3-Hydroxypyridine supplier

Name
3-Hydroxypyridine
EINECS 203-637-4
CAS No. 109-00-2
Article Data121
CAS DataBase
Density 1.172 g/cm³
Solubility 33g/L in water
Melting Point 123-130 °C
Formula C₅H₅NO
Boiling Point 318.9 °C at 760 mmHg
Molecular Weight 95.1008
Flash Point 146.6 °C
Transport Information
Appearance yellow to brownish crystal
Safety 26-36-37/39-22
Risk Codes 36/37/38-40
Molecular Structure
Hazard Symbols Xi,Xn
Synonyms 3-Pyridol;3-Oxopyridine;.beta.-Hydroxypyridine;3-Pyridinol;3-Hydroxy Pyridine;3-Pyridone;pyridin-3-ol;
PSA 33.12000
LogP 0.78720

Synthetic route

: 462-08-8
pyridin-3-ylamine

: 109-00-2
3-HYDROXYPYRIDINE

Conditions

Conditions	Yield
Stage #1: pyridin-3-ylamine With sulfuric acid at 20℃; Cooling with ice; Stage #2: With sodium nitrite In water Reflux;	100%
With sulfuric acid Diazotization;
With sulfuric acid; water; sodium nitrite at 0℃; Erwaermen des Reaktionsgemisches auf 50grad;
With sulfuric acid; water; sodium nitrite at 0℃; Erwaermen des Reaktionsgemisches auf 80grad.;

: 6602-28-4
3-hydroxypyridine N-oxide

: 109-00-2
3-HYDROXYPYRIDINE

Conditions

Conditions	Yield
With methyloxorhenium(V)(2-(mercaptomethyl)thiophenolate) triphenylphosphine; triphenylphosphine In benzene at 20℃; for 7h;	99%
With triphenylphosphine; N-fused tetraphenylporphyrin rhenium(VII) trioxide In toluene at 80℃; for 4.5h;	98%
With 1,1,2,2-tetrabutyl-1,2-dichloro distannane In tetrahydrofuran for 1h; Heating;	88%

: 7295-76-3
3-methoxypyridine

: 109-00-2
3-HYDROXYPYRIDINE

Conditions

Conditions	Yield
With toluene-4-sulfonic acid; lithium chloride In 1-methyl-pyrrolidin-2-one at 180℃; for 1h;	99%
With L-Selectride In tetrahydrofuran for 24h; Reflux; Inert atmosphere; chemoselective reaction;	89%
With hexamethyldisilathiane; sodium methylate In various solvent(s) at 180℃; for 24h;	61%
With trimethylammonium heptachlorodialuminate In dichloromethane Heating;

: 626-60-8
3-Chloropyridine

: 109-00-2
3-HYDROXYPYRIDINE

Conditions

Conditions	Yield
With 2-di-tertbutylphosphino-3,4,5,6-tetramethyl-2',4',6'-triisopropyl-1,1'-biphenyl; potassium hydroxide; tris-(dibenzylideneacetone)dipalladium(0) In 1,4-dioxane; water at 100℃; for 10h;	97%
With [(2-di-tert-butylphosphino-3-methoxy-6-methyl-2,4,6-triisopropyl-1,1-biphenyl)-2-(2-aminobiphenyl)]palladium(II) methanesulfonate; caesium carbonate; Benzaldoxime In N,N-dimethyl-formamide at 80℃; for 18h; Inert atmosphere; Glovebox; Sealed tube;	92%
Stage #1: 3-Chloropyridine With sodium hydroxide In propylene glycol at 140℃; for 2h; Stage #2: With hydrogenchloride In water at 60 - 70℃; for 0.666667h; pH=6 - 7;	90%
Stage #1: 3-Chloropyridine With sodium hydroxide In propylene glycol at 140℃; for 2h; Stage #2: With hydrogenchloride In methanol; water at 60 - 70℃; for 0.666667h; Temperature;	90%
With copper acetylacetonate; N1-(4-hydroxy-2,6-dimethylphenyl)-N2-(4-hydroxy-3,5-dimethylphenyl)oxalamide; water In water; dimethyl sulfoxide at 130℃; for 24h; Schlenk technique; Inert atmosphere;	80%

: 17747-43-2
3-pyridyl acetate

: 109-00-2
3-HYDROXYPYRIDINE

Conditions

Conditions	Yield
With sodium tetrahydroborate; cobalt(II) chloride In ethanol at 0 - 25℃; for 10h;	97%
With Rsp3690 from Rhodobacter sphaeroides In dimethyl sulfoxide at 30℃; pH=8.3; Kinetics; Enzymatic reaction;

: 50717-82-3, 74279-87-1, 74279-88-2
piperidin-3-one

: 109-00-2
3-HYDROXYPYRIDINE

Conditions

Conditions	Yield
With hydrogen bromide; bromine In dichloromethane at -35 - 35℃; for 5h;	93.7%

: 1120-90-7
3-iodopyridine

: 109-00-2
3-HYDROXYPYRIDINE

Conditions

Conditions	Yield
With copper(I) oxide; water; potassium carbonate; Sucrose at 140℃; for 3h; Sealed tube; Inert atmosphere;	93%
With lithium salt of proline; tetrabutylammomium bromide; potassium hydroxide; copper dichloride In water at 120℃; for 0.666667h; Microwave irradiation; Green chemistry;	83%
With copper acetylacetonate; N1-(4-hydroxy-2,6-dimethylphenyl)-N2-(4-hydroxy-3,5-dimethylphenyl)oxalamide; potassium hydroxide In water; dimethyl sulfoxide at 60℃; for 24h; Schlenk technique; Inert atmosphere;	82%
Multi-step reaction with 2 steps 1.1: copper(l) iodide; 1,10-Phenanthroline; caesium carbonate / toluene / 14 h / 110 °C / Inert atmosphere; Sealed tube 2.1: cesium fluoride / N,N-dimethyl-formamide / 1 h / 60 °C / Inert atmosphere 2.2: Inert atmosphere View Scheme

: 1338215-39-6
3-(2-trimethylsilanylethoxy)pyridine

: 109-00-2
3-HYDROXYPYRIDINE

Conditions

Conditions	Yield
Stage #1: 3-(2-trimethylsilanylethoxy)pyridine With cesium fluoride In N,N-dimethyl-formamide at 60℃; for 1h; Inert atmosphere; Stage #2: With water In N,N-dimethyl-formamide Inert atmosphere;	93%

: 1692-25-7
3-pyridylboronic acid

: 109-00-2
3-HYDROXYPYRIDINE

Conditions

Conditions	Yield
With dihydrogen peroxide In acetonitrile at 30 - 35℃; for 0.166667h; Schlenk technique;	92%
With water; caesium carbonate; hydrazine hydrate at 80℃; for 24h;	91%
With urea hydrogen peroxide adduct In acetonitrile at 27 - 29℃; for 6h; Green chemistry; chemoselective reaction;	91%

: 115437-94-0
3-(tert-butyldimethylsilyloxy)pyridine

: 109-00-2
3-HYDROXYPYRIDINE

Conditions

Conditions	Yield
With lithium acetate In water; N,N-dimethyl-formamide at 25℃; for 2.5h; Inert atmosphere;	90%

: 849774-31-8
3-[(triisopropylsilyl)oxy]pyridine

: 109-00-2
3-HYDROXYPYRIDINE

Conditions

Conditions	Yield
With potassium acetate In water; N,N-dimethyl-formamide at 25℃; for 4h;	89%

: 329214-79-1
3-(4,4,5,5,-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine

: 109-00-2
3-HYDROXYPYRIDINE

Conditions

Conditions	Yield
With menadione; sodium hydrogencarbonate; sodium L-ascorbate In ethanol; water at 20℃; under 760.051 Torr; for 24h; pH=8.5; Darkness; Green chemistry;	83%
With 3,4,5-trihydroxybenzoic acid; sodium hydrogencarbonate In ethanol; water at 20℃; for 24h; Green chemistry;	79%

: 252974-70-2
3-(dimethylsilyl)pyridine

: 109-00-2
3-HYDROXYPYRIDINE

Conditions

Conditions	Yield
With water; dihydrogen peroxide; potassium hydrogencarbonate In tetrahydrofuran; methanol at 20℃; for 2h;	78%

: 626-55-1
3-Bromopyridine

: 109-00-2
3-HYDROXYPYRIDINE

Conditions

Conditions	Yield
With lithium salt of proline; tetrabutylammomium bromide; potassium hydroxide; copper dichloride In water at 120℃; for 0.666667h; Microwave irradiation; Green chemistry;	75%
With copper(l) iodide; lithium pipecolinate; tetrabutyl ammonium fluoride; sodium hydroxide In water at 130℃; for 24h;	74%
With potassium phosphate; copper(l) iodide; water; N,N`-dimethylethylenediamine at 20 - 180℃; for 0.5h; Microwave irradiation;	70%

: 874-24-8
3-hydroxypyridine-2-carboxylic acid

: 611-10-9
2-ethoxycarbonyl-1-cyclopentanone

A: 109-00-2
3-HYDROXYPYRIDINE

B: 6,7,8,9-tetrahydrocyclopenta<4,5>pyrano<3,2-b>pyridin-6-one

Conditions

Conditions	Yield
at 160℃; for 6h;	A 74% B 25%

...Expand

: 874-24-8
3-hydroxypyridine-2-carboxylic acid

: 5394-63-8
2,2,6-trimethyl-4H-1,3-dioxin-4-one

A: 109-00-2
3-HYDROXYPYRIDINE

B: 771-03-9
3-acetyl-4-hydroxy-6-methyl-2H-pyran-2-one

C: 4-methyl-2H-pyrano<3,2-b>pyridine-2-one

Conditions

Conditions	Yield
In toluene for 6h; Mechanism; Heating; other 3-substituted picolinic acids; other acetylketenes; var. temperatures and solvents;	A 70% B 29.7% C 25%
In toluene for 6h; Heating;	A 70% B 29.7% C 25%

...Expand

: 5394-63-8
2,2,6-trimethyl-4H-1,3-dioxin-4-one

A: 109-00-2
3-HYDROXYPYRIDINE

B: 771-03-9
3-acetyl-4-hydroxy-6-methyl-2H-pyran-2-one

C: 4-methyl-2H-pyrano<3,2-b>pyridine-2-one

Conditions

Conditions	Yield
With 3-hydroxypyridine-2-carboxylic acid In toluene for 6h; Heating;	A 70% B 29.7% C 25%

...Expand

: 110-86-1
pyridine

: 109-00-2
3-HYDROXYPYRIDINE

Conditions

Conditions	Yield
With sulfuric acid; mercury(II) sulfate at 210℃; for 10h; Temperature;	62%
Multi-step reaction with 2 steps 1: concentrated sulfuric acid 2: bei der Kalischmelze View Scheme

: 3-(5,5-dimethyl-1,3,2-dioxaborinan-2-yl) pyridine

: 109-00-2
3-HYDROXYPYRIDINE

Conditions

Conditions	Yield
With [bis(acetoxy)iodo]benzene; water; triethylamine In acetonitrile at 20℃; for 1h;	59%
With sodium periodate; iodobenzene In water; acetonitrile at 80℃; for 8h;	59%

: 39871-47-1
α-azidocyclopentanone

A: 109-00-2
3-HYDROXYPYRIDINE

B: 57147-25-8
2-oxo-1,2,3,4-tetrahydropyridine

Conditions

Conditions	Yield
at 600℃; under 0.01 Torr; for 1h; Flash photolysis;	A 7% B 55%

: 74115-13-2
5-bromopyridine-3-ol

: 109-72-8, 29786-93-4
n-butyllithium

: 1066-45-1
trimethyltin(IV)chloride

A: 109-00-2
3-HYDROXYPYRIDINE

B: 142929-09-7
<3,3'-Bipyridin>-5,5'-diol

C: 5-n-butyl-3-pyridinol

D: 918631-14-8
5-trimethylstannanyl-pyridin-3-ol

Conditions

Conditions	Yield
Stage #1: 5-bromopyridine-3-ol; n-butyllithium In tetrahydrofuran at -78℃; Stage #2: trimethyltin(IV)chloride In tetrahydrofuran	A 24% B 29% C 11% D 33%

...Expand

: 2168-13-0
2-[(dimethylamino)methyl]pyridin-3-ol

: 62-53-3
aniline

A: 109-00-2
3-HYDROXYPYRIDINE

B: 65974-47-2
2-[(phenylimino)methyl]-1-azabenzene-3-ol

C: 74803-54-6
2-[(phenylamino)methyl]-1-azabenzene-3-ol

Conditions

Conditions	Yield
In diphenylether at 250℃; for 15h;	A 30% B 10% C 20%

...Expand

: 3-allyloxy-2-pentamethyldisilanylpyridine

A: 109-00-2
3-HYDROXYPYRIDINE

B: C18H22N2O2Si

Conditions

Conditions	Yield
In benzene for 3h; Irradiation; Inert atmosphere;	A 15% B 9%

: 110-89-4
piperidine

: 99073-54-8
(5-nitro-[2]pyridyl)-[3]pyridyl ether

A: 109-00-2
3-HYDROXYPYRIDINE

B: 26820-61-1
5-nitro-2-piperidinopyridine

...Expand

: 98-01-1
furfural

: 109-00-2
3-HYDROXYPYRIDINE

Conditions

Conditions	Yield
With ammonium sulfate; water; urea at 160℃; unter Druck;
With ammonium sulfate; ammonium oxalate; water at 160℃; unter Druck;
With ammonium chloride In methanol; aq. phosphate buffer at 100℃; for 22h; pH=8; Time; Temperature; Sealed tube;

: 98-01-1
furfural

A: 109-00-2
3-HYDROXYPYRIDINE

B: 5154-01-8
pyridine-2,5-diol

Conditions

Conditions	Yield
With ethanol; water; hydrazinium sulfate at 153℃; unter Druck;

: 14773-50-3
3-ethoxypyridine

: 109-00-2
3-HYDROXYPYRIDINE

Conditions

Conditions	Yield
With hydrogen iodide at 110 - 120℃;

: 15069-92-8
5-hydroxypicolinic acid

: 109-00-2
3-HYDROXYPYRIDINE

Conditions

Conditions	Yield
With calcium oxide
at 300℃; unter vermindertem Druck;

: 874-24-8
3-hydroxypyridine-2-carboxylic acid

: 109-00-2
3-HYDROXYPYRIDINE

Conditions

Conditions	Yield
bei der trocknen Destillation;

: 109-00-2
3-HYDROXYPYRIDINE

: 1121-76-2
4-chloropyridine N-oxide

: 75734-24-6
3-hydroxy-1-(1-oxido-4-pyridyl)pyridinium chloride

Conditions

Conditions	Yield
In chlorobenzene for 12h; Heating;	100%

: 109-00-2
3-HYDROXYPYRIDINE

: 103057-44-9
N-(tert-butoxycarbonyl)-3-hydroxypyrrolidine

: 224818-73-9
(+/-)-3-oxy(3-pyridyl)-1-tert-butoxycarbonylpyrrolidine

Conditions

Conditions	Yield
With triphenylphosphine; diethylazodicarboxylate In tetrahydrofuran at 40℃; for 15h; Condensation;	100%
With triphenylphosphine; diethylazodicarboxylate In tetrahydrofuran Mitsunobu reaction;
With triphenylphosphine; diethylazodicarboxylate In tetrahydrofuran
Stage #1: With triphenylphosphine; diethylazodicarboxylate In tetrahydrofuran at -20℃; for 0.166667h; Stage #2: N-(tert-butoxycarbonyl)-3-hydroxypyrrolidine In tetrahydrofuran at -20℃; for 0.166667h; Stage #3: 3-HYDROXYPYRIDINE In tetrahydrofuran at 20℃; Mitsunobu reaction;
With triphenylphosphine; diethylazodicarboxylate In tetrahydrofuran at 0 - 20℃; Mitsunobu reaction; Inert atmosphere;

: 109-00-2
3-HYDROXYPYRIDINE

: 88-88-0
2,4,6-trinitrochlorobenzene

: 3-pyridinyl 2,4,6-trinitrophenylether

Conditions

Conditions	Yield
In tetrahydrofuran at 30℃; Product distribution; Kinetics; Further Variations:; Solvents;	100%
Stage #1: 3-HYDROXYPYRIDINE With sodium hydride In tetrahydrofuran for 0.166667h; Stage #2: 2,4,6-trinitrochlorobenzene In tetrahydrofuran for 0.166667h;

: 109-00-2
3-HYDROXYPYRIDINE

: 100-39-0
benzyl bromide

: 61995-15-1
3-benzyloxy-N-benzyl-1,2,5,6-tetrahydropyridine

Conditions

Conditions	Yield
Stage #1: 3-HYDROXYPYRIDINE; benzyl bromide With sodium methylate In methanol Heating / reflux; Stage #2: With sodium tetrahydroborate In methanol at 20℃; Stage #3: With potassium carbonate In diethyl ether; water for 1h;	100%

: 109-00-2
3-HYDROXYPYRIDINE

: 59142-68-6
2-bromo-4-fluorobenzaldehyde

: 1196474-75-5
2-bromo-4-(pyridine-3-yloxy)-benzaldehyde

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 80℃; for 16h;	100%

: 109-00-2
3-HYDROXYPYRIDINE

: 7-chloro-1-(2,2-diethoxyethyl)-1,2-dihydro-1,8-naphthyridin-2-one

: 1-(2,2-diethoxyethyl)-7-(pyridin-3-yloxy)-1,2-dihydro-1,8-naphthyridin-2-one

Conditions

Conditions	Yield
With caesium carbonate In N,N-dimethyl-formamide at 70℃; for 17h; Inert atmosphere;	100%
With caesium carbonate In N,N-dimethyl-formamide at 70℃; for 17h; Inert atmosphere;	100%

: 109-00-2
3-HYDROXYPYRIDINE

: 1246303-46-7
dihydroxo[5,10,15,20-tetrakis(2-thienyl)porphyrinato]tin(IV)

: trans-[tin(IV)(3-oxypyridyl)2(meso-tetra(2-thienyl)porphyrin)]

Conditions

Conditions	Yield
In chloroform for 4h; Reflux;	100%

: 109-00-2
3-HYDROXYPYRIDINE

: 26334-89-4
trans-dihydroxo(meso-tetraphenylporphyrinato)tin(IV)

: 1365636-06-1
trans-bis(phenolato)-[5,10,15,20-tetrakis(phenyl)porphyrinato]tin(IV)

Conditions

Conditions	Yield
In chloroform for 4h; Reflux;	100%

: 109-00-2
3-HYDROXYPYRIDINE

: 100-39-0
benzyl bromide

: 62214-78-2
1-benzyl-3-hydroxypyridin-1-ium bromide

Conditions

Conditions	Yield
In isopropyl alcohol for 16h; Reflux; Inert atmosphere;	99%
In acetone Ambient temperature;	97%
With toluene

: 109-00-2
3-HYDROXYPYRIDINE

: 74-88-4
methyl iodide

: 7500-05-2
3-hydroxy-1-methylpyridin-1-ium iodide

Conditions

Conditions	Yield
In isopropyl alcohol for 16h; Reflux; Inert atmosphere;	99%
In toluene Reflux;	89%
In methanol for 6h; Heating;	86%

: 109-00-2
3-HYDROXYPYRIDINE

: 3433-80-5
1-Bromo-2-bromomethyl-benzene

: 123100-48-1
1-(2-bromobenzyl)-3-hydroxypyridin-1-ium bromide

Conditions

Conditions	Yield
In tetrahydrofuran for 16h; Reflux; Inert atmosphere;	99%
In tetrahydrofuran for 2.5h; Heating;	80%

: 109-00-2
3-HYDROXYPYRIDINE

: 1609-47-8
diethyl dicarbonate

: ethyl pyrid-3-yl carbonate

Conditions

Conditions	Yield
With magnesium(II) perchlorate at 40℃; for 5.5h;	99%

: 109-00-2
3-HYDROXYPYRIDINE

: silver nitrate

: 40867-15-0
3-Hydroxypyridine, Silver Salt

Conditions

Conditions	Yield
With sodium hydroxide In water	99%

: 109-00-2
3-HYDROXYPYRIDINE

: 98-74-8
4-Nitrobenzenesulfonyl chloride

: pyridin-3-yl 4-nitrobenzenesulfonate

Conditions

Conditions	Yield
With potassium carbonate In acetonitrile at 30℃; for 0.5h; Reagent/catalyst; Solvent; Temperature; Inert atmosphere;	99%

: 109-00-2
3-HYDROXYPYRIDINE

: 459-46-1
4-Fluorobenzyl bromide

: 1-(4-fluorobenzyl)-3-hydroxypyridin-1-ium bromide

Conditions

Conditions	Yield
In tetrahydrofuran for 16h; Reflux; Inert atmosphere;	99%

: 109-00-2
3-HYDROXYPYRIDINE

: 61150-57-0
2-bromo-4-fluorobenzyl bromide

: 1-(2-bromo-4-fluorobenzyl)-3-hydroxypyridin-1-ium bromide

Conditions

Conditions	Yield
In tetrahydrofuran for 16h; Reflux; Inert atmosphere;	99%

: 109-00-2
3-HYDROXYPYRIDINE

: 6859-99-0
3-hydroxypiperazine

Conditions

Conditions	Yield
With aluminum oxide; 1.5% Rh/SiO2; hydrogen In water at 85℃; under 52505.3 Torr; Reagent/catalyst; Pressure; Temperature; Autoclave;	98.7%
With hydrogen; Rh on carbon In water at 80℃; under 3800 Torr; for 2h;	96%
With 10% Rh/C; hydrogen In water at 80℃; under 3800.26 Torr; for 2h;	96%

: 109-00-2
3-HYDROXYPYRIDINE

: 74780-46-4
trans-1-(2-chloro-5-nitrophenyl)-3-chloroprop-2-en-1-one

: 74780-45-3
1--3-hydroxypyridinium chloride

Conditions

Conditions	Yield
In tetrahydrofuran at 20℃; for 3h;	98%

: 109-00-2
3-HYDROXYPYRIDINE

: 26127-08-2
(1R,2S,5R)-1-(chloromethoxy)-2-isopropyl-5-methylcyclohexane

: 3-hydroxy-1-[(1R,2S,5R)-(-)-menthoxymethyl]pyridinium chloride

Conditions

Conditions	Yield
In N,N-dimethyl-formamide at 20℃; Menschutkin quaternization;	98%

: 109-00-2
3-HYDROXYPYRIDINE

: 609-39-2
2-nitrofuran

: 1304134-64-2
3-[(5-nitrofuran-2-yl)oxy]pyridine

Conditions

Conditions	Yield
With potassium carbonate In dichloromethane; water at 20℃; for 3h;	98%

: 109-00-2
3-HYDROXYPYRIDINE

: 1202403-70-0
3-(2-chloroacetamido)-7,8-dehydrorutaecarpine

: 1443150-25-1
3-(2-(pyridin-3-yloxy)-acetamino)-7,8-dehydrorutaecarpine

Conditions

Conditions	Yield
for 8h; Reflux;	98%

: 109-00-2
3-HYDROXYPYRIDINE

: pyridin-3-yl sulfurofluoridate

Conditions

Conditions	Yield
Stage #1: 3-HYDROXYPYRIDINE With triethylamine In dichloromethane at 20℃; for 0.166667h; Stage #2: With fluorosulfonyl fluoride In dichloromethane at 20℃; for 2h; chemoselective reaction;	98%
With fluorosulfonyl fluoride; triethylamine In dichloromethane at 20℃;	95%
With fluorosulfonyl fluoride; triethylamine In dichloromethane at 20℃; under 760.051 Torr; for 24h;	80%

: 109-00-2
3-HYDROXYPYRIDINE

: 112-82-3
hexadecanyl bromide

: 1-hexadecyl-3-hydroxypyridinium bromide

Conditions

Conditions	Yield
In acetonitrile for 48h; Menshutkin Reaction; Reflux;	98%

: 109-00-2
3-HYDROXYPYRIDINE

: 112-89-0
1-Bromooctadecane

: 3-hydroxy-1-octadecylpyridinium bromide

Conditions

Conditions	Yield
In acetonitrile for 48h; Menshutkin Reaction; Reflux;	98%

: 109-00-2
3-HYDROXYPYRIDINE

: 3-methyl-1-(methyldithiocarbonyl)imidazolium iodide

: 1258190-63-4
S-methyl pyridine-3-dithiocarbamate

Conditions

Conditions	Yield
With triethylamine In acetonitrile at 0℃; for 1h; Inert atmosphere;	98%

: 109-00-2
3-HYDROXYPYRIDINE

: 100-44-7
benzyl chloride

: 3323-73-7
1-Benzyl-3-hydroxypyridinium chloride

Conditions

Conditions	Yield
at 110℃;	97%
In toluene for 1h; Alkylation; Heating;	94%
In toluene for 1h; Heating;	94%

: 109-00-2
3-HYDROXYPYRIDINE

(CF3SO2)2NC6H4-O-(PEG-3400)-OC6H4N(SO2CF3)2: (CF3SO2)2NC6H4-O-(PEG-3400)-OC6H4N(SO2CF3)2

: 107658-27-5
pyridin-3-yl trifluoromethanesulfonate

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃; for 8h; Acylation;	97%

3-Hydroxypyridine Consensus Reports

Reported in EPA TSCA Inventory.

3-Hydroxypyridine Specification

The 3-Pyridinol, with the CAS registry number 109-00-2, is also known as beta-Hydroxypyridine. It belongs to the product categories of Pyridine; Pyridines, Pyrimidines, Purines and Pteredines; Pyridines Derivatives; Pyridines Derivates. Its EINECS registry number is 203-637-4. This chemical's molecular formula is C₅H₅NO and molecular weight is 95.0993. Its IUPAC name is called pyridin-3-ol. What's more, this chemical's classification codes are Antioxidants; Protective Agents. It is white to light yellow crystal which is used in organic synthesis, medicine and dye preparation.

Physical properties of 3-Pyridinol: (1)ACD/LogP: 0.64; (2)ACD/LogD (pH 5.5): 0.35; (3)ACD/LogD (pH 7.4): 0.41; (4)ACD/BCF (pH 5.5): 1; (5)ACD/BCF (pH 7.4): 1.06; (6)ACD/KOC (pH 5.5): 27.32; (7)ACD/KOC (pH 7.4): 31.28; (8)#H bond acceptors: 2; (9)#H bond donors: 1; (10)#Freely Rotating Bonds: 1; (11)Index of Refraction: 1.56; (12)Molar Refractivity: 26.22 cm³; (13)Molar Volume: 81 cm³; (14)Surface Tension: 50.7 dyne/cm; (15)Density: 1.172 g/cm³; (16)Flash Point: 146.6 °C; (17)Enthalpy of Vaporization: 58.27 kJ/mol; (18)Boiling Point: 318.9 °C at 760 mmHg; (19)Vapour Pressure: 0.000188 mmHg at 25°C.

Preparation of 3-Pyridinol: this chemical can be prepared by 3-methoxy-pyridine. This reaction will need reagents hexamethyldisilathiane, sodium methoxide and various solvents. The reaction time is 24 hours with reaction temperature of 180 °C. The yield is about 61%.

3-Pyridinol can be prepared by 3-methoxy-pyridine

Uses of 3-Pyridinol: it can be used to produce pyridin-3-yloxy-acetic acid ethyl ester with chloroacetic acid ethyl ester by heating. This reaction will need reagent K₂CO₃ and solvent acetone with reaction time of 20 hours. The yield is about 88%.

3-Pyridinol can be used to produce pyridin-3-yloxy-acetic acid ethyl ester with chloroacetic acid ethyl ester by heating

When you are using this chemical, please be cautious about it as the following:
This chemical may cause inflammation to the skin or other mucous membranes. It is irritating to eyes, respiratory system and skin. In case of contact with eyes, you should rinse immediately with plenty of water and seek medical advice. Whenever you will contact it, please wear suitable protective clothing, gloves and eye/face protection.

You can still convert the following datas into molecular structure:
(1)Canonical SMILES: C1=CC(=CN=C1)O
(2)InChI: InChI=1S/C5H5NO/c7-5-2-1-3-6-4-5/h1-4,7H
(3)InChIKey: GRFNBEZIAWKNCO-UHFFFAOYSA-N

The toxicity data is as follows:

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
bird - wild	LD50	oral	750mg/kg (750mg/kg)		Archives of Environmental Contamination and Toxicology. Vol. 12, Pg. 355, 1983.
mammal (species unspecified)	LD50	unreported	900mg/kg (900mg/kg)	BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)	Pharmaceutical Chemistry Journal Vol. 16, Pg. 259, 1982.
mouse	LD50	intraperitoneal	1822mg/kg (1822mg/kg)		Toxicon. Vol. 23, Pg. 815, 1985.

Product Name

3-Hydroxypyridine

Synthetic route

3-Hydroxypyridine Consensus Reports

3-Hydroxypyridine Specification

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