2-Pyridinecarboxaldehyde supplier

Name
2-Pyridinecarboxaldehyde
EINECS 214-333-6
CAS No. 1121-60-4
Article Data169
CAS DataBase
Density 1.135 g/cm³
Solubility Miscible with water
Melting Point -21--22 °C
Formula C₆H₅NO
Boiling Point 180.2 °C at 760 mmHg
Molecular Weight 107.112
Flash Point 54.4 °C
Transport Information UN 1989 3/PG 3
Appearance Yellow liquid
Safety 7-26-61-53-45-36/37/39-29-16
Risk Codes 10-22-36/37/38-51/53-46-43-34-23
Molecular Structure
Hazard Symbols T,N
Synonyms Picolinic aldehyde;2-Picolinaldehyde;Pyridine-2-carbaldehyde;Picolinal;2-Pyridaldehyde;o-Nicotinaldehyde;Pyridine-2-aldehyde;Picolinaldehyde;Picolinaldehyde (8CI);2-Formylpyridine;Pyridine-2-carboxaldehyde;2-Picolinealdehyde;2-Pyridylaldehyde;2-Pyridinemethanol or 2-pyridinecarboxaldehyde;2-Pyridine carboxadehyde;
PSA 29.96000
LogP 0.89410

Synthetic route

: 586-98-1
2-Hydroxymethylpyridine

: 1121-60-4
pyridine-2-carbaldehyde

Conditions

Conditions	Yield
With sodium hypochlorite; β‐cyclodextrin In water at 50℃; for 1h;	99%
With tert.-butylhydroperoxide; V/SiO2 In decane; tert-butyl alcohol at 25℃; for 5h;	99.1%
With 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; oxygen In acetonitrile at 75℃; under 760.051 Torr; for 12h;	99%

: 100-70-9
2-Cyanopyridine

: 1121-60-4
pyridine-2-carbaldehyde

Conditions

Conditions	Yield
With potassium carbonate In water; dimethyl sulfoxide at 60℃; for 8h; High pressure; Green chemistry;	99.9%
With C13H26B(1-)*K(1+) In tetrahydrofuran for 24h; Ambient temperature;	73%
Stage #1: 2-Cyanopyridine With diisobutylaluminium hydride In toluene at 20℃; for 0.222222h; Flow reactor; Stage #2: With water; sodium L-tartrate In toluene at 0℃; chemoselective reaction;	56%

: 100-69-6
2-vinylpyridine

: 1121-60-4
pyridine-2-carbaldehyde

Conditions

Conditions	Yield
With dihydrogen peroxide In water at 100℃; for 4h;	95%
With sodium periodate; C53H44As2N2O3Ru In water; ethyl acetate; acetonitrile at 25℃; for 0.5h;	82%
Stage #1: 2-vinylpyridine With oxygen; ozone In dichloromethane at -78℃; Stage #2: With poly(ethylene glycol)-triphenylphosphine In dichloromethane at -78 - 20℃;	63%

: 2524-52-9
ethyl-2-picolinate

: 1121-60-4
pyridine-2-carbaldehyde

Conditions

Conditions	Yield
With n-butyllithium; diisobutylaluminium hydride; tert-butyl alcohol In tetrahydrofuran; hexane at 0℃;	94%
Multi-step reaction with 2 steps 1: diethyl ether; lithium alanate 2: lead (IV)-acetate; benzene View Scheme
With diisobutylaluminium hydride In dichloromethane; water; isopropyl alcohol; toluene

: 274-59-9
triazolopyridine

: 1121-60-4
pyridine-2-carbaldehyde

Conditions

Conditions	Yield
With selenium(IV) oxide In chlorobenzene at 132℃; for 6h;	92%

: 2-[1,3]Dithiolan-2-yl-pyridine

: 1121-60-4
pyridine-2-carbaldehyde

Conditions

Conditions	Yield
With thionyl chloride; dihydrogen peroxide In acetonitrile at 25℃; for 0.0166667h;	92%

: 98-98-6
2-Picolinic acid

: 1121-60-4
pyridine-2-carbaldehyde

Conditions

Conditions	Yield
With (CH3)2NCH2NpSiH2Ph at 110 - 140℃;	90%
With D-glucose; sodium citrate; magnesium chloride In aq. phosphate buffer at 28℃; for 3h; pH=7.4; Enzymatic reaction;
With carboxylic acid reductase Kinetics; Green chemistry; Enzymatic reaction;

: 109-06-8
α-picoline

: 1121-60-4
pyridine-2-carbaldehyde

Conditions

Conditions	Yield
With nickel-doped graphene carbon nitride nanoparticles; air In ethanol at 25℃; for 8h; Irradiation; Green chemistry;	89%
With sodium persulfate; Ni(N,N′‑dimethyl‑N,N′‑bis(pyridine‑2‑ylmethyl)‑1,2‑diaminoethane)Cl2 In acetonitrile at 20℃; for 6h;	81%
With water; oxygen; CrV0.95P0.05O4 at 299.84℃;	50.2%

: 873-69-8
2-pyridinealdoxime

: 1121-60-4
pyridine-2-carbaldehyde

Conditions

Conditions	Yield
With zinc(II) nitrate; silica gel for 0.0666667h; deoxymation; Irradiation;	89%
With cellulose supported Cu-nanoparticles In water at 80℃; for 0.0833333h; Microwave irradiation; Green chemistry;	79%
With iodine; sodium dodecyl-sulfate In water at 25 - 40℃; for 4h;	71%
With aluminum(III) nitrate nonahydrate; sodium bromide In dichloromethane at 20℃; for 30.5h;	58%

: 21035-59-6
N-methyl-2-pyridinemethanamine

: 1121-60-4
pyridine-2-carbaldehyde

Conditions

Conditions	Yield
With 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione In chloroform for 24h; Reflux;	89%
With 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione In chloroform for 24h; Reflux;	85%

: 117227-38-0
3,6,6-Trimethyl-4-{[1-pyridin-2-yl-meth-(E)-ylidene]-amino}-4,6-dihydro-1H-cyclopenta[1,2,4]triazine-5,7-dicarboxylic acid dimethyl ester

A: 1121-60-4
pyridine-2-carbaldehyde

B: 100-70-9
2-Cyanopyridine

Conditions

Conditions	Yield
With sodium methylate In ethanol for 3h; Product distribution; Heating;	A 8% B 88%

: 2-pyridinylidenehydrazinodiacetic acid

: 1121-60-4
pyridine-2-carbaldehyde

Conditions

Conditions	Yield
With copper(II) nitrate hexahydrate In dichloromethane; water at 20℃; for 3h;	88%

: 7216-40-2
2-pyridinecarboxaldehyde N-oxide

: 1121-60-4
pyridine-2-carbaldehyde

Conditions

Conditions	Yield
With ammonium formate; silica gel; zinc In methanol at 20℃; for 0.166667h; chemoselective reaction;	88%

: 5693-54-9
2-(1,3-dioxolan-2-yl)pyridine

: 1121-60-4
pyridine-2-carbaldehyde

Conditions

Conditions	Yield
With ammonium nitrate; Montmorillonite-K10 for 0.05h; deprotection; microwave irradiation;	86%
With lithium chloride In water; dimethyl sulfoxide at 130℃; for 18h;	76%

: (CH3CNO)2(CH3CNOH)2Co(C5H5N)(OOCH2C5H4N)

A: 1121-60-4
pyridine-2-carbaldehyde

B: 586-98-1
2-Hydroxymethylpyridine

Conditions

Conditions	Yield
In methanol decomposition of the complex by refluxing in methanol under N2 for 6-8 h; evapn. of the solvent, extn. of the organic compounds with ether, gas chromatography;	A 14% B 86%

: 13115-43-0
2-pyridineacetic acid

: 1121-60-4
pyridine-2-carbaldehyde

Conditions

Conditions	Yield
With potassium carbonate In chloroform at 20℃; for 24h; Irradiation; Inert atmosphere;	85%

: 2-nitrooxymethylpyridine

: 1121-60-4
pyridine-2-carbaldehyde

Conditions

Conditions	Yield
With 1,4-diaza-bicyclo[2.2.2]octane In ethanol for 3h; Ambient temperature;	84%

: C15H16Cl2N2O

: 1121-60-4
pyridine-2-carbaldehyde

Conditions

Conditions	Yield
With methanesulfonic acid In [D3]acetonitrile at 20℃; for 24h; Molecular sieve;	84%

: 1141-05-5
1,2-di(pyridin-2-yl)ethane-1,2-dio

: 1121-60-4
pyridine-2-carbaldehyde

Conditions

Conditions	Yield
With oxygen; cetyltrimethylammonim bromide In water at 20℃; under 760.051 Torr; for 5h; Irradiation; Green chemistry;	83%
With lead(IV) acetate; benzene
With Na0274MnO2*6H2O; oxygen In butan-1-ol at 100℃; under 760.051 Torr; for 1h; Green chemistry;	99 %Chromat.

: 5029-67-4
2-iodopyridine

: 64-18-6
formic acid

: 1121-60-4
pyridine-2-carbaldehyde

Conditions

Conditions	Yield
Stage #1: 2-iodopyridine; formic acid With palladium diacetate; acetic anhydride; tricyclohexylphosphine In N,N-dimethyl-formamide at 30℃; for 1h; Inert atmosphere; Green chemistry; Stage #2: With triethylamine In N,N-dimethyl-formamide at 80℃; for 6h; Inert atmosphere; Green chemistry;	83%
Stage #1: 2-iodopyridine With iodine; triethylamine; triphenylphosphine In dichloromethane; toluene at 20℃; for 0.0833333h; Sealed tube; Green chemistry; Stage #2: formic acid In dichloromethane; toluene at 70℃; for 1.5h; Sealed tube; Green chemistry;	80%
With 1,4-diaza-bicyclo[2.2.2]octane; palladium diacetate; dicyclohexyl-carbodiimide at 100℃; for 10h; Sealed tube;	70%
With palladium diacetate; triethylamine; dicyclohexyl-carbodiimide; tricyclohexylphosphine In N,N-dimethyl-formamide at 60℃; for 10h; Inert atmosphere; Sealed tube;	52%

: 3731-51-9
(2-aminomethylpyridine)

: 1121-60-4
pyridine-2-carbaldehyde

Conditions

Conditions	Yield
With 1,4-bis(triphenylphosphonium)butane cerium nitrate In water; acetic acid for 0.583333h; Reflux;	80%
Aufbewahren unter Luftzutritt;
With riboflavin tetraacetate In dimethylsulfoxide-d6; water-d2 for 0.166667h; Irradiation; In air;

: 109-04-6
2-bromo-pyridine

: 201230-82-2
carbon monoxide

: 1121-60-4
pyridine-2-carbaldehyde

Conditions

Conditions	Yield
With palladium diacetate; hydrogen; triphenylphosphine; 2,4,6-trimethyl-pyridine; tributyl-amine In acetonitrile at 120℃; under 22501.8 Torr; for 18h;	80%
With 4-methoxy-N'-tetramethylethylenediamine; hydrogen; catacxium A; palladium diacetate In toluene at 100℃; under 3750.3 Torr; for 16h;	7 % Chromat.
With dichloro [1,1'-bis(diphenylphosphino)propane]palladium(II); sodium carbonate In N,N-dimethyl-formamide; 1,3,5-trimethyl-benzene at 90℃; under 2250.23 Torr; for 18h; Sealed tube;	100 %Chromat.

: 65007-00-3
pyridin-2-yl trifluoromethanesulfonate

: 201230-82-2
carbon monoxide

: 1121-60-4
pyridine-2-carbaldehyde

Conditions

Conditions	Yield
With palladium diacetate; hydrogen; triphenylphosphine; 2,4,6-trimethyl-pyridine; tributyl-amine In acetonitrile at 120℃; under 22501.8 Torr; for 18h;	80%

: 109-06-8
α-picoline

: 6025-60-1
2-(1H-pyrrol-1-yl)aniline

A: 1121-60-4
pyridine-2-carbaldehyde

B: 2-(pyridin-2-yl)pyrrolo[1,2-a]quinoxaline

Conditions

Conditions	Yield
With oxygen; copper diacetate; trifluoroacetic acid In N,N-dimethyl-formamide at 120℃; for 1h;	A 10% B 78%

...Expand

: 35250-74-9
2-[(ethylsulfanyl)methyl]pyridine

A: 1121-60-4
pyridine-2-carbaldehyde

B: 2-ethanesulfinylmethyl-pyridine

Conditions

Conditions	Yield
With oxygen; rose bengal In methanol for 0.166667h; Oxidation; Irradiation;	A 3% B 74%

: 219879-85-3
2-pyridine

: 1121-60-4
pyridine-2-carbaldehyde

Conditions

Conditions	Yield
With trifluoroacetic acid In water; acetonitrile at 20℃; for 3h;	73%

: (2-Styrylpyridin-3-yl)carbamic acid 2-bis(2-trimethylsilylethyl)phosphonooxy-5-chlorobenzyl ester

: 538-49-8
2-[(E)-2-phenylethenyl]pyridine

A: 1121-60-4
pyridine-2-carbaldehyde

B: 412318-66-2
(2-Formylpyridin-3-yl)carbamic acid 2-bis(2-trimethylsilylethyl)phosphonooxy-5-chlorobenzyl ester

Conditions

Conditions	Yield
With dimethylsulfide; nitrogen In ethanol; dichloromethane	A 72% B n/a

...Expand

: 100-69-6
2-vinylpyridine

A: 1121-60-4
pyridine-2-carbaldehyde

B: 55967-94-7
2-oxiranylpyridine

Conditions

Conditions	Yield
With 1H-imidazole; sodium periodate; MnCl-TPP-(PEO750)4 In water; acetonitrile at 80℃; for 24h;	A 25% B 70%

: 586-98-1
2-Hydroxymethylpyridine

: 1972-28-7
diethylazodicarboxylate

A: 1121-60-4
pyridine-2-carbaldehyde

B: 4114-28-7
diethyl hydrazodicarboxylate

Conditions

Conditions	Yield
With zinc dibromide In toluene for 2.5h; Reflux;	A 70% B n/a

...Expand

: 1121-60-4
pyridine-2-carbaldehyde

: 613-94-5
benzoic acid hydrazide

: 1215-55-0
2-pyridyl carboxaldehyde benzoylhydrazone (E-isomer)

Conditions

Conditions	Yield
In ethanol for 6h; Reflux;	100%
With acetic acid In ethanol for 3h; Reflux;	87%
With hydrogenchloride In ethanol at 20℃; for 0.5h; Condensation;	85%

: 1121-60-4
pyridine-2-carbaldehyde

: 100-63-0
phenylhydrazine

: 30915-38-9
(E)-1-(2-pyridinyl)methylene-2-phenylhydrazine

Conditions

Conditions	Yield
In ethanol for 6h; Reflux;	100%
With acetic acid In ethanol for 3h; Reflux;	91%
With 1-deoxy-1-(methylamino)-D-glucitol In ethanol; water at 20℃; for 0.666667h; Green chemistry;	85%

: 1121-60-4
pyridine-2-carbaldehyde

: 2026-48-4
(S)-valinol

: 149197-27-3
(S,E)-3-methyl-2-(pyridin-2-ylmethyleneamino)butan-1-ol

Conditions

Conditions	Yield
In benzene for 2h; Condensation; Heating;	100%
With NaSO4 In benzene Ambient temperature; Yield given;
With magnesium sulfate In dichloromethane for 2h; Yield given;

: 1121-60-4
pyridine-2-carbaldehyde

: 932-30-9
2-Hydroxybenzylamine

: 134777-97-2
2-Pyridin-2-yl-3,4-dihydro-2H-benzo[e][1,3]oxazine

Conditions

Conditions	Yield
In ethanol for 2h; Ambient temperature;	100%

: 1121-60-4
pyridine-2-carbaldehyde

: 14838-15-4
u-2-amino-1-phenylpropan-1-ol

: 134778-00-0, 134778-01-1, 134876-45-2, 134876-46-3
2-((4S,5R)-4-Methyl-5-phenyl-oxazolidin-2-yl)-pyridine

Conditions

Conditions	Yield
In ethanol for 2h; Ambient temperature; Further byproducts given;	100%

: 1121-60-4
pyridine-2-carbaldehyde

: 492-39-7
(1S,2S)-2-amino-1-phenylpropanol

: (1S,2S)-1-Phenyl-2-{[1-pyridin-2-yl-meth-(E)-ylidene]-amino}-propan-1-ol

Conditions

Conditions	Yield
In benzene for 2h; Condensation; Heating;	100%
With magnesium sulfate In methanol at 50℃; for 1h;

: 1121-60-4
pyridine-2-carbaldehyde

: 37577-07-4
Norpseudoephedrine

: 134778-00-0, 134778-01-1, 134876-45-2, 134876-46-3
2-((4R,5R)-4-Methyl-5-phenyl-oxazolidin-2-yl)-pyridine

Conditions

Conditions	Yield
In ethanol for 2h; Ambient temperature; Further byproducts given;	100%

: 1121-60-4
pyridine-2-carbaldehyde

: 104-94-9
4-methoxy-aniline

: 26930-67-6, 42910-70-3
(E)-N-(4-methoxyphenyl)-1-(pyridin-2-yl)methanimine

Conditions

Conditions	Yield
In toluene at 20℃; for 24h;	100%
With magnesium sulfate In benzene for 20h; Ambient temperature;	98%
With magnesium sulfate In ethanol at 25℃; for 16h;	91%

: 1121-60-4
pyridine-2-carbaldehyde

: 124-68-5
2-Amino-2-methyl-1-propanol

: 134777-99-4
4,4-dimethyl-2-pyridin-2-yl-1,3-oxazolidine

Conditions

Conditions	Yield
In ethanol for 2h; Ambient temperature;	100%
In ethanol at 20℃; for 3h;	94%

: 1121-60-4
pyridine-2-carbaldehyde

: 107-15-3
ethylenediamine

: 4608-34-8
N,N'-bis(2-pyridylmethyl)ethylenediamine

Conditions

Conditions	Yield
With hydrogen; palladium on activated charcoal In methanol under 2585.74 Torr; for 24h;	100%
Stage #1: pyridine-2-carbaldehyde; ethylenediamine In methanol for 5h; Reflux; Stage #2: With sodium tetrahydroborate In methanol Reflux;	86%
Stage #1: pyridine-2-carbaldehyde; ethylenediamine In methanol at 0℃; for 1h; Stage #2: With sodium tetrahydroborate In methanol for 1h;	85%

: 1121-60-4
pyridine-2-carbaldehyde

: 107-13-1
acrylonitrile

: 153274-57-8
(+/-)-2-[(hydroxy)(pyridin-2-yl)methyl]acrylonitrile

Conditions

Conditions	Yield
With 1,4-diaza-bicyclo[2.2.2]octane at 0℃; for 0.5h; Morita-Baylis-Hillman reaction;	100%
With 1,4-diaza-bicyclo[2.2.2]octane In neat (no solvent) at 0℃; for 0.5h; Catalytic behavior; Solvent; Time; Temperature; Morita-Baylis-Hillman Alkylation;	100%
With 1,4-diaza-bicyclo[2.2.2]octane at 80℃; for 0.5h; Morita-Baylis-Hillman Alkylation; Microwave irradiation;	100%

: 1121-60-4
pyridine-2-carbaldehyde

: 292638-85-8
acrylic acid methyl ester

: 118488-74-7
2-(hydroxy-pyridin-2-yl-methyl)-acrylic acid methyl ester

Conditions

Conditions	Yield
With 1,4-diaza-bicyclo[2.2.2]octane In 1,4-dioxane; water at 20℃; for 1h; Baylis-Hillman reaction;	100%
With 1,4-diaza-bicyclo[2.2.2]octane at 0℃; for 5h; Morita-Baylis-Hillman Alkylation;	100%
With 1,4-diaza-bicyclo[2.2.2]octane at 80℃; for 0.166667h; Baylis-Hillman reaction; Microwave irradiation; neat (no solvent);	99%

: 1121-60-4
pyridine-2-carbaldehyde

: 62-53-3
aniline

: 7032-25-9
2-(phenyliminomethyl)pyridine

Conditions

Conditions	Yield
In toluene at 20℃; for 24h; Inert atmosphere;	100%
In toluene for 24h; Reflux;	98%
In water at 25℃; for 3h; Inert atmosphere;	95%

: 1121-60-4
pyridine-2-carbaldehyde

: 156-87-6
propan-1-ol-3-amine

: 134777-96-1
tetrahydro-2-(2-pyridinyl)-2H-1,3-oxazine

Conditions

Conditions	Yield
In ethanol for 2h; Product distribution; Ambient temperature; other aminoalcohols, other pyridinecarbaldehydes;	100%
In ethanol for 2h; Ambient temperature;	100%

: 1121-60-4
pyridine-2-carbaldehyde

: 100-46-9
benzylamine

: 19198-87-9
1-phenyl-N-(pyridin-2-ylmethylene)methanamine

Conditions

Conditions	Yield
for 6h; Kinetics; Molecular sieve; Reflux;	100%
With sodium sulfate In tetrahydrofuran at 20℃;	84%
With formic acid In neat (no solvent) at 20℃;	80%

: 1121-60-4
pyridine-2-carbaldehyde

: 1099-45-2
ethyl (triphenylphosphoranylidene)acetate

: 7340-23-0, 33788-40-8, 70526-11-3
(E)-ethyl 3-(2-pyridyl)-propenoate

Conditions

Conditions	Yield
In tetrahydrofuran for 24h;	100%
In dichloromethane for 26h; Wittig reaction; Heating;	93%
In ethanol at 80℃; Wittig Olefination;	80%

: 1121-60-4
pyridine-2-carbaldehyde

: 586-98-1
2-Hydroxymethylpyridine

Conditions

Conditions	Yield
With 1-Benzyl-3,5-bis(1-pyrrolidinylcarbonyl)-1,4-dihydropyridine; zinc(II) perchlorate; anionic SDS micelle In water at 50℃; Rate constant; different Zn(ClO4)2*6H2O concentration, in the presence and without of SDS;	100%
With magnesium(II) perchlorate; polymer-bound NADH (2a) In acetonitrile; benzene at 80℃; for 120h; Further byproducts given;	100%
With 1-Benzyl-3,5-bis(1-pyrrolidinylcarbonyl)-1,4-dihydropyridine; zinc(II) perchlorate; anionic SDS (C12H25OSO3Na) micelle In water at 50℃;	100%

: 1121-60-4
pyridine-2-carbaldehyde

: 873-69-8
2-pyridinealdoxime

Conditions

Conditions	Yield
With hydroxylamine hydrochloride; sodium acetate In ethanol at 60℃; for 2h;	100%
Stage #1: pyridine-2-carbaldehyde With hydroxylamine hydrochloride In ethanol; water at 20℃; for 0.0166667h; Sealed tube; Stage #2: In ethanol; water at 120℃; for 1h; Sealed tube; Microwave irradiation;	98%
With hydroxylamine hydrochloride; sodium hydroxide In ethanol; water at 50℃; for 2h;	93.4%

: 1121-60-4
pyridine-2-carbaldehyde

: 75-16-1
methylmagnesium bromide

: 20988-55-0, 18728-61-5, 27911-63-3, 59042-90-9
1-(pyridine-2-yl)ethanol

Conditions

Conditions	Yield
In diethyl ether at 0℃; for 2h;	100%
In diethyl ether at 0 - 5℃; for 2h; Inert atmosphere;	61%
Yield given;

: 1121-60-4
pyridine-2-carbaldehyde

: 4097-89-6
2,2',2''-triaminotriethylamine

: 122329-11-7
N'-(pyridin-2-ylmethyl)-N,N-bis{2-[(pyridin-2-ylmethyl)amino]ethyl}ethane-1,2-diamine

Conditions

Conditions	Yield
With hydrogen; palladium on activated charcoal In methanol under 2585.74 Torr; for 24h;	100%
With hydrogen; palladium on activated charcoal In methanol under 760 Torr; for 12h; Ambient temperature;	89%

: 1121-60-4
pyridine-2-carbaldehyde

: 29841-69-8
(S,S)-1,2-diphenyl-1,2-diaminoethane

: (1S,2S)-N,N'-bis(2-pyridylmetheno)-1,2-diphenylethylenediimine

Conditions

Conditions	Yield
In benzene for 2h; Heating;	100%
In methanol	22%

: 1121-60-4
pyridine-2-carbaldehyde

: 3886-69-9
(R)-1-phenyl-ethyl-amine

: 38010-70-7
(R,E)-N-(1-phenylethyl)-1-(pyridin-2-yl)methanimine

Conditions

Conditions	Yield
In toluene Reflux; Inert atmosphere; Dean-Stark;	100%
With magnesium sulfate In diethyl ether for 4h; Ambient temperature;	90%
With aluminum oxide
In diethyl ether for 1h; Molecular sieve; Inert atmosphere;

: 1121-60-4
pyridine-2-carbaldehyde

: 111-40-0
1,5-diamino-3-azapentane

: 58214-73-6
N-pyridin-2-ylmethyl-N'-{2-[(pyridin-2-ylmethyl)amino]ethyl}ethane-1,2-diamine

Conditions

Conditions	Yield
With hydrogen; palladium on activated charcoal In methanol under 2585.74 Torr; for 24h;	100%
Stage #1: pyridine-2-carbaldehyde; 3-azapentane-1,5-diamine In ethanol at 50℃; for 2h; Inert atmosphere; Stage #2: With sodium tetrahydroborate In ethanol at 50℃; for 2h; Inert atmosphere; chemoselective reaction;	92%
Stage #1: pyridine-2-carbaldehyde; 3-azapentane-1,5-diamine With acetic acid; zinc In methanol at 70 - 80℃; for 4.5h; Stage #2: With hydrogenchloride In methanol at 20℃; Stage #3: With sodium hydroxide In water	85%

: 1121-60-4
pyridine-2-carbaldehyde

: 109-81-9
N-methyl-ethane-1,2-diamine

: 63671-67-0
N1-methyl-N2-(pyridin-2-ylmethyl)ethane-1,2-diamine

Conditions

Conditions	Yield
With hydrogen; palladium on activated charcoal In methanol under 2585.74 Torr; for 24h;	100%
Stage #1: pyridine-2-carbaldehyde; N-methyl-ethane-1,2-diamine In methanol Stage #2: With sodium tetrahydroborate In methanol for 24h;	70%
Stage #1: pyridine-2-carbaldehyde; N-methyl-ethane-1,2-diamine In methanol at 20℃; for 24h; Stage #2: With sodium tetrahydroborate In methanol at 20℃; for 24h;	30%

: 1121-60-4
pyridine-2-carbaldehyde

: 78603-97-1
(S)-2-amino-1,1-diphenyl-4-methylpentan-1-ol

: (S)-4-Methyl-1,1-diphenyl-2-{[1-pyridin-2-yl-meth-(E)-ylidene]-amino}-pentan-1-ol

Conditions

Conditions	Yield
In benzene for 2h; Condensation; Heating;	100%
In benzene Heating;

: 1121-60-4
pyridine-2-carbaldehyde

: 79868-78-3
(S)-(-)-2-amino-1,1,3-triphenyl-1-propanol

: (S)-1,1,3-Triphenyl-2-{[1-pyridin-2-yl-meth-(E)-ylidene]-amino}-propan-1-ol

Conditions

Conditions	Yield
In benzene for 2h; Condensation; Heating;	100%
In benzene Heating;

: 1121-60-4
pyridine-2-carbaldehyde

: 78603-95-9
1,1-diphenyl-L-valinol

: (S)-3-Methyl-1,1-diphenyl-2-{[1-pyridin-2-yl-meth-(E)-ylidene]-amino}-butan-1-ol

Conditions

Conditions	Yield
In benzene for 2h; Condensation; Heating;	100%
In benzene Heating;

: 1121-60-4
pyridine-2-carbaldehyde

: 3731-51-9
(2-aminomethylpyridine)

: 119715-60-5
(E)-1-(pyridine-2-yl)-N-(pyridine-2-ylmethylene)methaneamine

Conditions

Conditions	Yield
With magnesium sulfate In dichloromethane at 20℃; for 3h;	100%
In dichloromethane at 20℃; for 12h; Molecular sieve;	98%
In ethanol

: 1121-60-4
pyridine-2-carbaldehyde

: 62-53-3
aniline

: 7032-25-9, 40468-86-8, 88785-71-1
(E)-N-(2-pyridylmethylene)aniline

Conditions

Conditions	Yield
In toluene at 20℃; for 24h;	100%
In tert-Amyl alcohol at 20℃; for 24h; Inert atmosphere;	100%
With magnesium sulfate In dichloromethane at 20℃; for 24h;	99%

: 1121-60-4
pyridine-2-carbaldehyde

: 109-55-7
1-amino-3-(dimethylamino)propane

: (E)-N1,N1-dimethyl-N3-(pyridin-2-ylmethylene)propane-1,3-diamine

Conditions

Conditions	Yield
With sodium carbonate In ethanol for 72h;	100%
In methanol

2-Pyridinecarboxaldehyde Chemical Properties

IUPAC Name: Pyridine-2-carbaldehyde
Systematic of 2-Pyridinecarboxaldehyde (CAS NO.1121-60-4): 2-Formylpyridine ; 2-Picolinaldehyde ; 2-Picolinealdehyde ; 2-Pyridaldehyde ; 2-Pyridinecarboxaldehyde ; 2-Pyridylaldehyde ; AI3-33230 ; EINECS 214-333-6 ; NSC 8951 ; Picolinal ; Picolinic aldehyde ; Pyridine-2-aldehyde ; o-Nicotinaldehyde ; Picolinaldehyde (8CI) ; Pyridine-2-carbaldehyde
CAS NO: 1121-60-4
Molecular Formula of 2-Pyridinecarboxaldehyde (CAS NO.1121-60-4): C₆H₅NO
Molecular Weight: 107.11
Molecular Structure:

ProductCategories: Pyridine ; Pyridine series ; Aldehydes ; Pyridines ; Pyridines derivates ; Heterocyclic Compounds
Melting Point: -21--22°C
Polar Surface Area: 29.96 Å²
Index of Refraction: 1.573
Molar Refractivity: 31.09 cm³
Molar Volume: 94.3 cm³
Surface Tension: 46.6 dyne/cm
Density of 2-Pyridinecarboxaldehyde (CAS NO.1121-60-4): 1.135 g/cm³
Flash Point: 54.4 °C
Enthalpy of Vaporization: 41.65 kJ/mol
Boiling Point: 180.2 °C at 760 mmHg
Vapour Pressure: 0.906 mmHg at 25°C

2-Pyridinecarboxaldehyde Safety Profile

Hazard Codes: Harmful Xn,Xi, Dangerous N, Toxic T,F
Risk Statements: 10-22-36/37/38-51/53-46-43-34-23
R10: Flammable.
R22: Harmful if swallowed.
R36/37/38: Irritating to eyes, respiratory system and skin.
R51/53: Toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment.
R46: May cause heritable genetic damage.
R43: May cause sensitization by skin contact.
R34: Causes burns.
R23: Toxic by inhalation.
Safety Statements: 7-26-61-53-45-36/37/39-29-16
S7:Keep container tightly closed.
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S61:Avoid release to the environment. Refer to special instructions / safety data sheets.
S53:Avoid exposure - obtain special instructions before use.
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection.
S29:Do not empty into drains.
S16:Keep away from sources of ignition.
RIDADR UN: 1989 3/PG 3
WGK Germany: 3
F: 8-10-23
Hazard Note: Irritant/Keep Cold/Air Sensitive
HazardClass: 6.1
PackingGroup: III
HS Code: 29333999

Product Name

2-Pyridinecarboxaldehyde

Synthetic route

2-Pyridinecarboxaldehyde Chemical Properties

2-Pyridinecarboxaldehyde Safety Profile

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