5-(4-Methoxy-benzoyl)-2-methyl-isothiazol-3-one
2-methyl-3-isothiazolone
Conditions | Yield |
---|---|
With sodium hydroxide In benzene Ambient temperature; | 100% |
Conditions | Yield |
---|---|
With chlorine; potassium iodide In ethyl acetate at 35 - 50℃; for 0.0833333h; | 90% |
Stage #1: N,N'-dimethyl-3,3'-dithiodipropionamide With thionyl chloride In ethyl acetate at 15℃; for 0.166667h; Stage #2: With chlorine In ethyl acetate at 15℃; for 5h; Reagent/catalyst; Temperature; Solvent; | 84.9% |
With hydrogenchloride; chlorine In water; ethyl acetate at 15 - 25℃; Large scale; | 75% |
With sulfuryl dichloride In 1,2-dichloro-ethane |
Conditions | Yield |
---|---|
With copper (I) fluoride In chlorobenzene at 130℃; for 24h; Schlenk technique; Inert atmosphere; | 80% |
(Z)-3-(benzylsulfinyl)-N-methylpropenamide
2-methyl-3-isothiazolone
Conditions | Yield |
---|---|
With trichloroacetic acid anhydride In dichloromethane 1.) 0 deg C, 1 h, 2.) room temperature, 2 h; | 66% |
N,N'-dimethyl-3,3'-dithiodipropionamide
A
5-chloro-2-methyl-2H-isothiazol-3-one
B
2-methyl-3-isothiazolone
Conditions | Yield |
---|---|
With thionyl chloride In 1,2-dichloro-ethane at 10℃; for 2h; | A 18% B 56% |
With chlorine In ethyl acetate; acetonitrile at 5 - 10℃; for 1h; Solvent; Temperature; Overall yield = 85 percent; |
N,N'-dimethyl-3,3'-dithiodipropionamide
A
5-chloro-2-methyl-2H-isothiazol-3-one
B
4,5-Dichloro-2-methyl-3(2H)-isothiazolone
C
2-methyl-3-isothiazolone
Conditions | Yield |
---|---|
With thionyl chloride In 1,2-dichloro-ethane | A 34% B 8% C 44% |
tert-Butyl peroxybenzoate
2-methyl-isothiazolidin-3-one
2-methyl-3-isothiazolone
Conditions | Yield |
---|---|
With copper(l) chloride In benzene for 4h; Heating; |
Conditions | Yield |
---|---|
With sulfuryl dichloride In tetrachloromethane Ambient temperature; |
2-methyl-3-isothiazolone
Conditions | Yield |
---|---|
With thiourea In methanol; dichloromethane | 1.0 g (29%) |
2-methyl-3-isothiazolone
Conditions | Yield |
---|---|
10.4 g (53%) |
N-methyl-3-mercaptopropionamide
A
5-chloro-2-methyl-2H-isothiazol-3-one
B
2-methyl-3-isothiazolone
Conditions | Yield |
---|---|
With chlorine In N,N-dimethyl acetamide; chlorobenzene at 40 - 45℃; for 1h; Overall yield = 74 percent; | |
Stage #1: N-methyl-3-mercaptopropionamide With acetyl chloride In benzene at 25℃; for 0.666667h; Stage #2: With chlorine In benzene at 25℃; for 1h; Reagent/catalyst; Temperature; Solvent; Overall yield = 86.2 percent; |
2-methyl-3-isothiazolone
3-Chlor-2-methylisothiazolium Chlorid (II)
Conditions | Yield |
---|---|
With oxalyl dichloride In toluene at 80℃; | 85% |
2-methyl-3-isothiazolone
Conditions | Yield |
---|---|
With 3-chloro-benzenecarboperoxoic acid In dichloromethane at 20 - 25℃; for 15h; | 85% |
With 3-chloro-benzenecarboperoxoic acid In dichloromethane at 30℃; for 17.5h; | 85% |
2-methyl-3-isothiazolone
Conditions | Yield |
---|---|
In ethanol at 20℃; for 2h; | 71% |
pentaamminetrifluoromethanesulfonato ruthenium(III) trifluoromethanesulfonate
2-methyl-3-isothiazolone
Conditions | Yield |
---|---|
In acetone for 0.166667h; Reflux; Microwave irradiation; | 63% |
Conditions | Yield |
---|---|
With hydrogenchloride at 80℃; | A n/a B 60% |
With hydrogenchloride at 80℃; Yields of byproduct given; |
Conditions | Yield |
---|---|
With hydrogenchloride In chloroform-d1 at 80℃; | 20% |
aquapentaammineruthenium(II) hexafluorophosphate
2-methyl-3-isothiazolone
Conditions | Yield |
---|---|
In water at 50℃; for 0.25h; Inert atmosphere; Schlenk technique; | 14% |
potassium tetrachloroplatinate(II)
dibenzo-18-crown-6
2-methyl-3-isothiazolone
Conditions | Yield |
---|---|
In chloroform; water at 20℃; for 72h; | 9.6% |
trifluoromethanesulfonatopentaamminecobalt(III) trifluoromethanesulfonate
water
2-methyl-3-isothiazolone
Conditions | Yield |
---|---|
Stage #1: trifluoromethanesulfonatopentaamminecobalt(III) trifluoromethanesulfonate; 2-methyl-3-isothiazolone In acetone for 0.333333h; Reflux; Microwave irradiation; Stage #2: sodium perchlorate; water at -0.16℃; | 6.8% |
2-methyl-3-isothiazolone
4,5-dibromo-2-methyl-isothiazol-3-one
Conditions | Yield |
---|---|
(i) Br2, DMF, AcOEt, (ii) Br2; Multistep reaction; |
2-methyl-3-isothiazolone
4-bromo-2-methyl-isothiazol-3-one
Conditions | Yield |
---|---|
With bromine In 1,2-dichloro-ethane |
2-methyl-3-isothiazolone
4,5-Dichloro-2-methyl-3(2H)-isothiazolone
Conditions | Yield |
---|---|
With sulfuryl dichloride In ethyl acetate | |
With sulfuryl dichloride In ethyl acetate |
2-methyl-3-isothiazolone
isothiazol-3-yl-methyl-amine
Conditions | Yield |
---|---|
(i) POCl3, (ii) NH3, MeCN; Multistep reaction; | |
Stage #1: 2-methyl-3-isothiazolone With trichlorophosphate Stage #2: With ammonia In acetonitrile at 0 - 20℃; |
Conditions | Yield |
---|---|
In sodium hydroxide; acidic aq. solution at 26℃; pH=4; Kinetics; |
5-chloro-2-methyl-2H-isothiazol-3-one
2-methyl-3-isothiazolone
2-octyl-isothiazol-3-one
Conditions | Yield |
---|---|
With sodium chloride | |
With sodium chloride |
5-chloro-2-methyl-2H-isothiazol-3-one
2-methyl-3-isothiazolone
2-octyl-isothiazol-3-one
Conditions | Yield |
---|---|
With potassium chloride; sodium chloride | |
With potassium chloride; sodium chloride |
5-chloro-2-methyl-2H-isothiazol-3-one
2-methyl-3-isothiazolone
2-octyl-isothiazol-3-one
Conditions | Yield |
---|---|
With sodium chloride | |
With sodium chloride |
EPA FIFRA 1988 pesticide subject to registration or re-registration.
The 2-Methyl-4-Isothiazolin-3-one, with the CAS registry number 2682-20-4, is also known as 2-Methyl-3-isothiazolone; 2-Methylisothiazol-3-one; Methyl-3(2H)-isothiazolone.It belongs to the product organic raw material. Its EINECS number is 220-239-6. This chemical's molecular formula is C4H5NOS and molecular weight is 115.15.What's more,Its systematic name is 2-Methyl-4-Isothiazolin-3-one. The 2-Methyl-4-Isothiazolin-3-one is a powerful biocide and preservative within the group of isothiazolinones,used in shampoos and body care products.
Physical properties about 2-Methyl-4-Isothiazolin-3-one are:(1)ACD/LogP: 0.119; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): 0.12; (4)ACD/LogD (pH 7.4): 0.12; (5)ACD/BCF (pH 5.5): 1.00; (6)ACD/BCF (pH 7.4): 1.00; (7)ACD/KOC (pH 5.5): 27.64; (8)ACD/KOC (pH 7.4): 27.64; (9)#H bond acceptors: 2; (10)#H bond donors: 0; (11)#Freely Rotating Bonds: 0; (12)Index of Refraction: 1.589; (13)Molar Refractivity: 30.006 cm3; (14)Molar Volume: 89.04 cm3; (15)Surface Tension: 46.1279983520508 dyne/cm; (16)Density: 1.293 g/cm3; (17)Flash Point: 64.333 °C; (18)Enthalpy of Vaporization: 41.901 kJ/mol.
2-Methyl-4-Isothiazolin-3-one may cause damage to health. please be cautious about it as the following:(1)Very Toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment; (2)Very Toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment ; (3)Causes burns; (4)May cause sensitization by skin contact ; (5)May cause long-term adverse effects in the aquatic environment; (6)Wear suitable protective clothing, gloves and eye/face protection; (7)Avoid contact with skin; (8)In case of contact with eyes, rinse immediately with plenty of water and seek medical advice; (9)In case of accident or if you feel unwell, seek medical advice immediately (show label where possible); (10)This material and/or its container must be disposed of as hazardous waste; (11)Avoid release to the environment. Refer to special instructions safety data sheet.
You can still convert the following datas into molecular structure:
(1)SMILES:O=C1/C=C\SN1C;
(2)Std. InChI:InChI=1S/C4H5NOS/c1-5-4(6)2-3-7-5/h2-3H,1H3;
(3)Std. InChIKey:BEGLCMHJXHIJLR-UHFFFAOYSA-N.
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