2-Pyridylethylamine supplier

Name
2-Pyridylethylamine
EINECS 220-295-1
CAS No. 2706-56-1
Article Data25
CAS DataBase
Density 1.025 g/cm³
Solubility Soluble in water (partly), and most common polar solvent. Insoluble in non-polar solvents, and oils.
Melting Point 198-200 °C(Solv: ethanol (64-17-5))
Formula C₇H₁₀N₂
Boiling Point 207.9 °C at 760 mmHg
Molecular Weight 122.17
Flash Point 100.6 °C
Transport Information UN 2735
Appearance clear colorless to yellow liquid
Safety 26-36-45-36/37/39
Risk Codes 36/37/38-34
Molecular Structure
Hazard Symbols Xi
Synonyms Pyridine,2-(2-aminoethyl)- (6CI,7CI,8CI);2-(2-Aminoethyl)pyridine;2-(2-Pyridinyl)ethanamine;2-(2-Pyridinyl)ethylamine;2-(2-Pyridyl)ethylamine;2-(2'-Aminoethyl)pyridine;2-(2'-Pyridyl)ethylamine;2-(a-Pyridyl)ethylamine;2-(b-Aminoethyl)pyridine;2-Aminoethylpyridine;2'-Aminoethyl-2-pyridine;Demethylbetahistine;N-[2-(2-Pyridinyl)ethyl]amine;NSC 71989;a-(2-Aminoethyl)pyridine;a-Pyridylethylamine;
PSA 38.91000
LogP 1.28310

Synthetic route

: 2-(2-azidoethyl)pyridine

: 2706-56-1
2-(aminoethyl)pyridine

Conditions

Conditions	Yield
With palladium on activated charcoal; hydrogen In 1,4-dioxane; ethanol at 20℃; for 4h;	91%

: 4055-39-4
mitomycin A

A: 2706-56-1
2-(aminoethyl)pyridine

B: 1,1a,2,8,8a,8b-Hexahydro-8-(hydroxymethyl)-8a-methoxy-5-methyl-6-[2-(2-pyridyl)ethylamino]-azirino[2',3':3,4]pyrrolo[1,2-a]indole-4,7-dione carbamate

Conditions

Conditions	Yield
	A 56% B n/a

: 100-69-6
2-vinylpyridine

A: 2706-56-1
2-(aminoethyl)pyridine

B: 15496-36-3
bis[2-(2-pyridyl)ethyl]amine

Conditions

Conditions	Yield
With ammonium chloride In methanol; water for 8h; Heating;	A 30% B 50%
With ammonium chloride In methanol Heating;

: 100-69-6
2-vinylpyridine

: 2706-56-1
2-(aminoethyl)pyridine

Conditions

Conditions	Yield
With ammonium chloride In methanol; water for 16h; Reflux;	29%
With ammonium chloride

: 16927-00-7
2-(2-chloroethyl)pyridine

: 2706-56-1
2-(aminoethyl)pyridine

Conditions

Conditions	Yield
With ethanol; ammonia at 100℃;
Multi-step reaction with 2 steps 1: sodium azide / N,N-dimethyl-formamide / 12 h / 70 °C 2: palladium on activated charcoal; hydrogen / ethanol; 1,4-dioxane / 4 h / 20 °C View Scheme

: 75140-33-9
2-amino-1-[2]pyridyl-ethanone

: 2706-56-1
2-(aminoethyl)pyridine

Conditions

Conditions	Yield
With hydrogenchloride; platinum Hydrogenation;

: 89943-14-6
α-(aminomethyl)-2-pyridinemethanol

: 2706-56-1
2-(aminoethyl)pyridine

Conditions

Conditions	Yield
With hydrogenchloride; platinum Hydrogenation;

: 855184-57-5
(2-[2]pyridyl-ethyl)-carbamic acid methyl ester

: 2706-56-1
2-(aminoethyl)pyridine

Conditions

Conditions	Yield
With hydrogenchloride

: 80500-20-5
Diphenyl-(2-pyridin-2-yl-ethylamino)-methanol

A: 2706-56-1
2-(aminoethyl)pyridine

B: 119-61-9
benzophenone

Conditions

Conditions	Yield
With water In acetonitrile at 30℃; Rate constant;

: 100-69-6
2-vinylpyridine

: 67-56-1
methanol

: ammonium chloride

: 7732-18-5
water

: 2706-56-1
2-(aminoethyl)pyridine

...Expand

2-<β-bromo-ethyl>-pyridine: 2-<β-bromo-ethyl>-pyridine

A: 2706-56-1
2-(aminoethyl)pyridine

B β.β'-di-α-pyridyl-diethylamine: β.β'-di-α-pyridyl-diethylamine

Conditions

Conditions	Yield
With ammonia at 125℃; im Rohr;

: 39232-04-7
2-(2-bromoethyl)pyridine

: 2706-56-1
2-(aminoethyl)pyridine

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1: aqueous ethanol 2: aqueous H2O2; aqueous KOH 3: methanol; bromine 4: aqueous HCl View Scheme

: 35549-47-4
2-(2-Cyanoethyl)pyridine

: 2706-56-1
2-(aminoethyl)pyridine

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: aqueous H2O2; aqueous KOH 2: methanol; bromine 3: aqueous HCl View Scheme

: 15197-75-8
3-(pyridin-2-yl)propanoic acid

: 2706-56-1
2-(aminoethyl)pyridine

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1: methanol. HCl 2: aqueous NH3 3: methanol; bromine 4: aqueous HCl View Scheme

: 84199-91-7
3-(pyridin-2-yl)propanamide

: 2706-56-1
2-(aminoethyl)pyridine

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: methanol; bromine 2: aqueous HCl View Scheme

: 28819-26-3
methyl 3-(pyridin-2-yl)propanoate

: 2706-56-1
2-(aminoethyl)pyridine

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: aqueous NH3 2: methanol; bromine 3: aqueous HCl View Scheme

: 26510-52-1
ethyl 2-pyridylcarbonylacetate

: 2706-56-1
2-(aminoethyl)pyridine

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: aqueous NaOH; NaNO2 2: ethanol; SnCl2+2 H2O; concentrated aqueous HCl 3: platinum; aqueous HCl / Hydrogenation View Scheme

: 2-hydroxyimino-3-oxo-3-[2]pyridyl-propionic acid ethyl ester

: 2706-56-1
2-(aminoethyl)pyridine

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: ethanol; SnCl2+2 H2O; concentrated aqueous HCl 2: platinum; aqueous HCl / Hydrogenation View Scheme

: 51746-81-7
2-amino-1-[2]pyridyl-ethanone; dihydrochloride

: 2706-56-1
2-(aminoethyl)pyridine

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: palladium; aqueous HCl / Hydrogenation 2: platinum; aqueous HCl / Hydrogenation View Scheme

: 103-74-2
2-(2-Hydroxyethyl)pyridine

: 2706-56-1
2-(aminoethyl)pyridine

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: benzene; thionyl chloride; hydrogen chloride 2: ethanol; NH3 / 100 °C View Scheme
Multi-step reaction with 3 steps 1: thionyl chloride / dichloromethane / 1 h / 20 °C 2: sodium azide / N,N-dimethyl-formamide / 12 h / 70 °C 3: palladium on activated charcoal; hydrogen / ethanol; 1,4-dioxane / 4 h / 20 °C View Scheme

: 2739-97-1
pyridine-2-acetonitrile

: 2706-56-1
2-(aminoethyl)pyridine

Conditions

Conditions	Yield
With ammonium hydroxide; chloro(1,5-cyclooctadiene)rhodium(I) dimer; hydrogen at 100℃; under 20686.5 Torr; for 24h; Autoclave; Green chemistry; chemoselective reaction;
With aluminum (III) chloride; sodium tetrahydroborate In diethyl ether at 20℃; for 6h;	0.6 g

: 31106-82-8
2-(bromomethyl)pyridine hydrobromide

: 2706-56-1
2-(aminoethyl)pyridine

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1.1: sodium hydrogencarbonate / water 1.2: 24 h / 75 °C 2.1: sodium tetrahydroborate; aluminum (III) chloride / diethyl ether / 6 h / 20 °C View Scheme

: 2706-56-1
2-(aminoethyl)pyridine

: 3328-69-6
2-hydroxy-isophthalaldehyde

: 115010-23-6
2,6-bis-1-hydroxybenzene

Conditions

Conditions	Yield
In methanol for 1h; Heating;	100%
In dichloromethane for 1h;

: 2706-56-1
2-(aminoethyl)pyridine

: 78213-68-0
3,6-diformylpyridazine

: (2-Pyridin-2-yl-ethyl)-[1-(6-{[(E)-2-pyridin-2-yl-ethylimino]-methyl}-pyridazin-3-yl)-meth-(E)-ylidene]-amine

Conditions

Conditions	Yield
In acetonitrile	100%

: 2706-56-1
2-(aminoethyl)pyridine

: 286011-67-4
tert-butyl 2-(1-oxidopyridin-2-yl)ethylcarbamate

Conditions

Conditions	Yield
Stage #1: 2-(aminoethyl)pyridine With di-tert-butyl dicarbonate In N,N-dimethyl-formamide at 20℃; for 1h; Stage #2: With 3-chloro-benzenecarboperoxoic acid In chloroform at 0℃; for 3.5h;	100%
Multi-step reaction with 2 steps 1: tetrahydrofuran / 3.5 h / 0 - 20 °C 2: 3-chloro-benzenecarboperoxoic acid / ethyl acetate / 15 h / 20 °C View Scheme

: 2706-56-1
2-(aminoethyl)pyridine

: 4-[4-(6-bromohexyloxy)phenyl]-7-methoxy-2,2-dimethyl-3-phenylchroman

: {6-[4-(7-methoxy-2,2-dimethyl-3-phenylchroman-4-yl)phenoxy]hexyl}-(2-pyridin-2-ylethyl)amine

Conditions

Conditions	Yield
In methanol for 72h; Inert atmosphere; Reflux;	100%

: 2706-56-1
2-(aminoethyl)pyridine

: methyl pyrazine-2-carboxylate hydrochloride

: 1043233-10-8
N-(2-(pyridin-2-yl)ethyl)pyrazine-2-carboxamide

Conditions

Conditions	Yield
In methanol at 20℃; for 22h; Reflux;	100%

: 2706-56-1
2-(aminoethyl)pyridine

: 13750-81-7
N-methyl-2-imidazolcarboxaldehyde

: 173412-72-1
2-(2-(((1'-methyl-2'-imidazolyl)methylene)amino)ethyl)pyridine

Conditions

Conditions	Yield
In methanol Reflux;	100%
In methanol for 4h; Reflux;	65%
In methanol at 60℃; for 4h;	60%
In ethanol at 60℃; for 4h;

: 1121-60-4
pyridine-2-carbaldehyde

: 2706-56-1
2-(aminoethyl)pyridine

: 15395-61-6
(2-pyridin-2-yl-ethyl)-pyridin-2-ylmethyl-amine

Conditions

Conditions	Yield
With sodium tetrahydroborate In methanol	100%
Stage #1: pyridine-2-carbaldehyde; 2-(aminoethyl)pyridine In dichloromethane at 20℃; for 12h; Sealed tube; Molecular sieve; Stage #2: With methanol; sodium tetrahydroborate at 0℃; for 5h; Inert atmosphere;	100%
With sodium tris(acetoxy)borohydride In 1,2-dichloro-ethane at 20℃; for 2.5h; Inert atmosphere;	97%

: 2706-56-1
2-(aminoethyl)pyridine

: 24424-99-5
di-tert-butyl dicarbonate

: 143185-43-7
tert-butyl (2-(pyridin-2-yl)ethyl)carbamate

Conditions

Conditions	Yield
In tetrahydrofuran at 0 - 20℃; for 3.5h;	99%
In dichloromethane Ambient temperature;
With triethylamine In N-methyl-acetamide

: 2706-56-1
2-(aminoethyl)pyridine

: chloromethyl(1,5-cyclooctadiene)palladium(II)

: 185123-28-8
[PdCl(Me)(2-(2-aminoethyl)pyridine-N,N')]

Conditions

Conditions	Yield
In dichloromethane byproducts: COD; N2-atmosphere; stirring at room temp. for 3 h; evapn., washing (Et2O), drying; can be recrystallized (Et2O diffusion into MeCN soln.); elem. anal.;	99%

: 2706-56-1
2-(aminoethyl)pyridine

: sodium azide

: nickel(II) perchlorate hexahydrate

: Ni(2+)*C5H4N(CH2CH2NH2)*2N3(1-) = [Ni(C5H4N(CH2CH2NH2))(N3)2]

Conditions

Conditions	Yield
In water addn. of the amine to the Ni salt in H2O, filtration, addn. of aq. NaN3; slow evapn. (room temp.);	99%

...Expand

: 1003-29-8
2-pyrrole aldehyde

: 2706-56-1
2-(aminoethyl)pyridine

: 1093853-11-2
N-(1H-pyrrol-2-ylmethylene)-2-(pyridin-2-yl)ethanamine

Conditions

Conditions	Yield
In ethanol	99%

: 1121-60-4
pyridine-2-carbaldehyde

: 2706-56-1
2-(aminoethyl)pyridine

: 15684-35-2
cobalt(II) tetrafluoroborate hexahydrate

: [Co(C5H4NC(H)NCH2CH2C5H4N)2](2+)*2BF4(1-)=[Co(C5H4NC(H)NCH2CH2C5H4N)2](BF4)2

Conditions

Conditions	Yield
With glacial acetic acid In ethanol ligands dissolved in EtOH (2 drops of glacial acetic acid), refluxed for2 h, cooled to room temp., Fe compd. added (2:2:1 molar ratio), stirred for 1 h; ppt. filtered off, dried (vac.), elem. anal.;	99%

...Expand

: 2706-56-1
2-(aminoethyl)pyridine

: 1560894-34-9
(Z)-ethyl 2-hydroxy-4-oxo-4-(pyridin-2-yl)but-2-enoate

: 1571-08-0
methyl 4-formylbenzoate

: methyl 4-(3-acetyl-4-hydroxy-1-(3-hydroxyphenethyl)-5-oxo-2,5-dihydro-1H-pyrrol-2-yl)benzoate

Conditions

Conditions	Yield
With pyridinium p-toluenesulfonate In methanol; diethyl ether at -10℃; for 1h;	99%

...Expand

: 2706-56-1
2-(aminoethyl)pyridine

: 5241-64-5
Boc-D-Trp-OH

: tert-butyl (R)-(3-(1H-indol-3-yl)-1-oxo-1-((2-(pyridin-2-yl)ethyl)amino)propan-2-yl)carbamate

Conditions

Conditions	Yield
Stage #1: Boc-D-Trp-OH With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 0℃; for 0.166667h; Inert atmosphere; Stage #2: 2-(aminoethyl)pyridine With triethylamine In dichloromethane at 0 - 20℃; Inert atmosphere;	99%

: 2706-56-1
2-(aminoethyl)pyridine

: 1210-05-5
Biphenyl-2,2'-dicarbaldehyde

: 132733-14-3
(2-Pyridin-2-yl-ethyl)-[1-(2'-{[(E)-2-pyridin-2-yl-ethylimino]-methyl}-biphenyl-2-yl)-meth-(E)-ylidene]-amine

Conditions

Conditions	Yield
With magnesium sulfate In chloroform at 20℃; for 4h; Inert atmosphere;	98%
In chloroform Condensation; Heating;

: 2706-56-1
2-(aminoethyl)pyridine

: 911693-62-4
3-[8-(2,6-difluorophenyl)-2-(methylsulfinyl)-7-oxo-5,6,7,8-tetrahydropyrimido[4,5-d]pyrimidin-4-yl]-4-methyl-N-(1-methylethyl)benzamide

: C30H29F2N7O2

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In tetrahydrofuran; chloroform at 20℃;	98%

: 2706-56-1
2-(aminoethyl)pyridine

: 100198-05-8
2,7-diacetyl-1,8-dihydroxy-3,6-dimethylnaphthalene

: palladium dichloride

: 146221-40-1
C10H2(CH3)2(OH)(COCH3)C(CH3)N(CH2)2C5H4NPd(Cl)O

Conditions

Conditions	Yield
With LiCl In methanol heating suspn. of PdCl2, LiCl and dihydroxynaphthalene (reflux) until complete dissoln., addn. of aminoethylpyridine; concg. by boiling at atm. pressure until crystn. commences, cooling, collecting crystals, washing with MeOH;	98%

...Expand

: 2706-56-1
2-(aminoethyl)pyridine

: 1761-61-1
5-bromosalicyclaldehyde

: 112359-98-5
N-(pyridine-2-ylethyl)-2-hydroxy-5-bromo-benzylideneamine

Conditions

Conditions	Yield
In methanol for 5h; Reflux;	98%
In methanol Reflux;	52%
In methanol for 3h; Reflux;

: 2706-56-1
2-(aminoethyl)pyridine

: C52H50Br2O8

: C66H68N4O8

Conditions

Conditions	Yield
With triethylamine In acetonitrile for 12h; Inert atmosphere; Reflux;	98%

: 2706-56-1
2-(aminoethyl)pyridine

: 120085-99-6
2,9‐bis(4-formylphenyl)‐1,10‐phenanthroline

: 2,9-bis[4-(pyridin-2-ylethyliminomethyl)phenyl]-1,10-phenanthroline

Conditions

Conditions	Yield
In toluene at 20℃; for 24h; Molecular sieve;	98%

: 2706-56-1
2-(aminoethyl)pyridine

: 623-27-8
terephthalaldehyde,

: 153530-40-6
(2-Pyridin-2-yl-ethyl)-[1-(4-{[(E)-2-pyridin-2-yl-ethylimino]-methyl}-phenyl)-meth-(E)-ylidene]-amine

Conditions

Conditions	Yield
In ethanol Heating;	97%
In benzene at 20℃; for 24h;

: 2706-56-1
2-(aminoethyl)pyridine

: 118-93-4
o-hydroxyacetophenone

: 105516-43-6
N-(2-hydroxyacetophenonyl)-2-iminoethylpyridine

Conditions

Conditions	Yield
With 4 A molecular sieve In methanol for 0.5h;	97%
In ethanol Reflux;

: 2706-56-1
2-(aminoethyl)pyridine

: 1795-48-8
Isopropyl isocyanate

: 87345-03-7
1-isopropyl-3-(2-pyridylethyl)urea

Conditions

Conditions	Yield
In dichloromethane at 20℃; for 2h; Addition;	97%

: 2706-56-1
2-(aminoethyl)pyridine

: 686-69-1
diethylchlorophosphine

: C15H28N2P2

Conditions

Conditions	Yield
With triethylamine In dichloromethane	97%
With triethylamine In dichloromethane at 20℃; for 20h;	97%

: 2706-56-1
2-(aminoethyl)pyridine

: 1934-75-4
sodium dicyanamide

: cadmium(II) iodide

A: [CdI2(2-aminoethylpyridine)]n

B: [CdI(dicyanamide)(2-aminoethylpyridine)]n

Conditions

Conditions	Yield
In methanol; water addn. of methanolic soln. of 1 equiv. of pyridine deriv. into hot methanolic soln. of 1 equiv. of cadmium compd., addn. of aq. soln. of dicyanamide salt, stirring for 2 h; filtration, keeping in desiccator with CaCl2 for few wks., isolation of crystals, elem. anal.;	A 97% B 0%

...Expand

: 2706-56-1
2-(aminoethyl)pyridine

: 910053-75-7
4-chloro-2-(3,4-difluorophenyl)pyrimidine-5-carboxylic acid ethyl ester

: 1176197-57-1
ethyl 2-(3,4-difluorophenyl)-4-(2-(pyridin-2-yl)ethylamino)pyrimidine-5-carboxylate

Conditions

Conditions	Yield
With triethylamine In N,N-dimethyl-formamide at 20℃; for 0.5h;	97%

: 2706-56-1
2-(aminoethyl)pyridine

: 97-51-8
5-Nitrosalicylaldehyde

: 101079-17-8
N-(pyridine-2-ylethyl)-2-hydroxy-5-nitro-benzylideneamine

Conditions

Conditions	Yield
In methanol for 5h; Reflux;	97%
In methanol Reflux;	86%

: 2706-56-1
2-(aminoethyl)pyridine

: 630-19-3
pivalaldehyde

: 1252012-71-7
C12H18N2

Conditions

Conditions	Yield
With toluene-4-sulfonic acid In chloroform for 48h; Reflux;	97%
With magnesium sulfate In chloroform at 20℃; for 4h; Inert atmosphere;	90%

: 2706-56-1
2-(aminoethyl)pyridine

: 1158844-09-7
dimethyl 1-[3-(diethoxyphosphoryl)ethyl]-1H-1,2,3-triazole-4,5-dicarboxylate

: 1378311-25-1
diethyl [2-[4,5-bis[[[2-(2-pyridinyl)ethyl]amino]carbonyl]-1H-1,2,3-triazol-1-yl]ethyl]phosphonate

Conditions

Conditions	Yield
In methanol at 20℃; for 14h;	97%

: 2706-56-1
2-(aminoethyl)pyridine

: 66-99-9
β-naphthaldehyde

: 1638114-53-0
C18H16N2

Conditions

Conditions	Yield
With magnesium sulfate In chloroform at 20℃; for 4h; Inert atmosphere;	97%

2-Pyridylethylamine Specification

2-Pyridylethylamine, with the CAS Registry Number 2706-56-1, has the Synonyms of 2-Aminoethylpyridine; 2-Pyridineethanamine; 2-(2-Aminoethyl)pyridine; 2-(2-Pyridyl)ethylamine. The Molecular Formula is C₇H₁₀N₂ and Molecular Weight is122.17. It Appearances in yellowish clear liquid. 2-Pyridylethylamine is a histamine agonist which is selective for the H₁subtype. 2-Pyridylethylamine can be used as pharmaceutical intermediate.

Physical properties about 2-Pyridylethylamine are: (1)ACD/LogP: -0.11; (2)ACD/LogD (pH 5.5): -3.09; (3)ACD/LogD (pH 7.4): -1.77; (4)ACD/BCF (pH 5.5): 1.00; (5)ACD/BCF (pH 7.4): 1.00; (6)ACD/KOC (pH 5.5): 1.00; (7)ACD/KOC (pH 7.4): 1.00; (8)#H bond acceptors: 2; (9)#H bond donors: 2; (10)#Freely Rotating Bonds: 3; (11)Index of Refraction: 1.541; (12)Molar Refractivity: 37.429 cm³; (13)Molar Volume: 119.152 cm³; (14)Polarizability: 14.838 10-24cm³; (15)Surface Tension: 44.101001739502 dyne/cm; (16)Density: 1.025 g/cm³; (17)Flash Point: 100.556 °C; (18)Enthalpy of Vaporization: 44.418 kJ/mol; (19)Boiling Point: 207.923 °C at 760 mmHg; (20)Vapour Pressure: 0.219999998807907 mmHg at 25°C

When you are using this chemical, please be cautious about it as the following:
1. In case of contact with eyes, rinse immediately with plenty of water and seek medical advice;
2. Wear suitable protective clothing;
3. In case of accident or if you feel unwell, seek medical advice immediately (show label where possible);
4. Wear suitable protective clothing, gloves and eye/face protection;

You can still convert the following datas into molecular structure:
(1)InChI=1S/C7H10N2/c8-5-4-7-3-1-2-6-9-7/h1-3,6H,4-5,8H2;
(2)InChIKey=XPQIPUZPSLAZDV-UHFFFAOYSA-N;
(3)Smilesn1c(cccc1)CCN

Product Name

2-Pyridylethylamine

Synthetic route

2-Pyridylethylamine Specification

Related Products

Hot Products