3-Fluorophenylboronic acid supplier

Name
3-Fluorophenylboronic acid
EINECS 476-720-8
CAS No. 768-35-4
Article Data18
CAS DataBase
Density 1.24 g/cm³
Solubility 27.1g/L at 20℃
Melting Point 214-218 °C(lit.)
Formula C₆H₆BFO₂
Boiling Point 271.4 °C at 760 mmHg
Molecular Weight 139.922
Flash Point 117.9 °C
Transport Information
Appearance white to light yellow crystal powder
Safety 22-24/25-37/39-26-36
Risk Codes 36/37/38-22
Molecular Structure
Hazard Symbols Xn, Xi
Synonyms (3-fluorophenyl)boronic acid
PSA 40.46000
LogP -0.49450

Synthetic route

: 625-98-9
3-chlorofluorobenzene

: 768-35-4
3-fluorophenylboronic acid

Conditions

Conditions	Yield
	95%

: 1073-06-9
3-fluorobromobenzene

: 768-35-4
3-fluorophenylboronic acid

Conditions

Conditions	Yield
Stage #1: 3-fluorobromobenzene With diisobutylaluminium hydride; magnesium; lithium chloride In tetrahydrofuran; toluene at 20℃; for 15h; Inert atmosphere; Stage #2: With Trimethyl borate In tetrahydrofuran; toluene at 0℃; Inert atmosphere; Stage #3: With hydrogenchloride; water In tetrahydrofuran; toluene at 0℃; Inert atmosphere;	83%
Stage #1: 3-fluorobromobenzene With n-butyllithium In tetrahydrofuran; toluene at -78℃; for 1.5h; Inert atmosphere; Stage #2: With Trimethyl borate In tetrahydrofuran; toluene at -78 - 20℃; for 1h; Inert atmosphere;	70%
Stage #1: 3-fluorobromobenzene With magnesium In diethyl ether Grignard reaction; Stage #2: With Trimethyl borate In diethyl ether at 3℃; for 3h; boronation; Stage #3: With hydrogenchloride In diethyl ether Hydrolysis;

: 13675-18-8
tetrahydroxydiboron

: 1073-06-9
3-fluorobromobenzene

: 768-35-4
3-fluorophenylboronic acid

Conditions

Conditions	Yield
In methanol at 15℃; for 3h; Microwave irradiation;	83%
With bis(di-tert-butyl(4-dimethylaminophenyl)phosphine)dichloropalladium(II); N-ethyl-N,N-diisopropylamine In 2-methyltetrahydrofuran; methanol at 50 - 55℃; Inert atmosphere;	85 %Chromat.

: 5419-55-6
Triisopropyl borate

1-halo-3-fluorobenzene: 1-halo-3-fluorobenzene

: 768-35-4
3-fluorophenylboronic acid

Conditions

Conditions	Yield
With hydrogenchloride; n-butyllithium In tetrahydrofuran; hexane; water; toluene at -78 - 20℃; Inert atmosphere; Schlenk technique;	80%

: 372-19-0
meta-fluoroaniline

: 13675-18-8
tetrahydroxydiboron

: 768-35-4
3-fluorophenylboronic acid

Conditions

Conditions	Yield
Stage #1: meta-fluoroaniline With hydrogenchloride; sodium nitrite In water at 0℃; for 0.25h; Stage #2: tetrahydroxydiboron With sodium acetate In water at 20℃; for 0.333333h;	67%

: 5419-55-6
Triisopropyl borate

: 1073-06-9
3-fluorobromobenzene

: 768-35-4
3-fluorophenylboronic acid

Conditions

Conditions	Yield
Stage #1: 3-fluorobromobenzene With n-butyllithium In tetrahydrofuran; hexane at -78℃; for 0.5h; Inert atmosphere; Stage #2: Triisopropyl borate In tetrahydrofuran; hexane at -78 - 20℃; for 0.833333h; Inert atmosphere;	65%

: 13675-18-8
tetrahydroxydiboron

: 1996-38-9
3-fluorobenzenediazonium tetrafluoroborate

: 768-35-4
3-fluorophenylboronic acid

Conditions

Conditions	Yield
In N,N-dimethyl-formamide at 20℃; for 0.25h;	59%

: 688-74-4
boric acid tributyl ester

3-fluoro-phenyl magnesium bromide: 3-fluoro-phenyl magnesium bromide

: 768-35-4
3-fluorophenylboronic acid

Conditions

Conditions	Yield
With diethyl ether und anschliessenden Hydrolyse;

: 121-43-7
Trimethyl borate

: 1073-06-9
3-fluorobromobenzene

: 768-35-4
3-fluorophenylboronic acid

Conditions

Conditions	Yield
With n-butyllithium In tetrahydrofuran N2; BuLi dropping into org. compd. soln. at -78°C, mixt. keeping 3 h, B-compd. soln. addn. dropwise at -78°C, mixt. allowing to warm to room temp. overnight , stirring 1 h with 10% HCl, extn. (Et2O); org. extracts washing (water), drying, solvent vac. removal;
With n-butyllithium In tetrahydrofuran at -78℃; for 1h; Inert atmosphere;

: 688-74-4
boric acid tributyl ester

: 17318-03-5
bromo(3-fluorophenyl)magnesium

: 768-35-4
3-fluorophenylboronic acid

: C8H10BFO2

: 768-35-4
3-fluorophenylboronic acid

Conditions

Conditions	Yield
With hydrogenchloride In water at 20℃; Inert atmosphere; Schlenk technique;

: 372-19-0
meta-fluoroaniline

: 768-35-4
3-fluorophenylboronic acid

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1.1: water / 0.03 h / 20 °C 1.2: 0.25 h / 0 °C 2.1: N,N-dimethyl-formamide / 0.25 h / 20 °C View Scheme

: 5419-55-6
Triisopropyl borate

: C11H13FO2Zn

: 768-35-4
3-fluorophenylboronic acid

Conditions

Conditions	Yield
With copper(I) iodide-lithium chloride In tetrahydrofuran at 20℃; Schlenk technique; Inert atmosphere;

: 768-35-4
3-fluorophenylboronic acid

: 110526-62-0
2',3',5'-tris-O-(tert-butyldimethylsilyl)-2'-deoxyinosine

: 864847-17-6
N1-(3-fluorophenyl)-2',3',5'-tris-(O-tert-butyldimethylsilyl)-inosine

Conditions

Conditions	Yield
With pyridine; pyridine N-oxide; oxygen; 4 A molecular sieve; copper diacetate In dichloromethane at 20℃; under 760 Torr; for 24h;	100%
With pyridine; pyridine N-oxide; oxygen; copper diacetate In dichloromethane at 20℃; for 24h; 4Å molecular sieves;	67%

: 768-35-4
3-fluorophenylboronic acid

: 126-30-7
2,2-Dimethyl-1,3-propanediol

: 2-(3-fluorophenyl)-5,5-dimethyl-1,3,2-dioxaborinane

Conditions

Conditions	Yield
With magnesium sulfate In diethyl ether at 20℃; for 20h;	100%
In toluene at 20℃; for 2h;	55%
In benzene Reflux;
In toluene at 20℃; for 12h;
With magnesium sulfate In dichloromethane at 20℃; Inert atmosphere;

: 25026-64-6
3-chloro-5-fluoro-benzoic acid

: 768-35-4
3-fluorophenylboronic acid

: 1214352-53-0
3-fluoro-5-(3-fluorophenyl)benzoic acid

Conditions

Conditions	Yield
Stage #1: 3-chloro-5-fluoro-benzoic acid; 3-fluorophenylboronic acid With sodium 2'‐(dicyclohexylphosphaneyl)‐2,6‐diisopropyl‐[1,1'‐biphenyl]‐3‐sulfonate; potassium carbonate; palladium diacetate In water at 20℃; for 96h; Inert atmosphere; Stage #2: With hydrogenchloride In water pH=4;	100%

: 768-35-4
3-fluorophenylboronic acid

: 202982-72-7
4-chloro-3-iodophenol

: 1354787-35-1
6-chloro-3'-fluorobiphenyl-3-ol

Conditions

Conditions	Yield
With caesium carbonate; tetrakis(triphenylphosphine) palladium(0) In 1,4-dioxane; water at 70℃; for 5h; Suzuki Coupling; Inert atmosphere;	100%

: 1263795-03-4
tert-butyl 8-bromo-2,3-dihydrothieno[2,3-f][1,4]oxazepine-4(5H)-carboxylate

: 768-35-4
3-fluorophenylboronic acid

: 1263795-09-0
tert-butyl 8-(3-fluorophenyl)-2,3-dihydrothieno[2,3-f][1,4]oxazepine-4(5H)-carboxylate

Conditions

Conditions	Yield
With sodium carbonate; tetrakis(triphenylphosphine) palladium(0) In ethanol; water; toluene at 100℃; for 12h; Inert atmosphere;	100%

: 5613-27-4
5-bromo-2,3-dimethyl-benzoic acid

: 768-35-4
3-fluorophenylboronic acid

: 1427407-47-3
5-bromo-2,3-dimethyl-benzoic acid

Conditions

Conditions	Yield
With tetrakis(triphenylphosphine) palladium(0); sodium carbonate In water; N,N-dimethyl-formamide at 95℃; Inert atmosphere;	100%

: 14804-38-7
5-bromo-2-methoxy-1,3-dimethylbenzene

: 768-35-4
3-fluorophenylboronic acid

: C15H15FO

Conditions

Conditions	Yield
With tetrakis(triphenylphosphine) palladium(0); sodium carbonate In ethanol; water; toluene at 70℃; for 18h; Inert atmosphere;	100%
With potassium phosphate; C43H47Cl3N4O2Pd In N,N-dimethyl-formamide at 80℃; for 22h; Reagent/catalyst; Suzuki Coupling; Inert atmosphere; Schlenk technique;

: 768-35-4
3-fluorophenylboronic acid

: tert-butyl ((1S,4s)-4-((6-chloro-2-(((R)-1-methoxypropan-2-yl)amino)pyrido[3,2-d]pyrimidin-4-yl)amino)cyclohexyl)carbamate

: tert-butyl ((1S,4s)-4-((6-(3-fluorophenyl)-2-(((R)-1-methoxypropan-2-yl)amino)pyrido[3,2-d]pyrimidin-4-yl)amino)cyclohexyl)carbamate

Conditions

Conditions	Yield
With potassium phosphate; tetrakis(triphenylphosphine) palladium(0) In 1,4-dioxane; water at 130℃; for 0.5h; Microwave irradiation;	100%

: 1355483-74-7
2-(4-bromophenyl)-5,6,7-trimethoxy-4H-chromen-4-one

: 768-35-4
3-fluorophenylboronic acid

: C24H19FO5

Conditions

Conditions	Yield
With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium carbonate In 1,4-dioxane; water at 120℃; Inert atmosphere;	100%

: 1003-98-1
2-bromo-4-fluoroaniline

: 768-35-4
3-fluorophenylboronic acid

: 3',5-difluoro-[1,1'-biphenyl]-2-amine

Conditions

Conditions	Yield
With palladium diacetate; diisopropylamine In water at 100℃; for 0.5h; Suzuki-Miyaura Coupling;	100%
With bis-triphenylphosphine-palladium(II) chloride; potassium carbonate In water; N,N-dimethyl-formamide at 80℃; for 24h; Inert atmosphere;

: 1279123-63-5
potassium hydrogenfluoride

: 768-35-4
3-fluorophenylboronic acid

: potassium 3-fluorophenyl trifluoroborate

Conditions

Conditions	Yield
In methanol; water for 0.5h;	100%
In diethyl ether; water at 20℃; for 3h;	99%

: 1312684-68-6
7-{[methoxy(methyl)amino]carbonyl}quinolin-8-yl trifluoromethanesulfonate

: 768-35-4
3-fluorophenylboronic acid

: 8-(3-fluorophenyl)-N-methoxy-N-methylquinoline-7-carboxamide

Conditions

Conditions	Yield
With tetrakis(triphenylphosphine) palladium(0); sodium carbonate In 1,4-dioxane; water at 100℃; for 3h; Inert atmosphere;	100%

: 5-bromo-3-isopropyl(trans-4-methylcyclohexylcarbonyl)amino-thiophene-2-carboxylic acid methyl ester

: 768-35-4
3-fluorophenylboronic acid

: 5-(3-fluoro-phenyl)-3-[isopropyl-(4-methyl-cyclohexanecarbonyl)-amino]-thiphene-2-carboxylic acid methyl ester

Conditions

Conditions	Yield
With sodium carbonate; tetrakis(triphenylphosphine) palladium(0) In methanol; water; toluene at 70℃; for 18h; Heating / reflux;	99%

: 5-acetyl-4-[(3,5-dichlorophenyl)amino]-2-ethyl-6-phenylpyridazin-3(2H)-one

: 768-35-4
3-fluorophenylboronic acid

: 5-acetyl-4-[N-(3,5-dichlorophenyl)-N-(3-fluorophenyl)amino]-2-ethyl-6-phenylpyridazin-3(2H)-one

Conditions

Conditions	Yield
With oxygen; copper diacetate; triethylamine In dichloromethane at 20℃; for 72h; Molecular sieve;	99%

: 768-35-4
3-fluorophenylboronic acid

: 64794-30-5
N-(3-tert-butylphenyl)-2-chloronicotinamide

: 1231732-11-8
N-(3-tert-butylphenyl)-2-(3-fluorophenyl)nicotinamide

Conditions

Conditions	Yield
With potassium carbonate; tetrakis(triphenylphosphine) palladium(0) In water; toluene at 90℃; for 3h; Inert atmosphere;	99%

: 1312686-23-9
6-acetyl-4-chloro-2-cyano-3-methylphenyl trifluoromethanesulfonate

: 768-35-4
3-fluorophenylboronic acid

: 1312686-24-0
6-acetyl-4-chloro-3'-fluoro-3-methylbiphenyl-2-carbonitrile

Conditions

Conditions	Yield
With sodium hydrogencarbonate; tetrakis(triphenylphosphine) palladium(0) In water; toluene at 80℃; for 2h;	99%
With sodium hydrogencarbonate; tetrakis(triphenylphosphine) palladium(0) In water; toluene at 80℃; for 2h; Inert atmosphere;	99%
With tetrakis(triphenylphosphine) palladium(0); sodium hydrogencarbonate In water; toluene at 80℃; for 2h; Inert atmosphere;	98.5%

: 4-bromo-13,15-dimethyl-14-oxa-10,15-diazatetracyclo[8.7.0.0(2,7).0(12,16)]heptadeca-2,4,6-trien-11-one

: 768-35-4
3-fluorophenylboronic acid

: C22H23FN2O2

Conditions

Conditions	Yield
With bis(tri-t-butylphosphine)palladium(0); caesium carbonate In 1,4-dioxane at 100℃; Suzuki coupling;	99%

: 930-88-1
N-methylmaleimide

: 768-35-4
3-fluorophenylboronic acid

: 1314427-25-2
(R)-3-(3-fluorophenyl)-1-methyl-2,5-pyrrolidinedione

Conditions

Conditions	Yield
With [Rh(OH)(cod)]2; (R)-MeO-F12-BIPHEP In diethyl ether; water at 0℃; for 36h; Schlenk technique; Inert atmosphere;	99%

: 1611473-65-4
8-bromo-N-(2-(methylsulfonyl)ethyl)-1,6-naphthyridine-2-carboxamide

: 768-35-4
3-fluorophenylboronic acid

: 1611473-13-2
8-(3-fluorophenyl)-N-(2-(methylsulfonyl)ethyl)-1,6-naphthyridine-2-carboxamide

Conditions

Conditions	Yield
With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; caesium carbonate In 1,4-dioxane; water at 80℃; for 3h;	99%

: 3-amino-N-(6-chloropyridin-3-yl)-4-(trifluoromethoxy)benzamide

: 768-35-4
3-fluorophenylboronic acid

: 3-amino-N-[6-(3-fluorophenyl)pyridin-3-yl]-4-(trifluoromethoxy)benzamide

Conditions

Conditions	Yield
With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; potassium carbonate In 1,2-dimethoxyethane; water at 90℃; Inert atmosphere; Sealed tube;	99%

: 768-35-4
3-fluorophenylboronic acid

: 54450-20-3
5-bromo-3(2H)-benzofuranone

: 5-(3-fluorophenyl)benzofuran-3(2H)-one

Conditions

Conditions	Yield
With tetrakis(triphenylphosphine) palladium(0); caesium carbonate In toluene at 80℃; Schlenk technique; Inert atmosphere; Sealed tube;	99%

: 2-methylbenzyl carbamate

: 768-35-4
3-fluorophenylboronic acid

: C14H13F

Conditions

Conditions	Yield
With NHC-Pd(II)-Im; lithium tert-butoxide In water at 80℃; for 12h; Suzuki-Miyaura Coupling; Inert atmosphere; Schlenk technique; Green chemistry;	99%

: 768-35-4
3-fluorophenylboronic acid

: 84640-24-4
4-methoxybenzyl N,N-dimethylcarbamate

: 1-fluoro-3-(4-methoxybenzyl)benzene

Conditions

Conditions	Yield
With NHC-Pd(II)-Im; lithium tert-butoxide In water at 80℃; for 12h; Suzuki-Miyaura Coupling; Inert atmosphere; Schlenk technique; Green chemistry;	99%

: 16605-27-9
3-methylbenzyl N,N-dimethylcarbamate

: 768-35-4
3-fluorophenylboronic acid

: C14H13F

Conditions

Conditions	Yield
With NHC-Pd(II)-Im; lithium tert-butoxide In water at 80℃; for 12h; Suzuki-Miyaura Coupling; Inert atmosphere; Schlenk technique; Green chemistry;	99%

: 89488-29-9
2-bromo-4-methoxypyridine

: 768-35-4
3-fluorophenylboronic acid

: 2-(3-fluorophenyl)-4-methoxypyridine

Conditions

Conditions	Yield
With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium carbonate In 1,4-dioxane; water at 85℃; Inert atmosphere;	99%

: 768-35-4
3-fluorophenylboronic acid

: ethyl 4-bromo-1-(4-(3,4-dichlorophenyl)-5-(isopropylthio)thiazol-2-yl)-3-isopropyl-1H-pyrazole-5-carboxylate

: ethyl 1-(4-(3,4-dichlorophenyl)-5-(isopropylthio)thiazol-2-yl)-4-(3-fluorophenyl)-3-isopropyl-1H-pyrazole-5-carboxylate

Conditions

Conditions	Yield
With tetrakis(triphenylphosphine) palladium(0); sodium carbonate In 1,4-dioxane; water at 85℃; for 16h; Inert atmosphere; Sealed tube;	99%
With tetrakis(triphenylphosphine) palladium(0); sodium carbonate In 1,4-dioxane; water at 20 - 85℃; for 16h; Inert atmosphere; Sealed tube;	99%

: 768-35-4
3-fluorophenylboronic acid

: 717-41-9
2-benzyl-1,2,6-thiadiazine 1,1-dioxide

: (S)-6-benzyl-3-(3-fluorophenyl)-3,6-dihydro-2H-1,2,6-thiadiazine 1,1-dioxide

Conditions

Conditions	Yield
Stage #1: 3-fluorophenylboronic acid; 2-benzyl-1,2,6-thiadiazine 1,1-dioxide With chlorobis(cyclooctene)rhodium(I) dimer; C18H23NOS In toluene at 20℃; for 0.5h; Inert atmosphere; Stage #2: With potassium hydroxide In water; toluene at 60℃; Inert atmosphere; enantioselective reaction;	99%

: 768-35-4
3-fluorophenylboronic acid

: 144511-93-3
2-chloro-N-phenylquinazolin-4-amine

: 1304764-81-5
4-anilino-2-(3-fluorophenyl)quinazoline

Conditions

Conditions	Yield
With C34H48Cl2N4Pd; potassium hydroxide In ethanol at 60℃; for 36h; Inert atmosphere;	99%
With NHC-Pd(II)-Im; potassium hydroxide In ethanol at 20℃; for 24h; Suzuki-Miyaura Coupling; Schlenk technique;	98%

: 768-35-4
3-fluorophenylboronic acid

: C19H17NO3

: C25H22FNO3

Conditions

Conditions	Yield
With nickel(II) acetate tetrahydrate; (S)-4-tert-butyl-2-[2-(diphenylphosphino)phenyl]-4,5-dihydro-1,3-oxazol In 2,2,2-trifluoroethanol at 80℃; for 24h; enantioselective reaction;	99%

: 5325-66-6, 20890-12-4, 72491-18-0
1-phenyl-3-(2-pyridyl)propen-1-one

: 768-35-4
3-fluorophenylboronic acid

: (S)-3-(3-fluorophenyl)-1-phenyl-3-(pyridin-2-yl)propan-1-one

Conditions

Conditions	Yield
With (R)-(+)-(4,4'-bi-1,3-benzodioxole)-5,5'-diylbis(di(3,5-dimethylphenyl)phosphine); di-μ-chloro-bis[bis(cyclo-octene)rhodium]; potassium hydroxide In tetrahydrofuran; water at 80℃; for 12h; Inert atmosphere; Schlenk technique; enantioselective reaction;	99%

3-Fluorophenylboronic acid Chemical Properties

Molecular structure of 3-Fluorophenylboronic acid (CAS NO.768-35-4) is:

Product Name: 3-Fluorophenylboronic acid
CAS Registry Number: 768-35-4
IUPAC Name: (3-Fluorophenyl)boronic acid
Molecular Weight: 139.920043 [g/mol]
Molecular Formula: C₆H₆BFO₂
H-Bond Donor: 2
H-Bond Acceptor: 3
Melting Point: 214-218 °C(lit.)
storage temp. 0-6 °C
Surface Tension: 38.6 dyne/cm
Density: 1.24 g/cm³
Flash Point: 117.9 °C
Enthalpy of Vaporization: 53.83 kJ/mol
Boiling Point: 271.4 °C at 760 mmHg
Vapour Pressure: 0.00318 mmHg at 25°C
Product Categories: blocks; BoronicAcids; FluoroCompounds; Boronic Acid series; Fluoro-Aromatics; Boron, Nitrile, Thio,& TM-Cpds; Substituted Boronic Acids; Boronic Acids & Esters; Phenyls & Phenyl-Het; Fluorobenzene; Heterocyclic Compounds; Boronic Acid; Aryl; Fluorinated; Organoborons; B (Classes of Boron Compounds); Boronic Acids; Chiral chemicals; Boronic Acids & Esters; Phenyls & Phenyl-Het

3-Fluorophenylboronic acid Uses

3-Fluorophenylboronic acid (CAS NO.768-35-4) is used as intermediates of Liquid Crystals.

3-Fluorophenylboronic acid Safety Profile

Safty information about 3-Fluorophenylboronic acid (CAS NO.768-35-4) is:
Hazard Codes: Harmful Xn,Xi
Risk Statements: 36/37/38-22
R36/37/38:Irritating to eyes, respiratory system and skin.
R22:Harmful if swallowed.
Safety Statements: 22-24/25-37/39-26-36
S22:Do not breathe dust.
S24/25:Avoid contact with skin and eyes.
S37/39:Wear suitable gloves and eye/face protection.
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36:Wear suitable protective clothing.
WGK Germany: 3
Hazard Note: Irritant
HazardClass: IRRITANT

3-Fluorophenylboronic acid Specification

3-Fluorophenylboronic acid , its cas register number is 768-35-4. It also can be called 3-Fluorobenzeneboronic acid . It is a white to light yellow crystal powder.

Product Name

3-Fluorophenylboronic acid

Synthetic route

3-Fluorophenylboronic acid Chemical Properties

3-Fluorophenylboronic acid Uses

3-Fluorophenylboronic acid Safety Profile

3-Fluorophenylboronic acid Specification

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