3,4-Dichlorotoluene supplier

Name
3,4-Dichlorotoluene
EINECS 202-447-9
CAS No. 95-75-0
Article Data25
CAS DataBase
Density 1.242 g/cm³
Solubility Insoluble in water. Miscible with ethanol, ethyl ether, acetone, benzene, carbon tetrachloride.
Melting Point -15.2 °C
Formula C₇H₆Cl₂
Boiling Point 208.919 °C at 760 mmHg
Molecular Weight 161.031
Flash Point 80.172 °C
Transport Information UN 2810
Appearance clear colorless to slightly yellow liquid
Safety 23-24/25
Risk Codes 36/37/38-22
Molecular Structure
Hazard Symbols Xn
Synonyms Toluene, 3,4-dichloro- (8CI);Benzene, 1,2-dichloro-4-methyl-;
PSA 0.00000
LogP 3.30180

Synthetic route

: 6287-38-3
3,4-dichlorobenzaldehyde

: 95-75-0
3,4-Dichlorotoluene

Conditions

Conditions	Yield
With potassium hydroxide; hydrazine hydrate In diethylene glycol for 6h; Wolff-Kishner reduction; Heating;	89%
Multi-step reaction with 2 steps 1: methanol / 60 °C / Inert atmosphere 2: potassium carbonate; methanol; hydrogen; palladium 10% on activated carbon / 24 h / 65 °C / 760.05 Torr View Scheme

: 108-41-8
1-chloro-3-methylbenzene

A: 19398-61-9
2,5-dichlorotoluene

B: 95-75-0
3,4-Dichlorotoluene

Conditions

Conditions	Yield
With aluminium; mercury durch Chlorierung;
bei der Chlorierung;
With aluminium; mercury durch Chlorieren;

: 106-43-4
para-chlorotoluene

A: 95-75-0
3,4-Dichlorotoluene

B: 95-73-8
2,4-dichlorotoluene

Conditions

Conditions	Yield
bei der Chlorierung;
With aluminium; mercury durch Chlorieren;
With iodine; chlorine

: 6640-27-3
2-chloro-p-cresol

: 95-75-0
3,4-Dichlorotoluene

Conditions

Conditions	Yield
With phosphorus pentachloride

: 496-72-0
4-methyl-1,2-diaminobenzene

: 95-75-0
3,4-Dichlorotoluene

Conditions

Conditions	Yield
Diazotization.Behandlung der Diazoniumsalz-Loesung mit CuCl;

: 108-88-3
toluene

: 95-75-0
3,4-Dichlorotoluene

Conditions

Conditions	Yield
With iodine durch Chlorieren;
With molybdenum(V) chloride durch Chlorieren;

: 615-65-6
2-chloro-4-methyl-benzenamine

: 95-75-0
3,4-Dichlorotoluene

Conditions

Conditions	Yield
Diazotization.Behandlung der Diazoniumchloridloesung mit Cuprochlorid;

: 89-62-3
4-methyl-2-nitroaniline

: 95-75-0
3,4-Dichlorotoluene

Conditions

Conditions	Yield
Austausch der Aminogruppe gegen Chlor, Reduktion der Nitrogruppe und Ersatz der neu entstandenen Aminogruppe durch Chlor;

: 10026-13-8, 874483-75-7
phosphorus pentachloride

: 2-methyl-8-nitro-thianthrene-5,5,10,10-tetraoxide

A: 95-75-0
3,4-Dichlorotoluene

B 4-nitro-benzene-disulfonic acid-(1.2)-dichloride (?): 4-nitro-benzene-disulfonic acid-(1.2)-dichloride (?)

Conditions

Conditions	Yield
at 250 - 280℃; im Rohr;

...Expand

: 7791-25-5
sulfuryl dichloride

: 108-88-3
toluene

A: 106-43-4
para-chlorotoluene

B: 95-75-0
3,4-Dichlorotoluene

C: 100-44-7
benzyl chloride

Conditions

Conditions	Yield
at 160℃; Product distribution;

...Expand

: 106-43-4
para-chlorotoluene

iron: iron

A: 95-75-0
3,4-Dichlorotoluene

B: 95-73-8
2,4-dichlorotoluene

Conditions

Conditions	Yield
at 20℃; sowie bei 40grad; Chlorierung;

...Expand

3.4-dichloro-toluene-sulfonic acid-(2): 3.4-dichloro-toluene-sulfonic acid-(2)

: 95-75-0
3,4-Dichlorotoluene

Conditions

Conditions	Yield
With steam; sulfuric acid at 190 - 230℃;

4.5-dichloro-toluene-sulfonic acid-(3): 4.5-dichloro-toluene-sulfonic acid-(3)

: 95-75-0
3,4-Dichlorotoluene

Conditions

Conditions	Yield
With steam; sulfuric acid at 190 - 230℃;

: 108-88-3
toluene

A: 95-75-0
3,4-Dichlorotoluene

B p-chloro-toluene; benzyl chloride: p-chloro-toluene; benzyl chloride

Conditions

Conditions	Yield
With sulfuryl dichloride at 160℃;

: dinitrodichlorotoluene

: 53278-85-6
1,2-dichloro-4-methyl-3,5-dinitro-benzene

: 95-75-0
3,4-Dichlorotoluene

Conditions

Conditions	Yield
In methanol

: 3,4-dichlorobenzaldehyde p-toluenesulfonylhydrazone

: 95-75-0
3,4-Dichlorotoluene

Conditions

Conditions	Yield
With methanol; palladium 10% on activated carbon; hydrogen; potassium carbonate at 65℃; under 760.051 Torr; for 24h; Catalytic behavior;

: 106-43-4
para-chlorotoluene

: 95-49-8
2-methylchlorobenzene

A: 95-75-0
3,4-Dichlorotoluene

B: 95-73-8
2,4-dichlorotoluene

Conditions

Conditions	Yield
With aluminum (III) chloride; chlorine; iron at 40℃; for 16h; Molecular sieve; Overall yield = 90.5 %;

...Expand

: 598-42-5
glycolamide

: 95-75-0
3,4-Dichlorotoluene

: 39522-26-4
6-methyl-4H-benzo[1,4]oxazin-3-one

Conditions

Conditions	Yield
With copper acetylacetonate; potassium hydroxide; N,N`-dimethylethylenediamine In dichloromethane; N,N-dimethyl-formamide at 60℃; for 5h; Reagent/catalyst;	98.4%

: 95-75-0
3,4-Dichlorotoluene

: 7494-45-3
1,2-dichloro-4-methyl-5-nitrobenzene

Conditions

Conditions	Yield
With nitric acid at 0 - 20℃; for 2h;	98%
With sulfuric acid; cis-nitrous acid	95%
With nitric acid In 1,2-dichloro-ethane at 40 - 45℃; for 2h; Temperature;	95%

: 95-75-0
3,4-Dichlorotoluene

: 31020-78-7
2-(4-chlorobenzylidene)-1-cyclohexanone

: 31480-68-9
4-chloro-2'-hydroxydiphenylmethane

Conditions

Conditions	Yield
With hydrogenchloride; sodium hydroxide; hydrogen sulfide; nitrogen In ethyl acetate; toluene	97.8%

: 95-75-0
3,4-Dichlorotoluene

: 51-44-5
3,4-dichlorbenzoic acid

Conditions

Conditions	Yield
With sulfuric acid; ozone; acetic acid; manganese(II) acetate at 16℃; for 2.91667h;	96%
With sodium bromate; sulfuric acid; sodium bromide In water at 100℃; for 8h; Irradiation;	83%
Stage #1: 3,4-Dichlorotoluene With tert.-butylhydroperoxide; sodium hydroxide; tungsten(VI) oxide In water at 80℃; for 10h; Stage #2: With hydrogenchloride In water	80%

: 1295-35-8
bis(1,5-cyclooctadiene)nickel (0)

: 95-75-0
3,4-Dichlorotoluene

: 554-70-1
triethylphosphine

: Ni(2+)*2P(C2H5)3*C6H3(CH3)Cl(1-)*Cl(1-)=Ni(Cl)(C6H3(CH3)Cl)(P(C2H5)3)2

Conditions

Conditions	Yield
In hexane N2-atmosphere; filtering, crystn.; elem. anal.;	95%

...Expand

: 95-75-0
3,4-Dichlorotoluene

: 4,5-dichloro-2-methylbenzene-1-sulfonyl chloride

Conditions

Conditions	Yield
With chlorosulfonic acid; thionyl chloride at 0 - 20℃; for 20h;	95%

: 95-75-0
3,4-Dichlorotoluene

: dichlorodinitrotoluene

Conditions

Conditions	Yield
In 2-methylundecane	94.4%
With sulfuric acid; nitric acid In dichloromethane
With nitric acid In 2-methylundecane; water
With nitric acid In 2-methylundecane

: 95-75-0
3,4-Dichlorotoluene

: 13014-24-9
3,4-dichloro-1-trichloromethylbenzene

Conditions

Conditions	Yield
With chlorine; dibenzoyl peroxide at 90℃; Temperature; Green chemistry;	93.9%
With chlorine at 115 - 117℃; for 24h;
With chlorine at 115 - 117℃; for 24h; Temperature;
With chlorine at 115 - 117℃; for 24h; Temperature;

: 95-75-0
3,4-Dichlorotoluene

: 5720-05-8
4-methylphenylboronic acid

: 128644-83-7
4'-methyl-4,4''-dimethyl-(1,1',2',1'')-terphenyl

Conditions

Conditions	Yield
With C28H44N2PPd; potassium carbonate In ethanol; water at 60℃; for 6h; Suzuki coupling;	93%

: 75-77-4
chloro-trimethyl-silane

: 95-75-0
3,4-Dichlorotoluene

: 101300-64-5
1,2-bis(trimethylsilyl)-4-methylbenzene

Conditions

Conditions	Yield
With 1,3-dimethyl-2-imidazolidinone; magnesium; copper(l) chloride; lithium chloride at 55℃; for 17h;	92%
With N,N,N,N,N,N-hexamethylphosphoric triamide; iodine; magnesium at 130℃; for 96h; Substitution;	62%

: 95-75-0
3,4-Dichlorotoluene

: 75-36-5
acetyl chloride

: 53803-91-1
2-methyl-4,5-dichloroacetophenone

Conditions

Conditions	Yield
With aluminium trichloride In carbon disulfide for 24h; Heating;	90%
With aluminium trichloride

: 95-75-0
3,4-Dichlorotoluene

: 98-88-4
benzoyl chloride

: 33184-51-9
4,5-Dichloro-2-methylbenzophenon

Conditions

Conditions	Yield
With aluminium trichloride In carbon disulfide for 192h; Heating;	88%

: 95-75-0
3,4-Dichlorotoluene

: 6425-25-8
3,4-dichlorobenzyl dibromide

Conditions

Conditions	Yield
With sodium bromate; 2,2'-azobis(isobutyronitrile); sulfuric acid; sodium bromide In water; 1,2-dichloro-ethane Reflux;	82%
With bromine

: 95-75-0
3,4-Dichlorotoluene

: 18880-04-1
3,4-dichlorobenzyl bromide

Conditions

Conditions	Yield
With sodium bromate; 2,2'-azobis(isobutyronitrile); sulfuric acid; sodium bromide; dibenzoyl peroxide In water; 1,2-dichloro-ethane Reflux;	81%
With bromine	66%
With hydrogen bromide; dihydrogen peroxide In water at 0℃; Incandescent lamp light;	61.1%

: 95-75-0
3,4-Dichlorotoluene

: 74483-51-5
1,2-Cl2-4-CF3-5-MeC6H2

Conditions

Conditions	Yield
With hydrogen fluoride In tetrachloromethane	74%

: 95-75-0
3,4-Dichlorotoluene

: 1670-14-0
benzamidine monohydrochloride

: 5-(3,4-dichlorophenyl)-3-phenyl-1,2,4-oxadiazole

Conditions

Conditions	Yield
With tert.-butylhydroperoxide; potassium phosphate; copper diacetate In 1,2-dichloro-ethane at 20℃; for 12h;	74%

: 95-75-0
3,4-Dichlorotoluene

: 6574-99-8
3,4-dichloro-benzonitrile

Conditions

Conditions	Yield
With bismuth(III) vanadate; ammonia at 440℃; under 760.051 Torr; Catalytic behavior; Temperature;	73.1%
With ammonia at 380℃; Reagent/catalyst; Flow reactor;	72.5%
With vanadyl pyrophosphate; ammonia; water; oxygen at 414.84℃;	55%
With ammonia; oxygen; DC-108 at 425℃; Yield given;

: 95-75-0
3,4-Dichlorotoluene

: 103-84-4
Acetanilid

: 1415473-87-8
N-(2-(3,4-dichlorobenzoyl)phenyl)acetamide

Conditions

Conditions	Yield
With tert.-butylhydroperoxide; palladium diacetate In dimethyl sulfoxide at 100℃; for 20h; regioselective reaction;	67%

: 95-75-0
3,4-Dichlorotoluene

: N-(2-(methylthio)phenyl)ferrocene-1-carboxamide

: 2,5-bis(3,4-dichlorobenzyl)-N-(quinolin-8-yl)ferrocenecarboxamide

Conditions

Conditions	Yield
With di-tert-butyl peroxide; palladium diacetate; iron(II) chloride at 110℃; for 10h; Inert atmosphere; regioselective reaction;	67%

: 95-75-0
3,4-Dichlorotoluene

: 137-07-5
2-amino-benzenethiol

: 6265-89-0
2-(3,4-dichlorophenyl)-1,3-benzothiazole

Conditions

Conditions	Yield
With methanesulfonic acid; di-tert-butyl peroxide; copper(II) oxide at 120℃; for 20h;	60%

: 95-75-0
3,4-Dichlorotoluene

A: 18880-04-1
3,4-dichlorobenzyl bromide

B: 3,4-dichlorophenylmethyl nitrate

Conditions

Conditions	Yield
With cerium(III) ammonium nitrate; potassium bromide In acetic acid at 80 - 90℃; for 1.5h;	A 57% B 35%

: 95-75-0
3,4-Dichlorotoluene

: 90-04-0
2-methoxy-phenylamine

A: 1613638-37-1
(2-chloro-4-methylphenyl)(2-methoxyphenyl)amine

B: 1613638-38-2
(2-chloro-5-methylphenyl)(2-methoxyphenyl)amine

Conditions

Conditions	Yield
With bis(η3-allyl-μ-chloropalladium(II)); 1,2-bis(diphenylphosphino)-1′-(diisopropylphosphino)-4-tert-butylferrocene; sodium t-butanolate In toluene at 115℃; for 20h; Schlenk technique; Inert atmosphere; Overall yield = 85 %; regioselective reaction;	A 57% B 28%

...Expand

: 95-75-0
3,4-Dichlorotoluene

: 536-90-3
m-Anisidine

A: 1613638-39-3
(2-chloro-4-methylphenyl)(3-methoxyphenyl)amine

B: 1613638-40-6
(2-chloro-5-methylphenyl)(3-methoxyphenyl)amine

Conditions

Conditions	Yield
With bis(η3-allyl-μ-chloropalladium(II)); 1,2-bis(diphenylphosphino)-1′-(diisopropylphosphino)-4-tert-butylferrocene; sodium t-butanolate In toluene at 115℃; for 20h; Schlenk technique; Inert atmosphere; Overall yield = 79 %; regioselective reaction;	A 24% B 55%

...Expand

: 95-75-0
3,4-Dichlorotoluene

: 122-04-3
4-nitro-benzoyl chloride

: 280744-28-7
3,4-dichloro-2-(4-nitrobenzoyl)toluene

Conditions

Conditions	Yield
With aluminium trichloride In 1,2-dichloro-ethane for 5h; Heating;	53%

: 95-75-0
3,4-Dichlorotoluene

: (2,2’-bipyridine)Zn(CF3)2

: 1,2-dichloro-4-(2,2,2-trifluoroethyl)benzene

Conditions

Conditions	Yield
With copper(II) bis(trifluoromethanesulfonate); 1-methyl-4-fluoro-1,4-diazoniabicyclo[2.2.2]octane bis(hexafluorophosphate) In dichloromethane; acetonitrile at 20℃; for 24h; Sealed tube; Inert atmosphere;	52%

: 95-75-0
3,4-Dichlorotoluene

: 62-53-3
aniline

A: 1449248-80-9
2-chloro-4-methyl-N-phenylaniline

B: 1613638-34-8
(2-chloro-5-methyl)diphenylamine

Conditions

Conditions	Yield
With bis(η3-allyl-μ-chloropalladium(II)); 1,2-bis(diphenylphosphino)-1′-(diisopropylphosphino)-4-tert-butylferrocene; sodium t-butanolate In toluene at 115℃; for 20h; Schlenk technique; Inert atmosphere; Overall yield = 68 %; regioselective reaction;	A 51% B 17%

...Expand

: 95-75-0
3,4-Dichlorotoluene

A: 106-49-0
p-toluidine

B: 108-88-3
toluene

C: 108-44-1
1-amino-3-methylbenzene

Conditions

Conditions	Yield
With ammonia; sodium at 25℃; for 0.00833333h; Product distribution; Further Variations:; Reagents; Dehalogenation; substitution;	A 32% B 47% C 18%

...Expand

: 95-75-0
3,4-Dichlorotoluene

: 104-94-9
4-methoxy-aniline

A: 1227060-11-8
(2-chloro-5-methylphenyl)(4-methoxyphenyl)amine

B: 857601-15-1
(2-chloro-4-methylphenyl)(4-methoxyphenyl)amine

Conditions

Conditions	Yield
With bis(η3-allyl-μ-chloropalladium(II)); 1,2-bis(diphenylphosphino)-1′-(diisopropylphosphino)-4-tert-butylferrocene; sodium t-butanolate In toluene at 115℃; for 20h; Schlenk technique; Inert atmosphere; Overall yield = 71 %; regioselective reaction;	A 46% B 25%

...Expand

3,4-Dichlorotoluene Specification

The 3,4-Dichlorotoluene, with the CAS registry number 95-75-0, is also known as Benzene, 1,2-dichloro-4-methyl-. It belongs to the product categories of Organics; Aryl; C7; Halogenated Hydrocarbons; Alpha Sort; Analytical Standards; Aromatics Chemical Class; Chemical Class; ChloroVolatiles/ Semivolatiles; Halogenated. Its EINECS number is 202-447-9. This chemical's molecular formula is C₇H₆Cl₂ and molecular weight is 161.03. What's more, its systematic name is 1,2-Dichloro-4-methylbenzene. This chemical should be sealed and stored in a cool, ventilated and dry place. Moreover, it should be protected from oxides, heat and fire. It is used as a solvent and an organic synthesis intermediate.

Physical properties of 3,4-Dichlorotoluene are: (1)ACD/LogP: 3.743; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): 3.74; (4)ACD/LogD (pH 7.4): 3.74; (5)ACD/BCF (pH 5.5): 412.04; (6)ACD/BCF (pH 7.4): 412.04; (7)ACD/KOC (pH 5.5): 2590.45; (8)ACD/KOC (pH 7.4): 2590.45; (9)#H bond acceptors: 0; (10)#H bond donors: 0; (11)#Freely Rotating Bonds: 0; (12)Index of Refraction: 1.543; (13)Molar Refractivity: 40.868 cm³; (14)Molar Volume: 129.61 cm³; (15)Polarizability: 16.201×10^-24cm³; (16)Surface Tension: 35.63 dyne/cm; (17)Density: 1.242 g/cm³; (18)Flash Point: 80.172 °C; (19)Enthalpy of Vaporization: 42.702 kJ/mol; (20)Boiling Point: 208.919 °C at 760 mmHg; (21)Vapour Pressure: 0.3 mmHg at 25°C.

Uses of 3,4-Dichlorotoluene: it can be used to produce 1-(4,5-dichloro-2-methyl-phenyl)-ethanone by heating. It will need reagent AlCl₃ and solvent CS₂ with the reaction time of 24 hours. The yield is about 90%.

3,4-Dichlorotoluene can be used to produce 1-(4,5-dichloro-2-methyl-phenyl)-ethanone by heating

When you are using this chemical, please be cautious about it as the following:
This chemical is irritating to eyes, respiratory system and skin. It is harmful if swallowed. You should not breathe gas/fumes/vapour/spray (appropriate wording to be specified by the manufacturer). When using it, you must avoid contact with skin and eyes.

You can still convert the following datas into molecular structure:
(1)SMILES: Cc1cc(Cl)c(Cl)cc1
(2)Std. InChI: InChI=1S/C7H6Cl2/c1-5-2-3-6(8)7(9)4-5/h2-4H,1H3
(3)Std. InChIKey: WYUIWKFIFOJVKW-UHFFFAOYSA-N

Product Name

3,4-Dichlorotoluene

Synthetic route

3,4-Dichlorotoluene Specification

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