3,4-Difluorobenzaldehyde supplier

Name
3,4-Difluorobenzaldehyde
EINECS 422-180-3
CAS No. 34036-07-2
Article Data21
CAS DataBase
Density 1.297 g/cm³
Solubility
Melting Point
Formula C₇H₄F₂O
Boiling Point 185.1 °C at 760 mmHg
Molecular Weight 142.105
Flash Point 65.6 °C
Transport Information
Appearance Light yellow clear liquid
Safety 26-36-37/39-36/37
Risk Codes 36/37/38
Molecular Structure
Hazard Symbols Xi
Synonyms Benzaldehyde, 3,4-difluoro-;
PSA 17.07000
LogP 1.77730

Synthetic route

: 348-61-8
1-bromo-3,4-difluorobenzene

: 68-12-2, 33513-42-7
N,N-dimethyl-formamide

: 34036-07-2
3,4 difluorobenzaldehyde

Conditions

Conditions	Yield
Stage #1: 1-bromo-3,4-difluorobenzene With magnesium; 3,4-difluorophenylmagnesium bromide In tetrahydrofuran; toluene at 0.7 - 30℃; for 1h; Inert atmosphere; Molecular sieve; Stage #2: N,N-dimethyl-formamide In tetrahydrofuran; toluene at 10 - 15℃; for 1.5h; Reagent/catalyst; Solvent; Temperature; Molecular sieve; Inert atmosphere;	96.2%
Stage #1: 1-bromo-3,4-difluorobenzene With iodine; magnesium In tetrahydrofuran at 20℃; for 2h; Inert atmosphere; Stage #2: N,N-dimethyl-formamide In tetrahydrofuran at 0℃; for 0.5h; Inert atmosphere;	63%

: 75-29-6
isopropyl chloride

: 348-61-8
1-bromo-3,4-difluorobenzene

: 68-12-2, 33513-42-7
N,N-dimethyl-formamide

: 34036-07-2
3,4 difluorobenzaldehyde

Conditions

Conditions	Yield
Stage #1: isopropyl chloride With iodine; magnesium In tetrahydrofuran at 20 - 40℃; for 5.66667h; Inert atmosphere; Stage #2: 1-bromo-3,4-difluorobenzene In tetrahydrofuran at 0 - 10℃; Stage #3: N,N-dimethyl-formamide In tetrahydrofuran at 0 - 10℃; for 0.666667h;	86%

...Expand

: 348-61-8
1-bromo-3,4-difluorobenzene

: 109-94-4
formic acid ethyl ester

A: 34036-07-2
3,4 difluorobenzaldehyde

B: 182192-98-9
bis(3,4-difluorophenyl)methanol

Conditions

Conditions	Yield
With n-butyllithium In diethyl ether; hexane 1.) -78 deg C, 30 min, 2.) -78 to 20 deg C, overnight;	A 5.6% B 80%

...Expand

: C14H8F4O

A: 64248-62-0
3,4-Difluorobenzonitrile

B: 34036-07-2
3,4 difluorobenzaldehyde

Conditions

Conditions	Yield
With sodium azide; copper(II) choride dihydrate; oxygen In N,N-dimethyl-formamide at 100℃; for 10h; Schlenk technique; Sealed tube;	A 69% B 65%

: 85118-05-4
(3,4-difluorophenyl)methanol

A: 455-86-7
3,4-Difluorobenzoic acid

B: 34036-07-2
3,4 difluorobenzaldehyde

Conditions

Conditions	Yield
With peracetic acid; C24H29INO5 In acetic acid at 30℃; for 48h;	A 62% B 18%

: 2927-34-6
3,4-difluorotoluene

: 34036-07-2
3,4 difluorobenzaldehyde

Conditions

Conditions	Yield
With sodium molybdate; dihydrogen peroxide; cobalt(II) acetate; acetic acid; sodium bromide at 65℃; Temperature;	30.7%
With bromine; calcium carbonate In dichloromethane
With bromine; calcium carbonate In dichloromethane; water

: 4885-02-3
Dichloromethyl methyl ether

: 367-11-3
ortho-difluorobenzene

A: 34036-07-2
3,4 difluorobenzaldehyde

B: 32248-39-8
tris(3,4-difluorophenyl)methane

Conditions

Conditions	Yield
With aluminum (III) chloride In dichloromethane	A 12% B 26 %Chromat.

...Expand

: 348-61-8
1-bromo-3,4-difluorobenzene

: 34036-07-2
3,4 difluorobenzaldehyde

Conditions

Conditions	Yield
With sodium formate; bis(triphenylphosphine)palladium(II) dichloride In CO; N,N-dimethyl-formamide

: 367-11-3
ortho-difluorobenzene

A 5,6-difluoro-2-methyl-1-(3,4,5-trimethoxybenzylidene)-indenyl-3-acetic acid: 5,6-difluoro-2-methyl-1-(3,4,5-trimethoxybenzylidene)-indenyl-3-acetic acid

B: 34036-07-2
3,4 difluorobenzaldehyde

Conditions

Conditions	Yield
aluminium trichloride In dichloromethyl methylether; dichloromethane

: 7732-18-5
water

: 2927-34-6
3,4-difluorotoluene

: 34036-07-2
3,4 difluorobenzaldehyde

Conditions

Conditions	Yield
With bromine; calcium carbonate In dichloromethane
With bromine; calcium carbonate In dichloromethane
With bromine; calcium carbonate In dichloromethane
With bromine; calcium carbonate In dichloromethane

dichloromethyl methylether: dichloromethyl methylether

: 367-11-3
ortho-difluorobenzene

: 34036-07-2
3,4 difluorobenzaldehyde

Conditions

Conditions	Yield
aluminium trichloride In dichloromethane
aluminium trichloride In dichloromethane

dichloromethyl methylether: dichloromethyl methylether

: 367-11-3
ortho-difluorobenzene

A 5,6-Difluoro-2-Methyl-1-(ρ-Methylsulfinylbenzylidene)-Indenyl-3-Acetic Acid: 5,6-Difluoro-2-Methyl-1-(ρ-Methylsulfinylbenzylidene)-Indenyl-3-Acetic Acid

B: 34036-07-2
3,4 difluorobenzaldehyde

Conditions

Conditions	Yield
aluminium trichloride In dichloromethane

...Expand

: N-[(3,4-difluorophenyl)methylene]-2,2-dimethoxyethanamine

A: 1009309-81-2
2-(3,4-difluorobenzyl)pyrazine

B: 34036-07-2
3,4 difluorobenzaldehyde

Conditions

Conditions	Yield
With trifluoroacetic acid at 75℃; for 0.666667h;

: 34036-07-2
3,4 difluorobenzaldehyde

: 557-20-0
diethylzinc

: 847448-30-0
(S)-1-(3,4-Difluoro-phenyl)-propan-1-ol

Conditions

Conditions	Yield
With titanium(IV) isopropylate; N,N’-(1R,2R)-cyclohexane-1,2-diylbis(1,1,1-trifluoromethanesulfonamide) In toluene at -78℃;	100%
Stage #1: diethylzinc With titanium(IV) isopropylate; C48H34O4 In diethyl ether; hexane at 0℃; for 0.5h; Inert atmosphere; Stage #2: 3,4 difluorobenzaldehyde In diethyl ether; hexane at 20℃; for 5h; Inert atmosphere; optical yield given as %ee; enantioselective reaction;	92%

: 34036-07-2
3,4 difluorobenzaldehyde

: 593-56-6
N-methoxylamine hydrochloride

: 646051-28-7
3,4-difluorobenzaldehyde O-methyloxime

Conditions

Conditions	Yield
	100%

: 177755-45-2
2-(3-fluoro-4-methoxyphenyl)-2-[(trimethylsilyl)oxy]acetonitrile

: 34036-07-2
3,4 difluorobenzaldehyde

: 177755-69-0
3,4-difluoro-α-[(trimethylsilyl)oxy]benzeneacetonitrile

Conditions

Conditions	Yield
	100%

: 34036-07-2
3,4 difluorobenzaldehyde

: 120-20-7
2-(3,4-dimethoxyphenyl)-ethylamine

: 355815-40-6
N-(3',4'-difluorophenyl)methyl-3,4-dimethoxyphenethylamine

Conditions

Conditions	Yield
Stage #1: 3,4 difluorobenzaldehyde; 2-(3,4-dimethoxyphenyl)-ethylamine In methanol for 2 - 3h; Reflux; Stage #2: With sodium tetrahydroborate In methanol at 20℃; for 1h; Cooling;	100%

: 34036-07-2
3,4 difluorobenzaldehyde

: 97004-04-1
5-(aminomethyl)-2-chloropyridine

: C13H11ClF2N2

Conditions

Conditions	Yield
Stage #1: 3,4 difluorobenzaldehyde; 5-(aminomethyl)-2-chloropyridine In methanol at 20℃; Stage #2: With sodium tetrahydroborate In methanol at 20℃; for 0.416667h;	99.1%

: 69556-70-3
4-methoxy-5H-furan-2-one

: 34036-07-2
3,4 difluorobenzaldehyde

: C12H10F2O4

Conditions

Conditions	Yield
Stage #1: 4-methoxy-5H-furan-2-one With n-butyllithium Stage #2: 3,4 difluorobenzaldehyde In tetrahydrofuran at -78 - 20℃;	99%
Stage #1: 4-methoxy-5H-furan-2-one With n-butyllithium In tetrahydrofuran; hexane at -78℃; for 0.25h; Inert atmosphere; Stage #2: 3,4 difluorobenzaldehyde In tetrahydrofuran; hexane at -78 - 20℃; Inert atmosphere;

: 34036-07-2
3,4 difluorobenzaldehyde

: 124-40-3
dimethyl amine

: C9H10FNO

Conditions

Conditions	Yield
With tetrabutylammomium bromide; potassium carbonate In dimethyl sulfoxide; benzene at 90℃; for 6h;	99%
With tetrabutylammomium bromide; potassium carbonate In dimethyl sulfoxide at 90℃; for 7h; Inert atmosphere;	92%

: 34036-07-2
3,4 difluorobenzaldehyde

: 1099-45-2
ethyl (triphenylphosphoranylidene)acetate

: ethyl (2E)-3-(3,4-difluorophenyl)prop-2-enoate

Conditions

Conditions	Yield
In dichloromethane at 20℃; for 16h;	99%
In toluene at 80℃; for 1h;	67%

: 34036-07-2
3,4 difluorobenzaldehyde

: 132310-87-3
2-(trans-4-butylcyclohexyl)-1,3-propanediol

: trans-5-(trans-4-butylcyclohexyl)-2-(3,4-difluorophenyl)-1,3-dioxane

Conditions

Conditions	Yield
With hydrogenchloride; calcium chloride In water at 50℃; for 9h; Inert atmosphere; stereoselective reaction;	99%

: 34036-07-2
3,4 difluorobenzaldehyde

: 25015-63-8
4,4,5,5-tetramethyl-[1,3,2]-dioxaboralane

: 2-((3,4-difluorobenzyl)oxy)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

Conditions

Conditions	Yield
With C34H28N6Zn In neat (no solvent) at 20℃; for 2h; Glovebox; Schlenk technique;	99%

: 110-89-4
piperidine

: 34036-07-2
3,4 difluorobenzaldehyde

: 105-45-3
acetoacetic acid methyl ester

: methyl 2-{(3,4-difluorophenyl)methylene}-3-oxobutyrate

Conditions

Conditions	Yield
With acetic acid In ethyl acetate; benzene	98.3%
With acetic acid In ethyl acetate; benzene	98.3%
With acetic acid In ethyl acetate; benzene	98.3%
With acetic acid In ethyl acetate; benzene	98.3%
With acetic acid In ethyl acetate; benzene	98.3%

...Expand

: 34036-07-2
3,4 difluorobenzaldehyde

: 182192-98-9
bis(3,4-difluorophenyl)methanol

Conditions

Conditions	Yield
Stage #1: 1-bromo-3,4-difluorobenzene With n-butyllithium In diethyl ether; hexane at -78℃; for 3h; Stage #2: 3,4 difluorobenzaldehyde at -70 - 20℃;	98%

: 34036-07-2
3,4 difluorobenzaldehyde

: 177-11-7
4,4-ethylenedioxy-piperidine

: 935777-21-2
8-(3,4-difluorobenzyl)-1,4-dioxa-8-azaspiro[4.5]decane

Conditions

Conditions	Yield
With sodium tris(acetoxy)borohydride; acetic acid In dichloromethane at 20℃; for 18h;	98%

: 34036-07-2
3,4 difluorobenzaldehyde

: 2-(4-(((1-((1-(2-hydrazinyl-2-oxoethyl)-1H-1,2,3-triazol-4-yl)methyl)-1H-benzo[d]imidazol-2-yl)thio)methyl)-1H-1,2,3-triazol-1-yl)acetohydrazide

: N'-(3,4-difluorobenzylidene)-2-(4-(((1-((1-(2-(2-(3,4-difluorobenzylidene)-hydrazinyl)-2-oxoethyl)-1H-1,2,3-triazol-4-yl)methyl)-1H-benzo[d]imidazol-2-yl)-thio)methyl)-1H-1,2,3-triazol-1-yl)acetohydrazide

Conditions

Conditions	Yield
With hydrogenchloride In ethanol; water for 0.0666667h; Sealed tube; Microwave irradiation; Green chemistry;	98%

: 558-13-4
carbon tetrabromide

: 34036-07-2
3,4 difluorobenzaldehyde

: 159957-01-4
3,4-Difluoro-β,β'-dibromostyrene

Conditions

Conditions	Yield
Stage #1: carbon tetrabromide With triphenylphosphine In dichloromethane at 0℃; for 1h; Inert atmosphere; Stage #2: 3,4 difluorobenzaldehyde In dichloromethane at 20℃; for 2h; Inert atmosphere;	97%
With triphenylphosphine; zinc 1.) CH2Cl2, 48 h, 2.) 3 h; Multistep reaction;
With triphenylphosphine; zinc 1.) CH2Cl2, r.t., 48 h, 2.) 2 h; Multistep reaction;

: 31273-58-2
1-(7-hydroxy-2,2-dimethylchroman-6-yl)ethanone

: 34036-07-2
3,4 difluorobenzaldehyde

: 1416511-87-9
3-(3,4-difluoro-phenyl)-1-(7-hydroxy-2,2-dimethyl-chroman-6-yl)-propenone

Conditions

Conditions	Yield
With potassium hydroxide In ethanol; water at 20℃; for 48h; Claisen-Schmidt Condensation;	97%

: 34036-07-2
3,4 difluorobenzaldehyde

: 3762-25-2
diethyl 4-methylbenzylphosphonate

: (E)-1,2-difluoro-4-(4-methylstyryl)benzene

Conditions

Conditions	Yield
Stage #1: diethyl 4-methylbenzylphosphonate With sodium hydride In tetrahydrofuran at 0 - 5℃; for 0.5h; Horner-Wadsworth-Emmons Olefination; Stage #2: 3,4 difluorobenzaldehyde In tetrahydrofuran at 0 - 20℃; for 20h; Horner-Wadsworth-Emmons Olefination;	97%

: 34036-07-2
3,4 difluorobenzaldehyde

: 5680-79-5
glycine ethyl ester hydrochloride

: (E)-methyl 2-((3,4-difluorobenz)amino)acetate

Conditions

Conditions	Yield
Stage #1: glycine ethyl ester hydrochloride With magnesium sulfate; triethylamine In dichloromethane at 20℃; for 1h; Inert atmosphere; Stage #2: 3,4 difluorobenzaldehyde In dichloromethane at 20℃; for 12h;	97%

: 34036-07-2
3,4 difluorobenzaldehyde

: 104-94-9
4-methoxy-aniline

: 224433-74-3
[1-(3,4-Difluoro-phenyl)-meth-(E)-ylidene]-(4-methoxy-phenyl)-amine

Conditions

Conditions	Yield
With DOWEX 50W X8-400 In benzene Heating;	96%

: 34036-07-2
3,4 difluorobenzaldehyde

: 186593-14-6
5-(trifluoromethyl)pyridin-3-ol

: 1620579-56-7
3-fluoro-4-((5-(trifluoromethyl)pyridin-3-yl)oxy)benzaldehyde

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 100℃; for 16h;	96%

: 20939-15-5
4-amino-5-methyl-2,4-dihydro-[1,2,4]triazole-3-thione

: 34036-07-2
3,4 difluorobenzaldehyde

: (E)-4-((3,4-difluorobenzylidene)amino)-2,4-dihydro-5-methyl-3H-1,2,4-triazole-3-thione

Conditions

Conditions	Yield
With acetic acid In ethanol for 0.0833333h; Time; Microwave irradiation;	96%

: 141-82-2
malonic acid

: 34036-07-2
3,4 difluorobenzaldehyde

: 112897-97-9
(E)-3-(3,4-difluorophenyl)acrylic acid

Conditions

Conditions	Yield
With piperidine; pyridine at 90℃; for 2h; Inert atmosphere;	95%
With piperidine; pyridine for 4h; Reagent/catalyst; Temperature; Knoevenagel Condensation; Reflux; diastereoselective reaction;	92%
With piperidine In pyridine at 65℃; for 4h;	87%

: 181758-85-0
2-(3-hydroxy-4-methoxyphenyl)-1,3-dioxolane

: 34036-07-2
3,4 difluorobenzaldehyde

: C17H15FO5

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 150℃; for 17h;	95%

: 1175944-69-0
1-(4-(4-benzylpiperidin-1-yl)phenyl)ethanone

: 34036-07-2
3,4 difluorobenzaldehyde

: (E)-1-(4-(4-benzylpiperidin-1-yl)phenyl)-3-(3,4-difluorophenyl)prop-2-en-1-one

Conditions

Conditions	Yield
With sodium hydroxide In methanol at 60℃; for 0.5h; Claisen-Schmidt Condensation; Microwave irradiation;	95%

: 34036-07-2
3,4 difluorobenzaldehyde

: 79-19-6
thiosemicarbazide

: 1570052-89-9
(E)-2-(3,4-difluoro-benzylidene)-hydrazine-carbothioamide

Conditions

Conditions	Yield
With acetic acid In ethanol; water for 24h; Inert atmosphere; Schlenk technique; Reflux;	95%
With acetic acid In ethanol Reflux;

: 34036-07-2
3,4 difluorobenzaldehyde

: 1393084-21-3
1,3,5-tris(3,4-dimethoxybenzyl)benzene

: 1569689-06-0
C54H30F6O6

Conditions

Conditions	Yield
With iron(III) chloride; acetic anhydride In nitromethane; dichloromethane at 20℃; Inert atmosphere;	95%

: 34036-07-2
3,4 difluorobenzaldehyde

: 2-(7-fluoro-2-methoxyquinolin-8-yl)acetohydrazide

: (E)-N'-(3,4-difluorobenzylidene)-2-(7-fluoro-2-methoxyquinolin-8-yl)acetohydrazide

Conditions

Conditions	Yield
In ethanol for 4h; Reflux;	95%
In ethanol for 4h; Reflux;

: 34036-07-2
3,4 difluorobenzaldehyde

: 79-19-6
thiosemicarbazide

: 3,4-difluoro-benzaldehyde thiosemicarbazone

Conditions

Conditions	Yield
With sulfuric acid In ethanol at 40℃; for 4h;	95%
With acetic acid In ethanol at 65 - 70℃; for 10h;

: 34036-07-2
3,4 difluorobenzaldehyde

: 63909-57-9
3-fluoro-1-diethylphosphonomethyl-benzene

: (E)-1,2-difluoro-4-(3-fluorostyryl)benzene

Conditions

Conditions	Yield
Stage #1: 3-fluoro-1-diethylphosphonomethyl-benzene With sodium hydride In tetrahydrofuran at 0 - 5℃; for 0.5h; Horner-Wadsworth-Emmons Olefination; Stage #2: 3,4 difluorobenzaldehyde In tetrahydrofuran at 0 - 20℃; for 20h; Horner-Wadsworth-Emmons Olefination;	95%

3,4-Difluorobenzaldehyde Specification

3,4-Difluorobenzaldehyde, with CAS number of 34036-07-2, can be called 3.4-Difluoro benzaldehyde; 3,4-Difluorobenzaldehyde; 3,4-fluorobenzaldehyde. It belongs to the product categories of Fluorin-contained benzaldehyde series; Fluoro-Aromatics; Aromatic Aldehydes & Derivatives (substituted); Benzaldehyde; Miscellaneous; Aromatics; Aldehydes; C7; Carbonyl Compounds; Benzaldehyde series. It is a light yellow clear liquid and can be used for Medicine, Pesticide, intermediates of LCD materials.

Physical properties about 3,4-Difluorobenzaldehyde are: (1)ACD/LogP: 1.672; (2)ACD/LogD (pH 5.5): 1.67; (3)ACD/LogD (pH 7.4): 1.67; (4)ACD/BCF (pH 5.5): 10.98; (5)ACD/BCF (pH 7.4): 10.98; (6)ACD/KOC (pH 5.5): 193.38; (7)ACD/KOC (pH 7.4): 193.38; (8)#H bond acceptors: 1; (9)#Freely Rotating Bonds: 1; (10)Index of Refraction: 1.514; (11)Molar Refractivity: 32.993 cm³; (12)Molar Volume: 109.519 cm³; (13)Polarizability: 13.08 10-24cm³; (14)Surface Tension: 35.1049995422363 dyne/cm; (15)Density: 1.297 g/cm³; (16)Flash Point: 67.84 °C; (17)Enthalpy of Vaporization: 42.131 kJ/mol; (18)Boiling Point: 185.078 °C at 760 mmHg; (19)Vapour Pressure: 0.709999978542328 mmHg at 25°C

When you are using 3,4-Difluorobenzaldehyde, please be cautious about it as the following:
1. In case of contact with eyes, rinse immediately with plenty of water and seek medical advice;
2. Wear suitable protective clothing;
3. Wear suitable gloves and eye/face protection;
4. Wear suitable protective clothing and gloves;

You can still convert the following datas into molecular structure:
(1)SMILES:Fc1ccc(C=O)cc1F;
(2)Std. InChI:InChI=1S/C7H4F2O/c8-6-2-1-5(4-10)3-7(6)9/h1-4H;
(3)Std. InChIKey:JPHKMYXKNKLNDF-UHFFFAOYSA-N

Product Name

3,4-Difluorobenzaldehyde

Synthetic route

3,4-Difluorobenzaldehyde Specification

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