3-Ethoxy-4-methoxybenzaldehyde supplier

Name
3-Ethoxy-4-methoxybenzaldehyde
EINECS 642-869-4
CAS No. 1131-52-8
Article Data28
CAS DataBase
Density 1.088 g/cm³
Solubility
Melting Point 51 °C
Formula C₁₀H₁₂O₃
Boiling Point 289.4 °C at 760 mmHg
Molecular Weight 180.203
Flash Point 119.6 °C
Transport Information
Appearance
Safety 23-24/25
Risk Codes
Molecular Structure
Hazard Symbols Xi
Synonyms Benzaldehyde, 3-ethoxy-4-methoxy-;
PSA 35.53000
LogP 1.90640

Synthetic route

: 621-59-0
isovanillin

: 74-96-4
ethyl bromide

: 1131-52-8
3-ethoxy-4-methoxybenzaldehyde

Conditions

Conditions	Yield
With tetrabutyl ammonium fluoride; sodium hydroxide In water at 25℃; for 4h; Reagent/catalyst;	96.1%

: 121-32-4
4-hydroxy-3-ethoxybenzaldehyde

: 75-57-0
tetramethlyammonium chloride

: 1131-52-8
3-ethoxy-4-methoxybenzaldehyde

Conditions

Conditions	Yield
With caesium carbonate In 1,2-dimethoxyethane at 145℃; for 1h; Microwave irradiation; Inert atmosphere; Sealed vessel;	96%
With potassium carbonate at 150 - 160℃; for 6h;	75%

: 621-59-0
isovanillin

: 64-67-5
diethyl sulfate

: 1131-52-8
3-ethoxy-4-methoxybenzaldehyde

Conditions

Conditions	Yield
With sodium hydroxide
With potassium hydroxide

: 92-42-2
4-methoxy-3-ethoxy-1-trans-propenyl-benzene

: 1131-52-8
3-ethoxy-4-methoxybenzaldehyde

Conditions

Conditions	Yield
With potassium dichromate; sulfuric acid at 50℃;
With dihydrogen peroxide; iron(II) sulfate

: 621-59-0
isovanillin

: 75-03-6
ethyl iodide

: 1131-52-8
3-ethoxy-4-methoxybenzaldehyde

Conditions

Conditions	Yield
With sodium hydroxide

: 121-32-4
4-hydroxy-3-ethoxybenzaldehyde

: 77-78-1
dimethyl sulfate

: 1131-52-8
3-ethoxy-4-methoxybenzaldehyde

Conditions

Conditions	Yield
With sodium hydroxide

: 121-32-4
4-hydroxy-3-ethoxybenzaldehyde

: 74-88-4
methyl iodide

: 1131-52-8
3-ethoxy-4-methoxybenzaldehyde

Conditions

Conditions	Yield
With ethanol
Stage #1: 4-hydroxy-3-ethoxybenzaldehyde With potassium hydroxide In methanol; water Stage #2: methyl iodide In methanol; water for 3h; Reflux;
With potassium carbonate In N,N-dimethyl-formamide at 0 - 5℃; for 2h; Solvent; Temperature;
Stage #1: 4-hydroxy-3-ethoxybenzaldehyde With sodium hydride In N,N-dimethyl-formamide at 0℃; Stage #2: methyl iodide at 20℃;

: 74-88-4
methyl iodide

potassium-salt of 4-hydroxy-3-ethoxy-benzaldehyde: potassium-salt of 4-hydroxy-3-ethoxy-benzaldehyde

: 1131-52-8
3-ethoxy-4-methoxybenzaldehyde

Conditions

Conditions	Yield
With ethanol

: 621-59-0
isovanillin

toluene-sulfonic acid-(4)-ethyl ester: toluene-sulfonic acid-(4)-ethyl ester

: 1131-52-8
3-ethoxy-4-methoxybenzaldehyde

Conditions

Conditions	Yield
With potassium hydroxide

: 92-42-2
4-methoxy-3-ethoxy-1-trans-propenyl-benzene

: 7722-84-1
dihydrogen peroxide

FeSO2: FeSO2

: 1131-52-8
3-ethoxy-4-methoxybenzaldehyde

...Expand

: 7664-93-9
sulfuric acid

: 92-42-2
4-methoxy-3-ethoxy-1-trans-propenyl-benzene

K2cr2O7: K2cr2O7

: 1131-52-8
3-ethoxy-4-methoxybenzaldehyde

Conditions

Conditions	Yield
at 50 - 53℃;

...Expand

: 519-05-1
opianic acid

: 1131-52-8
3-ethoxy-4-methoxybenzaldehyde

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: water / 200 °C 2: aqueous methanol. KOH View Scheme

: 3-ethoxy-α,α,4-trimethoxytoluene

: 1131-52-8
3-ethoxy-4-methoxybenzaldehyde

Conditions

Conditions	Yield
With water Acidic conditions;

: 121-32-4
4-hydroxy-3-ethoxybenzaldehyde

: 67-68-5
dimethyl sulfoxide

: 1131-52-8
3-ethoxy-4-methoxybenzaldehyde

Conditions

Conditions	Yield
With oxygen; palladium diacetate; sodium hydroxide at 100℃; under 1500.15 Torr; for 6h; Reagent/catalyst; Time; Large scale;

: 1809-20-7
diisopropyl hydrogenphosphonate

: 1131-52-8
3-ethoxy-4-methoxybenzaldehyde

: 181178-76-7
[(3-Ethoxy-4-methoxy-phenyl)-hydroxy-methyl]-phosphonic acid diisopropyl ester

Conditions

Conditions	Yield
With aluminum oxide for 48h; Ambient temperature;	100%

: 1131-52-8
3-ethoxy-4-methoxybenzaldehyde

1-Bromo-3-ethoxy-4-methoxybenzene: 1-Bromo-3-ethoxy-4-methoxybenzene

: 851958-79-7
bis-(3-ethoxy-4-methoxy-phenyl)-methanol

Conditions

Conditions	Yield
With n-butyllithium In tetrahydrofuran; water	100%

: 909854-81-5
2-(piperidin-4-ylamino)-benzooxazole-7-carboxylic acid

: 1131-52-8
3-ethoxy-4-methoxybenzaldehyde

: 2-[1-(3-ethoxy-4-methoxy-benzyl)-piperidin-4-ylamino]-benzooxazole-7-carboxylic acid

Conditions

Conditions	Yield
Stage #1: 2-(piperidin-4-ylamino)-benzooxazole-7-carboxylic acid; 3-ethoxy-4-methoxybenzaldehyde With acetic acid; N-ethyl-N,N-diisopropylamine In ethanol at 50℃; for 1.5h; Stage #2: With sodium cyanoborohydride In ethanol at 50℃;	99%

: 1131-52-8
3-ethoxy-4-methoxybenzaldehyde

: 56517-30-7
2-bromo-5-ethoxy-4-methoxybenzaldehyde

Conditions

Conditions	Yield
Stage #1: 3-ethoxy-4-methoxybenzaldehyde In toluene at 65 - 70℃; for 0.5h; Large scale; Stage #2: With bromine In methanol; water at 15 - 45℃; for 3.5h; Autoclave; Large scale;	97.8%
With bromine; acetic acid

: 1131-52-8
3-ethoxy-4-methoxybenzaldehyde

: 621-59-0
isovanillin

Conditions

Conditions	Yield
With water at 65℃; for 3h; Reagent/catalyst; Time; Large scale;	97.2%

: 558-13-4
carbon tetrabromide

: 1131-52-8
3-ethoxy-4-methoxybenzaldehyde

: 881919-85-3
1,1-dibromo-2-(3-ethoxy-4-methoxyphenyl)ethene

Conditions

Conditions	Yield
With triphenylphosphine In dichloromethane for 0.666667h; cooling;	96%
With triphenylphosphine In dichloromethane at 0℃; for 0.166667 - 0.25h; Corey-Fuchs reaction;
With triphenylphosphine In dichloromethane at 0℃; for 0.166667 - 0.25h;

: 1131-52-8
3-ethoxy-4-methoxybenzaldehyde

: 60758-86-3
3-ethoxy-4-methoxybenzenecarbonitrile

Conditions

Conditions	Yield
With hydroxylamine hydrochloride In acetonitrile at 5 - 84℃; Product distribution / selectivity;	95.5%
Multi-step reaction with 2 steps 1: hydroxylamine hydrochloride, sodium hydroxide / aq. ethanol; H2O / Ambient temperature 2: acetic anhydride / Heating View Scheme
With hydroxylamine hydrochloride In acetonitrile Reflux;
With hydroxylamine hydrochloride In formic acid at 85 - 90℃; Temperature;	600 g

: 43100-38-5
4-tert-butylbenzoic acid hydrazide

: 1131-52-8
3-ethoxy-4-methoxybenzaldehyde

: 4-tert-butyl-N-[(3-ethoxy-4-methoxyphenyl)methylidene]benzhydrazide

Conditions

Conditions	Yield
In ethanol for 3h; Reflux;	95%

: 1131-52-8
3-ethoxy-4-methoxybenzaldehyde

: 2-(2,4,5-trifluorophenyl)acetohydrazide

: N'-(3-ethoxy,4-methoxybenzylidene)-2-(2,4,5-trifluorophenyl)acetohydrazide

Conditions

Conditions	Yield
With perchloric acid In ethanol at 20℃; for 0.583333h;	95%

: 1131-52-8
3-ethoxy-4-methoxybenzaldehyde

: 28144-70-9
anthranilic acid amide

: 101575-17-1
2,3-dihydro-2-(3-ethoxy-4-methoxyphenyl)quinazolin-4(1H)-one

Conditions

Conditions	Yield
With thionyl chloride In ethanol at 20℃; for 0.583333h;	94%

: 578-66-5
8-amino quinoline

: 1131-52-8
3-ethoxy-4-methoxybenzaldehyde

: 1223077-67-5
C28H26N4O2

Conditions

Conditions	Yield
In methanol Reflux;	93%

: 1131-52-8
3-ethoxy-4-methoxybenzaldehyde

: 92-67-1
4-Aminobiphenyl

: C22H21NO2

Conditions

Conditions	Yield
In methanol for 0.5h; Heating;	92%

: 143-27-1
hexadecylamine

: 1131-52-8
3-ethoxy-4-methoxybenzaldehyde

: 1215097-91-8
(E)-N-(3-ethoxy-4-methoxybenzylidene)hexadecan-1-amine

Conditions

Conditions	Yield
In methanol for 0.333333h; Reflux;	92%

: 223650-44-0
N-(4-methylpentan-2-yl)hydroxylamine

: 1131-52-8
3-ethoxy-4-methoxybenzaldehyde

: α-(3-ethoxy-4-methoxyphenyl)-N-(4-methylpent-2-yl)nitrone

Conditions

Conditions	Yield
With p-toluenesulfonic acid monohydrate In ethyl acetate; benzene	91.8%

: 67-71-0
dimethylsulfone

: 1131-52-8
3-ethoxy-4-methoxybenzaldehyde

: 253168-94-4
2-(3-ethoxy-4-methoxyphenyl)-1-(methylsulfonyl)eth-2-ylamine

Conditions

Conditions	Yield
Stage #1: dimethylsulfone With n-butyllithium In tetrahydrofuran; hexane at -20 - 0℃; for 1h; Stage #2: 3-ethoxy-4-methoxybenzaldehyde With lithium hexamethyldisilazane In tetrahydrofuran; hexane at -40 - -30℃; for 1h; Stage #3: With boron trifluoride diethyl etherate In tetrahydrofuran; hexane at -30 - 0℃; Temperature;	91.5%
Stage #1: 3-ethoxy-4-methoxybenzaldehyde With lithium hexamethyldisilazane at -78℃; Stage #2: dimethylsulfone With n-butyllithium; boron trifluoride diethyl etherate at -78℃;	41%

: 57-55-6
propylene glycol

: 1131-52-8
3-ethoxy-4-methoxybenzaldehyde

: 1412860-31-1
C13H18O4

Conditions

Conditions	Yield
With FIBAN K-1 cation exchanger In benzene Dean-Stark; Reflux;	90%

: 4248-19-5
tert-butyl carbamate

: 1131-52-8
3-ethoxy-4-methoxybenzaldehyde

: 824-79-3
sodium 4-methylbenzenesulfinate

: tert-butyl N-[(3-ethoxy-4-methoxyphenyl)-p-tolylsulfonylmethyl]carbamate

Conditions

Conditions	Yield
With formic acid In water at 25 - 30℃; for 48h;	90%
With formic acid In water; butan-1-ol at 20 - 25℃; for 48h; Inert atmosphere;	300 g

...Expand

: 1131-52-8
3-ethoxy-4-methoxybenzaldehyde

: 1501-84-4, 33122-80-4, 33122-81-5, 33298-76-9
rimantadine hydrochloride

: (E)-1-(1-adamantyl)-N-(3-ethoxy-4-methoxybenzylidene)ethanamine

Conditions

Conditions	Yield
With potassium hydroxide In ethanol pH=7; Heating;	89%

: 1131-52-8
3-ethoxy-4-methoxybenzaldehyde

: 139-59-3
4-phenoxyanilin

: 1211396-46-1
N-[(E)-3-ethoxy-4-methoxybenzylidene]-4-phenoxyaniline

Conditions

Conditions	Yield
In methanol for 0.25h; Reflux;	89%

: 1131-52-8
3-ethoxy-4-methoxybenzaldehyde

: 156-43-4
4-Ethoxyaniline

: 1417182-59-2
C18H21NO3

Conditions

Conditions	Yield
In methanol Reflux;	89%

: 1131-52-8
3-ethoxy-4-methoxybenzaldehyde

: 126-81-8
dimedone

: 109-77-3
malononitrile

: 309724-39-8
2-amino-4-(3-ethoxy-4-methoxyphenyl)-7,7-dimethyl-5-oxo-5,6,7,8-tetrahydro-4H-chromene-3-carbonitrile

Conditions

Conditions	Yield
With piperdinium acetate In neat (no solvent) at 20℃; Green chemistry;	89%

...Expand

: 1131-52-8
3-ethoxy-4-methoxybenzaldehyde

: 504-63-2
trimethyleneglycol

: 1427307-71-8
2-(4-methoxy-3-ethoxyphenyl)-1,3-dioxane

Conditions

Conditions	Yield
With sulfo cation exchanger FIBAN K-1 In benzene Heating; Dean-Stark;	86%

: 1131-52-8
3-ethoxy-4-methoxybenzaldehyde

: 90-41-5
2-phenylaniline

: 1198406-61-9
C22H21NO2

Conditions

Conditions	Yield
In methanol Heating;	85%

: 1131-52-8
3-ethoxy-4-methoxybenzaldehyde

: 255065-87-3
2‐(2,4,5‐triphenyl‐1H‐imidazol‐1‐yl)acetohydrazide

: 1263432-10-5
2-(2,4,5-triphenyl-1H-imidazol-1-yl)-N'-(3-ethoxy-4-methoxybenzylidene)acetohydrazide

Conditions

Conditions	Yield
With acetic acid In dimethyl sulfoxide for 0.05h; Microwave irradiation;	85%

: 1131-52-8
3-ethoxy-4-methoxybenzaldehyde

: 96-24-2
3-monochloro-1,2-propanediol

: 1412860-57-1
C13H17ClO4

Conditions

Conditions	Yield
With FIBAN K-1 cation exchanger In benzene Dean-Stark; Reflux;	85%

: 75-52-5
nitromethane

: 1131-52-8
3-ethoxy-4-methoxybenzaldehyde

: (E)-1-ethoxy-2-methoxy-4-(2-nitrovinyl)benzene

Conditions

Conditions	Yield
With ammonium acetate for 16h; Henry Nitro Aldol Condensation; Reflux;	85%

: 1131-52-8
3-ethoxy-4-methoxybenzaldehyde

: 108-45-2
m-phenylenediamine

: C26H28N2O4

Conditions

Conditions	Yield
In methanol Reflux;	84%

3-Ethoxy-4-methoxybenzaldehyde Specification

The 3-Ethoxy-4-methoxybenzaldehyde is an organic compound with the formula C₁₀H₁₂O₃. The IUPAC name of this chemical is 3-ethoxy-4-methoxybenzaldehyde. With the CAS registry number 1131-52-8, it is also named as Benzaldehyde, 3-ethoxy-4-methoxy-. The product's category is Aromatic Aldehydes & Derivatives (substituted). Besides, it should be stored in a closed cool and dry place.

Physical properties about 3-Ethoxy-4-methoxybenzaldehyde are: (1)ACD/LogP: 2.14; (2)#H bond acceptors: 3; (3)#Freely Rotating Bonds: 4; (4)Polar Surface Area: 35.53 Å²; (5)Index of Refraction: 1.528; (6)Molar Refractivity: 50.99 cm³; (7)Molar Volume: 165.6 cm³; (8)Polarizability: 20.21×10^-24cm³; (9)Surface Tension: 35.9 dyne/cm; (10)Density: 1.088 g/cm³; (11)Flash Point: 119.6 °C; (12)Enthalpy of Vaporization: 52.87 kJ/mol; (13)Boiling Point: 289.4 °C at 760 mmHg; (14)Vapour Pressure: 0.0022 mmHg at 25°C.

You can still convert the following datas into molecular structure:
(1)SMILES: O=Cc1cc(OCC)c(OC)cc1
(2)InChI: InChI=1/C10H12O3/c1-3-13-10-6-8(7-11)4-5-9(10)12-2/h4-7H,3H2,1-2H3
(3)InChIKey: VAMZHXWLGRQSJS-UHFFFAOYAM
(4)Std. InChI: InChI=1S/C10H12O3/c1-3-13-10-6-8(7-11)4-5-9(10)12-2/h4-7H,3H2,1-2H3
(5)Std. InChIKey: VAMZHXWLGRQSJS-UHFFFAOYSA-N

Product Name

3-Ethoxy-4-methoxybenzaldehyde

Synthetic route

3-Ethoxy-4-methoxybenzaldehyde Specification

Related Products

Hot Products