
With nitric acid | |
With nitric acid |
2-Methyl-benzoic acid methyl ester
A
2-methyl-3-nitrobenzic acid
B
methyl 2-methyl-5-nitrobenzoate
Conditions | Yield |
---|---|
bei der Nitrierung; |
2-methyl-3-nitrobenzonitrile
2-methyl-3-nitrobenzic acid
Conditions | Yield |
---|---|
With sulfuric acid at 150℃; |
2,3-dimethylnitrobenzene
A
2-methyl-3-nitrobenzic acid
B
2-methyl-6-nitrobenzoic acid
C
3-nitrophthalic acid
Conditions | Yield |
---|---|
With potassium permanganate; cetyltrimethylammonim bromide In water at 75℃; for 4h; Product distribution; effect of the amount of KMnO4; further catalysts; | |
With potassium permanganate; cetyltrimethylammonim bromide In water at 75℃; for 4h; Yield given. Yields of byproduct given; | |
With potassium permanganate; tetrabutylammomium bromide In water | |
With oxygen; nitric acid at 130 - 140℃; under 16501.7 - 18751.9 Torr; for 7h; Temperature; Pressure; |
3-formyl-2-methyl-1-nitrobenzene
2-methyl-3-nitrobenzic acid
Conditions | Yield |
---|---|
With potassium permanganate; sodium hydrogencarbonate |
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: alcoholic potash 2: concentrated nitric acid View Scheme |
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: diluted nitric acid 2: concentrated nitric acid View Scheme | |
Multi-step reaction with 2 steps 1: nitric acid; sulfuric acid / water / 0.5 h / -10 °C 2: nitric acid / 1 h / 125 °C / High pressure View Scheme |
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: bei der Destillation 2: diluted nitric acid 3: concentrated nitric acid View Scheme |
2-methyl-3-nitrobenzol-1-methandiol diacetate
2-methyl-3-nitrobenzic acid
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: H2SO4 2: KMnO4, NaHCO3 View Scheme |
2,3-dimethylnitrobenzene
A
2-methyl-3-nitrobenzic acid
B
(2-methyl-3-nitrophenyl)methanol
C
3-formyl-2-methyl-1-nitrobenzene
Conditions | Yield |
---|---|
Stage #1: 2,3-dimethylnitrobenzene With C88H64CrMnN16O; cobalt isooctanoate; oxygen; 4-methyl-2-hydroxy-1(H)-isoindole-1,3-dione at 100℃; under 750.075 Torr; Stage #2: With water at 50℃; under 750.075 Torr; |
2,3-dimethylnitrobenzene
A
2-methyl-3-nitrobenzic acid
B
2-methyl-6-nitrobenzoic acid
C
3-nitrophthalic acid
Conditions | Yield |
---|---|
With oxygen; nitric acid at 145 - 150℃; under 26252.6 - 30003 Torr; for 8h; Temperature; Pressure; |
2,3-dimethylnitrobenzene
butan-1-ol
A
butyl 3-nitro-2-methylbenzoate
B
2-methyl-3-nitrobenzic acid
C
2-methyl-6-nitrobenzoic acid
Conditions | Yield |
---|---|
Stage #1: 2,3-dimethylnitrobenzene With oxygen; nitric acid at 130 - 140℃; under 16501.7 - 18751.9 Torr; for 7h; Stage #2: butan-1-ol With toluene-4-sulfonic acid Reflux; |
butyl 3-nitro-2-methylbenzoate
2-methyl-3-nitrobenzic acid
Conditions | Yield |
---|---|
With sodium hydroxide In water at 100℃; | 135 g |
2-methyl-3-nitrobenzic acid
(2-methyl-3-nitrophenyl)methanol
Conditions | Yield |
---|---|
With borane In tetrahydrofuran | 100% |
Stage #1: 2-methyl-3-nitrobenzic acid With sodium tetrahydroborate In tetrahydrofuran at 20℃; for 0.5h; Stage #2: With methanesulfonic acid In tetrahydrofuran | 84% |
Multi-step reaction with 2 steps 1: SOCl2 2: NaBH4 / tetrahydrofuran View Scheme |
2-methyl-3-nitrobenzic acid
5-bromo-2-methyl-3-nitro-benzoic acid
Conditions | Yield |
---|---|
With 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione; sulfuric acid at 20℃; for 5h; Product distribution / selectivity; | 100% |
Stage #1: 2-methyl-3-nitrobenzic acid With 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione; sulfuric acid at 20℃; for 5h; Stage #2: With water Product distribution / selectivity; Cooling; | 100% |
With 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione; sulfuric acid at 0℃; for 5h; | 100% |
Conditions | Yield |
---|---|
Stage #1: copper(l) cyanide With sodium iodide In acetonitrile at 20℃; for 0.0833333h; Inert atmosphere; Stage #2: 2-methyl-3-nitrobenzic acid In acetonitrile at 20℃; for 1h; Inert atmosphere; | 100% |
2-methyl-3-nitrobenzic acid
2-methyl-3-nitrobenzoyl chloride
Conditions | Yield |
---|---|
With thionyl chloride at 60℃; for 25.5h; Inert atmosphere; | 99% |
With thionyl chloride for 6h; Reflux; | 99% |
With thionyl chloride at 60℃; for 24h; | 98% |
methanol
2-methyl-3-nitrobenzic acid
2-methyl-3-nitro-benzoic acid methyl ester
Conditions | Yield |
---|---|
With sulfuric acid for 24h; Inert atmosphere; Reflux; | 99% |
Stage #1: 2-methyl-3-nitrobenzic acid With oxalyl dichloride; N,N-dimethyl-formamide In dichloromethane at 20℃; Stage #2: methanol In dichloromethane for 0.0833333h; | 99% |
With thionyl chloride for 2h; Reflux; | 98% |
2-methyl-3-nitrobenzic acid
3-amino-2-methylbenzoic acid
Conditions | Yield |
---|---|
With hydrogen; palladium on activated charcoal In ethanol at 20℃; Catalytic hydrogenation; | 98% |
With palladium on activated charcoal; hydrogen In ethyl acetate for 15h; | 90% |
With ammonium hydroxide; hydrogen sulfide |
Conditions | Yield |
---|---|
With sulfuric acid at 20℃; for 168h; | 98% |
With thionyl chloride at 0 - 70℃; | 79% |
1-bromo-hexane
2-methyl-3-nitrobenzic acid
hexyl 2-methyl-3-nitrobenzoate
Conditions | Yield |
---|---|
With potassium carbonate In acetone for 96h; Reflux; | 98% |
2-methyl-3-nitrobenzic acid
dimethyl sulfate
2-methyl-3-nitro-benzoic acid methyl ester
Conditions | Yield |
---|---|
Stage #1: 2-methyl-3-nitrobenzic acid With potassium carbonate In acetone at 20℃; for 0.166667h; Stage #2: dimethyl sulfate In acetone for 4h; Reflux; | 98% |
Stage #1: 2-methyl-3-nitrobenzic acid; dimethyl sulfate In acetone at 25 - 30℃; for 0.166667h; Stage #2: With potassium carbonate In acetone at 25 - 30℃; for 1.5h; | 97.53% |
2-methyl-3-nitrobenzic acid
Conditions | Yield |
---|---|
With N-iodo-succinimide; sulfuric acid at 60℃; for 2h; | 98% |
Conditions | Yield |
---|---|
With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine In dichloromethane at 0 - 20℃; for 3h; | 89% |
Conditions | Yield |
---|---|
With sulfuric acid for 72h; Heating; | 88% |
di-tert-butyl dicarbonate
2-methyl-3-nitrobenzic acid
3-<<(1,1-dimethylethoxy)carbonyl>amino>-2-methylbenzoic acid
Conditions | Yield |
---|---|
With hydrogen; palladium on activated charcoal In N,N-dimethyl-formamide under 2585.7 Torr; for 2.5h; | 86% |
2-methyl-3-nitrobenzic acid
methyl iodide
2-methyl-3-nitro-benzoic acid methyl ester
Conditions | Yield |
---|---|
With sodium hydrogencarbonate In N,N-dimethyl-formamide at 60℃; for 24h; | 86% |
With potassium hydrogencarbonate 1.) DMF, 40 deg C, 2.) DMF, RT, 12 h; Yield given; Multistep reaction; |
1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione
2-methyl-3-nitrobenzic acid
5-bromo-2-methyl-3-nitro-benzoic acid
Conditions | Yield |
---|---|
With sulfuric acid at 20℃; for 5h; | 84% |
2-methyl-3-nitrobenzic acid
N,N-dimethyl-formamide dimethyl acetal
Methyl trans-2-<β-(dimethylamino)vinyl>-3-nitrobenzoate
Conditions | Yield |
---|---|
In N,N-dimethyl-formamide at 115℃; for 24h; | 80% |
2-methyl-3-nitrobenzic acid
Conditions | Yield |
---|---|
With dmap; dicyclohexyl-carbodiimide In dichloromethane at 20℃; for 12h; Inert atmosphere; | 80% |
2'-hydroxy-6'-methoxyacetophenone
2-methyl-3-nitrobenzic acid
6'-methoxy-2'-(2-methyl-3-nitrobenzoyloxy)acetophenone
Conditions | Yield |
---|---|
With POCl2 In pyridine at 60 - 70℃; for 3h; | 78% |
Conditions | Yield |
---|---|
In methanol for 1h; Reflux; | 77.7% |
2-methyl-3-nitrobenzic acid
magnesium bis(3-ethoxy-3-oxopropanoate)
ethyl 3-(2-methyl-3-nitrophenyl)-3-oxopropionate
Conditions | Yield |
---|---|
With 1,1'-carbonyldiimidazole In tetrahydrofuran | 76% |
With 1,1'-carbonyldiimidazole In tetrahydrofuran |
2-methyl-3-nitrobenzic acid
3-amino-2-methylbenzoic acid hydrochloride
Conditions | Yield |
---|---|
Stage #1: 2-methyl-3-nitrobenzic acid With hydrogen; sodium hydroxide In water at 150℃; under 76005.1 Torr; for 12h; Stage #2: With hydrogenchloride In water pH=2; | 75% |
2-methyl-3-nitrobenzic acid
2-(4-methoxyphenyl)quinoline-4-carbohydrazide
Conditions | Yield |
---|---|
With trichlorophosphate Reflux; | 75% |
7-azaindoline
2-methyl-3-nitrobenzic acid
Conditions | Yield |
---|---|
Stage #1: 2-methyl-3-nitrobenzic acid With N-Bromosuccinimide; triphenylphosphine In dichloromethane at 0℃; for 0.5h; Stage #2: 7-azaindoline With triethylamine In dichloromethane at 20℃; for 1h; | 75% |
2-methyl-3-nitrobenzic acid
N,O-dimethylhydroxylamine*hydrochloride
N-methoxy-N,2-dimethyl-3-nitrobenzamide
Conditions | Yield |
---|---|
Stage #1: 2-methyl-3-nitrobenzic acid With N-Bromosuccinimide; triphenylphosphine In dichloromethane at 0℃; for 0.25h; Stage #2: N,O-dimethylhydroxylamine*hydrochloride With triethylamine In dichloromethane at 20℃; for 1h; chemoselective reaction; | 74% |
Stage #1: 2-methyl-3-nitrobenzic acid With 1,1'-carbonyldiimidazole In dichloromethane at 0 - 20℃; for 2.5h; Stage #2: N,O-dimethylhydroxylamine*hydrochloride In dichloromethane at 0 - 45℃; for 13.5h; | 21% |
2-methyl-3-nitrobenzic acid
Conditions | Yield |
---|---|
Stage #1: 2-methyl-3-nitrobenzic acid; 4-tert-butyl-5-(2,4-dichlorobenzyl)thiazol-2-amine With dmap In dichloromethane at 20℃; for 0.5h; Stage #2: With dicyclohexyl-carbodiimide In dichloromethane at 20℃; | 74% |
Conditions | Yield |
---|---|
With [RhCl2(p-cymene)]2; potassium carbonate In ethanol at 50℃; for 48h; | 73% |
2-methyl-3-nitrobenzic acid
3-acetoxy-2-methylbenzoic acid
Conditions | Yield |
---|---|
With sodium hydroxide; sulfuric acid; acetic anhydride; magnesium sulfate; sodium nitrite; palladium-carbon In pyridine; ethanol; ethyl acetate; toluene | 72% |
Conditions | Yield |
---|---|
In ethanol; hexane for 3h; Reflux; | 72% |
Product Name: 2-Methyl-3-nitrobenzoic acid
Synonyms: 3-NITRO-O-TOLUIC ACID;3-NITRO-2-METHYLBENZOIC ACID;3-Nitro-2-Toluic Acid;2-METHYL-3-NITROBENZOIC ACID / 3-NITRO-O-TOLUIC ACID;Benzoic acid, 2-methyl-3-nitro-;2-methyl-3-nitro-benzoicaci;AKOS BB-9542;2-METHYL-3-NITROBENZOIC ACID;
The Molecular formula of 2-Methyl-3-nitrobenzoic Acid(1975-50-4): C8H7NO4
The Molecular Weight of 2-Methyl-3-nitrobenzoic Acid(1975-50-4): 181.15
Molecular Structure :
EINECS: 217-826-4
Melting point: 182-184 °C(lit.)
Water Solubility: <0.1 g/100 mL at 22 oC
The productions of 2-Methyl-3-nitrobenzoic Acid(1975-50-4) include Fine Chemical and Intermediates,Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides and Salts,Benzoic acid,as well as Organic acids.
The Hazard Codes of 2-Methyl-3-nitrobenzoic Acid(1975-50-4) : Xi,Xn (Harmful and Irritant)
The Risk Statements information of 2-Methyl-3-nitrobenzoic Acid(1975-50-4):
36/37/38-20/21/22 (Irritating to eyes, respiratory system and skin by inhalation, in contact with skin and if swallowed )
The Safety Statements information of 2-Methyl-3-nitrobenzoic Acid(1975-50-4):
26-36-36/37/39-22 (Wear suitable protective clothing, gloves and eye/face protection ;do not breathe dust ;in case of contact with eyes, rinse immediately with plenty of water and seek medical advice )
Hazard Note : Irritant
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