2H-Pyran-2-ol,tetrahydro- supplier

Name
2-HYDROXYTETRAHYDROPYRAN
EINECS 229-509-8
CAS No. 694-54-2
Article Data104
CAS DataBase
Density 1.08 g/cm³
Solubility
Melting Point
Formula C₅H₁₀O₂
Boiling Point 170.5 °C at 760 mmHg
Molecular Weight 102.133
Flash Point 71.4 °C
Transport Information
Appearance
Safety 36/37/39-26
Risk Codes 36/37/38-20/22
Molecular Structure
Hazard Symbols Xn
Synonyms Pyran-2-ol,tetrahydro- (6CI,7CI);2-Hydroxytetrahydro-2H-pyran;2-Hydroxytetrahydropyran;NSC 244915;Tetrahydro-2-hydroxy-2H-pyran;Tetrahydro-2H-pyran-2-ol;Tetrahydropyran-2-ol;d-Valerolactol;
PSA 29.46000
LogP 0.50530

Synthetic route

: 110-87-2
3,4-dihydro-2H-pyran

: 694-54-2
tetrahydro-2H-2-pyranol

Conditions

Conditions	Yield
With hydrogenchloride; water at 0 - 20℃; for 1.25h; Inert atmosphere;	96%
With hydrogenchloride In water at 0 - 20℃; for 1.5h;	93%
With hydrogenchloride; water In water at 0 - 20℃; for 1.25h;	87%

: 2,2′-peroxybis(tetrahydro-2H-pyran)

: 694-54-2
tetrahydro-2H-2-pyranol

Conditions

Conditions	Yield
With methanol; iodine; magnesium at 40℃; for 3h;	96%

: 542-28-9
3,4,5,6-tetrahydro-2H-pyran-2-one

: 694-54-2
tetrahydro-2H-2-pyranol

Conditions

Conditions	Yield
With diisobutylaluminium hydride In diethyl ether; hexane at -78℃; for 2h; Reduction;	93%
With diisobutylaluminium hydride In hexane; dichloromethane at -78℃; for 2h;	91%
With diisobutylaluminium hydride In hexane; dichloromethane at -78℃; for 0.25h;	88%

: 110-87-2
3,4-dihydro-2H-pyran

: 629-11-8
1,6-hexanediol

A: 694-54-2
tetrahydro-2H-2-pyranol

B: 28659-22-5
6-(tetrahydro-2H-pyranyloxy)hexan-1-ol

C: 15057-15-5
1,6-bis(tetrahydropyranyloxy)hexane

Conditions

Conditions	Yield
With Dowex 50W x 2 In toluene at 30℃; for 2.5h; Etherification; hydration;	A n/a B 89% C 2%

...Expand

: 157136-52-2
ethyl 2-<1-(2-tetrahydropyranylperoxy)ethyl>propenoate

A: 694-54-2
tetrahydro-2H-2-pyranol

B: 592-84-7
n-butyl formate

C: ethyl 2-cyclohexylmethyl-2,3-epoxybutanoate

D: ethyl 2,3-epoxy-2-<5-(formyloxy)pentyl>butanoate

Conditions

Conditions	Yield
With tert-butyl peroxyacetate In cyclohexane at 110℃; under 0.001 Torr; for 12h; further solvents;	A 1 % Chromat. B 6 % Chromat. C 7% D 75%

...Expand

: 258331-72-5
5-triphenylmethoxypentanal

: 694-54-2
tetrahydro-2H-2-pyranol

Conditions

Conditions	Yield
Stage #1: 5-triphenylmethoxypentanal With boron trichloride In dichloromethane at -30℃; for 0.75h; Substitution; Stage #2: With methanol Cyclization; methanolysis; Further stages.;	75%

: 25073-26-1
(E)-pent-2-ene-1,5-diol

: 201230-82-2
carbon monoxide

A: 694-54-2
tetrahydro-2H-2-pyranol

B: 111-29-5
1 ,5-pentanediol

C: 123703-40-2
2,3,3aβ,4,5,6aβ-perhydrofuro<2,3b>furan

D: 3-hydroxymethyltetrahydropyran-2-ol

Conditions

Conditions	Yield
With chloro(1,5-cyclooctadiene)rhodium(I) dimer; hydrogen; triphenylphosphine In dichloromethane at 120℃; under 45003.6 Torr; for 20h; Product distribution; Further Variations:; Reagents; Solvents;	A n/a B n/a C 72% D n/a

...Expand

: 25073-26-1
(E)-pent-2-ene-1,5-diol

: 201230-82-2
carbon monoxide

A: 694-54-2
tetrahydro-2H-2-pyranol

B: 123703-40-2
2,3,3aβ,4,5,6aβ-perhydrofuro<2,3b>furan

Conditions

Conditions	Yield
With chloro(1,5-cyclooctadiene)rhodium(I) dimer; hydrogen; triphenylphosphine In dichloromethane at 120℃; under 45003.6 Torr; for 20h;	A n/a B 72%

...Expand

: 624-76-0
Iodoethanol

: 107-02-8
acrolein

: 694-54-2
tetrahydro-2H-2-pyranol

Conditions

Conditions	Yield
With copper(l) iodide; zinc In water ultrasonic irradiation;	70%

: 542-28-9
3,4,5,6-tetrahydro-2H-pyran-2-one

A: 694-54-2
tetrahydro-2H-2-pyranol

B: 4221-03-8
5-hydroxypentanal

Conditions

Conditions	Yield
With diisobutylaluminium hydride In dichloromethane; toluene at -70℃; for 3h; Inert atmosphere; Overall yield = 0.71 g;	A 65% B 25%

: 111-29-5
1 ,5-pentanediol

A: 694-54-2
tetrahydro-2H-2-pyranol

B: 542-28-9
3,4,5,6-tetrahydro-2H-pyran-2-one

Conditions

Conditions	Yield
With 1-methyl-1H-imidazole; [2,2]bipyridinyl; tetrakis(acetonitrile)copper(I) trifluoromethanesulfonate; 9-azabicyclo<3.3.1>nonane-N-oxyl In acetonitrile at 22℃; for 2h;	A 58% B 29%

: 69161-61-1, 4203-49-0
2-(prop-2-en-1-yloxy)oxane

: 75-24-1
trimethylaluminum

A: 694-54-2
tetrahydro-2H-2-pyranol

B: 2-(2-Methyl-hex-5-enyloxy)-tetrahydro-pyran

Conditions

Conditions	Yield
bis(triphenylphosphine)nickel(II) chloride In toluene	A n/a B 48%

...Expand

: 29293-07-0
pent-2-ene-1,5-diol

: 201230-82-2
carbon monoxide

A: 694-54-2
tetrahydro-2H-2-pyranol

B: 123703-40-2
2,3,3aβ,4,5,6aβ-perhydrofuro<2,3b>furan

C: 3-hydroxymethyltetrahydropyran-2-ol

Conditions

Conditions	Yield
With hydrogen; triphenylphosphine; chloro(1,5-cyclooctadiene)rhodium(I) dimer In 1,4-dioxane at 120℃; under 45004.5 Torr; for 20h;	A 7% B 35% C 34%

...Expand

: 142-68-7
TETRAHYDROPYRANE

: 694-54-2
tetrahydro-2H-2-pyranol

Conditions

Conditions	Yield
platinum In sulfuric acid; water at 35℃; for 1.15h; Product distribution; electrolysis, also with PtO2, RuO2;	91 % Turnov.
platinum In sulfuric acid; water at 35℃; for 1.15h; electrolysis;	91 % Turnov.

: 142-68-7
TETRAHYDROPYRANE

A: 694-54-2
tetrahydro-2H-2-pyranol

B: 542-28-9
3,4,5,6-tetrahydro-2H-pyran-2-one

Conditions

Conditions	Yield
With 1,1,1-trifluoro-2-propanone; methyltrifluoromethyldioxirane In dichloromethane at 0℃; for 0.25h; Yield given. Yields of byproduct given;
lead dioxide In sulfuric acid; water at 35℃; for 7.83333h; electrolysis;	A 5.4 % Turnov. B 73 % Turnov.
With oxone; methyltrifluoromethyldioxirane In dichloromethane at -15℃;	A 37 % Chromat. B 63 % Chromat.

: 110-87-2
3,4-dihydro-2H-pyran

A: 694-54-2
tetrahydro-2H-2-pyranol

B: 709-84-2
bis-tetrahydropyran-2-yl ether

C: 14194-86-6
5-(2-tetrahydropyranyloxy)pentanal

D: 4221-03-8
5-hydroxypentanal

Conditions

Conditions	Yield
With hydrogenchloride for 0.25h; Product distribution; Ambient temperature; other times and temperatures, other hydration reagent;
With hydrogenchloride; sodium sulfite at 25℃; for 24h; Yield given;
With hydrogenchloride at 25℃; for 0.25h; Yield given. Yields of byproduct given;

...Expand

: 110-87-2
3,4-dihydro-2H-pyran

A: 694-54-2
tetrahydro-2H-2-pyranol

B: 709-84-2
bis-tetrahydropyran-2-yl ether

C: 4221-03-8
5-hydroxypentanal

Conditions

Conditions	Yield
With hydrogenchloride 1.) 25 deg C, 1 h, 2.) reflux, 24 h; Yield given. Yields of byproduct given;

...Expand

: 110-87-2
3,4-dihydro-2H-pyran

A: 694-54-2
tetrahydro-2H-2-pyranol

B: 14194-86-6
5-(2-tetrahydropyranyloxy)pentanal

C: 4221-03-8
5-hydroxypentanal

Conditions

Conditions	Yield
With sodium metabisulfite; water at 25℃; for 24h; Yield given. Yields of byproduct given;

...Expand

: 110-94-1
1,5-pentanedioic acid

A: 694-54-2
tetrahydro-2H-2-pyranol

B: 542-28-9
3,4,5,6-tetrahydro-2H-pyran-2-one

C: 111-29-5
1 ,5-pentanediol

D: 1,7-dioxacyclododecane-2,6-dione

Conditions

Conditions	Yield
With H4Ru4(CO)84; hydrogen In diethyl ether; toluene at 200℃; under 98800 Torr; for 48h;	A 2.9 % Chromat. B 28.7 % Chromat. C 47.7 % Chromat. D 20.7 % Chromat.

...Expand

: 4203-50-3
2-phenoxytetrahydropyran

: 111-87-5
octanol

A: 694-54-2
tetrahydro-2H-2-pyranol

B: 70690-19-6
2-octyloxy-tetrahydro-pyran

C: 108-95-2
phenol

Conditions

Conditions	Yield
tris(2,2'-bipyridyl)ruthenium dichloride; Paraquat In acetonitrile at 20℃; for 30h; Product distribution; Irradiation; also with H2O, or molecular sieves 4 Angstroem;

...Expand

: 4203-50-3
2-phenoxytetrahydropyran

A: 694-54-2
tetrahydro-2H-2-pyranol

B: 70690-19-6
2-octyloxy-tetrahydro-pyran

C: 108-95-2
phenol

Conditions

Conditions	Yield
With water; tris(2,2'-bipyridyl)ruthenium dichloride; (MV)Cl2 In acetonitrile for 30h; Irradiation; Yields of byproduct given;

...Expand

: 69556-90-7, 77213-02-6
C5H9O2(1-)

: 694-54-2
tetrahydro-2H-2-pyranol

Conditions

Conditions	Yield
Thermodynamic data; protonation, ΔG0;

: 66-25-1
hexanal

: 139048-07-0
2-Acetyl-2-methyl-5-oxo-hexanoic acid allyl ester

A: 694-54-2
tetrahydro-2H-2-pyranol

B: 139025-72-2, 139025-73-3
3-(1-Hydroxy-hexyl)-3-methyl-heptane-2,6-dione

Conditions

Conditions	Yield
With bis(triphenylphosphine)nickel(II) chloride; zinc In N,N-dimethyl-formamide at 40℃; for 5h; Yield given. Title compound not separated from byproducts;

...Expand

: 627-27-0
homoalylic alcohol

: 201230-82-2
carbon monoxide

A: 694-54-2
tetrahydro-2H-2-pyranol

B: (R)-3-Methyl-tetrahydro-furan-2-ol

C: (S)-3-Methyl-tetrahydro-furan-2-ol

Conditions

Conditions	Yield
With acetylacetonatodicarbonylrhodium(l); (R,S)-binaphos; hydrogen In benzene at 60℃; under 22800 Torr; Yield given. Yields of byproduct given;
With acetylacetonatodicarbonylrhodium(l); (R,S)-binaphos; hydrogen In benzene at 60℃; under 22800 Torr; Yield given. Yields of byproduct given. Title compound not separated from byproducts;

...Expand

: 69161-61-1, 4203-49-0
2-(prop-2-en-1-yloxy)oxane

: 694-54-2
tetrahydro-2H-2-pyranol

Conditions

Conditions	Yield
With triethylaluminum; bis(triphenylphosphine)nickel(II) chloride In toluene

: 74266-26-5
α-bromopropionate de tetrahydropyrannyle

: 694-54-2
tetrahydro-2H-2-pyranol

Conditions

Conditions	Yield
With sodium hydroxide; potassium dihydrogenphosphate In water at 15℃; Rate constant; Mechanism;

: 2,2-Dimethyl-propionic acid tetrahydro-pyran-2-yl ester

: 694-54-2
tetrahydro-2H-2-pyranol

Conditions

Conditions	Yield
With sodium hydroxide; potassium dihydrogenphosphate In water at 15℃; Rate constant; Mechanism;

: 2-Chloro-propionic acid tetrahydro-pyran-2-yl ester

: 694-54-2
tetrahydro-2H-2-pyranol

Conditions

Conditions	Yield
With sodium hydroxide; potassium dihydrogenphosphate In water at 15℃; Rate constant; Mechanism;

: 3-Chloro-propionic acid tetrahydro-pyran-2-yl ester

: 694-54-2
tetrahydro-2H-2-pyranol

Conditions

Conditions	Yield
With sodium hydroxide; potassium dihydrogenphosphate In water at 15℃; Rate constant; Mechanism;

: Ethoxy-acetic acid tetrahydro-pyran-2-yl ester

: 694-54-2
tetrahydro-2H-2-pyranol

Conditions

Conditions	Yield
With sodium hydroxide; potassium dihydrogenphosphate In water at 15℃; Rate constant; Mechanism;

: 694-54-2
tetrahydro-2H-2-pyranol

: 513-81-5
2,3-dimethyl-buta-1,3-diene

: (5R,7S)-7,8-Dimethyl-non-8-ene-1,5-diol

Conditions

Conditions	Yield
With triethyl borane; bis(acetylacetonate)nickel(II) In tetrahydrofuran; hexane at 20℃; for 40h;	99%

: 694-54-2
tetrahydro-2H-2-pyranol

: 18113-18-3
2,5-dimethoxyphenol

: 109765-65-3
2,5-Dimethoxy-1-(tetrahydro-2H-pyran-2-yloxy)-benzol

Conditions

Conditions	Yield
With tributylphosphine; 1,1'-azodicarbonyl-dipiperidine In tetrahydrofuran at 0 - 20℃; for 18h; Inert atmosphere;	99%

: 694-54-2
tetrahydro-2H-2-pyranol

: 156-06-9
2-oxo-3-(phenyl)propionic acid

: C14H16O4

Conditions

Conditions	Yield
With 2-Sulfanylpyridine; FeIIFeIII2(μ3-O)(μ2-OOCCF3)6(OH2)3 In 1,2-dichloro-ethane at 60℃; for 24h; Reagent/catalyst;	99%

: 694-54-2
tetrahydro-2H-2-pyranol

: 55362-80-6
9-bromononan-1-ol

: 55695-90-4
2-(9-bromononyloxy)tetrahydropyran

Conditions

Conditions	Yield
With toluene-4-sulfonic acid In tetrahydrofuran at 20℃;	99%

: 694-54-2
tetrahydro-2H-2-pyranol

: 68731-27-1
(3-bromopropyl)(methyl)sulfane

: 8-(methylthio)octane-1,5-diol

Conditions

Conditions	Yield
Stage #1: (3-bromopropyl)(methyl)sulfane With iodine; magnesium In tetrahydrofuran Reflux; Inert atmosphere; Stage #2: tetrahydro-2H-2-pyranol In tetrahydrofuran at 20℃; for 2h; Inert atmosphere;	99%

: 694-54-2
tetrahydro-2H-2-pyranol

: 21382-82-1
(carbethoxyethylidene)triphenylphosphorane

: 74844-86-3
(E)-7-hydroxy-2-methyl-hept-2-enoic acid ethyl ester

Conditions

Conditions	Yield
	98%
In benzene for 12h; Ambient temperature;	80%
In toluene at 90℃; for 1h;
In benzene Wittig Olefination;	1.87 g

: 694-54-2
tetrahydro-2H-2-pyranol

: 67-63-0
isopropyl alcohol

: 1927-70-4
2-isopropoxytetrahydropyran

Conditions

Conditions	Yield
With carbon tetrabromide; triphenylphosphine at 20℃; for 16h;	97%
With titanium(IV) tetrabutoxide; (R)-Mandelic Acid at 20℃; for 24h;	94%

: 694-54-2
tetrahydro-2H-2-pyranol

: 100-51-6
benzyl alcohol

: 1927-62-4
tetrahydro-2-(benzyloxy)-2H-pyran

Conditions

Conditions	Yield
With pyrrolidine hydrochloride In toluene at 100℃; for 5h; Inert atmosphere;	96%

: 694-54-2
tetrahydro-2H-2-pyranol

: 41879-39-4
O-(tert-butyldimethylsilanyl)hydroxylamine

: 873692-60-5
5-hydroxypentanal O-tert-butyldimethylsilyloxime

Conditions

Conditions	Yield
With magnesium sulfate In diethyl ether at 20℃; for 1h;	94%

: 694-54-2
tetrahydro-2H-2-pyranol

: 110-87-2
3,4-dihydro-2H-pyran

: 709-84-2
bis-tetrahydropyran-2-yl ether

Conditions

Conditions	Yield
With N.N'-bis[3,5-bis(trifluoromethyl)phenyl]thiourea at 20℃; for 19h;	94%

: 694-54-2
tetrahydro-2H-2-pyranol

: 1439-36-7
1-triphenylphosphoranylidene-2-propanone

: 172877-31-5
(E)-8-Hydroxy-oct-3-en-2-one

Conditions

Conditions	Yield
	93%

: 694-54-2
tetrahydro-2H-2-pyranol

: 7103-09-5
4-but-1-enylmagnesium bromide

: 198637-27-3
non-8-ene-1,5-diol

Conditions

Conditions	Yield
In tetrahydrofuran for 1.5h; Ambient temperature;	93%

: 694-54-2
tetrahydro-2H-2-pyranol

: 50816-19-8
8-bromooctanol

: 130236-39-4
(R)-1-bromo-2-methyldecane

: (R)-10-methyloctadecyl-1-tetrahydropyranyl ether

Conditions

Conditions	Yield
With 1-methyl-pyrrolidin-2-one; Li2CuCl4 In tetrahydrofuran at 20℃; for 1h; Inert atmosphere; Schlenk technique;	93%

...Expand

: 694-54-2
tetrahydro-2H-2-pyranol

: 2508-29-4
5-hydroxypentylamine

Conditions

Conditions	Yield
With ammonium hydroxide; hydrogen In water at 80℃; under 15001.5 Torr; for 6h; Pressure; Temperature;	93%
With ammonia; hydrogen In water at 80℃; under 15001.5 Torr; for 1h; Reagent/catalyst; Autoclave;
With ammonium hydroxide; hydrogen In water at 60℃; under 15001.5 Torr; for 1h; Catalytic behavior; Temperature; Autoclave;

: 694-54-2
tetrahydro-2H-2-pyranol

: 645-96-5
Benzeneselenol

: 64042-26-8
tetrahydro-2-(phenylseleno)-2H-Pyran

Conditions

Conditions	Yield
With toluene-4-sulfonic acid In benzene at 25℃;	92%

: 694-54-2
tetrahydro-2H-2-pyranol

: 1100-88-5
benzyltriphenylphosphonium chloride

: 98078-15-0
6-phenylhex-5-en-1-ol

Conditions

Conditions	Yield
Stage #1: benzyltriphenylphosphonium chloride With potassium tert-butylate In tert-butyl alcohol at 20℃; for 0.5h; Stage #2: tetrahydro-2H-2-pyranol In tert-butyl alcohol at 20℃; for 0.5h;	92%

: 694-54-2
tetrahydro-2H-2-pyranol

: 3156-43-2
2-(2-nitro-vinyl)-phenol

A: (4aR,5S,10aS)-5-(nitromethyl)-2,3,4,4a,5,10a-hexahydropyrano[2,3-b]chromene

B: 5-(nitromethyl)-2,3,4,4a,5,10a-hexahydropyrano[2,3-b]chromene

Conditions

Conditions	Yield
With (2S)-2-{diphenyl[(trimethylsilyl)oxy]methyl}pyrrolidine; benzoic acid In chloroform at 23℃; for 24h; Michael Addition; enantioselective reaction;	A 92% B n/a
Stage #1: tetrahydro-2H-2-pyranol; 2-(2-nitro-vinyl)-phenol With (2S)-2-{diphenyl[(trimethylsilyl)oxy]methyl}pyrrolidine; benzoic acid In chloroform at 25℃; for 24h; Stage #2: With hydrogenchloride In dichloromethane; water for 2h; Overall yield = 92 %;	A n/a B n/a

...Expand

: 694-54-2
tetrahydro-2H-2-pyranol

: 103-82-2
phenylacetic acid

: 931-53-3
Cyclohexyl isocyanide

: 6-hydroxy-1-[(cyclohexyl)amino]-1-oxohexan-2-yl phenylacetate

Conditions

Conditions	Yield
In neat (no solvent) at 20℃; for 18h; Passerini Condensation;	92%

...Expand

: 694-54-2
tetrahydro-2H-2-pyranol

: 109-96-6
3-Pyrroline

: 5-(1H-pyrrol-1-yl)pentan-1-ol

Conditions

Conditions	Yield
With benzoic acid In toluene at 110℃; for 24h; Inert atmosphere;	90%

: 694-54-2
tetrahydro-2H-2-pyranol

: 60669-22-9
n-undecyltriphenylphosphonium bromide

: 149011-67-6
5-(Z,E)-hexadecenol

Conditions

Conditions	Yield
Stage #1: n-undecyltriphenylphosphonium bromide With n-butyllithium In tetrahydrofuran; hexane at 0℃; for 1h; Stage #2: tetrahydro-2H-2-pyranol In tetrahydrofuran; hexane at 0 - 20℃; Wittig reaction;	89%

: 694-54-2
tetrahydro-2H-2-pyranol

: 60-12-8
2-phenylethanol

: 1927-61-3
2-(2-phenylethoxy)tetrahydro-2H-pyran

Conditions

Conditions	Yield
With rhenium(VII) oxide In dichloromethane at 20℃; Time; Inert atmosphere;	89%

: 694-54-2
tetrahydro-2H-2-pyranol

: 103-82-2
phenylacetic acid

: 2769-64-4
n-butyl isonitrile

: 6-hydroxy-1-[(n-butyl)amino]-1-oxohexan-2-yl phenylacetate

Conditions

Conditions	Yield
In neat (no solvent) at 20℃; for 18h; Passerini Condensation;	89%

...Expand

: 694-54-2
tetrahydro-2H-2-pyranol

: 63922-69-0
(2-trimethylsilylethylidene)triphenylphosphorane

: 119554-49-3
7-(trimethylsilyl)-(E,Z)-5-hepten-1-ol

Conditions

Conditions	Yield
	88%
In tetrahydrofuran -78 deg C to r.t.;	80%

: 694-54-2
tetrahydro-2H-2-pyranol

: 1099-45-2
ethyl (triphenylphosphoranylidene)acetate

: 96251-91-1, 105198-41-2, 110935-49-4
ethyl cis/trans-7-hydroxy-2-heptenoate

Conditions

Conditions	Yield
In dichloromethane for 1.5h; Wittig reaction; Heating;	88%
	85%
	79%

: 694-54-2
tetrahydro-2H-2-pyranol

: 1099-45-2
ethyl (triphenylphosphoranylidene)acetate

: 96251-91-1
ethyl (E)-7-hydroxyhept-2-enoate

Conditions

Conditions	Yield
In tetrahydrofuran Wittig reaction; Heating;	88%
In dichloromethane for 48h; Ambient temperature;	83%
In dichloromethane at 23℃; for 96h; Inert atmosphere;	80%

: 694-54-2
tetrahydro-2H-2-pyranol

: 59555-69-0
2-methyl-5-(phenylsulfonyl)-2-pentene

: 116893-79-9, 116893-80-2
9-methyl 6-phenylsulphonyl 8-decen 1,5-diol

Conditions

Conditions	Yield
With lithium diisopropyl amide at 20℃; for 18h;	87%

2H-Pyran-2-ol,tetrahydro- Specification

The 2H-Pyran-2-ol,tetrahydro- is an organic compound with the formula C₅H₁₀O₂. The IUPAC name of this chemical is Oxan-2-ol. With the CAS registry number 694-54-2, it is also named as 2-Tetrahydropyranol. Besides, it is clear colorless liquid, which should be stored in a cool, sealed, dry place.

Physical properties about 2H-Pyran-2-ol,tetrahydro- are: (1)ACD/LogP: -0.36; (2)ACD/LogD (pH 5.5): -0.36; (3)ACD/LogD (pH 7.4): -0.36; (4)ACD/BCF (pH 5.5): 1; (5)ACD/BCF (pH 7.4): 1; (6)ACD/KOC (pH 5.5): 15.15; (7)ACD/KOC (pH 7.4): 15.15; (8)#H bond acceptors: 2; (9)#H bond donors: 1; (10)#Freely Rotating Bonds: 1; (11)Polar Surface Area: 18.46 Å²; (12)Index of Refraction: 1.467; (13)Molar Refractivity: 26.25 cm³; (14)Molar Volume: 94.4 cm³; (15)Polarizability: 10.4×10^-24 cm³; (16)Surface Tension: 36 dyne/cm; (17)Density: 1.08 g/cm³; (18)Flash Point: 71.4 °C; (19)Enthalpy of Vaporization: 47.37 kJ/mol; (20)Boiling Point: 170.5 °C at 760 mmHg; (21)Vapour Pressure: 0.471 mmHg at 25 °C.

Preparation: this chemical can be prepared by Tetrahydro-pyran-2-one. This reaction will need reagent diisobutylaluminum hydride (DIBAL-H) and solvent toluene. The reaction time is 1 hour with reaction temperature of -70 °C.

2H-Pyran-2-ol,tetrahydro- can be obtained by Tetrahydro-pyran-2-one

Uses of 2H-Pyran-2-ol,tetrahydro-: it can be used to produce 2-Phenylselanyl-tetrahydro-pyran at temperature of 25 °C. It will need reagent p-toluenesulfonic acid and solvent benzene. The yield is about 92%.

2H-Pyran-2-ol,tetrahydro- and Benzeneselenol can be used to produce 2-Phenylselanyl-tetrahydro-pyran

When you are using this chemical, please be cautious about it as the following:
It is harmful by inhalation and if swallowed. Besides, this chemical is irritating to eyes, respiratory system and skin. When you are using it, wear suitable protective clothing, gloves and eye/face protection. In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.

You can still convert the following datas into molecular structure:
(1)InChI: InChI=1/C5H10O2/c6-5-3-1-2-4-7-5/h5-6H,1-4H2
(2)InChIKey: CELWCAITJAEQNL-UHFFFAOYAE
(3)Std. InChI: InChI=1S/C5H10O2/c6-5-3-1-2-4-7-5/h5-6H,1-4H2
(4)Std. InChIKey: CELWCAITJAEQNL-UHFFFAOYSA-N

Product Name

2-HYDROXYTETRAHYDROPYRAN

Synthetic route

2H-Pyran-2-ol,tetrahydro- Specification

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