3-Nitrophenol supplier | CasNO.554-84-7

Name
3-Nitrophenol
EINECS 209-073-5
CAS No. 554-84-7
Article Data277
CAS DataBase
Density 1.49 g/cm³
Solubility 13.5 g/L (25 °C) in water
Melting Point 89-95 °C
Formula C₆H₅NO₃
Boiling Point 277.6 °C at 760 mmHg
Molecular Weight 139.111
Flash Point 126.9 °C
Transport Information UN 1663 6.1/PG 3
Appearance yellow to brown crystalline powder
Safety 26-36/37-45-36/37/39-22-28
Risk Codes 22-38-41-36/37/38-33-20/21/22
Molecular Structure
Hazard Symbols Xn,Xi
Synonyms Phenol,m-nitro- (8CI);1-Hydroxy-3-nitrobenzene;3-Hydroxynitrobenzene;m-Hydroxynitrobenzene;m-Nitrophenol;
PSA 66.05000
LogP 1.82360

Synthetic route

: 13331-27-6
m-nitrobenzene boronic acid

: 554-84-7
meta-nitrophenol

Conditions

Conditions	Yield
With dihydrogen peroxide In water at 30℃; Green chemistry;	99%
With 2,5-dimethylfuran; zinc(II) phthalocyanine; oxygen In tetrahydrofuran at 25℃; under 760.051 Torr; for 1.5h; Irradiation; Sealed tube; Schlenk technique;	98%
With water; 3-chloro-benzenecarboperoxoic acid In ethanol at 20℃; for 6h;	97%

: 32578-25-9
trifluoromethanesulfonic acid 3-nitrophenyl ester

: 554-84-7
meta-nitrophenol

Conditions

Conditions	Yield
With tetraethylammonium hydroxide In 1,4-dioxane at 20℃; for 1h;	99%
With caesium carbonate In toluene at 80℃; for 15h;	85%

: 645-00-1
m-iodonitrobenzene

: 554-84-7
meta-nitrophenol

Conditions

Conditions	Yield
Stage #1: m-iodonitrobenzene With copper(l) iodide; 2-methyl-8-quinolinol; tetra(n-butyl)ammonium hydroxide In water; dimethyl sulfoxide at 70℃; for 5h; Stage #2: With hydrogenchloride In water; N,N-dimethyl-formamide at 20℃;	98%
With glycolic Acid; copper hydroxide; sodium hydroxide In water; dimethyl sulfoxide at 120℃; for 6h; Inert atmosphere; Schlenk technique;	97%
Stage #1: m-iodonitrobenzene With copper(l) iodide; 8-Hydroxyquinoline-N-oxide In dimethyl sulfoxide at 20℃; for 0.166667h; Inert atmosphere; Stage #2: With cesiumhydroxide monohydrate In water; dimethyl sulfoxide at 100℃; for 15h; Inert atmosphere;	88%

: potassium 3-nitrophenyltrifluoroborate

: 554-84-7
meta-nitrophenol

Conditions

Conditions	Yield
With Oxone; water In acetone at 20℃; for 0.0333333h;	98%

: 58621-55-9
1-allyloxy-3-nitro-benzene

: 554-84-7
meta-nitrophenol

Conditions

Conditions	Yield
With potassium hydroxide In methanol at 20℃; for 9h;	97%
With bis(benzonitrile)palladium(II) dichloride In benzene for 20h; Heating;	90%

: 28659-20-3
3-(2-tetrahydropyranyloxy)nitrobenzene

: 554-84-7
meta-nitrophenol

Conditions

Conditions	Yield
With acid-washed bentonite In acetone at 40 - 50℃; for 0.833333h;	97%
With montmorillonite K-10 In methanol at 40 - 50℃; for 0.4h;	96%

: 1523-06-4
3-nitrophenyl acetate

: 554-84-7
meta-nitrophenol

Conditions

Conditions	Yield
silica gel; toluene-4-sulfonic acid In water; toluene at 80℃; for 8h;	96%
With lithium aluminium tetrahydride In diethyl ether for 2h; Heating;	70%
With water In acetonitrile for 3h; Irradiation;

: 1441-07-2
p-Nitrophenylvinylether

: 554-84-7
meta-nitrophenol

Conditions

Conditions	Yield
With acetic acid; trifluoroacetic acid In water for 0.75h; Reflux;	95%

: 24318-00-1
3-(benzyloxy)nitrobenzol

: 554-84-7
meta-nitrophenol

Conditions

Conditions	Yield
With thiophene; sodium hydrogen sulfate; silica gel for 5h; Heating;	94%
With methyl-phenyl-thioether; trifluoroacetic acid In toluene at 20℃; for 36h;	75%
With sulfosuccinic acid functionalized mesoporous silica In ethanol at 100℃;

: 621-52-3
1-ethoxy-3-nitrobenzene

: 554-84-7
meta-nitrophenol

Conditions

Conditions	Yield
With 1-n-butyl-3-methylimidazolim bromide at 200 - 220℃; for 0.416667h; Microwave irradiation; Inert atmosphere;	94%

: 99-09-2
3-nitro-aniline

: 554-84-7
meta-nitrophenol

Conditions

Conditions	Yield
With sulfuric acid; sodium nitrite at 12.5 - 90℃;	92.3%
Stage #1: 3-nitro-aniline With sulfuric acid In water at 15 - 95℃; Stage #2: With sulfuric acid In water at 90 - 99℃; for 0.416667h; Temperature;	82%
Stage #1: 3-nitro-aniline With sulfuric acid at 20℃; Cooling with ice; Stage #2: With sodium nitrite In water Reflux;	75%

: 915394-31-9
diethyl-carbamic acid 3-nitro-phenyl ester

: 554-84-7
meta-nitrophenol

Conditions

Conditions	Yield
With zirconocene dichloride In tetrahydrofuran at 20℃; Inert atmosphere;	91%

: 78687-53-3
Carbonic acid 3-nitro-phenyl ester 2-trimethylsilanyl-ethyl ester

A: 74-85-1
ethene

B: 420-56-4
trimethylsilyl fluoride

C: 554-84-7
meta-nitrophenol

Conditions

Conditions	Yield
With tetrabutyl ammonium fluoride In tetrahydrofuran at 20℃; for 0.166667h; deprotection of TMSEC derivat with various catalyst;	A n/a B n/a C 90%

...Expand

: 585-79-5
3-Bromonitrobenzene

: 554-84-7
meta-nitrophenol

Conditions

Conditions	Yield
Stage #1: m-nitrobromobenzene With copper(l) iodide; tetra(n-butyl)ammonium hydroxide In water at 60℃; for 24h; Inert atmosphere; Sealed tube; Stage #2: With hydrogenchloride In water; ethyl acetate at 20℃; for 2h; Inert atmosphere; chemoselective reaction;	87%
Stage #1: m-nitrobromobenzene With copper(l) iodide; 8-Hydroxyquinoline-N-oxide In dimethyl sulfoxide at 20℃; for 0.166667h; Inert atmosphere; Stage #2: With cesiumhydroxide monohydrate In water; dimethyl sulfoxide at 110℃; for 15h; Inert atmosphere;	85%
Stage #1: m-nitrobromobenzene With copper(l) iodide; cesiumhydroxide monohydrate; 1,3-diphenylpropanedione In water; dimethyl sulfoxide at 130℃; for 24h; Inert atmosphere; Stage #2: With hydrogenchloride In dichloromethane; water; dimethyl sulfoxide at 20℃; Inert atmosphere; chemoselective reaction;	78%
With dicyclohexyl-(2′,4′,6′-triisopropyl-3,6-dimethoxy-[1,1′-biphenyl]-2-yl)phosphine; boric acid; palladium diacetate; caesium carbonate In 1-methyl-pyrrolidin-2-one at 80℃; for 24h; Schlenk technique; Inert atmosphere;	78%
Stage #1: m-nitrobromobenzene With copper(ll) sulfate pentahydrate; water; sodium L-ascorbate; potassium hydroxide In dimethyl sulfoxide at 120℃; for 24h; Schlenk technique; Green chemistry; Stage #2: With hydrogenchloride In water; dimethyl sulfoxide at 20℃; for 0.5h; pH=2 - 3; Catalytic behavior; Schlenk technique; Green chemistry;	75%

: 41076-06-6
3-nitrophenyl benzenesulfonate

: 554-84-7
meta-nitrophenol

Conditions

Conditions	Yield
With potassium hydroxide In toluene; tert-butyl alcohol at 100℃; for 0.5h; Inert atmosphere;	87%

: 591-27-5
m-Hydroxyaniline

: 554-84-7
meta-nitrophenol

Conditions

Conditions	Yield
With 1,9-diperoxynonanedioic acid In acetonitrile at 50℃; for 0.5h;	82%
With water; fluorine In chloroform; acetonitrile at -15℃; for 0.0333333h;	71%
With caro's acid
With 2A, 3B, 2D, 3E-tetra-O-formylmethyl-2B, C, E-G, 3A,C, D, F, G, 6A-G-heptakaideca-O-methyl-β-CD; dihydrogen peroxide In aq. phosphate buffer at 25℃; pH=7; Kinetics; Reagent/catalyst;

: 13331-27-6
m-nitrobenzene boronic acid

A: 554-84-7
meta-nitrophenol

B: 99-09-2
3-nitro-aniline

Conditions

Conditions	Yield
With ammonium hydroxide; potassium nitrate In water at 20℃; for 2h; Electrochemical reaction; chemoselective reaction;	A n/a B 81%

: 5978-70-1
(R)-Octan-2-ol

: 88-75-5
2-hydroxynitrobenzene

: 1972-28-7
diethylazodicarboxylate

A (S)- [4-(1-methylheptyloxy)-3-nitrophenyl]-benzoate: (S)- [4-(1-methylheptyloxy)-3-nitrophenyl]-benzoate

B: 554-84-7
meta-nitrophenol

Conditions

Conditions	Yield
With triphenylphosphine In tetrahydrofuran; water	A 80% B n/a

...Expand

: 127-68-4
sodium 3-nitrobenzenesulfonate

: 554-84-7
meta-nitrophenol

Conditions

Conditions	Yield
With potassium hydroxide; sodium hydroxide In water for 0.0166667h; microwave irradiation;	78%

: 26646-35-5
2-(3-nitrophenoxy)ethanamine

A: C8H9N2O3(1-)

B: 554-84-7
meta-nitrophenol

C: 55131-09-4
N-(2-hydroxyethyl)-3-nitroaniline

D: 141-43-5
ethanolamine

Conditions

Conditions	Yield
With deuteriated sodium hydroxide In water-d2 at 20℃; for 0.833333h; Smiles rearrangement; UV-irradiation;	A 15% B n/a C 73% D n/a

...Expand

: 555-03-3
3-nitroanisole

: 554-84-7
meta-nitrophenol

Conditions

Conditions	Yield
With 1-butylpyridinium bromide for 0.0666667h; microwave irradiation;	71%
With lithium chloride In N,N-dimethyl-formamide for 6h; Heating;	50%
With sodium hydroxide In water Quantum yield; Irradiation; other reagent, reagents ratio;

: 1523-13-3
3-nitrophenyl benzoate

A: 554-84-7
meta-nitrophenol

B: 100-51-6
benzyl alcohol

Conditions

Conditions	Yield
With lithium aluminium tetrahydride In diethyl ether for 2h; Heating;	A 70% B n/a

: 20942-49-8
C10H14N4O2

: 554-84-7
meta-nitrophenol

Conditions

Conditions	Yield
With water; sulfonic acid resin (H+ form) In acetonitrile Heating;	68%

: 121-73-3
3-Chloronitrobenzene

: 554-84-7
meta-nitrophenol

Conditions

Conditions	Yield
Stage #1: 3-Nitrochlorobenzene With copper(ll) sulfate pentahydrate; water; sodium L-ascorbate; potassium hydroxide In dimethyl sulfoxide at 120℃; for 24h; Schlenk technique; Green chemistry; Stage #2: With hydrogenchloride In water; dimethyl sulfoxide at 20℃; for 0.5h; pH=2 - 3; Catalytic behavior; Schlenk technique; Green chemistry;	66%
With steam at 420℃; Leiten ueber aktivierte Kieselsaeure;

: 28355-48-8
2-(3-nitrophenoxy)pyridine

: 554-84-7
meta-nitrophenol

Conditions

Conditions	Yield
Stage #1: 2-(3-nitrophenoxy)pyridine With methyl trifluoromethanesulfonate In toluene at 100℃; for 2h; Inert atmosphere; Stage #2: With sodium In methanol for 0.25h; Inert atmosphere; Reflux;	65%

: 98-95-3
nitrobenzene

A: 100-02-7
4-nitro-phenol

B: 554-84-7
meta-nitrophenol

C: 88-75-5
2-hydroxynitrobenzene

Conditions

Conditions	Yield
With Fe2(N,N-bis(pyridin-2-ylmethyl)prop-2-yn-1-amine)2(μ2-Cl)2Cl2; dihydrogen peroxide In acetonitrile at 70℃; for 2h;	A 28% B 62% C 13%
With oxygen; iron(II) sulfate In water at 40℃; for 3h; Product distribution; pH 6.8 buffer;	A 4% B 4% C 1%
With [(4-bromophenyl)diazenyl](phenyl)methyl hydroperoxide; oxygen for 3h; Product distribution; Irradiation; reaction under Ar, reaction in acetonitrile; isomer ratio of nitrophenols obtained; isomer ratio distribution in the reaction of aromatics with the hydroxy radical under argon or oxygen gas;

...Expand

: 68716-48-3
4,4,5,5-tetramethyl-2-(3-nitrophenyl)-1,3,2-dioxaborolane

: 554-84-7
meta-nitrophenol

Conditions

Conditions	Yield
With sodium hydroxide; hydroxylamine hydrochloride In ethanol at 20℃; for 48h;	52%

: 98-95-3
nitrobenzene

: 554-84-7
meta-nitrophenol

Conditions

Conditions	Yield
With dihydrogen peroxide; bis(triphenyl)oxodiphosphonium trifluoromethanesulfonate salt In ethanol; water at 20℃; for 1h;	50%
With Pt/titania; water for 3h; Reactivity; Reagent/catalyst; Wavelength; Photolysis; regioselective reaction;

: 374588-08-6
1-but-3-enyloxy-3-nitrobenzene

: 554-84-7
meta-nitrophenol

Conditions

Conditions	Yield
With gold(III) chloride; silver trifluoromethanesulfonate In 1,2-dichloro-ethane at 80℃; for 2h; Inert atmosphere;	50%

: 554-84-7
meta-nitrophenol

: 591-27-5
m-Hydroxyaniline

Conditions

Conditions	Yield
With hydrogen In ethanol at 60℃; under 7500.75 Torr; for 2h;	100%
With palladium on activated charcoal; hydrogen In methanol at 20℃; for 12h;	100%
With sodium tetrahydroborate In methanol; water at 20℃; for 3h;	100%

: 554-84-7
meta-nitrophenol

: 108-24-7
acetic anhydride

: 1523-06-4
3-nitrophenyl acetate

Conditions

Conditions	Yield
With SBA-15-Ph-Pr-SO3H at 20℃; for 0.75h;	100%
With silver trifluoromethanesulfonate at 60℃; for 0.0166667h; neat (no solvent);	99%
Montmorillonite KSF for 5h; Ambient temperature;	98%

: 554-84-7
meta-nitrophenol

: 15933-59-2
1,1,3,3-tetramethyldisilazane

: 79516-19-1
Dimethyl-(3-nitro-phenoxy)-silane

Conditions

Conditions	Yield
	100%

: 554-84-7
meta-nitrophenol

: 125787-05-5
(3R)-1-methoxycarbonylpyrrolidin-2-ol

: 741290-76-6
methyl (3S)-3-(3-nitrophenoxy)pyrrolidine-1-carboxylate

Conditions

Conditions	Yield
With triphenylphosphine; diethylazodicarboxylate In tetrahydrofuran at 20℃;	100%

: 36865-41-5
3-bromopropanol methyl ether

: 554-84-7
meta-nitrophenol

: 1041399-44-3
1-(3-methoxypropoxy)-3-nitrobenzene

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 90℃;	100%
Stage #1: meta-nitrophenol With sodium hydride In N,N-dimethyl-formamide for 0.166667h; Stage #2: 3-bromopropanol methyl ether In N,N-dimethyl-formamide at 20℃; for 18.0833h;	83%

: 554-84-7
meta-nitrophenol

: 3-methyl-1-(morpholin-4-ylcarbonyl)-1H-imidazol-3-ium iodide

: 501104-91-2
C11H12N2O5

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 20℃; for 16h;	100%

: 627-27-0
homoalylic alcohol

: 554-84-7
meta-nitrophenol

: 374588-08-6
1-but-3-enyloxy-3-nitrobenzene

Conditions

Conditions	Yield
With di-isopropyl azodicarboxylate; triphenylphosphine In tetrahydrofuran	100%

: 5394-18-3
2-(4-bromobutyl)isoindoline-1,3-dione

: 554-84-7
meta-nitrophenol

: 666719-64-8
2-[4-(3-Nitro-phenoxy)-butyl]-isoindole-1,3-dione

Conditions

Conditions	Yield
Stage #1: meta-nitrophenol With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 0.166667h; Stage #2: 2-(4-bromobutyl)isoindoline-1,3-dione In DMF (N,N-dimethyl-formamide) at 60℃; for 4h;	100%

: 554-84-7
meta-nitrophenol

: 59142-68-6
2-bromo-4-fluorobenzaldehyde

: 1196474-70-0
2-bromo-4-(3-nitro-phenoxy)-benzaldehyde

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 80℃; for 4h;	100%

: 554-84-7
meta-nitrophenol

: 1523-15-5
2,4-dinitrophenyl benzoate

A: 1523-13-3
3-nitrophenyl benzoate

B: 14314-69-3
potassium 2,4-dinitrophenolate

Conditions

Conditions	Yield
With potassium hydrogencarbonate In N,N-dimethyl-formamide at 25℃; for 5h;	A 100% B n/a

...Expand

: 918538-05-3
2,4-dichloro-pyrrolo[2,1-f][1,2,4]triazine

: 554-84-7
meta-nitrophenol

: 1313036-56-4
2-chloro-4-(3-nitrophenoxy)pyrrolo[2,1-f][1,2,4]triazine

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 0.5h;	100%
With potassium carbonate In tetrahydrofuran; methanol at 20℃;

: 17392-83-5
(R)-Methyl lactate

: 554-84-7
meta-nitrophenol

: 153546-07-7
methyl (R)-2-(3-nitrophenoxy)propanoate

Conditions

Conditions	Yield
Stage #1: (R)-Methyl lactate; meta-nitrophenol With triphenylphosphine In dichloromethane at 0℃; for 0.166667h; Mitsunobu Displacement; Stage #2: With diethylazodicarboxylate In dichloromethane at 0 - 20℃; for 8h; Mitsunobu Displacement;	100%

: 27871-49-4
(S)-Methyl lactate

: 554-84-7
meta-nitrophenol

: methyl (S)-2-(3-nitrophenoxy)propanoate

Conditions

Conditions	Yield
Stage #1: (S)-Methyl lactate; meta-nitrophenol With triphenylphosphine In dichloromethane at 0℃; for 0.166667h; Mitsunobu Displacement; Stage #2: With diethylazodicarboxylate In dichloromethane at 0 - 20℃; for 8h; Mitsunobu Displacement;	100%

: 554-84-7
meta-nitrophenol

: 67820-94-4
3,4-bis(4-methoxyphenyl)-6-chloropyridazine

: 3,4-bis(4-methoxyphenyl)-6-(3-nitrophenoxy)pyridazine

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 150℃; for 17h;	99.9%
at 150℃; for 17h;	99.9%

: 554-84-7
meta-nitrophenol

benzyl halide: benzyl halide

: 24318-00-1
3-(benzyloxy)nitrobenzol

Conditions

Conditions	Yield
With potassium carbonate; sodium iodide In acetone Reflux;	99.81%

: 109-65-9
1-bromo-butane

: 554-84-7
meta-nitrophenol

: 122329-01-5
n-butyl 3-nitrophenylether

Conditions

Conditions	Yield
Stage #1: meta-nitrophenol With sodium hydride In N,N-dimethyl-formamide; mineral oil for 0.0833333h; Inert atmosphere; Stage #2: 1-bromo-butane In N,N-dimethyl-formamide; mineral oil at 125℃; Inert atmosphere;	99%
With potassium carbonate; acetone
With sodium hydride 1.) DMF, RT, 0.5 h, 2.) 120-140 deg C, 2 h; Yield given. Multistep reaction;

: 554-84-7
meta-nitrophenol

: 96-32-2
bromoacetic acid methyl ester

: 81720-19-6
1-methoxycarbonylmethyloxy-3-nitrobenzene

Conditions

Conditions	Yield
With potassium carbonate In acetone at 60℃; for 7h;	99%
With potassium carbonate In acetone at 20℃; for 5h; Inert atmosphere; Reflux;	96%
With caesium carbonate In acetone at 50℃; for 1h;	84.7%

: 18742-02-4
2-bromo-2-(2-ethyl)dioxolane

: 554-84-7
meta-nitrophenol

: 929267-27-6
C11H13NO5

Conditions

Conditions	Yield
With potassium carbonate In acetonitrile at 50℃; for 24h;	99%

: 18226-42-1
1,3,5-Tris(bromomethyl)benzene

: 554-84-7
meta-nitrophenol

: 1095314-52-5
1,3,5-tris(3-nitrophenoxymethyl)benzene

Conditions

Conditions	Yield
With potassium carbonate In acetone at 0 - 70℃; Inert atmosphere;	99%
With potassium carbonate In acetone at 0 - 70℃; Inert atmosphere;	99%
With potassium carbonate In acetone at 0 - 20℃; Inert atmosphere;	90%

: 554-84-7
meta-nitrophenol

: 76513-69-4
(2-trimethylethylsilylethoxy)methyl chloride

: 1333239-18-1
C12H19NO4Si

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃; for 2h;	99%

: 554-84-7
meta-nitrophenol

: 1428775-54-5
2,4-dichloro-5-fluoro-7-((2-(trimethyisilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidine

: 1428775-55-6
2-chloro-5-fluoro-4-(3-nitrophenoxy)-7-{[2-(trimethylsilyl)ethoxy]methyl}-7H-pyrrolo[2,3-d]pyrimidine

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 60℃; for 1h;	99%

: 554-84-7
meta-nitrophenol

: 65-85-0
benzoic acid

: 1523-13-3
3-nitrophenyl benzoate

Conditions

Conditions	Yield
With iodine; triethylamine; triphenylphosphine In dichloromethane at 0 - 20℃; for 0.333333h;	99%

: 554-84-7
meta-nitrophenol

: 23713-86-2
1,3-phenylene-3,3'-bis(2-propenoic) acid

: C24H16N2O8

Conditions

Conditions	Yield
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In tetrahydrofuran at 23℃;	99%

: 31352-60-0, 31352-61-1, 54353-18-3
(SP)-(1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl phenylphosphinate

: 554-84-7
meta-nitrophenol

: (-)-menthyl O-3-nitrophenyl phenylphosphonate

Conditions

Conditions	Yield
With triethylamine In tetrachloromethane at 20℃; for 12h; Inert atmosphere;	99%

: 554-84-7
meta-nitrophenol

: 80858-83-9
3-nitrophenoxysulfonyl fluoride

Conditions

Conditions	Yield
With fluorosulfonyl fluoride; triethylamine In dichloromethane at 20℃; Sealed tube;	99%
Stage #1: meta-nitrophenol With triethylamine In acetonitrile at 20℃; for 0.166667h; Stage #2: With 1-(fluorosulfuryl)-2,3-dimethyl-1H-imidazol-3-ium trifluoromethanesulfonate In acetonitrile for 1h; Inert atmosphere;	85%
With fluorosulfonyl fluoride; triethylamine In ethanol; water at 25℃; for 4h;

: 554-84-7
meta-nitrophenol

: 177338-13-5
3-(tert-butyldiphenylsilyloxy)propyl bromide

: C25H29NO4Si

Conditions

Conditions	Yield
In N,N-dimethyl-formamide at 80℃; for 5h;	99%

: 16234-14-3
2,4-dichlorothieno[3,2-d]pyrimidine

: 554-84-7
meta-nitrophenol

: 1353553-07-7
2-chloro-4-(3-nitrophenoxy)thieno[3,2-d]pyrimidine

Conditions

Conditions	Yield
With caesium carbonate In 1,4-dioxane at 20℃; for 4h;	98.7%
With caesium carbonate In N,N-dimethylsulfoneamide at 20℃; for 1h;	91.8%
With N-ethyl-N,N-diisopropylamine In 1,4-dioxane at 70℃;

: 554-84-7
meta-nitrophenol

substituted benzyl halide: substituted benzyl halide

: 1-chloro-3-((3-nitrophenoxy)methyl)benzene

Conditions

Conditions	Yield
With potassium carbonate; sodium iodide In acetone Reflux;	98.67%

3-Nitrophenol Chemical Properties

Molecular Structure of 3-Nitrophenol (CAS NO.554-84-7):

IUPAC Name: 3-nitrophenol
Empirical Formula: C₆H₅NO₃
Molecular Weight: 139.1088
EINECS: 209-073-5
Boiling Point: 277.6 °C at 760 mmHg
Flash Point: 126.9 °C
Index of Refraction: 1.612
Molar Refractivity: 34.67 cm³
Molar Volume: 99.7 cm³
Surface Tension: 60.2 dyne/cm
Density: 1.395 g/cm³
Enthalpy of Vaporization: 53.69 kJ/mol
Vapour Pressure: 0.00266 mmHg at 25°C
Water Solubility: 13.5 g/L (25°C )
Merck: 14,6619
BRN: 1907946
Melting point: 89-95 °C
Product Categories: Aromatic Phenols; Phenoles and thiophenoles; Analytical Chemistry; Indicator (pH); pH Indicators; Organic Building Blocks; Oxygen Compounds; Phenols; Essential Chemicals; Reagent Plus; Routine Reagents

3-Nitrophenol Toxicity Data With Reference

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
dog	LD50	intravenous	83mg/kg (83mg/kg)		"Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986Vol. -, Pg. 675, 1986.
frog	LDLo	subcutaneous	160mg/kg (160mg/kg)	BEHAVIORAL: TREMOR BEHAVIORAL: MUSCLE WEAKNESS BEHAVIORAL: ATAXIA	Revue Medicale de la Suisse Romande. Vol. 16, Pg. 449, 1896.
guinea pig	LDLo	subcutaneous	500mg/kg (500mg/kg)	BEHAVIORAL: MUSCLE WEAKNESS BEHAVIORAL: COMA	Revue Medicale de la Suisse Romande. Vol. 16, Pg. 449, 1896.
mammal (species unspecified)	LD50	oral	250mg/kg (250mg/kg)		Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 45(10), Pg. 16, 1980.
mammal (species unspecified)	LD50	skin	543mg/kg (543mg/kg)		Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 45(10), Pg. 16, 1980.
mouse	LD50	oral	1070mg/kg (1070mg/kg)		Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 25(8), Pg. 50, 1981.
mouse	LDLo	intraperitoneal	70mg/kg (70mg/kg)		Revue Belge de Pathologie et de Medecine Experimentale. Vol. 22, Pg. 1, 1952.
rat	LD50	oral	328mg/kg (328mg/kg)		Gigiena Truda i Professional'naya Patologiya v Estonskoi SSR. Labor Hygiene and Occupational Pathology in the Estonian SSR. Vol. 8, Pg. 145, 1972.
rat	LDLo	subcutaneous	500mg/kg (500mg/kg)	BEHAVIORAL: MUSCLE WEAKNESS BEHAVIORAL: COMA	Revue Medicale de la Suisse Romande. Vol. 16, Pg. 449, 1896.

3-Nitrophenol Consensus Reports

EPA Genetic Toxicology Program. Reported in EPA TSCA Inventory.

3-Nitrophenol Safety Profile

Poison by ingestion, subcutaneous, and intraperitoneal routes. Moderately toxic by skin contact. A skin and severe eye irritant. When heated to decomposition it emits toxic fumes of NO_x.
The Hazard Codes of 3-Nitrophenol (CAS NO.554-84-7): Harmful Xn,Xi
Hazard Note: Harmful/Irritant
HazardClass: 6.1
The Risk Statements information:
22: Harmful if swallowed
33: Danger of cumulative effects
38: Irritating to the skin
41: Risk of serious damage to eyes
20/21/22: Harmful by inhalation, in contact with skin and if swallowed
36/37/38: Irritating to eyes, respiratory system and skin
The Safety Statements information:
22: Do not breathe dust
26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
28: After contact with skin, wash immediately with plenty of ... (to be specified by the manufacturer)
45: In case of accident or if you feel unwell, seek medical advice immediately (show label where possible)
36/37: Wear suitable protective clothing and gloves
36/37/39: Wear suitable protective clothing, gloves and eye/face protection
RIDADR: UN 1663 6.1/PG 3
WGK Germany: 3
RTECS: SM1925000
F: 8
PackingGroup: III
HS Code: 29089000

3-Nitrophenol Standards and Recommendations

DOT Classification: 6.1; Label: KEEP AWAY FROM FOOD

3-Nitrophenol Specification

3-Nitrophenol , with CAS number of 554-84-7, can be called Phenol,m-nitro- (8CI) ; 1-Hydroxy-3-nitrobenzene ; 3-Hydroxynitrobenzene ; m-Hydroxynitrobenzene ; m-Nitrophenol . It is a yellow to brown crystalline powder, 3-Nitrophenol (CAS NO.554-84-7) is used as a medicine, dyes intermediates.

Product Name

3-Nitrophenol

Synthetic route

3-Nitrophenol Chemical Properties

3-Nitrophenol Toxicity Data With Reference

3-Nitrophenol Consensus Reports

3-Nitrophenol Safety Profile

3-Nitrophenol Standards and Recommendations

3-Nitrophenol Specification

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