Conditions | Yield |
---|---|
With iron(II) sulfate In water; dimethyl sulfoxide Ambient temperature; | 100% |
With HbO2(2+) In phosphate buffer; dimethyl sulfoxide for 1h; pH=7.4; | 89 % Chromat. |
Conditions | Yield |
---|---|
With trifluorormethanesulfonic acid In 1,2-dichloro-ethane at 25 - 90℃; for 5.5h; Inert atmosphere; | 99% |
Conditions | Yield |
---|---|
With ammonium hydroxide at 150 - 220℃; under 90009 - 150015 Torr; | 98.6% |
With ammonium hydroxide at 150 - 220℃; under 90009 - 150015 Torr; | 98% |
With copper(ll) sulfate pentahydrate; ammonium hydroxide In PEG1000-DIL; methyl cyclohexane at 60℃; for 4h; | 95% |
Conditions | Yield |
---|---|
With hydrogen at 20℃; under 760.051 Torr; for 1h; | 98% |
With hydrogen; 1-(2-benzimidazolyl)-C(CH3)=NH-NHCSNH2-Pd(II) In tetrahydrofuran at 20℃; for 2h; atmospheric pressure; | 95% |
With triethylamine In water at 80℃; for 2h; Inert atmosphere; Green chemistry; chemoselective reaction; | 95% |
Conditions | Yield |
---|---|
With 1-n-butyl-3-methylimidazolium azide; sulfuric acid; acetic acid at 54℃; for 4h; Schmidt Reaction; | 97% |
With sodium azide; chloroform; sulfuric acid | |
With thionyl chloride; hydroxylamine-O-sulfonic acid 1) 1h, reflux, 2) toluene, 2h, reflux; Yield given. Multistep reaction; |
Conditions | Yield |
---|---|
With 1,8-diazabicyclo[5.4.0]undec-7-ene In methanol for 0.5h; Product distribution; Further Variations:; Solvents; reaction time; Heating; | 95% |
With sodium hydroxide In ethanol Reflux; | 80% |
With hydrogenchloride; water for 2h; Reflux; | 77% |
Conditions | Yield |
---|---|
With ammonium hydroxide; copper(l) iodide; N,N-dimethylethylenediamine In dimethyl sulfoxide at 130℃; for 6h; Reagent/catalyst; Time; Sealed tube; Inert atmosphere; | 95% |
Stage #1: 2-nitrophenyl bromide With copper(l) iodide; D-glucosamine hydrochloride; potassium carbonate In water; acetone at 90℃; for 0.166667h; Stage #2: With ammonia In water; acetone at 90℃; for 24h; | 83% |
With ammonium hydroxide; copper(l) iodide; potassium carbonate; 4R-4-hydroxyproline In dimethyl sulfoxide at 70℃; for 24h; | 78% |
Conditions | Yield |
---|---|
With 1,9-diperoxynonanedioic acid In acetonitrile at 50℃; for 0.5h; Reagent/catalyst; | 95% |
With dihydrogen peroxide; acetonitrile In aq. buffer at 20℃; for 20h; pH=11; Green chemistry; | 86% |
With dihydrogen peroxide; potassium carbonate In water; acetonitrile at 20℃; | 75% |
With sodium peroxide | |
palladium-carbon In triethylene glycol dimethyl ether |
Conditions | Yield |
---|---|
Stage #1: o-azidonitrobenzene With hydrazine hydrate for 0.166667h; Inert atmosphere; Stage #2: for 4h; Catalytic behavior; Reagent/catalyst; Irradiation; chemoselective reaction; | 95% |
With methanol; sodium tetrahydroborate In tetrahydrofuran for 1h; Heating; | 94% |
Stage #1: o-azidonitrobenzene With 3-benzyl-5-(2-hydroxyethyl)-4-methyl-1,3-thiazol-3-ium chloride; tert-butyl alcohol In tetrahydrofuran at 20℃; for 0.0833333h; Inert atmosphere; Stage #2: With sodium t-butanolate In tetrahydrofuran at 20℃; for 5h; Inert atmosphere; chemoselective reaction; | 94% |
Conditions | Yield |
---|---|
With 1,8-diazabicyclo[5.4.0]undec-7-ene In methanol for 1h; Product distribution; Further Variations:; Solvents; reaction time; Heating; | 95% |
With lithium aluminium tetrahydride In diethyl ether at 27℃; for 1h; | 66 % Turnov. |
2-(2-nitrophenoxy)propanamide
2-nitro-aniline
Conditions | Yield |
---|---|
With potassium hydroxide In dimethyl sulfoxide at 140℃; for 3h; Green chemistry; | 95% |
Conditions | Yield |
---|---|
With potassium carbonate; potassium iodide; Chloroacetamide In N,N-dimethyl-formamide at 90 - 150℃; for 4h; Reagent/catalyst; Smiles Aromatic Rearrangement; | 92% |
With ammonia; water at 160 - 170℃; | |
With sodium tetrahydroborate In water at 20℃; |
Conditions | Yield |
---|---|
With phosphoric acid In sulfolane at 120℃; Reagent/catalyst; Solvent; Temperature; | 91% |
With hydrogenchloride at 170 - 180℃; Erhitzen des Kaliumsalzes; | |
With sulfuric acid; water |
Conditions | Yield |
---|---|
With nickel ammonium sulfate; nitric acid In chloroform; water at 20℃; for 4h; | A 88% B 12% |
With potassium hydrogensulfate; potassium metaperiodate; silica gel; sodium nitrite In neat (no solvent) for 0.0833333h; Reagent/catalyst; Solvent; Microwave irradiation; | A 86% B n/a |
With Iron(III) nitrate nonahydrate at 84.84℃; for 0.25h; regioselective reaction; | A 77% B 23% |
Conditions | Yield |
---|---|
With copper(l) iodide; tetra(n-butyl)ammonium hydroxide; ammonia In water at 25℃; for 24h; Inert atmosphere; Sealed tube; chemoselective reaction; | 87% |
With ammonium hydroxide; copper(l) iodide; N,N-dimethylethylenediamine In dimethyl sulfoxide at 110℃; for 6h; Sealed tube; Inert atmosphere; | 84% |
With acetamidine hydrochloride; caesium carbonate In N,N-dimethyl-formamide at 130℃; for 20h; Inert atmosphere; Green chemistry; | 82% |
2-(trimethylsilanyl)ethanesulfonic acid (2-nitrophenyl)amide
2-nitro-aniline
Conditions | Yield |
---|---|
With cesium fluoride In N,N-dimethyl-formamide at 130℃; for 36h; | 87% |
2-nitro-aniline
Conditions | Yield |
---|---|
With sodium hydroxide In 1,4-dioxane at 110℃; for 22h; | 84% |
4-tert-butyl-2-(2-nitrophenylazo)phenol
A
2-Methyl-1H-benzimidazole
B
N-formyldiethylamine
C
2-(5-tert-butyl-2-hydroxyphenyl)benzotriazole
D
2-nitro-aniline
Conditions | Yield |
---|---|
With carbon monoxide; triethylamine In 1,2-dichloro-benzene at 200℃; under 60800 Torr; for 8h; Further byproducts given; | A n/a B n/a C 63% D 82% |
4-methyl-2-(2-nitrophenylazo)phenol
A
2-Methyl-1H-benzimidazole
B
5-methylbenzo[d]oxazol-2(3H)-one
C
2-nitro-aniline
D
2-(2-Hydroxy-5-methylphenyl)benzotriazole
Conditions | Yield |
---|---|
With carbon monoxide; triethylamine In 1,2-dichloro-benzene at 200℃; under 60800 Torr; for 8h; Further byproducts given; | A n/a B n/a C 7% D 82% |
o-azidonitrobenzene
(3R,4S)-2,3,4,5-Tetraphenyl-3,4-dihydro-2H-[1,2,3]diazaphosphole
A
2-nitro-aniline
2,3,4r,5-tetraphenyl-3,4-dihydro-2H-[1,2,3]diazaphosphole 3c-oxide
Conditions | Yield |
---|---|
In benzene for 2h; Ambient temperature; | A 20% B n/a C 80% |
Conditions | Yield |
---|---|
With iron(II) sulfate In water; dimethyl sulfoxide for 1.5h; Ambient temperature; | A 80% B 20% |
Conditions | Yield |
---|---|
With ammonium hydroxide; sodium sulfite In methanol at 70℃; for 144h; | 80% |
Conditions | Yield |
---|---|
With hydrogen bromide; acetic acid; aniline for 19h; Heating; | 80% |
With sodium acetate In ethanol at 30℃; under 600 Torr; for 0.5h; Reagent/catalyst; Temperature; Inert atmosphere; | 74.6% |
Conditions | Yield |
---|---|
Stage #1: o-azidonitrobenzene With hydrazine hydrate for 0.166667h; Inert atmosphere; Stage #2: for 4h; Irradiation; | A 20% B 80% |
Conditions | Yield |
---|---|
Stage #1: 1,2-Dinitrobenzene With sodium tetrahydroborate In water at 20℃; for 0.25h; Inert atmosphere; Green chemistry; Stage #2: In water at 20℃; for 0.75h; Inert atmosphere; Green chemistry; | A 78% B 15% |
With sodium tetrahydroborate; water at 0 - 20℃; for 24h; | A 24% B 53% |
With titanium dioxide In ethanol for 1.5h; Irradiation; Green chemistry; | A 55 %Chromat. B 30 %Chromat. |
Conditions | Yield |
---|---|
With copper(ll) sulfate pentahydrate; potassium phosphate tribasic heptahydrate; water; Sucrose In water at 90℃; for 15h; Catalytic behavior; Green chemistry; | 78% |
2-nitro-aniline
Conditions | Yield |
---|---|
With sodium hydroxide In 1,4-dioxane at 110℃; for 22h; | 78% |
Conditions | Yield |
---|---|
With sodium hydroxide; benzyltrimethylazanium tribroman-2-uide In water at 70℃; for 1h; | 76% |
Conditions | Yield |
---|---|
With potassium tert-butylate; N,N-tetramethylene-thiocarbamoyl-sulphenamide In N,N-dimethyl-formamide at 20℃; for 0.333333h; Product distribution; Mechanism; other sulfenamide reagents, other nitroarenes; | A 71% B 14% |
With potassium tert-butylate; N,N-tetramethylene-thiocarbamoyl-sulphenamide In N,N-dimethyl-formamide at 20℃; for 0.333333h; | A 71% B 14% |
With potassium tert-butylate; N,N-tetramethylene-thiocarbamoyl-sulphenamide In N,N-dimethyl-formamide at 20℃; for 0.333333h; | A 71% B 14% |
Conditions | Yield |
---|---|
In acetic acid at 20℃; for 36h; Heating / reflux; | 100% |
With acetic acid for 24h; Heating; | 89% |
With N,N-dimethyl-formamide for 0.0666667h; microwave irradiation; | 84% |
2-nitro-aniline
p-toluenesulfonyl chloride
4-methyl-N-(2-nitrophenyl)benzene sulfonamide
Conditions | Yield |
---|---|
With triethylamine In dichloromethane at 4℃; | 100% |
With pyridine In dichloromethane at 20℃; for 48h; | 90% |
With pyridine In dichloromethane at 20℃; for 16h; | 75% |
2-nitro-aniline
4-iodo-2-nitroaniline
Conditions | Yield |
---|---|
With N-iodo-succinimide In acetic acid at 95℃; for 1h; | 100% |
With sodium periodate; potassium iodide; sodium chloride In water; acetic acid at 25℃; for 8h; | 98% |
With sodium periodate; sulfuric acid; iodine; potassium iodide; sodium sulfite In water; acetic acid at 25℃; for 4h; Reagent/catalyst; | 98% |
Conditions | Yield |
---|---|
Stage #1: 2-nitro-aniline With boron trifluoride diethyl etherate In dichloromethane at -15℃; for 0.25h; Stage #2: With tert.-butylnitrite In dichloromethane at -15 - 0℃; for 1h; | 100% |
With tert.-butylnitrite; boron trifluoride diethyl etherate In dichloromethane at 0 - 20℃; | 95% |
With dinitrogen tetraoxide; benzene entsteht das Nitrat; |
Conditions | Yield |
---|---|
With hydrazine hydrate at 90℃; for 1.16667h; chemoselective reaction; | 100% |
With hydrazine hydrate In ethanol; water at 80℃; for 3h; chemoselective reaction; | 100% |
With sodium tetrahydroborate In water for 0.116667h; Kinetics; Catalytic behavior; Reagent/catalyst; | 100% |
Conditions | Yield |
---|---|
Stage #1: cyanoacetic acid With phosphorus pentachloride In dichloromethane for 0.5h; Reflux; Stage #2: 2-nitro-aniline In dichloromethane for 2h; Reflux; | 100% |
With dicyclohexyldiimide In N,N-dimethyl-formamide for 1h; Ambient temperature; | 74% |
With phosphorus pentachloride In benzene |
methyl trans-3-(4-methoxyphenyl)glycidate
2-nitro-aniline
2-Hydroxy-3-(4-methoxy-phenyl)-3-(2-nitro-phenylamino)-propionic acid methyl ester
Conditions | Yield |
---|---|
zinc(II) iodide In toluene at 22℃; for 21h; Product distribution; various solvents, additives, temperatures, times; | 100% |
zinc(II) iodide In toluene at 22℃; for 21h; | 100% |
di-tert-butyl dicarbonate
2-nitro-aniline
(2-nitro-phenyl)-carbamic acid tert-butyl ester
Conditions | Yield |
---|---|
Stage #1: 2-nitro-aniline With sodium hydride In tetrahydrofuran at 0 - 20℃; for 0.666667h; Stage #2: di-tert-butyl dicarbonate In tetrahydrofuran at 20℃; for 1h; | 100% |
With 12-TPA/SBA 15 at 20℃; for 0.1h; Neat (no solvent); | 97% |
Stage #1: 2-nitro-aniline With sodium hydride In tetrahydrofuran at 0 - 20℃; for 0.666667h; Stage #2: di-tert-butyl dicarbonate In tetrahydrofuran at 20℃; for 2h; | 96% |
2-nitro-aniline
p-tert-butyl benzoyl chloride
N-(2-nitrophenyl)-4-(1,1-dimethylethyl)-benzamide
Conditions | Yield |
---|---|
With pyridine Acylation; | 100% |
With pyridine In dichloromethane Acylation; |
Conditions | Yield |
---|---|
With tin(ll) chloride at 130℃; for 0.0833333h; microwave; | 100% |
With hydrogenchloride; iron In water at 70 - 100℃; |
2-bromo-1-chlorobenzene
2-nitro-aniline
N-(2-chlorophenyl)-N-(2-nitrophenyl)amine
Conditions | Yield |
---|---|
With caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; bis(dibenzylideneacetone)-palladium(0) In toluene at 120℃; for 24h; Buchwald-Hartwig coupling; Inert atmosphere; | 100% |
With caesium carbonate; tris-(dibenzylideneacetone)dipalladium(0); 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl In toluene Buchwald-Hartwig reaction; | 99% |
With caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; bis(dibenzylideneacetone)-palladium(0) In toluene at 120℃; Inert atmosphere; | 86% |
With caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; tris(dibenzylideneacetone)dipalladium (0) In toluene at 110℃; for 30h; | 65% |
Conditions | Yield |
---|---|
With tin(ll) chloride at 130℃; for 0.0833333h; microwave; | 100% |
bis(trichloromethyl) carbonate
2-nitro-aniline
2-nitrophenyl isocyanate
Conditions | Yield |
---|---|
With triethylamine In dichloromethane | 100% |
In toluene for 3h; Heating; | |
In dichloromethane at 0℃; for 0.5h; |
Conditions | Yield |
---|---|
With aluminum tri-bromide at -20℃; | 100% |
Stage #1: Cyclopentane; carbon monoxide With aluminum tri-bromide; carbon tetrabromide In various solvent(s) at 0℃; under 760.051 Torr; for 4h; Stage #2: 2-nitro-aniline In various solvent(s) at -20 - 20℃; under 760.051 Torr; Further stages.; | 100 % Chromat. |
Stage #1: Cyclopentane; carbon monoxide With 2AlBr3*CBr4 In dibromomethane Stage #2: 2-nitro-aniline In dibromomethane at 0℃; for 2h; chemoselective reaction; | 97 %Chromat. |
Conditions | Yield |
---|---|
In tetrahydrofuran at 20℃; | 100% |
5-methoxymethylene-2,2-dimethyl-1,3-dioxane-4,6-dione
2-nitro-aniline
2,2-dimethyl-5-((2-nitrophenylamino)methylene)-1,3-dioxane-4,6-dione
Conditions | Yield |
---|---|
In acetonitrile at 20℃; for 0.25h; | 100% |
Conditions | Yield |
---|---|
With palladium with copper supported on alumina In water at 179.84℃; under 26252.6 Torr; for 12h; Autoclave; | 100% |
With JRC-TIO-7-supported iridium catalyst In 1,3,5-trimethyl-benzene at 80℃; for 18h; Reagent/catalyst; Solvent; Inert atmosphere; Schlenk technique; | 99% |
With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride In toluene at 160℃; for 24h; Catalytic behavior; Reagent/catalyst; Temperature; Solvent; Schlenk technique; Inert atmosphere; Sealed tube; | 97% |
Conditions | Yield |
---|---|
at 20℃; for 0.133333h; Milling; Inert atmosphere; | 100% |
Conditions | Yield |
---|---|
With N-chloro-N-(benzenesulfonyl)benzenesulfonamide In acetonitrile at 20 - 25℃; for 0.0833333h; Green chemistry; | 99.2% |
With copper dichloride; 1-hexyl-3-methylimidazol-1-ium chloride at 40℃; for 16h; regioselective reaction; | 85% |
With N-chloro-succinimide In acetonitrile for 10h; Heating; | 57% |
Multi-step reaction with 2 steps 1: diethyl ether; hypochlorous acid / 20 °C 2: hydrochloric acid; diethyl ether / -20 °C View Scheme |
Conditions | Yield |
---|---|
With triethylamine; dmap In dichloromethane at 0 - 20℃; for 18h; | 99% |
With pyridine at 25℃; for 15h; | 97% |
With pyridine; dmap | 93% |
Conditions | Yield |
---|---|
With dmap; triethylamine In dichloromethane at 20℃; | 99% |
With montmorillonite K-10 In dichloromethane for 1.5h; Ambient temperature; | 98% |
With carbon-silica composite from starch (7.5 molpercent SO3H) at 60℃; for 0.75h; solvent-free conditions; | 95% |
Conditions | Yield |
---|---|
With hydrogen bromide; dihydrogen peroxide In methanol at 0 - 20℃; for 12h; | 99% |
With HMTAB In dichloromethane at 20℃; for 0.5h; | 98% |
With 1-butyl-3-methylpyridinium tribromide at 20℃; | 98% |
Conditions | Yield |
---|---|
With bromine In methanol; dichloromethane at 20℃; for 1h; | 99% |
With bromine; acetic acid at 45℃; for 4h; | 98% |
With bromine; acetic acid at 45℃; for 4h; | 98% |
3-methylbutyric acid trimethylsilyl ester
2-nitro-aniline
3-methyl-2'-nitrobutananilide
Conditions | Yield |
---|---|
With 4-(trifluoromethyl)benzoic anhydride; silver trifluoromethanesulfonate; titanium tetrachloride In dichloromethane for 20h; Ambient temperature; | 99% |
With 4-(trifluoromethyl)benzoic anhydride; silver trifluoromethanesulfonate; titanium tetrachloride In dichloromethane for 20h; Ambient temperature; | 99% |
Conditions | Yield |
---|---|
With potassium carbonate In dimethyl sulfoxide at 120℃; for 36h; | 99% |
With potassium carbonate In dimethyl sulfoxide at 120℃; for 36h; Inert atmosphere; | 95% |
With potassium carbonate In dimethyl sulfoxide at 130℃; for 20h; Inert atmosphere; Schlenk technique; | 94% |
2-nitro-aniline
acetylacetone
3-(2-(2-nitrophenyl)hydrazineylidene)pentane-2,4-dione
Conditions | Yield |
---|---|
Stage #1: 2-nitro-aniline With hydrogenchloride; sodium nitrite Stage #2: acetylacetone With sodium hydroxide; sodium acetate In methanol; water at 0 - 20℃; for 1h; Further stages.; | 99% |
Stage #1: 2-nitro-aniline With hydrogenchloride; sodium nitrite In water at 0 - 5℃; for 0.5h; Stage #2: acetylacetone With sodium acetate In methanol; water at 20℃; | 87% |
Stage #1: 2-nitro-aniline With hydrogenchloride; sodium hydroxide; sodium nitrite In water at -0.16℃; Stage #2: acetylacetone In water at -0.16℃; for 1h; | 79% |
With hydrogenchloride; sodium acetate; sodium nitrite 1.) water, 0 deg C, 2.) acetone, 6 h; Multistep reaction; | |
Stage #1: 2-nitro-aniline With hydrogenchloride; sodium nitrite at 0℃; for 0.5h; Stage #2: acetylacetone With sodium acetate In ethanol; water at 0 - 20℃; for 3h; Further stages.; |
Conditions | Yield |
---|---|
Stage #1: 2-nitro-aniline With sulfuric acid; sodium nitrite In water at 20℃; for 0.333333h; Stage #2: β-naphthol In water at 20℃; for 2h; | 99% |
Stage #1: 2-nitro-aniline With hydrogenchloride; sodium nitrite In water at 0 - 20℃; for 4.25h; Stage #2: With aminosulfonic acid In water at 0℃; for 1h; Stage #3: β-naphthol In ethanol; water at 20℃; for 19.5h; | 93% |
Stage #1: 2-nitro-aniline With sodium nitrite In water at 20℃; Milling; Green chemistry; Stage #2: β-naphthol In water at 20℃; for 0.5h; Milling; Green chemistry; | 83% |
2-nitro-aniline
acrylic acid methyl ester
(E)-methyl 2-nitrocinnamate
Conditions | Yield |
---|---|
With tert.-butylnitrite; methanesulfonic acid; palladium diacetate; methoxybenzene In methanol at 0 - 25℃; for 48h; Reagent/catalyst; Heck Reaction; | 99% |
Stage #1: 2-nitro-aniline With tert.-butylnitrite In methanol at 0℃; for 0.5h; Stage #2: acrylic acid methyl ester With methanesulfonic acid; palladium diacetate In methanol at 0 - 25℃; Heck-Matsuda reaction; | 98% |
Stage #1: 2-nitro-aniline With tert.-butylnitrite In methanol at 0℃; for 0.5h; Heck-Matsuda reaction; Stage #2: acrylic acid methyl ester With methanesulfonic acid; palladium diacetate In methanol at 0 - 25℃; for 48h; Heck-Matsuda reaction; | 98% |
Conditions | Yield |
---|---|
With hydrogen In ethyl acetate at 20℃; under 7500.75 Torr; for 20h; Catalytic behavior; Activation energy; Reagent/catalyst; Temperature; Autoclave; Green chemistry; | 99% |
With hydrogen In ethyl acetate at 60℃; under 7500.75 Torr; for 20h; Reagent/catalyst; Solvent; Pressure; Time; Temperature; | 99% |
Stage #1: benzaldehyde; 2-nitro-aniline In 1,4-dioxane; water at 90℃; for 0.0833333h; Stage #2: With formic acid In 1,4-dioxane; water at 90℃; for 8h; Temperature; Sealed tube; | 96% |
IUPAC Name: 2-Nitroaniline
Synonyms of o-Nitroaniline (CAS NO.88-74-4): Aniline, o-nitro- ; Benzenamine, 2-nitro- ; o-Nitroaniline ; UN1661 ; o-Nitroaniline [UN1661] [Poison]
CAS NO: 88-74-4
Classification Code: Mutation data
Molecular Formula: C6H6N2O2
Molecular Weight: 138.124
Molecular Structure:
Melting Point: 70-73 °C
Polar Surface Area: 71.84 Å2
Index of Refraction: 1.634
Molar Refractivity: 37.03 cm3
Molar Volume: 103.5 cm3
Surface Tension: 60.3 dyne/cm
Density: 1.333 g/cm3
Flash Point: 126.1 °C
Enthalpy of Vaporization: 52.4 kJ/mol
Boiling Point: 284.9 °C at 760 mmHg
Vapour Pressure: 0.00289 mmHg at 25°C
o-Nitroaniline (CAS NO.88-74-4) is rubber antioxidant MB, pesticides carbendazim, light stabilizer UV-P intermediates.It can be used as the goods azoic dyes for color-based (orange-GC), and other dye intermediates, can be used to hand Cotton fabric dyeing, the system could Color Yield amylin.
Adding ortho-nitrochlorobenzene into the filled with a certain concentration of ammonia Autoclave at 185-190 °C, 4-4.5 MPa for ammonia solution, o-nitroaniline crude via cooling and crystallization, filtration, derived products.
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
bird - wild | LD50 | oral | 750mg/kg (750mg/kg) | Archives of Environmental Contamination and Toxicology. Vol. 12, Pg. 355, 1983. | |
guinea pig | LD50 | oral | 2350mg/kg (2350mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD | Voprosy Kommunal'noi Gigieny. Problems of Communal Hygiene. Vol. 6, Pg. 89, 1966. |
mammal (species unspecified) | LD50 | unreported | 9441mg/kg (9441mg/kg) | Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 48(6), Pg. 22, 1983. | |
mouse | LD50 | oral | 1070mg/kg (1070mg/kg) | Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 25(8), Pg. 50, 1981. | |
quail | LD50 | oral | 750mg/kg (750mg/kg) | Archives of Environmental Contamination and Toxicology. Vol. 12, Pg. 355, 1983. | |
rat | LC50 | inhalation | > 2529mg/m3/4H (2529mg/m3) | LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION | National Technical Information Service. Vol. OTS0558766, |
rat | LD50 | oral | 1600mg/kg (1600mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD | Voprosy Kommunal'noi Gigieny. Problems of Communal Hygiene. Vol. 6, Pg. 89, 1966. |
rat | LDLo | intraperitoneal | 800mg/kg (800mg/kg) | "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982Vol. -, Pg. 91, 1982. |
Reported in EPA TSCA Inventory.
Hazard Symbols of o-Nitroaniline (CAS NO.88-74-4): T
Risk Codes: 23/24/25-33-52/53-39-11
R23/24/25:Toxic by inhalation, in contact with skin and if swallowed.
R33:Danger of cumulative effects.
R52/53:Harmful to aquatic organisms, may cause long-term adverse effects in the aquatic environment.
R39:Danger of very serious irreversible effects.
R11:Highly flammable.
Safety Description: S28;S36/37;S45;S61
S28: After contact with skin, wash immediately with plenty of soap-suds.
S36/37: Wear suitable protective clothing and gloves.
S45: In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
S61: Avoid release to the environment. Refer to special instructions / safety data sheets.
Transport Information: UN 1661
A poison. Moderately toxic by ingestion. Mildly toxic by skin contact. Mutation data reported. Mixtures with magnesium are hypergolic on contact with nitric acid. Forms extremely explosive addition compounds with hexanitroethane. Vigorous reaction with sulfuric acid above 200°C. When heated to decomposition it emits toxic fumes of NOx. See also m-NITROANILINE, p-NITROANILINE, and ANILINE DYES.
DOT Classification: 6.1; Label: Poison
Handling: Do not get in eyes, on skin, or on clothing. Do not breathe vapor. Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Use only with adequate ventilation or respiratory protection.
Storage: Store protected from light. Store in a cool, dry, well-ventilated area away from incompatible substances. Store in a tightly closed container.
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