3-Chlorophenylhydrazine hydrochloride supplier

Name
3-Chlorophenylhydrazine hydrochloride
EINECS 219-005-6
CAS No. 2312-23-4
Article Data10
CAS DataBase
Density
Solubility Soluble in water
Melting Point 240-245 °C (dec.)(lit.)
Formula C₆H₇ClN₂^.HCl
Boiling Point 266 °C at 760 mmHg
Molecular Weight 179.049
Flash Point 114.7 °C
Transport Information
Appearance white to light yellow crystal powder
Safety 26-37/39
Risk Codes 20/21/22
Molecular Structure
Hazard Symbols Xn
Synonyms Hydrazine,(3-chlorophenyl)-, monohydrochloride (9CI);Hydrazine, (m-chlorophenyl)-,hydrochloride (6CI,8CI);(3-Chlorophenyl)hydrazine monohydrochloride;3-Chlorophenylhydrazine hydrochloride;N-(3-Chlorophenyl)hydrazinehydrochloride;m-Chlorophenylhydrazine hydrochloride;
PSA 38.05000
LogP 3.20090

Synthetic route

: 108-37-2
1-bromo-3-chlorobenzene

: 2312-23-4
m-chlorophenylhydrazine hydrochloride

Conditions

Conditions	Yield
Stage #1: 1-bromo-3-chlorobenzene With potassium phosphate; copper(l) iodide; N,N′-bis(2,6-dimethylphenyl)oxalamide; cetyltrimethylammonim bromide In water at 80℃; for 0.25h; Schlenk technique; Inert atmosphere; Sealed tube; Stage #2: With hydrazine hydrate In water at 80℃; Inert atmosphere; Schlenk technique; Sealed tube; Stage #3: With hydrogenchloride In water pH=3 - 4; Inert atmosphere; Schlenk technique; Sealed tube;	82%

Yield

Stage #1: 1-bromo-3-chlorobenzene With potassium phosphate; copper(l) iodide; N,N′-bis(2,6-dimethylphenyl)oxalamide; cetyltrimethylammonim bromide In water at 80℃; for 0.25h; Schlenk technique; Inert atmosphere; Sealed tube;
Stage #2: With hydrazine hydrate In water at 80℃; Inert atmosphere; Schlenk technique; Sealed tube;
Stage #3: With hydrogenchloride In water pH=3 - 4; Inert atmosphere; Schlenk technique; Sealed tube;

82%

: 108-42-9
3-chloro-aniline

: 2312-23-4
m-chlorophenylhydrazine hydrochloride

Conditions

Conditions	Yield
With diazotizing agent; tin(ll) chloride Multistep reaction;
Stage #1: 3-chloro-aniline With hydrogenchloride; sodium nitrite at 0℃; Stage #2: With hydrogenchloride; tin(ll) chloride at 0℃; for 1h;
Stage #1: 3-chloro-aniline With hydrogenchloride; sodium nitrite In water for 0.333333h; Cooling with ice; Stage #2: With hydrogenchloride; tin(II) chloride dihdyrate In water at -10 - -5℃; for 2h;

: 121-73-3
3-Chloronitrobenzene

: 2312-23-4
m-chlorophenylhydrazine hydrochloride

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1.1: Fe; aq. NH4Cl / 48 h / Heating 2.1: NaNO2; aq. HCl / 0 °C 2.2: SnCl2; aq. HCl / 1 h / 0 °C View Scheme

: 2312-23-4
m-chlorophenylhydrazine hydrochloride

: 82874-96-2
2-methoxyimino-4-oxo-pentaneperoxoic acid ethyl ester

: 709654-29-5
ethyl 1-(3-chlorophenyl)-3-methyl-1H-pyrazole-5-carboxylate

Conditions

Conditions	Yield
In ethanol for 5h; Heating;	99%

: 2312-23-4
m-chlorophenylhydrazine hydrochloride

: 335151-67-2
3-benzoyl-4-hydroxy-1-phenylquinolin-2(1H)-one

: 1-(3-chlorophenyl)-3,5-diphenyl-1H-pyrazolo[4,3-c]quinolin-4(5H)-one

Conditions

Conditions	Yield
With sulfuric acid In acetic acid for 2h; Heating;	98%

: 958462-15-2
(3E)-1-benzoyl-3-(dimethylamino)methylidenepyrrolidin-2-one

: 2312-23-4
m-chlorophenylhydrazine hydrochloride

: 958462-28-7
N-{2-[1-(3-chlorophenyl)-5-hydroxy-1H-pyrazol-4-yl]ethyl}benzamide

Conditions

Conditions	Yield
In propan-1-ol for 4h; Heating;	97%

: 2312-23-4
m-chlorophenylhydrazine hydrochloride

: 15853-98-2, 17669-01-1, 56190-51-3, 7562-61-0
(+)-usnic acid

: 1-(3-chlorophenyl)-8-{1-[2-(3-chlorophenyl)hydrazono]ethyl}-5,7-dihydroxy-3,4a,6-trimethyl-1H-[1]benzofuro[3,2-f]indazol-4(4aH)-one

Conditions

Conditions	Yield
With pyridine In ethanol for 2h; Reflux;	95%

: 600-22-6
pyruvic acid methyl ester

: 2312-23-4
m-chlorophenylhydrazine hydrochloride

: 1609930-28-0
C10H11ClN2O2

Conditions

Conditions	Yield
In methanol Reflux;	95%

: 2312-23-4
m-chlorophenylhydrazine hydrochloride

: potassium salt of 2-formyldimedone

: 308248-83-1
2-(3-chlorophenylhydrazinomethylene)-5,5-dimethyl-1,3-cyclohexandione

Conditions

Conditions	Yield
In water at 80 - 90℃; Condensation;	94%

: 2312-23-4
m-chlorophenylhydrazine hydrochloride

: 17823-69-7
2-cyano-3,3-bis(methylthio)acrylamide

: 5-amino-4-carboxamido-1-(3-chlorophenyl)-3-(methylthio)pyrazole

Conditions

Conditions	Yield
With triethylamine In methanol Heating;	94%

: 1-[{1′-(6′′-deoxy-1′′,2′′:3′′,4′′-di-O-isopropylidene-α-D-galactopyranos-6′′-yl)-1′H-1′,2′,3′-triazol-4′-yl}methyl]indoline-2,3-dione

: 2312-23-4
m-chlorophenylhydrazine hydrochloride

: (Z)-3-{2-(3-chlorophenyl)hydrazono}-1-[{1′-(6′′-deoxy-1′′,2′′:3′′,4′′-di-O-isopropylidene-α-D-galactopyranos-6′′-yl)-1'H-1′,2′,3′-triazol-4′-yl}methyl]indoline-2,3-dione

Conditions

Conditions	Yield
With acetic acid In ethanol at 80℃; for 1h;	93%

: 2312-23-4
m-chlorophenylhydrazine hydrochloride

: 3,5-dinitropaeonol

: C15H13ClN4O6

Conditions

Conditions	Yield
With acetic acid In ethanol Reflux;	93%

: 952959-35-2
2,2,2-trifluoro-1-(2-phenyl-4,5-dihydro-1H-pyrrol-3-yl)ethanone

: 2312-23-4
m-chlorophenylhydrazine hydrochloride

: 4-(2-aminoethyl)-1-(3-chlorophenyl)-5-phenyl-3-trifluoromethyl-1H-pyrazole hydrochloride

Conditions

Conditions	Yield
With hydrogenchloride; acetic acid for 0.5h; Heating;	92%

: 2,3-Dichlor-2'-methoxy-chalcon

: 2312-23-4
m-chlorophenylhydrazine hydrochloride

: 1-(3-chlorophenyl)-5-(2,3-dichlorophenyl)-3-(2-methoxyphenyl)-4,5-dihydro-1H-pyrazole

Conditions

Conditions	Yield
With acetic acid In methanol Reflux;	92%

: C16H10Cl2O3

: 2312-23-4
m-chlorophenylhydrazine hydrochloride

: 3-(benzo[d][1,3]dioxol-5-yl)-1-(3-chlorophenyl)-5-(2,3-dichlorophenyl)-4,5-dihydro-1H-pyrazole

Conditions

Conditions	Yield
With acetic acid In methanol Reflux;	92%

: 1-[{1′-(2′′,3′′,4′′,6′′-tetra-O-acetyl-β-D-galactopyranosyl)-1′H-1′,2′,3′-triazol-4′-yl}methyl]indoline-2,3-dione

: 2312-23-4
m-chlorophenylhydrazine hydrochloride

: (Z)-3-{2-(3-chlorophenyl)hydrazono}-1-[{1′-(2′′,3′′,4′′,6′′-tetra-O-acetyl-β-D-galactopyranosyl)-1′H-1′,2′,3′-triazol-4′-yl}methyl]indoline-2,3-dione

Conditions

Conditions	Yield
With acetic acid In ethanol at 80℃; for 1h;	92%

: 24424-99-5
di-tert-butyl dicarbonate

: 2312-23-4
m-chlorophenylhydrazine hydrochloride

: tert-butyl 2-(3-chlorophenyl)hydrazine-1-carboxylate

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 20℃; for 24h;	91%

: 1-[{1′-(5′′-deoxy-1′′,2′′-O-isopropylidene-α-D-xylofuranos-5′′-yl)-1′H-1′,2′,3′-triazol-4′-yl}methyl]indoline-2,3-dione

: 2312-23-4
m-chlorophenylhydrazine hydrochloride

: (Z)-3-{2-(3-chlorophenyl)hydrazono}-1-[{1′-(5′′-deoxy-1′′,2′′-O-isopropylidene-α-D-xylofuranos-5′′-yl)-1′H-1′,2′,3′-triazol-4′-yl}methyl]indoline-2,3-dione

Conditions

Conditions	Yield
With acetic acid In ethanol at 80℃; for 1h;	91%

: 2312-23-4
m-chlorophenylhydrazine hydrochloride

: 333-20-0
potassium thioacyanate

: 454464-55-2
rac-3-(2-bromo-propionyl)-benzoic acid methyl ester

: 454464-58-5
3-[3-(3-chloro-phenylamino)-2-mercapto-5-methyl-3H-imidazol-4-yl]-benzoic acid methyl ester

Conditions

Conditions	Yield
Stage #1: potassium thioacyanate; rac-3-(2-bromo-propionyl)-benzoic acid methyl ester With acetic acid for 0.5h; Stage #2: m-chlorophenylhydrazine hydrochloride With acetic acid	90%

...Expand

: 27996-87-8
2-fluoro-5-nitrobenzaldehye

: 2312-23-4
m-chlorophenylhydrazine hydrochloride

: C13H9ClFN3O2

Conditions

Conditions	Yield
In N,N-dimethyl-formamide at 50℃; for 2h; Inert atmosphere;	90%

: 1427040-73-0
1-[{1′-(2′′,3′′,4′′,6′′-tetra-O-acetyl-β-D-glucopyranosyl)-1′H-1′,2′,3′-triazol-4′-yl} methyl]indoline-2,3-dione

: 2312-23-4
m-chlorophenylhydrazine hydrochloride

: (Z)-3-{2-(3-chlorophenyl)hydrazono}-1-[{1′-(2′′,3′′,4′′,6′′-tetra-O-acetyl-β-D-glucopyranosyl)-1′H-1′,2′,3′-triazol-4′-yl}methyl]indoline-2,3-dione

Conditions

Conditions	Yield
With acetic acid In ethanol at 80℃; for 1h;	90%

: 2312-23-4
m-chlorophenylhydrazine hydrochloride

: 108-37-2
1-bromo-3-chlorobenzene

Conditions

Conditions	Yield
With boron tribromide; dimethyl sulfoxide at 80℃; for 1h;	90%

: 2312-23-4
m-chlorophenylhydrazine hydrochloride

: 15046-59-0
phenyl-(6-phenyl-pyridazin-3-yl)-methanone

: N-(3-chloro-phenyl)-N'-[phenyl-(6-phenyl-pyridazin-3-yl)-methylene]-hydrazine

Conditions

Conditions	Yield
With sodium acetate In methanol for 1h; Condensation; Heating;	89%

: 2312-23-4
m-chlorophenylhydrazine hydrochloride

: 335151-68-3
2-benzoyl-1-hydroxy-6,7-dihydro-5H-benzo[ij]quinolizin-3-one

: 11-(3-chlorophenyl)-9-phenyl-5,6-dihydro-4H-11H-benzo[ij]pyrazolo[3,4-b]quinolizin-8-one

Conditions

Conditions	Yield
With sulfuric acid In acetic acid for 2h; Heating;	89%

: 2312-23-4
m-chlorophenylhydrazine hydrochloride

: 5305-40-8
2,6-dichloro-pyrimidine carbaldehyde

: 1429924-48-0
4,6-dichloro-5-((2-(3-chlorophenyl)hydrazono)methyl)pyrimidine

Conditions

Conditions	Yield
In N,N-dimethyl-formamide at 20℃; for 1h; Inert atmosphere;	89%

: 2312-23-4
m-chlorophenylhydrazine hydrochloride

: 5305-40-8
2,6-dichloro-pyrimidine carbaldehyde

: 4,6-dichloro-5-{[2-(3-chlorophenyl)hydrazono]methyl}pyrimidine

Conditions

Conditions	Yield
In N,N-dimethyl-formamide at 20℃; Inert atmosphere;	89%

: 458-37-7, 94875-80-6
curcumin

: 2312-23-4
m-chlorophenylhydrazine hydrochloride

: C27H23ClN2O4

Conditions

Conditions	Yield
In ethanol for 14h; Reflux;	89%

: 458-37-7
curcumin

: 2312-23-4
m-chlorophenylhydrazine hydrochloride

: 4,4′-((1E,1’E)-2,2′-(1-(3-chlorophenyl)-1H-pyrazole-3,5-diyl)bis(ethene-2,1-diyl))bis(2-methoxyphenol)

Conditions

Conditions	Yield
With sodium hydrogencarbonate In ethanol for 14h; Reflux;	89%

: C15H9Cl2FO

: 2312-23-4
m-chlorophenylhydrazine hydrochloride

: 1-(3-chlorophenyl)-5-(2,3-dichlorophenyl)-3-(4-fluorophenyl)-4,5-dihydro-1H-pyrazole

Conditions

Conditions	Yield
With acetic acid In methanol Reflux;	89%

: 766-40-5
Mucochloric acid

: 2312-23-4
m-chlorophenylhydrazine hydrochloride

: 41931-11-7
4,5-dichloro-2-(3-chlorophenyl)-2H-pyridazin-3-one

Conditions

Conditions	Yield
In water at 90℃;	89%

: 21086-33-9
2-bromo-1-(4-methoxyphenyl)-1-propanone

: 2312-23-4
m-chlorophenylhydrazine hydrochloride

: 333-20-0
potassium thioacyanate

: 1-(3-chloro-phenylamino)-5-(4-methoxy-phenyl)-4-methyl-1H-imidazole-2-thiol

Conditions

Conditions	Yield
Stage #1: 2-bromo-1-(4-methoxyphenyl)-1-propanone; potassium thioacyanate With acetic acid for 0.5h; Stage #2: m-chlorophenylhydrazine hydrochloride With acetic acid	88%

...Expand

: 41711-23-3
N-(1,3-dioxopropan-2-yl)benzamide

: 2312-23-4
m-chlorophenylhydrazine hydrochloride

: 1233698-51-5
N-(1-(3-chlorophenyl)-1H-pyrazol-4-yl)benzamide

Conditions

Conditions	Yield
Stage #1: N-(1,3-dioxopropan-2-yl)benzamide; m-chlorophenylhydrazine hydrochloride With hydrogenchloride In ethanol; water for 0.166667h; Reflux; Stage #2: With ammonium hydroxide In ethanol; water pH=11;	88%

: 1332635-72-9
C15H14F3NO3

: 2312-23-4
m-chlorophenylhydrazine hydrochloride

: 3-(3-chlorophenylhydrazonotrifluoroethyl)-7-(N,N-diethylamino)coumarin

Conditions

Conditions	Yield
With toluene-4-sulfonic acid In chlorobenzene Reflux;	88%

3-Chlorophenylhydrazine hydrochloride Specification

The Hydrazine,(3-chlorophenyl)-, hydrochloride (1:1), with the CAS registry number 2312-23-4 and EINECS registry number 219-005-6, has the the systematic name and IUPAC name of (3-chlorophenyl)hydrazine hydrochloride (1:1). It is a kind of white to light yellow crystal powder, and belongs to the following product categories: Amines and Anilines; Aromatic Hydrazides, Hydrazines, Hydrazones and Oximes; Phenylhydrazine; Hydrazines; Nitrogen Compounds; Organic Building Blocks. And the molecular formula of the chemical is C₆H₇ClN₂^.HCl.

The characteristics of Hydrazine,(3-chlorophenyl)-, hydrochloride (1:1) are as followings: (1)ACD/LogP: 2.28; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): 2.18; (4)ACD/LogD (pH 7.4): 2.28; (5)ACD/BCF (pH 5.5): 25.11; (6)ACD/BCF (pH 7.4): 31.72; (7)ACD/KOC (pH 5.5): 326.86; (8)ACD/KOC (pH 7.4): 412.95; (9)#H bond acceptors: 2; (10)#H bond donors: 3; (11)#Freely Rotating Bonds: 2; (12)Polar Surface Area: 6.48 Å² ; (13)Flash Point: 114.7 °C; (14)Enthalpy of Vaporization: 50.4 kJ/mol; (15)Boiling Point: 266 °C at 760 mmHg; (16)Vapour Pressure: 0.00887 mmHg at 25°C.

Uses of Hydrazine,(3-chlorophenyl)-, hydrochloride (1:1): It can react with 1,1,3,3-tetraethoxy-propane to produce 1-(3-chlorophenyl)-1H-pyrazole. This reaction will need reagent ethanol. The reaction time is 0.5 hours with heating, and the yield is about 69%.

You should be cautious while dealing with this chemical. It is harmful by inhalation, in contact with skin and if swallowed. Therefore, you had better take the following instructions: Wear suitable gloves and eye/face protection, and if in case of contacting with eyes, rinse immediately with plenty of water and seek medical advice.

Addtionally, the following datas could be converted into the molecular structure:
(1)SMILES: Clc1cc(NN)ccc1.Cl
(2)InChI: InChI=1/C6H7ClN2.ClH/c7-5-2-1-3-6(4-5)9-8;/h1-4,9H,8H2;1H
(3)InChIKey: CRRIAWUJYMLJOE-UHFFFAOYAK

Product Name

3-Chlorophenylhydrazine hydrochloride

Synthetic route

3-Chlorophenylhydrazine hydrochloride Specification

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