3,5-Dimethoxybenzaldehyde supplier

Name
3,5-Dimethoxybenzaldehyde
EINECS 230-772-6
CAS No. 7311-34-4
Article Data119
CAS DataBase
Density 1.114 g/cm³
Solubility insoluble in water
Melting Point 45-48 °C(lit.)
Formula C₉H₁₀O₃
Boiling Point 276.5 °C at 760 mmHg
Molecular Weight 166.177
Flash Point 119 °C
Transport Information
Appearance white to beige crystalline solid
Safety 26-36-24/25
Risk Codes 36/37/38
Molecular Structure
Hazard Symbols Xi
Synonyms Benzaldehyde, 3,5-dimethoxy-;
PSA 35.53000
LogP 1.51630

Synthetic route

: 34967-25-4
3,5-dimethoxybenzaldoxime

: 7311-34-4
3,5-dimethoxybenzaldehdye

Conditions

Conditions	Yield
With benzyltriphenylphosphonium dichromate In acetonitrile for 0.25h; Oxidation; Heating;	100%
With 1,4-dichloro-1,4-diazoniabicyclo[2,2,2]octane bischloride In water at 50℃; for 0.333333h; pH=7;	85%
With quinolinium chlorochromate(VI) for 0.583333h;	50%

: 705-76-0
3,5-dimethoxybenzyl alcohol

: 7311-34-4
3,5-dimethoxybenzaldehdye

Conditions

Conditions	Yield
With silica-supported Jones reagent In dichloromethane for 0.00269444h;	99.5%
With 1,2-dimethyl-3-[6-(methylsulfinyl)hexyl]-1H-imidazolium triflate; oxalyl dichloride; triethylamine In dichloromethane; acetonitrile at -78 - 20℃; Swern oxidation;	97%
With Dess-Martin periodane In dichloromethane at 0℃; Inert atmosphere;	96%

: 26153-38-8
3,5-dihydroxybenzaldehyde

: 74-88-4
methyl iodide

: 7311-34-4
3,5-dimethoxybenzaldehdye

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 50℃;	99%
With potassium carbonate In acetone at 80℃; for 12h; Inert atmosphere; Schlenk technique;	92%
With potassium carbonate In acetone Heating;	90%
Stage #1: 3,5-dihydroxybenzaldehyde With potassium carbonate In acetone at 20℃; for 0.5h; Inert atmosphere; Stage #2: methyl iodide In acetone for 6h; Reflux; Inert atmosphere;	69.4%

: 74726-76-4
2-bromo-3,5-dimethoxybenzyl alcohol

: 7311-34-4
3,5-dimethoxybenzaldehdye

Conditions

Conditions	Yield
Stage #1: 2-bromo-3,5-dimethoxybenzyl alcohol With water; lead(IV) tetraacetate; potassium nitrate at 37℃; for 1.5h; Stage #2: With rhenium(IV) sulfide at 45℃; for 2h; Temperature;	98.5%

: 4670-10-4
(3,5-dimethoxyphenyl)acetic acid

: 7311-34-4
3,5-dimethoxybenzaldehdye

Conditions

Conditions	Yield
With potassium carbonate In chloroform at 20℃; for 24h; Irradiation; Inert atmosphere;	96%
With dipotassium peroxodisulfate In water at 90℃; for 12h; Green chemistry;	62%

: 4179-19-5
1,3-dimethoxy-5-methylbenzene

: 7311-34-4
3,5-dimethoxybenzaldehdye

Conditions

Conditions	Yield
With nickel-doped graphene carbon nitride nanoparticles; air In ethanol at 25℃; for 8h; Irradiation; Green chemistry;	95%
Multi-step reaction with 2 steps 1: N-Bromosuccinimide / acetonitrile / 1 h / 25 °C / Inert atmosphere 2: hexamethylenetetramine / water / 12 h / 120 °C / Inert atmosphere View Scheme

: 15226-74-1, 61091-28-9, 61117-58-6
dicobalt octacarbonyl

: 20469-65-2
1-bromo-3,5-dimethoxybenzene

: 7311-34-4
3,5-dimethoxybenzaldehdye

Conditions

Conditions	Yield
With triethylsilane; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; sodium acetate In acetonitrile at 25℃; for 16h; Schlenk technique; Inert atmosphere;	87%

: (3aR,5R,6S,6aR)-6-(3,5-Dimethoxy-benzyloxy)-5-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-2,2-dimethyl-tetrahydro-furo[2,3-d][1,3]dioxole

A: 7311-34-4
3,5-dimethoxybenzaldehdye

B: 582-52-5
1,2:5,6-di-O-isopropylidene-α-D-glucofuranose

Conditions

Conditions	Yield
With 2,3-dicyano-5,6-dichloro-p-benzoquinone In dichloromethane; water for 2.5h; Ambient temperature;	A n/a B 86%

: 1-[(1R,2S)-4-Benzyloxy-1-ethyl-2-(4-methoxy-benzyloxymethyl)-butoxymethyl]-3,5-dimethoxy-benzene

A: 7311-34-4
3,5-dimethoxybenzaldehdye

B: 96016-38-5
(3R,4S)-6-Benzyloxy-4-(4-methoxy-benzyloxymethyl)-hexan-3-ol

Conditions

Conditions	Yield
With 2,3-dicyano-5,6-dichloro-p-benzoquinone In water; Petroleum ether at 5℃; for 0.08h;	A n/a B 86%

: 1-((1R,2S,3S)-2,4-Bis-benzyloxy-1,3-dimethyl-butoxymethyl)-3,5-dimethoxy-benzene

A: 7311-34-4
3,5-dimethoxybenzaldehdye

B: 96016-18-1
(2R,3S,4S)-3,5-Bis-benzyloxy-4-methyl-pentan-2-ol

Conditions

Conditions	Yield
With 2,3-dicyano-5,6-dichloro-p-benzoquinone In dichloromethane; water for 0.25h; Ambient temperature;	A n/a B 85%

: 1,3-Dimethoxy-5-[(1R,2R,3R)-3-(4-methoxy-benzyloxy)-2,4-bis-methoxymethoxy-1-methyl-butoxymethyl]-benzene

A: 7311-34-4
3,5-dimethoxybenzaldehdye

B: 123-11-5
4-methoxy-benzaldehyde

C: (2R,3S,4R)-4-(3,5-Dimethoxy-benzyloxy)-1,3-bis-methoxymethoxy-pentan-2-ol

D: 96016-37-4, 107297-50-7
(2R,3R,4R)-4-(4-Methoxy-benzyloxy)-3,5-bis-methoxymethoxy-pentan-2-ol

Conditions

Conditions	Yield
With 2,3-dicyano-5,6-dichloro-p-benzoquinone In water; Petroleum ether at 5℃; for 0.6h;	A n/a B n/a C 4% D 80%
With 2,3-dicyano-5,6-dichloro-p-benzoquinone In water; Petroleum ether at 5℃; for 0.6h;	A n/a B n/a C 4% D 4%

...Expand

: 20469-65-2
1-bromo-3,5-dimethoxybenzene

: 68-12-2, 33513-42-7
N,N-dimethyl-formamide

: 7311-34-4
3,5-dimethoxybenzaldehdye

Conditions

Conditions	Yield
Stage #1: 1-bromo-3,5-dimethoxybenzene With n-butyllithium In tetrahydrofuran; hexane for 0.333333h; Inert atmosphere; Cooling; Stage #2: N,N-dimethyl-formamide In tetrahydrofuran; hexane for 0.333333h; Cooling; Inert atmosphere;	78%

: 64-18-6
formic acid

: 25245-27-6
1-iodo-3,5-dimethoxybenzene

: 7311-34-4
3,5-dimethoxybenzaldehdye

Conditions

Conditions	Yield
With iodine; triethylamine; triphenylphosphine In toluene at 80℃; Inert atmosphere; Sealed tube;	77%

: 712329-47-0
1-(azidomethyl)-3,5-dimethoxybenzene

: 7311-34-4
3,5-dimethoxybenzaldehdye

Conditions

Conditions	Yield
Stage #1: 1-(azidomethyl)-3,5-dimethoxybenzene With sodium hydride In dimethyl sulfoxide; mineral oil at 20℃; for 4h; Inert atmosphere; Stage #2: With water In dimethyl sulfoxide; mineral oil for 0.25h; Inert atmosphere;	76%

: 1-[(2R,3R)-2-Benzyloxy-4-(4-methoxy-benzyloxy)-3-methoxymethoxy-butoxymethyl]-3,5-dimethoxy-benzene

A: 7311-34-4
3,5-dimethoxybenzaldehdye

B: 123-11-5
4-methoxy-benzaldehyde

C: (2R,3R)-3-Benzyloxy-4-(3,5-dimethoxy-benzyloxy)-2-methoxymethoxy-butan-1-ol

D: 96016-36-3
(2R,3R)-2-Benzyloxy-4-(4-methoxy-benzyloxy)-3-methoxymethoxy-butan-1-ol

Conditions

Conditions	Yield
With 2,3-dicyano-5,6-dichloro-p-benzoquinone In dichloromethane; water at 5℃; for 1.8h;	A n/a B n/a C 6.5% D 75%
With 2,3-dicyano-5,6-dichloro-p-benzoquinone In dichloromethane; water at 5℃; for 1.8h;	A n/a B n/a C 6.5% D 6.5%

...Expand

: C18H22O5

A: 7311-34-4
3,5-dimethoxybenzaldehdye

B: 123-11-5
4-methoxy-benzaldehyde

Conditions

Conditions	Yield
With quinoline; (1,3-dimesitylimidazolidin-2-yl)copper(I) chloride; oxygen In 1,4-dioxane at 100℃; under 760.051 Torr; for 24h;	A 74% B 61%

: 22255-22-7
3,5,4'-trimethoxy-trans-stilbene

A: 7311-34-4
3,5-dimethoxybenzaldehdye

B: 123-11-5
4-methoxy-benzaldehyde

Conditions

Conditions	Yield
Stage #1: 3,5,4'-trimethoxy-trans-stilbene With ozone In methanol; dichloromethane at -78℃; Stage #2: With triphenylphosphine In methanol; dichloromethane for 0.5h;	A 60% B 73%

: 17213-57-9
3,5-dimethoxybenzoyl chloride

: 7311-34-4
3,5-dimethoxybenzaldehdye

Conditions

Conditions	Yield
With hydrogen; sodium acetate; palladium on activated charcoal under 2427.2 Torr; 1h, then 60 degC, overnight;	70%
With tri-n-butyl-tin hydride In 1-methyl-pyrrolidin-2-one at 20℃; Inert atmosphere;	60%
With Pd-BaSO4; xylene at 140℃; Hydrogenation;

: 50-00-0
formaldehyd

: 20469-65-2
1-bromo-3,5-dimethoxybenzene

: 7311-34-4
3,5-dimethoxybenzaldehdye

Conditions

Conditions	Yield
With triethylsilane; dichloro bis(acetonitrile) palladium(II); sodium carbonate; 1,4-di(diphenylphosphino)-butane In N,N-dimethyl-formamide at 20 - 100℃; under 15001.5 Torr; for 20h; Inert atmosphere; Autoclave;	70%

: C18H22O5

A: 7311-34-4
3,5-dimethoxybenzaldehdye

B: 123-11-5
4-methoxy-benzaldehyde

Conditions

Conditions	Yield
With quinoline; (1,3-dimesitylimidazolidin-2-yl)copper(I) chloride; oxygen In 1,4-dioxane at 100℃; under 760.051 Torr; for 24h;	A 70% B 67%

: (4S,5R)-4-(3,5-Dimethoxy-benzyloxymethyl)-5-ethyl-2-(4-methoxy-phenyl)-4-methyl-[1,3]dioxolane

A: 7311-34-4
3,5-dimethoxybenzaldehdye

B: 96016-44-3, 107297-53-0
[(4S,5R)-5-Ethyl-2-(4-methoxy-phenyl)-4-methyl-[1,3]dioxolan-4-yl]-methanol

C: 96016-45-4
4-Methoxy-benzoic acid (1R,2S)-1-ethyl-2,3-dihydroxy-2-methyl-propyl ester

Conditions

Conditions	Yield
With 2,3-dicyano-5,6-dichloro-p-benzoquinone In water; Petroleum ether at 10℃; for 1h;	A n/a B 66% C 5.5%

...Expand

: 7311-34-4
3,5-dimethoxybenzaldehdye

: 705-76-0
3,5-dimethoxybenzyl alcohol

Conditions

Conditions	Yield
With sodium tetrahydroborate In methanol at 20℃; for 0.166667h;	100%
With sodium tetrahydroborate In methanol at 20℃; for 1h;	100%
With sodium tetrahydroborate In ethanol at 20℃; for 0.5h; Inert atmosphere;	100%

: 5425-44-5
2-Phenyl-[1,3]dithiane

: 7311-34-4
3,5-dimethoxybenzaldehdye

: 92989-59-8
(3,5-dimethoxyphenyl)(2-phenyl-[1,3]-dithian-2-yl)-methanol

Conditions

Conditions	Yield
Stage #1: 2-Phenyl-[1,3]dithiane With n-butyllithium In tetrahydrofuran at 0℃; for 0.5h; Stage #2: 3,5-dimethoxybenzaldehdye In tetrahydrofuran at 0 - 20℃; for 1.5h; Further stages.;	100%
Stage #1: 2-Phenyl-[1,3]dithiane With n-butyllithium In tetrahydrofuran at 0℃; Stage #2: 3,5-dimethoxybenzaldehdye In tetrahydrofuran at 0 - 20℃; for 1.5h;	100%
Stage #1: 2-Phenyl-[1,3]dithiane With n-butyllithium In tetrahydrofuran; cyclohexane at -78℃; Inert atmosphere; Stage #2: 3,5-dimethoxybenzaldehdye In tetrahydrofuran; cyclohexane at -78 - 20℃; Inert atmosphere;	90%

: 558-13-4
carbon tetrabromide

: 7311-34-4
3,5-dimethoxybenzaldehdye

: 205746-51-6
1-(2,2-dibromoethen-1-yl)-3,5-dimethoxybenzene

Conditions

Conditions	Yield
With triphenylphosphine In dichloromethane at 0℃; for 2h; Inert atmosphere;	100%
Stage #1: carbon tetrabromide With triphenylphosphine In dichloromethane at 0℃; for 0.5h; Inert atmosphere; Schlenk technique; Stage #2: 3,5-dimethoxybenzaldehdye In dichloromethane Inert atmosphere; Schlenk technique;	97%
With triphenylphosphine In dichloromethane at 0 - 20℃; for 0.5h;	96.4%

: 2537-48-6
diethyl 1-cyanomethylphosphonate

: 7311-34-4
3,5-dimethoxybenzaldehdye

: 153507-02-9
3-(3,5-dimethoxyphenyl)acrylonitrile

Conditions

Conditions	Yield
Stage #1: diethyl 1-cyanomethylphosphonate With sodium hydride In tetrahydrofuran at 20℃; for 0.25h; Stage #2: 3,5-dimethoxybenzaldehdye In tetrahydrofuran at 20℃; for 17h;	100%
Stage #1: diethyl 1-cyanomethylphosphonate With sodium hydride In tetrahydrofuran at 20℃; for 1h; Inert atmosphere; Stage #2: 3,5-dimethoxybenzaldehdye In tetrahydrofuran at 28℃;

: 123-75-1
pyrrolidine

: 7677-24-9
trimethylsilyl cyanide

: 7311-34-4
3,5-dimethoxybenzaldehdye

: 1108730-66-0
2-(3,5-dimethoxyphenyl)-2-(pyrrolidin-1-yl)acetonitrile

Conditions

Conditions	Yield
With polymer-supported scandium(III) bis(trifluoromethanesulfonate) In acetonitrile at 20℃; for 0.5h; Strecker reaction; Combinatorial reaction / High throughput screening (HTS); chemoselective reaction;	100%

...Expand

: 7677-24-9
trimethylsilyl cyanide

: 7311-34-4
3,5-dimethoxybenzaldehdye

: 2038-57-5
3-Phenylpropan-1-amine

: 1108730-65-9
2-(3,5-dimethoxyphenyl)-2-(3-phenylpropylamino)acetonitrile

Conditions

Conditions	Yield
With polymer-supported scandium(III) bis(trifluoromethanesulfonate) In acetonitrile at 20℃; for 1h; Strecker reaction; Combinatorial reaction / High throughput screening (HTS); chemoselective reaction;	100%

...Expand

: 7311-34-4
3,5-dimethoxybenzaldehdye

: 121056-95-9
trimethyl 2-(tert-butoxycarbonylamino)phosphonoacetate

: 1259394-66-5
(Z)-methyl 2-[(tert-butoxycarbonyl)amino]-3-(3,5-dimethoxyphenyl)acrylate

Conditions

Conditions	Yield
With caesium carbonate for 7h; Horner-Wadsworth-Emmons olefination; neat (no solvent, solid phase); stereoselective reaction;	100%

: 870-46-2
t-butoxycarbonylhydrazine

: 7311-34-4
3,5-dimethoxybenzaldehdye

: 106728-65-8
(E)-tert-butyl 2-(3,5-dimethoxybenzylidene)hydrazinecarboxylate

Conditions

Conditions	Yield
at 20℃; for 1h; Neat (no solvent); Ball-milling;	100%

: 7311-34-4
3,5-dimethoxybenzaldehdye

: 613-94-5
benzoic acid hydrazide

: 678536-02-2
(E)-N'-(3,5-dimethoxybenzylidene)benzohydrazide

Conditions

Conditions	Yield
at 20℃; for 2h; Neat (no solvent); Ball-milling;	100%
In ethanol Reflux;

: 7311-34-4
3,5-dimethoxybenzaldehdye

: 1576-35-8
toluene-4-sulfonic acid hydrazide

: 1338091-83-0
(E)-N′-(3,5-dimethoxybenzylidene)-4-methylbenzenesulfonohydrazide

Conditions

Conditions	Yield
at 20℃; for 3h; Neat (no solvent); Ball-milling;	100%
In methanol at 60℃; for 0.0833333 - 1h;	95%

: 7311-34-4
3,5-dimethoxybenzaldehdye

: 83171-41-9
(4-(allyloxy)phenyl)methanamine

: C19H21NO3

Conditions

Conditions	Yield
In toluene for 20h; Reflux; Molecular sieve;	100%

: 867-13-0
diethoxyphosphoryl-acetic acid ethyl ester

: 7311-34-4
3,5-dimethoxybenzaldehdye

: 29584-64-3, 42174-79-8
ethyl 3,5-dimethoxycinnamate

Conditions

Conditions	Yield
With potassium carbonate In tetrahydrofuran for 20h; Horner-Wadsworth-Emmons reaction; Reflux;	100%
With sodium tert-pentoxide at 0 - 20℃; for 1h; Horner-Wadsworth-Emmons Olefination; Green chemistry;

: 7311-34-4
3,5-dimethoxybenzaldehdye

: 540-63-6
ethane-1,2-dithiol

: 61571-96-8
2-(3,5-dimethoxy-phenyl)-1,3-dithiolane

Conditions

Conditions	Yield
With diethyl ether; boron trifluoride In dichloromethane for 15h;	99%
With amberlyst-15 In acetonitrile for 1h;	99.93%
With boron trifluoride diethyl etherate In dichloromethane at 0℃; for 2h;

: 109-80-8
1.3-propanedithiol

: 7311-34-4
3,5-dimethoxybenzaldehdye

: 57009-72-0
2-(3,5-dimethoxy-phenyl)-1,3-dithiane

Conditions

Conditions	Yield
With amberlyst-15 In acetonitrile for 1h;	99.91%
With nickel dichloride In methanol; dichloromethane at 20℃; Inert atmosphere;	90%
With hydrogenchloride In chloroform for 0.583333h;	78%
With hydrogenchloride In chloroform for 18h; Ambient temperature;	75.8%

: 7311-34-4
3,5-dimethoxybenzaldehdye

: 105-56-6
ethyl 2-cyanoacetate

: 2-cyano-3-(3,5-dimethoxy-phenyl)-acrylic acid ethyl ester

Conditions

Conditions	Yield
With piperazine In acetonitrile for 1h; Knoevenagel condensation; electroosmos;	99.9%

: 7677-24-9
trimethylsilyl cyanide

: 7311-34-4
3,5-dimethoxybenzaldehdye

: 64-04-0
phenethylamine

: 1108730-64-8
2-(3,5-dimethoxyphenyl)-2-(phenethylamino)acetonitrile

Conditions

Conditions	Yield
With polymer-supported scandium(III) bis(trifluoromethanesulfonate) In acetonitrile at 20℃; for 1h; Strecker reaction; Combinatorial reaction / High throughput screening (HTS); chemoselective reaction;	99.9%

...Expand

: 7677-24-9
trimethylsilyl cyanide

: 7311-34-4
3,5-dimethoxybenzaldehdye

: 100-46-9
benzylamine

: 2-(benzylamino)-2-(3,5-dimethoxyphenyl)acetonitrile

Conditions

Conditions	Yield
With polymer-supported scandium(III) bis(trifluoromethanesulfonate) In acetonitrile at 20℃; for 1h; Strecker reaction; Combinatorial reaction / High throughput screening (HTS); chemoselective reaction;	99.9%

...Expand

: 7311-34-4
3,5-dimethoxybenzaldehdye

: 105-56-6
ethyl 2-cyanoacetate

: 5864-90-4
3-(3,5-dimethoxyphenyl)-2-cyano-acrylic acid ethyl ester

Conditions

Conditions	Yield
With 3-(1-piperazino)propyl functionalised silica gel In acetonitrile Knoevenagel condensation;	99.5%
With 1,8-diazabicyclo[5.4.0]undec-7-ene In dichloromethane at 20℃; for 5h; Knoevenagel Condensation;	90%
With piperidine In ethanol at 20℃;
With sodium hydroxide In ethanol for 0.25h; air atmosphere;
With piperazine immobilized by 4-benzyl spacer on silica gel In acetonitrile at 20℃; for 0.0833333h; Knoevenagel Condensation; Flow reactor;

: 7311-34-4
3,5-dimethoxybenzaldehdye

: 105-56-6
ethyl 2-cyanoacetate

: 5864-90-4
3-(3,5-dimethoxyphenyl)-2-cyano acrylic acid ethyl ester

Conditions

Conditions	Yield
With 3-(1-piperazino)propyl-functionalised silica gel In acetonitrile Knoevenagel reaction; electroosmotic flow;	99.5%

: 7311-34-4
3,5-dimethoxybenzaldehdye

: 100-19-6
(4-nitrophenyl)ethanone

: C17H15NO5

Conditions

Conditions	Yield
Stage #1: (4-nitrophenyl)ethanone With lithium hydroxide monohydrate In methanol at 20℃; for 1h; Stage #2: 3,5-dimethoxybenzaldehdye In methanol at 20℃; for 3h;	99.5%

: 7311-34-4
3,5-dimethoxybenzaldehdye

: 149-73-5
trimethyl orthoformate

: 59276-34-5
3,5-dimethoxybenzaldehyde dimethyl acetal

Conditions

Conditions	Yield
With amberlyst-15 In acetonitrile for 1h; electroosmos;	99.4%
With amberlyst-15 In acetonitrile for 0.166667h;	98.4%
With ammonium chloride In methanol for 24h;	98%
With toluene-4-sulfonic acid

: 7311-34-4
3,5-dimethoxybenzaldehdye

: 109-77-3
malononitrile

: 26495-19-2
β,β-dicyano-3,5-dimethoxystyrene

Conditions

Conditions	Yield
With 3-(1-piperazino)propyl functionalised silica gel In acetonitrile Knoevenagel condensation;	99.2%
With 3-(1-piperazino)propyl-functionalised silica gel In acetonitrile Knoevenagel reaction; electroosmotic flow;	99.2%
With piperazine In acetonitrile for 1h; Knoevenagel condensation; electroosmos;	99.2%

: 7677-24-9
trimethylsilyl cyanide

: 7311-34-4
3,5-dimethoxybenzaldehdye

: 144758-83-8
α-(3,5-dimethoxyphenyl)-α-(trimethylsilyloxy)acetonitrile

Conditions

Conditions	Yield
With C32H39Br2MgN2(1-)*C16H32LiO4(1+) In chloroform-d1 at 20℃; for 3h; Inert atmosphere; Glovebox;	99%
With zinc(II) iodide In benzene for 1.5h; Ambient temperature;	93%
In acetonitrile at 45℃; for 4h;	89%

: 7311-34-4
3,5-dimethoxybenzaldehdye

: 57367-56-3
2-tert-Butoxycarbonyl-1-methoxycarbonylethylidene(triphenyl)phosphorane

: 115046-50-9
2-[1-(3,5-Dimethoxy-phenyl)-meth-(E)-ylidene]-succinic acid 4-tert-butyl ester 1-methyl ester

Conditions

Conditions	Yield
In benzene for 48h; Heating;	99%

: 7311-34-4
3,5-dimethoxybenzaldehdye

: 1132-21-4
3,5-dimethoxybenzoic acid

Conditions

Conditions	Yield
With 4H3N4H(1+)CuMo6O18(OH)6(4-); water; oxygen; sodium carbonate at 50℃; under 760.051 Torr; for 12h;	99%
With C4H11FeMo6NO24(3-)*3C16H36N(1+); water; oxygen; sodium carbonate at 50℃; under 760.051 Torr; for 8h; Green chemistry;	95%
With sodium perborate In acetic acid at 45 - 50℃; for 8h;	83%

: 7311-34-4
3,5-dimethoxybenzaldehdye

: 19179-31-8
3,5-dimethoxy-benzonitrile

Conditions

Conditions	Yield
With oxygen; copper; ammonium chloride In pyridine at 60℃; for 24h;	99%
With ammonium sulfate; sodium carbonate; sulfur In dimethyl sulfoxide at 120℃; for 10h; Sealed tube;	99%
With trimethylsilylazide; zirconium(IV) chloride In acetonitrile at 20℃; for 0.333333h;	69%
With ammonia; iodine In tetrahydrofuran; water at 20℃;

: 7311-34-4
3,5-dimethoxybenzaldehdye

: 2065-66-9
methyl-triphenylphosphonium iodide

: 40243-87-6
3,5-dimethoxystyrene

Conditions

Conditions	Yield
Stage #1: methyl-triphenylphosphonium iodide With sodium hydride In tetrahydrofuran; mineral oil at 0℃; for 1h; Wittig Olefination; Stage #2: 3,5-dimethoxybenzaldehdye In tetrahydrofuran; mineral oil at 0 - 20℃; for 10h; Wittig Olefination;	99%
Stage #1: methyl-triphenylphosphonium iodide With potassium tert-butylate In diethyl ether at 20℃; for 2h; Wittig reaction; Stage #2: 3,5-dimethoxybenzaldehdye In diethyl ether at 0 - 20℃; Wittig reaction;	96%
With potassium tert-butylate In N,N-dimethyl-formamide at -75℃; for 4h; Inert atmosphere;	86%

: 7311-34-4
3,5-dimethoxybenzaldehdye

: 1779-49-3
Methyltriphenylphosphonium bromide

: 40243-87-6
3,5-dimethoxystyrene

Conditions

Conditions	Yield
Stage #1: Methyltriphenylphosphonium bromide With potassium tert-butylate In tetrahydrofuran at 20℃; for 0.5h; Inert atmosphere; Stage #2: 3,5-dimethoxybenzaldehdye In tetrahydrofuran at -78 - 20℃; Inert atmosphere;	99%
Stage #1: Methyltriphenylphosphonium bromide With sodium hydride In tetrahydrofuran; mineral oil for 1h; Wittig Olefination; Inert atmosphere; Reflux; Stage #2: 3,5-dimethoxybenzaldehdye In tetrahydrofuran; mineral oil for 2h; Wittig Olefination; Inert atmosphere; Reflux;	99%
With potassium tert-butylate In tetrahydrofuran at -70 - 20℃; for 2h; Wittig reaction;	96%

3,5-Dimethoxybenzaldehyde Chemical Properties

Molecule structure of 3,5-Dimethoxybenzaldehyde (CAS NO.7311-34-4):

IUPAC Name: 3,5-Dimethoxybenzaldehyde
Molecular Weight: 166.1739 g/mol
Molecular Formula: C₉H₁₀O₃
Density: 1.114 g/cm³
Melting Point: 45-48 °C(lit.)
Boiling Point: 276.5 °C at 760 mmHg
Flash Point: 119 °C
Index of Refraction: 1.534
Molar Refractivity: 46.36 cm³
Molar Volume: 149.1 cm³
Surface Tension: 36.1 dyne/cm
Enthalpy of Vaporization: 51.5 kJ/mol
Vapour Pressure: 0.00478 mmHg at 25 °C
Water Solubility: insoluble
Sensitive: air sensitive
XLogP3-AA: 1.3
H-Bond Acceptor: 3
Rotatable Bond Count: 3
Exact Mass: 166.062994
MonoIsotopic Mass: 166.062994
Topological Polar Surface Area: 35.5
Heavy Atom Count: 12
Canonical SMILES: COC1=CC(=CC(=C1)C=O)OC
InChI: InChI=1S/C9H10O3/c1-11-8-3-7(6-10)4-9(5-8)12-2/h3-6H,1-2H3
InChIKey: VFZRZRDOXPRTSC-UHFFFAOYSA-N
EINECS: 230-772-6
Product Categories: Carbonyl Compounds;Aromatic Aldehydes & Derivatives (substituted); Adehydes, Acetals & Ketones; Anisoles, Alkyloxy Compounds & Phenylacetates; Building Blocks for Dendrimers; Functional Materials; Aldehydes; C9; Carbonyl Compounds

3,5-Dimethoxybenzaldehyde Uses

3,5-Dimethoxybenzaldehyde (CAS NO.7311-34-4) is mainly used for pharmaceutical intermediates.

3,5-Dimethoxybenzaldehyde Safety Profile

Hazard Codes: Irritant Xi
Risk Statements: 36/37/38
R36/37/38:Irritating to eyes, respiratory system and skin.
Safety Statements: 26-36-24/25
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36:Wear suitable protective clothing.
S24/25:Avoid contact with skin and eyes.
WGK Germany: 3
F: 9
Hazard Note: Irritant

3,5-Dimethoxybenzaldehyde Specification

3,5-Dimethoxybenzaldehyde (CAS NO.7311-34-4) is also named as Benzaldehyde, 3,5-dimiethoxy ; 3,5-Dimethoxybenzaldehyde 98% . 3,5-Dimethoxybenzaldehyde (CAS NO.7311-34-4) is white to beige crystalline solid.

Product Name

3,5-Dimethoxybenzaldehyde

Synthetic route

3,5-Dimethoxybenzaldehyde Chemical Properties

3,5-Dimethoxybenzaldehyde Uses

3,5-Dimethoxybenzaldehyde Safety Profile

3,5-Dimethoxybenzaldehyde Specification

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