2-Pyrazinecarboxylic acid supplier

Name
2-Pyrazinecarboxylic acid
EINECS 202-718-1
CAS No. 98-97-5
Article Data41
CAS DataBase
Density 1.403 g/cm³
Solubility soluble in cold water
Melting Point 222-225 °C
Formula C₅H₄N₂O₂
Boiling Point 313.1 °C at 760 mmHg
Molecular Weight 124.099
Flash Point 143.1 °C
Transport Information
Appearance white to off-white crystalline powder
Safety 22-24/25-45-36/37/39-26-16
Risk Codes 11-34
Molecular Structure
Hazard Symbols Xi,C,F
Synonyms Piazinecarboxylic acid;pyrazine-2-carboxylate;Pyrazine-2-carboxylic acid;Pyrazinemonocarboxylic acid;2- Piperazine carboxylic;Pyrazinecarboxylic acid;Paradiazinecarboxylic acid;2-Pyrazinoic acid;Pyrazinoate;2-Pyrazine carboxylic acid;Pyrazinoic acid;Pyrazinic acid;Pyazine-2-carboxylic acid;
PSA 63.08000
LogP 0.17480

Synthetic route

: 89-01-0
2,3-dicarboxypyrazine

: 98-97-5
2-pyrazylcarboxylic acid

Conditions

Conditions	Yield
With sulfuric acid; acetic acid for 2h; Heating;	85%
at 210℃; under 3 - 4 Torr;
With water; toluene
With nitrobenzene

: 109-08-0
2-Methylpyrazine

: 98-97-5
2-pyrazylcarboxylic acid

Conditions

Conditions	Yield
With 18-crown-6 ether; potassium tert-butylate; oxygen In 1,2-dimethoxyethane at 60℃; under 3800 Torr; for 24h;	64%
In water Ambient temperature; electrochemical oxidation on activated nickel hydroxide anode;	60%
With selenium(IV) oxide In acetic acid for 0.0833333h; Heating; microwave;	50%

: 123-32-0
2,5-dimethyl-pyrazine

A: 98-97-5
2-pyrazylcarboxylic acid

B: 5521-55-1
2-methylpyrazin-5-carboxylic acid

C: 122-05-4
2,5-pyrazinedicarboxylic acid

Conditions

Conditions	Yield
With cobalt(II) nitrate In water Ambient temperature; electrochemical oxidation on activated nickel hydroxide anode;	A 2% B 42% C 3%
In water Ambient temperature; electrochemical oxidation on activated nickel hydroxide anode;	A 12% B 22% C 5%
With chromium(III) nitrate In diethyl ether Product distribution; Ambient temperature; electrochemical oxidation; var. additives, var. reaction time vs. conversion;

...Expand

: 13925-00-3
2-ethylpyrazine

: 98-97-5
2-pyrazylcarboxylic acid

Conditions

Conditions	Yield
With potassium permanganate
With potassium permanganate In water at 20℃;

: 13481-25-9
pyrazine-2,3-dicarbonitrile

: 98-97-5
2-pyrazylcarboxylic acid

Conditions

Conditions	Yield
With hydrogenchloride

: 122-05-4
2,5-pyrazinedicarboxylic acid

A: 290-37-9
1,4-pyrazine

B: 98-97-5
2-pyrazylcarboxylic acid

C: 15719-64-9, 15719-76-3, 97762-63-5
methylammonium carbonate

Conditions

Conditions	Yield
at 282℃;

...Expand

: 89-01-0
2,3-dicarboxypyrazine

A: 290-37-9
1,4-pyrazine

B: 98-97-5
2-pyrazylcarboxylic acid

Conditions

Conditions	Yield
Destillation im Vakuum;
bei der Destillation im Vakuum;

: 103150-78-3
diethyl pyrazine-2,5-dicarboxylate

A: 290-37-9
1,4-pyrazine

B: 98-97-5
2-pyrazylcarboxylic acid

Conditions

Conditions	Yield
rasche Destillation;

: 6924-68-1
ethyl 2-pyrazinecarboxylate

: 98-97-5
2-pyrazylcarboxylic acid

Conditions

Conditions	Yield
With alkaline H2O In dimethyl sulfoxide at 30℃; Rate constant; other solvent (EtOH); variation of water concentrations;

: 109-08-0
2-Methylpyrazine

aqueous permanganate solution: aqueous permanganate solution

: 98-97-5
2-pyrazylcarboxylic acid

monopotassium-salt of/the/ pyrazine-2,3-dicarboxylic acid: monopotassium-salt of/the/ pyrazine-2,3-dicarboxylic acid

: 98-97-5
2-pyrazylcarboxylic acid

Conditions

Conditions	Yield
With diethylene glycol

: 34569-20-5
N-benzenesulfonyl-N'-pyrazinecarbonyl-hydrazine

: 107-21-1
ethylene glycol

Na2CO3: Na2CO3

A: 98-97-5
2-pyrazylcarboxylic acid

B: 98-96-4
pyrazinamide

C: 54571-25-4
N,N'-bis-(pyrazine-2-carbonyl)-hydrazine

D: 882-33-7
diphenyldisulfane

Conditions

Conditions	Yield
at 160℃;

...Expand

: 13961-37-0
2-ethylpiperazine

: 98-97-5
2-pyrazylcarboxylic acid

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: H2O; copper oxide-chromium oxide catalyst / 360 °C 2: KMnO4 View Scheme

: 109-08-0
2-Methylpyrazine

A: 25594-37-0
2-methylpyrazine 4-oxide

B: 31396-35-7
2-methylpyrazine 1-oxide

C: 98-97-5
2-pyrazylcarboxylic acid

D: 5780-66-5
pyrazinecarboxaldehyde

E: 874-54-4
pyrazine-2-carboxylic acid-4-oxide

F: 32046-09-6
pyrazine-2-carboxylic acid-1-oxide

Conditions

Conditions	Yield
With acetyl peroxyborate In water at 94.84℃; for 5h;	A n/a B n/a C 56.3 mol % D 4.5 mol % E n/a F n/a
With acetyl peroxyborate In water at 94.84℃; for 5h;	A n/a B n/a C 28.5 mol % D 41.2 mol % E n/a F n/a

...Expand

: 109-08-0
2-Methylpyrazine

A: 25594-37-0
2-methylpyrazine 4-oxide

B: 31396-35-7
2-methylpyrazine 1-oxide

C: 98-97-5
2-pyrazylcarboxylic acid

D: 874-54-4
pyrazine-2-carboxylic acid-4-oxide

E: 32046-09-6
pyrazine-2-carboxylic acid-1-oxide

Conditions

Conditions	Yield
With peroxyacetic acid In water; acetic acid at 94.84℃; for 5h;	A n/a B n/a C 19.2 mol % D n/a E n/a

...Expand

: 98-96-4
pyrazinamide

: 98-97-5
2-pyrazylcarboxylic acid

Conditions

Conditions	Yield
With recombinant Acinetobacter baumanii pyrazinamidase/nicotinamidase; water at 30℃; Kinetics; Enzymatic reaction;
With potassium permanganate; sulfuric acid Kinetics; Mechanism; Thermodynamic data; Concentration;
With water In aq. phosphate buffer at 30℃; for 3h; pH=7; Time; Enzymatic reaction;
Alkaline conditions;

: potassium pyrazinemonocarboxylate

: 98-97-5
2-pyrazylcarboxylic acid

Conditions

Conditions	Yield
With hydrogenchloride In water pH=2;

: 19847-12-2
2-pyrazine carbonitrile

: 98-97-5
2-pyrazylcarboxylic acid

Conditions

Conditions	Yield
With sodium hydroxide for 6h; Reflux;

2-Pyrazinecarboxylic acid Chemical Properties

IUPAC Name: Pyrazine-2-carboxylic acid
Synonyms of 2-Pyrazinecarboxylic acid (CAS NO.98-97-5): Pyrazinoic acid ; Pyrazine-2-carboxylic acid
CAS NO: 98-97-5
Molecular Formula: C₅H₄N₂O₂
Molecular Weight: 93.55
Molecular Structure:
EINECS: 202-718-1
H bond acceptors: 4
H bond donors: 1
Freely Rotating Bonds: 1
Polar Surface Area: 52.08 Å²
Index of Refraction: 1.578
Molar Refractivity: 29.36 cm³
Molar Volume: 88.4 cm³
Surface Tension: 72.1 dyne/cm
Density: 1.403 g/cm³
Flash Point: 143.1 °C
Enthalpy of Vaporization: 58.5 kJ/mol
Boiling Point: 313.1 °C at 760 mmHg
Vapour Pressure: 0.000217 mmHg at 25°C
Melting point: 222-225 °C
Water solubility: soluble in cold water
Appearance: white to off-white crystalline powder
SMILES: O=C(O)c1nccnc1
InChI: InChI=1/C5H4N2O2/c8-5(9)4-3-6-1-2-7-4/h1-3H,(H,8,9)
InChIKey: NIPZZXUFJPQHNH-UHFFFAOYAS
Std. InChI: InChI=1S/C5H4N2O2/c8-5(9)4-3-6-1-2-7-4/h1-3H,(H,8,9)
Std. InChIKey: NIPZZXUFJPQHNH-UHFFFAOYSA-N
Product Categories of 2-Pyrazinecarboxylic acid (CAS NO.98-97-5): Fluorobenzene;Carboxylic Acids;Pyrazines, Pyrimidines & Pyridazines;Pyrazine;Organic acids;Pyrazinecarboxylic Acid & Derivatives;Pyrazines;Carboxylic Acids;Pyrazines, Pyrimidines & Pyridazines;Building Blocks;Heterocyclic Building Blocks

2-Pyrazinecarboxylic acid Safety Profile

Safety Information about 2-Pyrazinecarboxylic acid (CAS NO.98-97-5):
Hazard Codes: Irritant Xi, Corrosive C,F
Risk Statements: 11-34
R11: Highly flammable.
R34: Causes burns.
Safety Statements: 22-24/25-45-36/37/39-26-16
S16: Keep away from sources of ignition.
S22: Do not breathe dust.
S24/25: Avoid contact with skin and eyes.
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36/37/39: Wear suitable protective clothing, gloves and eye/face protection.
S45: In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
WGK Germany: 3
HS Code: 29339990

2-Pyrazinecarboxylic acid Specification

General Information: As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear.
Extinguishing Media: In case of fire, use water, dry chemical, chemical foam, or alcohol-resistant foam.
Handling: Remove contaminated clothing and wash before reuse. Avoid contact with eyes, skin, and clothing. Avoid ingestion and inhalation.
Storage: Store in a cool, dry place. Keep container closed when not in use.

Product Name

2-Pyrazinecarboxylic acid

Synthetic route

2-Pyrazinecarboxylic acid Chemical Properties

2-Pyrazinecarboxylic acid Safety Profile

2-Pyrazinecarboxylic acid Specification

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