3,4,5-Trimethoxyphenylboronic acid supplier

Name
3,4,5-Trimethoxyphenylboronic acid
EINECS
CAS No. 182163-96-8
Article Data11
CAS DataBase
Density 1.21 g/cm³
Solubility
Melting Point >230 °C(lit.)
Formula C₉H₁₃BO₅
Boiling Point 370.6 °C at 760 mmHg
Molecular Weight 212.01
Flash Point 177.9 °C
Transport Information
Appearance beige crystalline powder
Safety 37/39-26-36
Risk Codes 36/37/38-22-20/21/22
Molecular Structure
Hazard Symbols Xn,Xi
Synonyms Boronicacid, (3,4,5-trimethoxyphenyl)- (9CI);Boronicacid, B-(3,4,5-trimethoxyphenyl)-;
PSA 68.15000
LogP -0.60780

Synthetic route

: 2675-79-8
1-bromo-3,4,5-trimethoxybenzene

: 182163-96-8
3,4,5-trimethoxyphenylboronic Acid

Conditions

Conditions	Yield
Stage #1: 1-bromo-3,4,5-trimethoxybenzene With n-butyllithium In tetrahydrofuran at -78℃; Inert atmosphere; Stage #2: With Trimethyl borate In tetrahydrofuran at -78 - 20℃; Inert atmosphere;	95%
Stage #1: 1-bromo-3,4,5-trimethoxybenzene With n-butyllithium In tetrahydrofuran; hexane at -85℃; for 1h; Stage #2: With Trimethyl borate In tetrahydrofuran at 20℃; for 18h; Further stages.;	64%
Stage #1: 1-bromo-3,4,5-trimethoxybenzene With n-butyllithium In tetrahydrofuran at -78℃; for 0.5h; Stage #2: With Trimethyl borate In tetrahydrofuran at -78℃; for 0.5h; Stage #3: With hydrogenchloride In tetrahydrofuran; water

: 121-43-7
Trimethyl borate

: 2675-79-8
1-bromo-3,4,5-trimethoxybenzene

: 182163-96-8
3,4,5-trimethoxyphenylboronic Acid

Conditions

Conditions	Yield
With Mg In tetrahydrofuran Mg (reflux), THF, B(OCH)3, bromobenzene-compound (-10°C) or n-butyllithium, B(OCH3)3, -78°C, THF;	95%

: 25245-29-8
5-iodo-1,2,3-trimethoxybenzene

: 182163-96-8
3,4,5-trimethoxyphenylboronic Acid

Conditions

Conditions	Yield
Stage #1: 5-iodo-1,2,3-trimethoxybenzene With tert.-butyl lithium In tetrahydrofuran at -78℃; Stage #2: With Trimethyl borate In tetrahydrofuran at -78 - 20℃; Further stages.;	69%

: 133095-91-7
3,4,5-trimethoxyphenylmagnesium bromide

: 182163-96-8
3,4,5-trimethoxyphenylboronic Acid

Conditions

Conditions	Yield
Stage #1: 3,4,5-trimethoxyphenylmagnesium bromide With Trimethyl borate In tetrahydrofuran at -78 - 20℃; Stage #2: With hydrogenchloride In water	65%

: 25245-29-8
5-iodo-1,2,3-trimethoxybenzene

: 121-43-7
Trimethyl borate

: 182163-96-8
3,4,5-trimethoxyphenylboronic Acid

Conditions

Conditions	Yield
Stage #1: 5-iodo-1,2,3-trimethoxybenzene With tert.-butyl lithium In tetrahydrofuran at -78℃; for 1h; Stage #2: Trimethyl borate In tetrahydrofuran at -78℃; for 1h;
Stage #1: 5-iodo-1,2,3-trimethoxybenzene In tetrahydrofuran at -78℃; for 0.5h; Inert atmosphere; Stage #2: With n-butyllithium In tetrahydrofuran; hexane at -78℃; for 1h; Inert atmosphere; Stage #3: Trimethyl borate In tetrahydrofuran; hexane at 20℃; for 14h; Inert atmosphere;

: 24313-88-0
3,4,5-Trimethoxyaniline

: 182163-96-8
3,4,5-trimethoxyphenylboronic Acid

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1.1: NaNO2; concd. H2SO4 / H2O / 5 - 10 °C 1.2: 70 percent / aq. CuBr / 0.5 h / Heating 2.1: nBuLi / tetrahydrofuran; hexane / 1 h / -85 °C 2.2: 64 percent / trimethylborate / tetrahydrofuran / 18 h / 20 °C View Scheme
Multi-step reaction with 2 steps 1.1: sodium nitrite; potassium iodide / water; sulfuric acid / 5 h / 50 °C / Inert atmosphere 2.1: tetrahydrofuran / 0.5 h / -78 °C / Inert atmosphere 2.2: 1 h / -78 °C / Inert atmosphere 2.3: 14 h / 20 °C / Inert atmosphere View Scheme

: 1016971-56-4
C27H33B3O12

: 182163-96-8
3,4,5-trimethoxyphenylboronic Acid

Conditions

Conditions	Yield
With water at 25℃; Equilibrium constant;

: 1016971-65-5
C27H33B3O8

A: 301699-39-8
(4-methoxy-3,5-dimethylphenyl)boronic acid

B: 182163-96-8
3,4,5-trimethoxyphenylboronic Acid

Conditions

Conditions	Yield
With water at 25℃; Equilibrium constant;

: 1016971-67-7
C27H33B3O10

A: 301699-39-8
(4-methoxy-3,5-dimethylphenyl)boronic acid

B: 182163-96-8
3,4,5-trimethoxyphenylboronic Acid

Conditions

Conditions	Yield
With water at 25℃; Equilibrium constant;

: 1016971-69-9
C39H57B3O8

A: 182163-96-8
3,4,5-trimethoxyphenylboronic Acid

B: 233584-42-4
4-methoxy-3,5-di-tert-butylphenylboronic acid pinacol ester

Conditions

Conditions	Yield
With water at 25℃; Equilibrium constant;

: 1016971-71-3
C33H45B3O10

A: 182163-96-8
3,4,5-trimethoxyphenylboronic Acid

B: 233584-42-4
4-methoxy-3,5-di-tert-butylphenylboronic acid pinacol ester

Conditions

Conditions	Yield
With water at 25℃; Equilibrium constant;

: 1016971-54-2
C25H29B3O6

A: 172975-69-8
3,5-dimethylphenyl boronic acid

B: 182163-96-8
3,4,5-trimethoxyphenylboronic Acid

Conditions

Conditions	Yield
With water at 25℃; Equilibrium constant;

: 2675-79-8
1-bromo-3,4,5-trimethoxybenzene

: 182163-96-8
3,4,5-trimethoxyphenylboronic Acid

Conditions

Conditions	Yield
Stage #1: 1-bromo-3,4,5-trimethoxybenzene With n-butyllithium In tetrahydrofuran at -78℃; Inert atmosphere; Stage #2: With Trimethyl borate In tetrahydrofuran at -78 - 20℃; Inert atmosphere;	95%
Stage #1: 1-bromo-3,4,5-trimethoxybenzene With n-butyllithium In tetrahydrofuran; hexane at -85℃; for 1h; Stage #2: With Trimethyl borate In tetrahydrofuran at 20℃; for 18h; Further stages.;	64%
Stage #1: 1-bromo-3,4,5-trimethoxybenzene With n-butyllithium In tetrahydrofuran at -78℃; for 0.5h; Stage #2: With Trimethyl borate In tetrahydrofuran at -78℃; for 0.5h; Stage #3: With hydrogenchloride In tetrahydrofuran; water

: 121-43-7
Trimethyl borate

: 2675-79-8
1-bromo-3,4,5-trimethoxybenzene

: 182163-96-8
3,4,5-trimethoxyphenylboronic Acid

Conditions

Conditions	Yield
With Mg In tetrahydrofuran Mg (reflux), THF, B(OCH)3, bromobenzene-compound (-10°C) or n-butyllithium, B(OCH3)3, -78°C, THF;	95%

: 25245-29-8
5-iodo-1,2,3-trimethoxybenzene

: 182163-96-8
3,4,5-trimethoxyphenylboronic Acid

Conditions

Conditions	Yield
Stage #1: 5-iodo-1,2,3-trimethoxybenzene With tert.-butyl lithium In tetrahydrofuran at -78℃; Stage #2: With Trimethyl borate In tetrahydrofuran at -78 - 20℃; Further stages.;	69%

: 133095-91-7
3,4,5-trimethoxyphenylmagnesium bromide

: 182163-96-8
3,4,5-trimethoxyphenylboronic Acid

Conditions

Conditions	Yield
Stage #1: 3,4,5-trimethoxyphenylmagnesium bromide With Trimethyl borate In tetrahydrofuran at -78 - 20℃; Stage #2: With hydrogenchloride In water	65%

: 25245-29-8
5-iodo-1,2,3-trimethoxybenzene

: 121-43-7
Trimethyl borate

: 182163-96-8
3,4,5-trimethoxyphenylboronic Acid

Conditions

Conditions	Yield
Stage #1: 5-iodo-1,2,3-trimethoxybenzene With tert.-butyl lithium In tetrahydrofuran at -78℃; for 1h; Stage #2: Trimethyl borate In tetrahydrofuran at -78℃; for 1h;
Stage #1: 5-iodo-1,2,3-trimethoxybenzene In tetrahydrofuran at -78℃; for 0.5h; Inert atmosphere; Stage #2: With n-butyllithium In tetrahydrofuran; hexane at -78℃; for 1h; Inert atmosphere; Stage #3: Trimethyl borate In tetrahydrofuran; hexane at 20℃; for 14h; Inert atmosphere;

: 24313-88-0
3,4,5-Trimethoxyaniline

: 182163-96-8
3,4,5-trimethoxyphenylboronic Acid

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1.1: NaNO2; concd. H2SO4 / H2O / 5 - 10 °C 1.2: 70 percent / aq. CuBr / 0.5 h / Heating 2.1: nBuLi / tetrahydrofuran; hexane / 1 h / -85 °C 2.2: 64 percent / trimethylborate / tetrahydrofuran / 18 h / 20 °C View Scheme
Multi-step reaction with 2 steps 1.1: sodium nitrite; potassium iodide / water; sulfuric acid / 5 h / 50 °C / Inert atmosphere 2.1: tetrahydrofuran / 0.5 h / -78 °C / Inert atmosphere 2.2: 1 h / -78 °C / Inert atmosphere 2.3: 14 h / 20 °C / Inert atmosphere View Scheme

: 1016971-56-4
C27H33B3O12

: 182163-96-8
3,4,5-trimethoxyphenylboronic Acid

Conditions

Conditions	Yield
With water at 25℃; Equilibrium constant;

: 1016971-65-5
C27H33B3O8

A: 301699-39-8
(4-methoxy-3,5-dimethylphenyl)boronic acid

B: 182163-96-8
3,4,5-trimethoxyphenylboronic Acid

Conditions

Conditions	Yield
With water at 25℃; Equilibrium constant;

: 1016971-67-7
C27H33B3O10

A: 301699-39-8
(4-methoxy-3,5-dimethylphenyl)boronic acid

B: 182163-96-8
3,4,5-trimethoxyphenylboronic Acid

Conditions

Conditions	Yield
With water at 25℃; Equilibrium constant;

: 1016971-69-9
C39H57B3O8

A: 182163-96-8
3,4,5-trimethoxyphenylboronic Acid

B: 233584-42-4
4-methoxy-3,5-di-tert-butylphenylboronic acid pinacol ester

Conditions

Conditions	Yield
With water at 25℃; Equilibrium constant;

: 1016971-71-3
C33H45B3O10

A: 182163-96-8
3,4,5-trimethoxyphenylboronic Acid

B: 233584-42-4
4-methoxy-3,5-di-tert-butylphenylboronic acid pinacol ester

Conditions

Conditions	Yield
With water at 25℃; Equilibrium constant;

: 1016971-54-2
C25H29B3O6

A: 172975-69-8
3,5-dimethylphenyl boronic acid

B: 182163-96-8
3,4,5-trimethoxyphenylboronic Acid

Conditions

Conditions	Yield
With water at 25℃; Equilibrium constant;

: 1016971-55-3
C26H31B3O9

A: 172975-69-8
3,5-dimethylphenyl boronic acid

B: 182163-96-8
3,4,5-trimethoxyphenylboronic Acid

Conditions

Conditions	Yield
With water at 25℃; Equilibrium constant;

: 5419-55-6
Triisopropyl borate

: 2675-79-8
1-bromo-3,4,5-trimethoxybenzene

: 7732-18-5
water

: 182163-96-8
3,4,5-trimethoxyphenylboronic Acid

Conditions

Conditions	Yield
Stage #1: 1-bromo-3,4,5-trimethoxybenzene With n-butyllithium In tetrahydrofuran at -78℃; Inert atmosphere; Stage #2: Triisopropyl borate In tetrahydrofuran at -78 - 0℃; Inert atmosphere; Stage #3: water With hydrogenchloride In tetrahydrofuran Inert atmosphere;

...Expand

: 182163-96-8
3,4,5-trimethoxyphenylboronic Acid

: 570402-53-8
1-[2-(4-methoxy-phenyl)-ethyl]-3,4-bis-trifluoromethanesulfonyloxy-1H-pyrrole-2,5-dicarboxylic acid dimethyl ester

: 220231-03-8
dimethyl 3,4-bis(3,4,5-trimethoxyphenyl)-1-<2-(4-methoxyphenyl)ethyl>pyrrole-2,5-dicarboxylate

Conditions

Conditions	Yield
With sodium carbonate; tetrakis(triphenylphosphine) palladium(0) In tetrahydrofuran for 20h; Suzuki cross-coupling; Heating;	100%

: 1283638-93-6
C26H24INO3

: 182163-96-8
3,4,5-trimethoxyphenylboronic Acid

: 1283639-68-8
C35H35NO6

Conditions

Conditions	Yield
With tetrakis(triphenylphosphine) palladium(0); caesium carbonate In ethanol; N,N-dimethyl-formamide at 120℃; for 0.333333h; Suzuki coupling; Microwave irradiation;	100%

: 1184926-29-1
2-bromo-5-(2-trimethylsilanyl-ethoxymethyl)-5H-pyrrolo[2,3-b]pyrazine

: 1334675-00-1
(R)-2-(3-cyano-azetidin-1-yl)-1-methyl-2-oxo-ethyl-ammonium trifluoroacetate

: 182163-96-8
3,4,5-trimethoxyphenylboronic Acid

: 1334675-29-4
2-(3,4,5-trimethoxyphenyl)-5-(2-trimethylsilanylethoxymethyl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid [(R)-2-(3-cyanoazetidin-1-yl)-1-methyl-2-oxoethyl]amide

Conditions

Conditions	Yield
Stage #1: 2-bromo-5-(2-trimethylsilanyl-ethoxymethyl)-5H-pyrrolo[2,3-b]pyrazine With Vilsmeier reagent In chloroform at 20℃; for 8h; Reflux; Inert atmosphere; Stage #2: With sodium hydrogencarbonate In chloroform Stage #3: (R)-2-(3-cyano-azetidin-1-yl)-1-methyl-2-oxo-ethyl-ammonium trifluoroacetate; 3,4,5-trimethoxyphenylboronic Acid	100%

...Expand

: 182163-96-8
3,4,5-trimethoxyphenylboronic Acid

: 583-53-9
1,2-dibromobenzene

: 2-bromo-3′,4′,5′-trimethoxybiphenyl

Conditions

Conditions	Yield
With palladium diacetate; potassium carbonate In ethanol; N,N-dimethyl acetamide at 20℃; for 3h; Suzuki Coupling;	100%

: 610-94-6
2-bromobenzoic acid methyl ester

: 182163-96-8
3,4,5-trimethoxyphenylboronic Acid

: 928847-09-0
3',4',5'-trimethoxybiphenyl-2-carboxylic acid methyl ester

Conditions

Conditions	Yield
With sodium carbonate; tetrakis(triphenylphosphine) palladium(0) In water; toluene at 100℃;	99%
With sodium carbonate; tetrakis(triphenylphosphine) palladium(0) In toluene at 100℃; Suzuki reaction;	45%

: 1033610-26-2
C15H12INO3

: 182163-96-8
3,4,5-trimethoxyphenylboronic Acid

: 1033609-97-0
6-methoxy-2-(4-methoxyphenyl)-3-(3,4,5-trimethoxyphenyl)furo[2,3-b]pyridine

Conditions

Conditions	Yield
With sodium hydrogencarbonate; tetrakis(triphenylphosphine) palladium(0) In 1,4-dioxane; water for 0.05h; Suzuki Coupling; Heating / reflux;	99%

: 1055900-77-0
3-chloro-2-(4-methylphenyl)-5-phenylfuran

: 182163-96-8
3,4,5-trimethoxyphenylboronic Acid

: 1055900-91-8
C26H24O4

Conditions

Conditions	Yield
With potassium fluoride; tris(dibenzylideneacetone)dipalladium (0); tri-tert-butyl phosphine at 120℃; for 10h; Suzuki -Miyaura coupling;	99%

: 182163-96-8
3,4,5-trimethoxyphenylboronic Acid

: 513-42-8
3-hydroxy-2-methyl-1-propene

: 1,2,3-trimethoxy-5-(2-methylallyl)benzene

Conditions

Conditions	Yield
With palladium diacetate; caesium carbonate; 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene at 100℃; for 12h; Temperature; Time; Suzuki-Miyaura Coupling;	99%
With palladium diacetate; caesium carbonate; 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene at 120 - 140℃; Microwave irradiation;

: 1309980-37-7
diethyl 1-[(4-methylbenzenesulfonyl)oxy]ethene-alpha-phosphonate

: 182163-96-8
3,4,5-trimethoxyphenylboronic Acid

: diethyl (1-(3,4,5-trimethoxyphenyl)vinyl)phosphonate

Conditions

Conditions	Yield
With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; palladium diacetate; caesium carbonate In toluene at 60℃; Suzuki Coupling; Schlenk technique; Inert atmosphere;	99%

: 182163-96-8
3,4,5-trimethoxyphenylboronic Acid

: 25245-29-8
5-iodo-1,2,3-trimethoxybenzene

Conditions

Conditions	Yield
With N-iodo-succinimide; potassium acetate In acetonitrile at 50℃; for 4h;	99%

: 586-78-7
para-nitrophenyl bromide

: 182163-96-8
3,4,5-trimethoxyphenylboronic Acid

: 4'-nitro-3,4,5-trimethoxy-biphenyl

Conditions

Conditions	Yield
With tetra-butylammonium acetate; Pd EnCat-30TM In ethanol at 120℃; for 0.166667h; Suzuki cross-coupling; microwave irradiation;	98%

: 580-13-2
2-bromonaphthalene

: 182163-96-8
3,4,5-trimethoxyphenylboronic Acid

: 2-(3,4,5-trimethoxyphenyl)naphthalene

Conditions

Conditions	Yield
With [1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene](3-chloropyridyl)palladium(ll) dichloride; potassium carbonate at 110℃; for 0.166667h; Suzuki-Miyaura coupling; Microwave irradiation; Neat (no solvent);	98%
With tetra-butylammonium acetate; Pd EnCat-30TM In ethanol at 120℃; for 0.166667h; Suzuki cross-coupling; microwave irradiation;

: C30H23BrO6S2

: 182163-96-8
3,4,5-trimethoxyphenylboronic Acid

: C39H34O9S2

Conditions

Conditions	Yield
With potassium phosphate; tetrakis(triphenylphosphine) palladium(0) In 1,4-dioxane; water at 90℃; Suzuki-Miyaura Coupling; Inert atmosphere;	98%

: 49669-13-8
1-(6-bromopyridin-2-yl)-ethanone

: 182163-96-8
3,4,5-trimethoxyphenylboronic Acid

: 1-(6-(3,4,5-trimethoxyphenyl)pyridin-2-yl)ethan-1-one

Conditions

Conditions	Yield
With potassium phosphate; palladium diacetate; triphenylphosphine In 1,4-dioxane; water at 110℃; Suzuki-Miyaura Coupling; Sealed tube; Inert atmosphere;	98%

: 37686-36-5
2-iodolselenophene

: 182163-96-8
3,4,5-trimethoxyphenylboronic Acid

: C13H14O3Se

Conditions

Conditions	Yield
Stage #1: 2-iodolselenophene; 3,4,5-trimethoxyphenylboronic Acid With palladium diacetate In 1,2-dichloro-ethane at 20℃; for 0.25h; Inert atmosphere; Stage #2: With potassium carbonate In water; 1,2-dichloro-ethane at 90℃; for 1h;	98%

: 1426436-21-6
C18H20O3

: 182163-96-8
3,4,5-trimethoxyphenylboronic Acid

: 1426436-34-1
C27H31N3O6

Conditions

Conditions	Yield
Stage #1: 3,4,5-trimethoxyphenylboronic Acid With sodium azide; copper(II) sulfate In methanol Stage #2: C18H20O3 With sodium L-ascorbate In methanol; water at 20℃;	97%

: 2-chloro-N-(4-fluorophenyl)quinazolin-4-amine

: 182163-96-8
3,4,5-trimethoxyphenylboronic Acid

: C23H20FN3O3

Conditions

Conditions	Yield
With NHC-Pd(II)-Im; potassium hydroxide In ethanol at 20℃; for 24h; Temperature; Suzuki-Miyaura Coupling; Schlenk technique;	97%

: 182163-96-8
3,4,5-trimethoxyphenylboronic Acid

: 566915-55-7
3-benzyloxy-3'-bromo-4-methoxy-biphenyl

: 847063-38-1
3-benzyloxy-4,3'',4'',5''-tetramethoxy-[1,1',3',1'']terphenyl

Conditions

Conditions	Yield
Stage #1: 3-benzyloxy-3'-bromo-4-methoxy-biphenyl With tetrakis(triphenylphosphine) palladium(0) In toluene at 20℃; for 0.166667h; Stage #2: 3,4,5-trimethoxyphenylboronic Acid With sodium carbonate In ethanol; toluene for 3h; Suzuki coupling; Heating;	96%
With sodium carbonate; tetrakis(triphenylphosphine) palladium(0) In ethanol; toluene Suzuki cross-coupling reaction;

: 946007-93-8
(3R,4S,5R)-5-(6-bromo-7-methoxy-benzo[1,3]dioxol-5-yl)-3,4-dimethyl-dihydro-furan-2-one

: 182163-96-8
3,4,5-trimethoxyphenylboronic Acid

: 139068-10-3
eupomatilone 4

Conditions

Conditions	Yield
With sodium hydrogencarbonate; tetrakis(triphenylphosphine) palladium(0) In 1,2-dimethoxyethane; water for 18h; Suzuki coupling; Heating;	96%

: 1144503-16-1
dimethyl N-benzyl-3,4-bis(trifluoromethanesulfonyloxy)pyrrole-2,5-dicarboxylate

: 182163-96-8
3,4,5-trimethoxyphenylboronic Acid

: 1144503-24-1
dimethyl N-benzyl-3,4-bis(3,4,5-trimethoxyphenyl)pyrrole-2,5-dicarboxylate

Conditions

Conditions	Yield
With tetrakis(triphenylphosphine) palladium(0); sodium carbonate In tetrahydrofuran; water at 20℃; Suzuki-Miyaura coupling; Reflux; Inert atmosphere;	96%

: (+/-)-(3R,4R)-ethyl 1-(3-amino-6-bromopyrazin-2-yl)-3-methylpiperidine-4-carboxylate

: 182163-96-8
3,4,5-trimethoxyphenylboronic Acid

: (+/-)-(3R,4R)-ethyl 1-(3-amino-6-(3,4,5-trimethoxyphenyl)pyrazin-2-yl)-3-methylpiperidine-4-carboxylate

Conditions

Conditions	Yield
With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; sodium carbonate In 1,2-dimethoxyethane; water at 105℃; for 2h; Suzuki coupling; Microwave irradiation; Inert atmosphere;	96%

: 5751-20-2
2-Methylthiouracil

: 182163-96-8
3,4,5-trimethoxyphenylboronic Acid

: 1388177-39-6
2-(methylsulfanyl)-4-(3,4,5-trimethoxyphenyl)pyrimidine

Conditions

Conditions	Yield
Stage #1: 2-Methylthiouracil With triethylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate In 1,4-dioxane at 20℃; for 2h; Inert atmosphere; Sealed tube; Stage #2: 3,4,5-trimethoxyphenylboronic Acid With bis-triphenylphosphine-palladium(II) chloride; sodium carbonate In 1,4-dioxane; water at 100℃; for 4h; Suzuki coupling; Inert atmosphere; Sealed tube; chemoselective reaction;	96%

: 1388177-38-5
4-(benzo[d][1,3]dioxol-5-yl)-2-(methylsulfanyl)pyrimidine

: 182163-96-8
3,4,5-trimethoxyphenylboronic Acid

: 1388177-59-0
4-(benzo[d][1,3]dioxol-5-yl)-2-(3,4,5-trimethoxyphenyl)pyrimidine

Conditions

Conditions	Yield
With tetrakis(triphenylphosphine) palladium(0); copper(I) thiophene-2-carboxylate In tetrahydrofuran at 100℃; for 1h; Liebeskind-Srogl reaction; Inert atmosphere; Microwave irradiation; regioselective reaction;	96%

: N-(2-((6-chloro-3-iodo-2-methylimidazo[1,2-b]pyridazin-8-yl)amino)ethyl)acetamide

: 182163-96-8
3,4,5-trimethoxyphenylboronic Acid

: N-(2-((6-chloro-2-methyl-3-(3,4,5-trimethoxyphenyl)imidazo[1,2-b]pyridazin-8-yl)amino)ethyl)acetamide

Conditions

Conditions	Yield
With tetrakis(triphenylphosphine) palladium(0); potassium carbonate In 1,4-dioxane; water at 95℃; for 16h; Suzuki Coupling; Inert atmosphere;	96%

: 3-bromo-1-tert-butyloxycarbonyl-5-methoxy-2-indolyl diphenyl phosphate

: 182163-96-8
3,4,5-trimethoxyphenylboronic Acid

: 1-tert-butyloxycarbonyl-3-(3,4,5-trimethoxyphenyl)-5-methoxy-2-indolyl diphenyl phosphate

Conditions

Conditions	Yield
Stage #1: 3-bromo-1-tert-butyloxycarbonyl-5-methoxy-2-indolyl diphenyl phosphate; 3,4,5-trimethoxyphenylboronic Acid With palladium diacetate; ruphos In toluene at 20℃; for 0.0833333h; Suzuki Coupling; Inert atmosphere; Stage #2: With potassium phosphate In water; toluene at 60℃; for 20h; Suzuki Coupling; Inert atmosphere; regioselective reaction;	96%

: 119072-55-8, 7188-38-7
tert-butylisonitrile

: 182163-96-8
3,4,5-trimethoxyphenylboronic Acid

: 118-41-2
Eudesmic acid

Conditions

Conditions	Yield
Stage #1: tert-butylisonitrile; 3,4,5-trimethoxyphenylboronic Acid With copper diacetate; palladium diacetate In N,N-dimethyl-formamide at 100℃; for 24h; Molecular sieve; Sealed tube; Stage #2: With water In N,N-dimethyl-formamide Molecular sieve; Sealed tube;	96%

: 93683-65-9
6-chloro-3-nitropicolinonitrile

: 182163-96-8
3,4,5-trimethoxyphenylboronic Acid

: 6-(3,4,5-trimethoxyphenyl)-3-nitropyridine-2-carbonitrile

Conditions

Conditions	Yield
With tetrakis(triphenylphosphine) palladium(0); potassium carbonate In 1,4-dioxane; water at 95℃; Suzuki Coupling; Inert atmosphere;	96%

3,4,5-Trimethoxyphenylboronic acid Chemical Properties

Molecular structure of 3,4,5-Trimethoxyphenylboronic acid (CAS NO.182163-96-8):

IUPAC Name: (3,4,5-Trimethoxyphenyl)boronic acid
Molecular Formula: C₉H₁₃BO₅
Molecular Weight: 212.01 g/mol
Density: 1.21 g/cm³
Melting Point: >230 °C(lit.)
Boiling Point: 370.6 °C at 760 mmHg
Flash Point: 177.9 °C
Index of Refraction: 1.513
Molar Refractivity: 52.38 cm³
Molar Volume: 174 cm³
Surface Tension: 43.6 dyne/cm
Enthalpy of Vaporization: 65.15 kJ/mol
Vapour Pressure: 3.79E-06 mmHg at 25 °C
Storage temp.: refrigerator (+4 °C)
H-Bond Donor: 2
H-Bond Acceptor: 5
Rotatable Bond Count: 4
Exact Mass: 212.085604
MonoIsotopic Mass: 212.085604
Topological Polar Surface Area: 68.2
Heavy Atom Count: 15
Canonical SMILES: B(C1=CC(=C(C(=C1)OC)OC)OC)(O)O
InChI: InChI=1S/C9H13BO5/c1-13-7-4-6(10(11)12)5-8(14-2)9(7)15-3/h4-5,11-12H,1-3H3
InChIKey: RULQUTYJXDLRFL-UHFFFAOYSA-N
Product Categories: Substituted Boronic Acids; Alkoxy; Aryl; Organoborons; Boronic acid; Boronic acid series; Boronic Acids; Boronic Acids and Derivatives; Boronic Acids

3,4,5-Trimethoxyphenylboronic acid Uses

3,4,5-Trimethoxyphenylboronic acid (CAS NO.182163-96-8) is commonly used as fine chemical material and pharmaceutical intermediate.

3,4,5-Trimethoxyphenylboronic acid Safety Profile

Hazard Codes: Harmful Xn, Irritant Xi
Risk Statements: 36/37/38-22-20/21/22
R36/37/38:Irritating to eyes, respiratory system and skin.
R22:Harmful if swallowed.
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed.
Safety Statements: 37/39-26-36
S37/39:Wear suitable gloves and eye/face protection.
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36:Wear suitable protective clothing.
WGK Germany: 3
Hazard Note: Irritant

3,4,5-Trimethoxyphenylboronic acid Specification

3,4,5-Trimethoxyphenylboronic acid (CAS NO.182163-96-8) is also named as Boronicacid, B-(3,4,5-trimethoxyphenyl)- ; Boronicacid, (3,4,5-trimethoxyphenyl)- (9CI) ; 3,4,5-Trimethoxybenzeneboronic acid . 3,4,5-Trimethoxyphenylboronic acid (CAS NO.182163-96-8) is beige crystalline powder.

Product Name

3,4,5-Trimethoxyphenylboronic acid

Synthetic route

3,4,5-Trimethoxyphenylboronic acid Chemical Properties

3,4,5-Trimethoxyphenylboronic acid Uses

3,4,5-Trimethoxyphenylboronic acid Safety Profile

3,4,5-Trimethoxyphenylboronic acid Specification

Related Products

Hot Products